Standard name | |
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Human Ortholog | |
Description | Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 5 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 2 | 4 | 4 | 5 | 13 | 2 | 0 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 157 | 106 | 36 | 82 | 108 | 138 | 159 | 246 | 97 | 134 | 77 | 130 | 216 | 304 | 340 | 250 | 178 | 113 | 149 | 94 | 65 | 173 | 203 | 125 |
Endoplasmic Reticulum | 2 | 0 | 0 | 0 | 1 | 3 | 8 | 16 | 2 | 11 | 2 | 4 | 3 | 1 | 2 | 3 | 5 | 3 | 1 | 0 | 0 | 2 | 3 | 5 |
Endosome | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 8 | 3 | 2 | 0 | 0 | 0 | 0 | 6 | 17 |
Golgi | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 9 | 8 | 3 | 1 | 0 | 0 | 0 | 4 | 17 |
Mitochondria | 2 | 0 | 0 | 3 | 3 | 1 | 10 | 12 | 13 | 20 | 22 | 40 | 0 | 1 | 1 | 4 | 4 | 3 | 1 | 0 | 0 | 0 | 1 | 0 |
Nucleus | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 6 | 6 | 4 | 3 | 5 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5 |
Vac/Vac Membrane | 0 | 1 | 0 | 2 | 2 | 1 | 5 | 13 | 3 | 9 | 4 | 19 | 1 | 2 | 5 | 31 | 16 | 7 | 0 | 4 | 1 | 0 | 2 | 7 |
Unique Cell Count | 161 | 106 | 36 | 85 | 114 | 143 | 181 | 282 | 123 | 175 | 106 | 188 | 220 | 308 | 350 | 302 | 201 | 124 | 157 | 102 | 71 | 181 | 233 | 200 |
Labelled Cell Count | 166 | 107 | 36 | 87 | 118 | 144 | 192 | 300 | 128 | 185 | 115 | 213 | 223 | 308 | 355 | 320 | 219 | 137 | 157 | 102 | 71 | 181 | 233 | 200 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 16.4 | 15.9 | 14.3 | 16.1 | 18.1 | 16.3 | 12.7 | 11.6 | 11.3 | 9.7 | 9.4 | 8.7 | 21.7 | 19.0 | 16.4 | 20.5 | 22.4 | 25.9 | 17.4 | 15.5 | 15.3 |
Std Deviation (1e-4) | 3.4 | 4.2 | 2.6 | 5.0 | 5.6 | 4.2 | 3.9 | 3.4 | 2.6 | 2.2 | 2.3 | 2.1 | 4.9 | 4.4 | 3.8 | 5.4 | 5.6 | 7.3 | 3.5 | 3.3 | 3.0 |
Intensity Change (Log2) | – | – | – | 0.17 | 0.34 | 0.18 | -0.17 | -0.3 | -0.34 | -0.56 | -0.61 | -0.71 | 0.6 | 0.41 | 0.2 | 0.52 | 0.65 | 0.86 | 0.28 | 0.12 | 0.1 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.1 | -1.4 | -1.1 | -2.2 | -2.3 | -3.0 | -3.2 | -3.5 | -3.9 | -0.8 | -0.7 | -1.0 | -2.7 | -2.1 | -1.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 19.8764 | 27.6844 | 23.7162 | 24.4965 | 22.8656 | 25.4811 | 16.445 | 22.3777 | 17.8079 | 16.6245 | 16.4993 | 18.6846 | 22.3961 | 31.3686 | 24.8372 | 22.1463 | 23.8482 | 24.9291 |
Actin | 0.0434 | 0.0153 | 0.0211 | 0.0351 | 0.003 | 0.0101 | 0.0274 | 0.0053 | 0.0277 | 0.022 | 0.0397 | 0.012 | 0.0344 | 0.0275 | 0.0371 | 0.0223 | 0.0055 | 0.0072 |
Bud | 0.0023 | 0.003 | 0.0043 | 0.0025 | 0.0039 | 0.0038 | 0.0015 | 0.002 | 0.0053 | 0.003 | 0.0076 | 0.0011 | 0.006 | 0.0016 | 0.0029 | 0.0177 | 0.0031 | 0.0015 |
Bud Neck | 0.0022 | 0.0018 | 0.0043 | 0.0019 | 0.0038 | 0.0152 | 0.0034 | 0.0018 | 0.0027 | 0.0023 | 0.0024 | 0.0068 | 0.0031 | 0.0012 | 0.0018 | 0.0043 | 0.0033 | 0.008 |
Bud Periphery | 0.0017 | 0.0018 | 0.0026 | 0.0009 | 0.0025 | 0.003 | 0.0009 | 0.0006 | 0.003 | 0.0005 | 0.0036 | 0.0004 | 0.0031 | 0.0005 | 0.0009 | 0.0138 | 0.0007 | 0.001 |
Bud Site | 0.0026 | 0.0103 | 0.0054 | 0.0014 | 0.0006 | 0.0014 | 0.0074 | 0.0098 | 0.013 | 0.001 | 0.0021 | 0.0005 | 0.0036 | 0.0025 | 0.0041 | 0.0017 | 0.0004 | 0.0003 |
Cell Periphery | 0.0008 | 0.0006 | 0.0007 | 0.0004 | 0.0004 | 0.0004 | 0.0003 | 0.0002 | 0.0006 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0001 | 0.0004 | 0.0006 | 0.0002 | 0.0001 |
Cytoplasm | 0.6889 | 0.8987 | 0.8164 | 0.8561 | 0.868 | 0.8131 | 0.7122 | 0.9366 | 0.8257 | 0.8635 | 0.8005 | 0.7854 | 0.7501 | 0.9221 | 0.8544 | 0.8566 | 0.8847 | 0.8528 |
Cytoplasmic Foci | 0.015 | 0.0185 | 0.0226 | 0.0226 | 0.0094 | 0.017 | 0.0672 | 0.0184 | 0.0278 | 0.0446 | 0.0371 | 0.0516 | 0.0245 | 0.0109 | 0.022 | 0.0233 | 0.0271 | 0.0243 |
Eisosomes | 0.0006 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0234 | 0.004 | 0.0121 | 0.0164 | 0.0067 | 0.0137 | 0.0224 | 0.002 | 0.0059 | 0.0034 | 0.0123 | 0.0085 | 0.0312 | 0.0021 | 0.0058 | 0.0084 | 0.0157 | 0.0099 |
Endosome | 0.0469 | 0.0121 | 0.0356 | 0.0215 | 0.0219 | 0.0398 | 0.0818 | 0.0103 | 0.0228 | 0.0274 | 0.0358 | 0.0743 | 0.0354 | 0.0133 | 0.0173 | 0.0148 | 0.0222 | 0.0356 |
Golgi | 0.0135 | 0.0046 | 0.0126 | 0.0096 | 0.0013 | 0.0054 | 0.0248 | 0.0037 | 0.0102 | 0.015 | 0.0224 | 0.0194 | 0.0071 | 0.0032 | 0.0131 | 0.0035 | 0.0028 | 0.0101 |
Lipid Particles | 0.0057 | 0.0004 | 0.0023 | 0.0055 | 0.0003 | 0.0063 | 0.0057 | 0.0002 | 0.0061 | 0.0002 | 0.0011 | 0.0047 | 0.0017 | 0.0001 | 0.0042 | 0.0007 | 0.0054 | 0.0002 |
Mitochondria | 0.0251 | 0.0059 | 0.0155 | 0.0053 | 0.0031 | 0.0046 | 0.0143 | 0.0018 | 0.0209 | 0.0032 | 0.0211 | 0.0138 | 0.0089 | 0.002 | 0.0042 | 0.0067 | 0.0019 | 0.0055 |
None | 0.0077 | 0.0005 | 0.0013 | 0.0007 | 0.001 | 0.0006 | 0.0021 | 0.0003 | 0.0005 | 0.0007 | 0.001 | 0.0007 | 0.0033 | 0.0003 | 0.0031 | 0.0023 | 0.0044 | 0.0007 |
Nuclear Periphery | 0.0427 | 0.0044 | 0.0159 | 0.0043 | 0.0168 | 0.0205 | 0.0065 | 0.0006 | 0.0022 | 0.0012 | 0.002 | 0.002 | 0.0361 | 0.0035 | 0.0057 | 0.0046 | 0.0097 | 0.0112 |
Nucleolus | 0.0014 | 0.0002 | 0.0007 | 0.0001 | 0.0009 | 0.0002 | 0.0001 | 0.0002 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0004 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0002 |
Nucleus | 0.0273 | 0.0055 | 0.0102 | 0.0053 | 0.0292 | 0.0179 | 0.0056 | 0.0017 | 0.0023 | 0.0026 | 0.0041 | 0.0037 | 0.0297 | 0.0045 | 0.0053 | 0.0082 | 0.0041 | 0.0149 |
Peroxisomes | 0.0021 | 0.0019 | 0.0022 | 0.0025 | 0.0005 | 0.0024 | 0.0057 | 0.0021 | 0.0068 | 0.0075 | 0.0031 | 0.0068 | 0.0025 | 0.0013 | 0.0085 | 0.0052 | 0.0017 | 0.0018 |
Punctate Nuclear | 0.0113 | 0.0004 | 0.0014 | 0.0012 | 0.0013 | 0.0012 | 0.0014 | 0.0002 | 0.006 | 0.0003 | 0.0004 | 0.0021 | 0.0062 | 0.0002 | 0.0023 | 0.0007 | 0.0024 | 0.0007 |
Vacuole | 0.026 | 0.0085 | 0.0081 | 0.0045 | 0.0165 | 0.015 | 0.0063 | 0.0016 | 0.0078 | 0.0009 | 0.0023 | 0.0036 | 0.0081 | 0.0024 | 0.0052 | 0.0033 | 0.0031 | 0.0093 |
Vacuole Periphery | 0.0094 | 0.0018 | 0.0045 | 0.0018 | 0.009 | 0.0083 | 0.0026 | 0.0006 | 0.0022 | 0.0006 | 0.0012 | 0.0022 | 0.0042 | 0.0006 | 0.0014 | 0.0013 | 0.0015 | 0.0045 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 156.0125 | 126.4585 | 115.2863 | 140.4903 | 117.3836 | 150.2708 | 151.6079 | 150.4055 | 155.4765 | 142.7239 |
Translational Efficiency | 1.2314 | 1.4363 | 1.3935 | 1.1152 | 1.2426 | 1.3849 | 1.2511 | 1.263 | 1.4794 | 1.352 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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