Standard name | |
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Human Ortholog | |
Description | Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 1 | 2 | 0 | 2 |
Bud | 2 | 0 | 1 | 0 | 4 | 0 | 0 | – | 4 | 6 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 6 | 6 | 10 |
Bud Neck | 0 | 0 | 1 | 0 | 1 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 11 | 0 | 9 | 8 | 14 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 1 | 2 | 6 | 5 | – | 1 | 9 | 0 | 3 | 9 | 13 | 19 | 4 | 5 | 11 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 138 | 312 | 98 | 111 | 108 | 168 | 266 | – | 205 | 220 | 148 | 104 | 396 | 495 | 546 | 596 | 350 | 421 | 204 | 357 | 125 | 412 | 354 | 382 |
Endoplasmic Reticulum | 1 | 22 | 5 | 7 | 4 | 5 | 3 | – | 2 | 1 | 0 | 4 | 10 | 15 | 2 | 9 | 5 | 8 | 4 | 6 | 4 | 3 | 5 | 11 |
Endosome | 6 | 0 | 0 | 1 | 0 | 0 | 2 | – | 1 | 2 | 2 | 0 | 0 | 0 | 2 | 3 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 1 |
Golgi | 1 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 3 | 0 | 0 | 1 | 0 |
Mitochondria | 5 | 8 | 0 | 1 | 11 | 11 | 20 | – | 121 | 68 | 86 | 59 | 0 | 0 | 1 | 9 | 0 | 2 | 2 | 5 | 3 | 4 | 2 | 0 |
Nucleus | 6 | 11 | 3 | 6 | 6 | 11 | 10 | – | 3 | 1 | 3 | 7 | 5 | 17 | 3 | 82 | 78 | 75 | 14 | 18 | 1 | 13 | 10 | 10 |
Nuclear Periphery | 5 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 3 | 0 | 0 | 0 | 1 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 3 | 1 | 2 |
Vac/Vac Membrane | 53 | 36 | 6 | 30 | 7 | 28 | 31 | – | 19 | 12 | 7 | 7 | 32 | 29 | 36 | 85 | 85 | 89 | 29 | 21 | 4 | 20 | 16 | 9 |
Unique Cell Count | 196 | 369 | 109 | 146 | 133 | 214 | 317 | 283 | 279 | 216 | 162 | 428 | 527 | 570 | 709 | 454 | 532 | 277 | 438 | 149 | 484 | 417 | 454 | |
Labelled Cell Count | 220 | 390 | 115 | 157 | 145 | 229 | 339 | 356 | 321 | 252 | 189 | 452 | 569 | 609 | 788 | 526 | 608 | 277 | 438 | 149 | 484 | 417 | 454 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.2 | 7.0 | 6.3 | 7.9 | 6.1 | 6.5 | 5.8 | – | 4.4 | 4.7 | 4.4 | 4.2 | 9.2 | 9.0 | 7.9 | 8.6 | 10.8 | 10.7 | 8.9 | 9.3 | 9.2 |
Std Deviation (1e-4) | 1.2 | 1.0 | 1.1 | 1.2 | 1.7 | 1.1 | 1.1 | – | 1.0 | 1.2 | 1.1 | 0.7 | 1.4 | 1.3 | 1.4 | 1.6 | 2.2 | 2.3 | 1.7 | 1.6 | 1.5 |
Intensity Change (Log2) | – | – | – | 0.33 | -0.03 | 0.05 | -0.11 | – | -0.52 | -0.4 | -0.49 | -0.58 | 0.56 | 0.52 | 0.33 | 0.46 | 0.79 | 0.78 | 0.51 | 0.57 | 0.56 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -2.9 | -1.9 | -2.5 | -1.5 | – | -3.7 | -2.5 | -4.2 | -4.8 | 0.9 | 1.5 | 2.5 | -1.6 | -3.0 | -2.6 |
Endoplasmic Reticulum | 0.1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 2.7 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.8 | 3.9 | 3.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 3.4 | -0.1 | 2.1 | 1.4 | – | 0.4 | -0.5 | 0 | -0.4 | 0.7 | 0 | 0.3 | 2.0 | 3.4 | 3.0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 6.4559 | 6.5966 | 6.4854 | 6.1022 | 5.9511 | 6.6761 | 4.9412 | 6.154 | 5.7454 | 5.7328 | 4.8738 | 5.4625 | 2.0657 | 3.6897 | 3.2767 | 2.7916 | 3.2332 | 3.0571 |
Actin | 0.0505 | 0.0117 | 0.0192 | 0.0078 | 0.0396 | 0.0009 | 0.0281 | 0.0011 | 0.01 | 0.002 | 0.0008 | 0.0006 | 0.0038 | 0.0009 | 0.0215 | 0.0012 | 0.0089 | 0.0021 |
Bud | 0.001 | 0.0002 | 0.0008 | 0.0002 | 0.0003 | 0.0001 | 0.0015 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0006 | 0.0002 | 0.0003 | 0.0001 | 0.0006 | 0.0002 |
Bud Neck | 0.0029 | 0.0015 | 0.0027 | 0.0018 | 0.0033 | 0.003 | 0.0017 | 0.0009 | 0.0007 | 0.0008 | 0.0019 | 0.0031 | 0.0009 | 0.0005 | 0.0011 | 0.0017 | 0.0108 | 0.0035 |
Bud Periphery | 0.0013 | 0.0002 | 0.0007 | 0.0002 | 0.0004 | 0.0001 | 0.0036 | 0 | 0.0006 | 0 | 0 | 0 | 0.0008 | 0.0001 | 0.0003 | 0 | 0.0008 | 0.0002 |
Bud Site | 0.0053 | 0.0048 | 0.0025 | 0.0013 | 0.0007 | 0.0002 | 0.0032 | 0.0015 | 0.0015 | 0.0003 | 0.0001 | 0.0002 | 0.0118 | 0.0022 | 0.005 | 0.0003 | 0.0095 | 0.0005 |
Cell Periphery | 0.0004 | 0.0007 | 0.0004 | 0.0005 | 0.0003 | 0.0001 | 0.0008 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0005 | 0.0002 | 0.0003 | 0.0001 | 0.0004 | 0.0001 |
Cytoplasm | 0.7531 | 0.8584 | 0.8404 | 0.7748 | 0.7409 | 0.881 | 0.7568 | 0.8395 | 0.7391 | 0.8479 | 0.7947 | 0.8503 | 0.6519 | 0.9289 | 0.7968 | 0.8889 | 0.6923 | 0.8717 |
Cytoplasmic Foci | 0.0158 | 0.0087 | 0.0086 | 0.0068 | 0.0159 | 0.0035 | 0.0115 | 0.0032 | 0.0065 | 0.0037 | 0.0027 | 0.0042 | 0.0381 | 0.0021 | 0.0073 | 0.0024 | 0.0144 | 0.0063 |
Eisosomes | 0.0003 | 0.0007 | 0.0001 | 0.0005 | 0.0005 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0 | 0 | 0.0004 | 0 | 0.0002 | 0 | 0.0002 | 0 |
Endoplasmic Reticulum | 0.0152 | 0.0055 | 0.0098 | 0.0101 | 0.0082 | 0.009 | 0.0277 | 0.0191 | 0.0102 | 0.0154 | 0.0056 | 0.0071 | 0.0145 | 0.0051 | 0.0118 | 0.0056 | 0.0064 | 0.0075 |
Endosome | 0.024 | 0.002 | 0.0038 | 0.0024 | 0.0045 | 0.0043 | 0.027 | 0.0013 | 0.0073 | 0.0024 | 0.001 | 0.0028 | 0.0285 | 0.0006 | 0.0046 | 0.0007 | 0.0233 | 0.0042 |
Golgi | 0.008 | 0.0005 | 0.0017 | 0.0024 | 0.0035 | 0.0054 | 0.0054 | 0.0001 | 0.0065 | 0.0002 | 0.0001 | 0.0002 | 0.0037 | 0.0001 | 0.0074 | 0.0001 | 0.0306 | 0.003 |
Lipid Particles | 0.0082 | 0.0004 | 0.0012 | 0.0037 | 0.0028 | 0.0008 | 0.0031 | 0.0002 | 0.0012 | 0.0002 | 0.0001 | 0.0001 | 0.0103 | 0.0001 | 0.005 | 0.0001 | 0.0421 | 0.0015 |
Mitochondria | 0.0032 | 0.0002 | 0.002 | 0.017 | 0.0015 | 0.0017 | 0.0046 | 0.0001 | 0.0211 | 0.0003 | 0.0002 | 0.0003 | 0.0445 | 0.0001 | 0.0048 | 0.0001 | 0.0636 | 0.0045 |
None | 0.0622 | 0.0534 | 0.057 | 0.1173 | 0.1451 | 0.0457 | 0.0709 | 0.0534 | 0.1428 | 0.0929 | 0.131 | 0.0634 | 0.0742 | 0.0322 | 0.0714 | 0.0434 | 0.0072 | 0.0397 |
Nuclear Periphery | 0.0216 | 0.0026 | 0.0043 | 0.0034 | 0.0024 | 0.003 | 0.0126 | 0.0032 | 0.0039 | 0.0076 | 0.0024 | 0.0028 | 0.0086 | 0.0021 | 0.0071 | 0.0029 | 0.0052 | 0.0028 |
Nucleolus | 0.0003 | 0.0002 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0049 | 0.0001 | 0.0001 | 0.0001 | 0.0034 | 0.0001 |
Nucleus | 0.0105 | 0.0442 | 0.0301 | 0.0248 | 0.0136 | 0.0377 | 0.0178 | 0.071 | 0.0435 | 0.022 | 0.0551 | 0.0616 | 0.0587 | 0.0218 | 0.0456 | 0.0481 | 0.0457 | 0.0467 |
Peroxisomes | 0.009 | 0.0005 | 0.0048 | 0.0214 | 0.0123 | 0.0001 | 0.0013 | 0.0001 | 0.0009 | 0.0001 | 0 | 0.0002 | 0.0323 | 0.0001 | 0.0043 | 0 | 0.0067 | 0.0027 |
Punctate Nuclear | 0.0036 | 0.0024 | 0.008 | 0.0026 | 0.0033 | 0.0025 | 0.0044 | 0.0038 | 0.0022 | 0.0024 | 0.0039 | 0.0019 | 0.0071 | 0.002 | 0.0042 | 0.0037 | 0.0239 | 0.0015 |
Vacuole | 0.0024 | 0.0011 | 0.0014 | 0.0007 | 0.0006 | 0.0008 | 0.0161 | 0.001 | 0.0008 | 0.0013 | 0.0003 | 0.0006 | 0.0024 | 0.0005 | 0.0007 | 0.0004 | 0.003 | 0.0011 |
Vacuole Periphery | 0.0013 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0014 | 0 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0013 | 0 | 0.0002 | 0.0001 | 0.001 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 35.4427 | 38.2594 | 37.2621 | 42.296 | 33.8145 | 24.061 | 45.0307 | 48.1387 | 44.5064 | 33.8465 |
Translational Efficiency | 1.4393 | 1.7388 | 1.5386 | 1.4976 | 1.2733 | 2.7584 | 1.3475 | 2.004 | 1.7298 | 1.364 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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