Standard name | |
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Human Ortholog | |
Description | NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 1 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 6 | 3 | 3 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 5 | 5 | 5 | 9 | 10 | 7 | 12 | 14 | 14 | 7 | 9 | 3 | 3 | 12 | 37 | 13 | 9 | 11 | 0 | 0 | 0 | 0 | 2 | 1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 2 | 0 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 |
Mitochondria | 4 | 26 | 0 | 0 | 2 | 5 | 6 | 11 | 62 | 41 | 27 | 26 | 1 | 1 | 2 | 5 | 3 | 2 | 0 | 4 | 2 | 0 | 0 | 3 |
Nucleus | 137 | 338 | 176 | 137 | 184 | 199 | 234 | 289 | 252 | 259 | 173 | 217 | 108 | 156 | 263 | 244 | 357 | 207 | 150 | 347 | 181 | 89 | 181 | 131 |
Nuclear Periphery | 0 | 2 | 0 | 0 | 3 | 1 | 1 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 6 | 5 | 1 | 2 | 5 | 6 | 5 | 11 | 37 | 30 | 23 | 30 | 5 | 0 | 1 | 5 | 8 | 7 | 0 | 0 | 1 | 0 | 3 | 9 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 4 | 2 | 1 | 0 | 1 | 3 | 6 | 4 | 3 | 0 | 3 | 0 | 0 | 2 | 9 | 3 | 2 | 3 | 5 | 4 | 4 | 18 | 35 |
Unique Cell Count | 147 | 355 | 184 | 147 | 196 | 209 | 253 | 313 | 300 | 298 | 196 | 244 | 113 | 169 | 305 | 267 | 375 | 226 | 162 | 368 | 196 | 99 | 213 | 189 |
Labelled Cell Count | 154 | 381 | 184 | 151 | 207 | 219 | 261 | 335 | 378 | 348 | 236 | 284 | 117 | 169 | 307 | 282 | 385 | 236 | 162 | 368 | 196 | 99 | 213 | 189 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 8.4 | 6.6 | 8.5 | 8.1 | 8.5 | 7.0 | 6.6 | 6.9 | 5.7 | 6.0 | 5.8 | 5.9 | 7.1 | 7.9 | 8.0 | 10.0 | 12.4 | 12.9 | 8.5 | 9.0 | 8.6 |
Std Deviation (1e-4) | 2.6 | 1.2 | 1.4 | 1.6 | 2.0 | 1.7 | 1.6 | 1.6 | 1.5 | 1.2 | 1.5 | 1.4 | 1.8 | 1.8 | 2.1 | 2.4 | 3.1 | 4.1 | 1.5 | 1.9 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.08 | -0.0 | -0.29 | -0.37 | -0.31 | -0.59 | -0.52 | -0.56 | -0.52 | -0.27 | -0.1 | -0.1 | 0.23 | 0.53 | 0.6 | -0.0 | 0.07 | 0.02 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.5 | 1.2 | 0.4 | 1.1 | 1.0 | 1.1 | 0 | 1.0 | 0 | 0 | 1.9 | 3.6 | 1.1 | 0 | 1.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 6.6 | 5.3 | 5.2 | 4.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -1.0 | -0.8 | -0.2 | -1.4 | -1.5 | -3.9 | -3.1 | -2.6 | -2.5 | 0 | -1.3 | -3.3 | -1.8 | -0.2 | -1.6 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 4.7 | 4.1 | 4.5 | 4.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 6.1233 | 7.5513 | 6.4417 | 6.2142 | 6.0536 | 6.8366 | 10.1834 | 9.1268 | 7.4032 | 6.611 | 5.927 | 7.4579 | 3.9644 | 4.7771 | 4.1202 | 4.3674 | 4.2654 | 4.0335 |
Actin | 0.0049 | 0 | 0.0201 | 0.0301 | 0.0002 | 0.0001 | 0.002 | 0 | 0.0137 | 0.0438 | 0.0371 | 0.002 | 0.0489 | 0 | 0.0136 | 0.0019 | 0.0007 | 0.0039 |
Bud | 0.0003 | 0 | 0.0001 | 0.0008 | 0.0002 | 0.0001 | 0.0003 | 0 | 0.0005 | 0 | 0.0005 | 0.0003 | 0.0003 | 0 | 0.0003 | 0.0001 | 0 | 0.0001 |
Bud Neck | 0.0022 | 0 | 0.0003 | 0.008 | 0.0002 | 0.0007 | 0.001 | 0 | 0.0002 | 0.0002 | 0.0005 | 0.0007 | 0.0027 | 0 | 0.0004 | 0.0002 | 0.0001 | 0.0003 |
Bud Periphery | 0.0004 | 0 | 0.0003 | 0.0015 | 0.0002 | 0.0002 | 0.0006 | 0 | 0.0005 | 0 | 0.0015 | 0.0004 | 0.0004 | 0 | 0.0005 | 0.0001 | 0 | 0.0003 |
Bud Site | 0.0029 | 0 | 0.0008 | 0.0056 | 0.0015 | 0.0001 | 0.0036 | 0 | 0.0048 | 0.0002 | 0.0012 | 0.0006 | 0.0018 | 0 | 0.0018 | 0.0002 | 0 | 0.0005 |
Cell Periphery | 0.0002 | 0 | 0.0001 | 0.001 | 0.0001 | 0 | 0.0033 | 0 | 0.0001 | 0 | 0.0012 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0.0001 |
Cytoplasm | 0.0022 | 0 | 0.0018 | 0.0012 | 0.0008 | 0.0001 | 0.0265 | 0 | 0.0026 | 0.0001 | 0.0184 | 0.0004 | 0.0024 | 0 | 0.0009 | 0.0003 | 0 | 0.0001 |
Cytoplasmic Foci | 0.0111 | 0 | 0.0061 | 0.0148 | 0.01 | 0 | 0.0115 | 0 | 0.0051 | 0.0039 | 0.0276 | 0.0008 | 0.0196 | 0 | 0.0055 | 0.0027 | 0.0009 | 0.001 |
Eisosomes | 0.0001 | 0 | 0.0005 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0004 | 0 | 0.0002 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0014 | 0 | 0.0009 | 0.0018 | 0.0003 | 0 | 0.0084 | 0 | 0.0037 | 0.0001 | 0.0094 | 0.0005 | 0.0028 | 0 | 0.0028 | 0.0004 | 0 | 0.0001 |
Endosome | 0.0072 | 0 | 0.0043 | 0.0221 | 0.0787 | 0.0001 | 0.0227 | 0 | 0.0047 | 0.0005 | 0.0342 | 0.0033 | 0.0123 | 0 | 0.0043 | 0.0034 | 0.0004 | 0.004 |
Golgi | 0.0026 | 0 | 0.0016 | 0.008 | 0.0118 | 0 | 0.0021 | 0 | 0.0019 | 0.0019 | 0.0088 | 0.0009 | 0.0048 | 0 | 0.0033 | 0.0044 | 0.0016 | 0.0016 |
Lipid Particles | 0.0085 | 0 | 0.0057 | 0.0322 | 0.0059 | 0 | 0.0209 | 0 | 0.0013 | 0.0039 | 0.0156 | 0.0012 | 0.0098 | 0 | 0.0048 | 0.0142 | 0.0313 | 0.0039 |
Mitochondria | 0.0032 | 0.0002 | 0.0007 | 0.0062 | 0.0034 | 0.0014 | 0.0044 | 0.0001 | 0.0016 | 0.0002 | 0.0136 | 0.0027 | 0.0012 | 0.0001 | 0.0029 | 0.0059 | 0.0019 | 0.0019 |
None | 0.0037 | 0 | 0.0111 | 0.001 | 0.0001 | 0 | 0.0076 | 0 | 0.0016 | 0.0002 | 0.022 | 0.0001 | 0.0035 | 0 | 0.0024 | 0.0002 | 0 | 0.0002 |
Nuclear Periphery | 0.0098 | 0.0011 | 0.0021 | 0.0061 | 0.0018 | 0.0006 | 0.0352 | 0.0003 | 0.0098 | 0.0002 | 0.0339 | 0.0026 | 0.0106 | 0.0005 | 0.0064 | 0.0095 | 0.002 | 0.0005 |
Nucleolus | 0.0079 | 0.0038 | 0.0055 | 0.0039 | 0.0185 | 0.024 | 0.0174 | 0.0025 | 0.0034 | 0.0135 | 0.0356 | 0.0181 | 0.0086 | 0.0049 | 0.0051 | 0.0077 | 0.0226 | 0.0121 |
Nucleus | 0.9032 | 0.9947 | 0.9305 | 0.8321 | 0.8546 | 0.972 | 0.808 | 0.997 | 0.9353 | 0.9195 | 0.7091 | 0.9627 | 0.8348 | 0.9944 | 0.937 | 0.9342 | 0.9247 | 0.9646 |
Peroxisomes | 0.0117 | 0 | 0.0044 | 0.0023 | 0.0019 | 0 | 0.0013 | 0 | 0.0007 | 0.011 | 0.0133 | 0.0009 | 0.0065 | 0 | 0.0018 | 0.0055 | 0.013 | 0.0026 |
Punctate Nuclear | 0.0148 | 0.0001 | 0.0025 | 0.003 | 0.0008 | 0.0001 | 0.0102 | 0 | 0.0076 | 0.0005 | 0.0032 | 0.0006 | 0.026 | 0 | 0.0033 | 0.0082 | 0.0005 | 0.001 |
Vacuole | 0.001 | 0 | 0.0002 | 0.0148 | 0.0069 | 0.0002 | 0.0093 | 0 | 0.0003 | 0 | 0.0083 | 0.0007 | 0.0015 | 0 | 0.0009 | 0.0003 | 0 | 0.0009 |
Vacuole Periphery | 0.0007 | 0.0001 | 0.0002 | 0.0032 | 0.002 | 0.0002 | 0.0036 | 0 | 0.0003 | 0 | 0.0047 | 0.0005 | 0.0008 | 0 | 0.0014 | 0.0004 | 0.0001 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 24.2888 | 29.7774 | 47.8749 | 25.6868 | 34.1907 | 20.8074 | 31.9896 | 22.4375 | 33.1478 | 28.704 |
Translational Efficiency | 1.6687 | 1.384 | 0.7554 | 1.7496 | 1.318 | 1.8081 | 1.1299 | 1.5255 | 1.1971 | 1.4671 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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