Standard name | |
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Human Ortholog | |
Description | AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 7 | 17 | 8 | 2 | 1 | 1 | 0 | 10 | – | 4 | 7 | 10 | 16 | 59 | 28 | – | – | – | 4 | 8 | 9 | 5 | 26 | 41 |
Bud | 20 | 20 | 29 | 31 | 44 | 58 | 96 | 124 | – | 101 | 56 | 74 | 11 | 29 | 10 | – | – | – | 1 | 0 | 2 | 3 | 2 | 3 |
Bud Neck | 1 | 0 | 1 | 0 | 1 | 1 | 3 | 6 | – | 2 | 3 | 1 | 3 | 6 | 1 | – | – | – | 1 | 2 | 2 | 0 | 2 | 3 |
Bud Site | 7 | 5 | 19 | 10 | 18 | 28 | 35 | 38 | – | 41 | 29 | 37 | 7 | 8 | 1 | – | – | – | – | – | – | – | – | – |
Cell Periphery | 1 | 2 | 1 | 0 | 2 | 1 | 5 | 1 | – | 1 | 1 | 1 | 1 | 2 | 1 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 4 | 4 | 17 | 16 | 10 | 15 | 23 | 32 | – | 18 | 14 | 17 | 1 | 13 | 10 | – | – | – | 0 | 0 | 0 | 1 | 1 | 2 |
Endoplasmic Reticulum | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1 | – | 1 | 0 | 1 | 0 | 4 | 5 | – | – | – | 0 | 0 | 2 | 1 | 3 | 6 |
Endosome | 27 | 1 | 35 | 20 | 47 | 41 | 68 | 65 | – | 23 | 13 | 47 | 5 | 20 | 37 | – | – | – | 29 | 21 | 44 | 18 | 24 | 22 |
Golgi | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 7 | 18 | – | – | – | 2 | 6 | 6 | 2 | 6 | 8 |
Mitochondria | 156 | 130 | 164 | 97 | 131 | 253 | 371 | 279 | – | 349 | 273 | 316 | 40 | 33 | 10 | – | – | – | 6 | 7 | 13 | 5 | 17 | 9 |
Nucleus | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 8 | – | 0 | 0 | 2 | 0 | 1 | 1 | – | – | – | 0 | 0 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 2 | 3 | 5 | 1 | 2 | 5 | 4 | 1 | – | 5 | 1 | 3 | 1 | 2 | 0 | – | – | – | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleolus | 5 | 3 | 6 | 2 | 11 | 11 | 16 | 19 | – | 9 | 10 | 13 | 0 | 1 | 4 | – | – | – | 0 | 1 | 0 | 0 | 0 | 0 |
Peroxisomes | 211 | 58 | 282 | 213 | 304 | 316 | 522 | 403 | – | 313 | 210 | 286 | 59 | 84 | 101 | – | – | – | 246 | 98 | 285 | 132 | 313 | 281 |
SpindlePole | 46 | 4 | 86 | 57 | 124 | 112 | 213 | 252 | – | 144 | 120 | 150 | 59 | 84 | 68 | – | – | – | 5 | 5 | 23 | 11 | 9 | 5 |
Vac/Vac Membrane | 1 | 0 | 1 | 1 | 4 | 0 | 3 | 1 | – | 0 | 4 | 8 | 2 | 2 | 2 | – | – | – | 0 | 1 | 0 | 1 | 1 | 2 |
Unique Cell Count | 285 | 148 | 389 | 278 | 406 | 503 | 808 | 764 | 615 | 464 | 587 | 137 | 220 | 220 | 300 | 156 | 397 | 190 | 413 | 394 | ||||
Labelled Cell Count | 490 | 250 | 655 | 450 | 702 | 844 | 1361 | 1240 | 1011 | 741 | 966 | 206 | 355 | 297 | 300 | 156 | 397 | 190 | 413 | 394 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.5 | 5.0 | 4.9 | 5.0 | 4.7 | 4.1 | 4.0 | 4.1 | – | 3.6 | 3.7 | 3.7 | 5.9 | 5.9 | 6.5 | 3.4 | 3.9 | 4.8 | 6.3 | 6.4 | 7.0 |
Std Deviation (1e-4) | 0.9 | 1.0 | 1.3 | 1.5 | 1.5 | 1.6 | 1.3 | 1.5 | – | 1.0 | 1.0 | 1.0 | 0.8 | 1.0 | 0.9 | 0.7 | 0.7 | 0.9 | 1.5 | 1.5 | 2.0 |
Intensity Change (Log2) | – | – | – | 0.04 | -0.05 | -0.25 | -0.3 | -0.26 | – | -0.46 | -0.42 | -0.39 | 0.26 | 0.25 | 0.4 | -0.52 | -0.32 | -0.03 | 0.36 | 0.38 | 0.5 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 4.6 | 9.4 | 5.4 | – | – | – |
Bud | 1.6 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0.2 | 2.3 | -1.4 | – | – | – |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud Site | -0.8 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0.1 | -0.7 | -2.9 | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Cytoplasm | 0.8 | -1.5 | -1.1 | -1.4 | -0.1 | – | -1.2 | -1.1 | -1.2 | 0 | 0.8 | 0.1 | – | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Endosome | -0.8 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | -2.0 | 0 | 2.9 | – | – | – |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 5.7 | – | – | – |
Mitochondria | -1.9 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | -2.7 | -6.9 | -9.9 | – | – | – |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Peroxisomes | 1.2 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | -6.2 | -8.3 | -6.5 | – | – | – |
SpindlePole | -0.5 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 4.7 | 4.2 | 2.4 | – | – | – |
Vacuole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | 0.0554 | 0.0291 | 0.0498 | 0.0234 | 0.0262 | 0.0189 | 0.0307 | 0.0509 | 0.0451 | 0.0444 | 0.0302 | 0.0212 | 0.1112 | 0.0079 | 0.1152 | 0.0098 | 0.0009 | 0.0066 |
Bud | 0.001 | 0.001 | 0.001 | 0.0061 | 0.0003 | 0.0001 | 0.0003 | 0.0002 | 0.0014 | 0.0001 | 0.0005 | 0.0001 | 0.0005 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0001 |
Bud Neck | 0.0018 | 0.0007 | 0.0059 | 0.0006 | 0.0008 | 0.0009 | 0.0014 | 0.0065 | 0.0063 | 0.0082 | 0.0003 | 0.0008 | 0.0008 | 0 | 0.0004 | 0.0775 | 0.0006 | 0.0013 |
Bud Periphery | 0.0013 | 0.001 | 0.0015 | 0.0031 | 0.0004 | 0.0002 | 0.0003 | 0.0001 | 0.0022 | 0.0001 | 0.0005 | 0.0001 | 0.0005 | 0 | 0.0004 | 0.0001 | 0.0001 | 0.0001 |
Bud Site | 0.0069 | 0.0198 | 0.0067 | 0.0029 | 0.0009 | 0.0006 | 0.0058 | 0.019 | 0.01 | 0.0012 | 0.0078 | 0.0005 | 0.0045 | 0.0002 | 0.0008 | 0.0035 | 0.0003 | 0.0003 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 |
Cytoplasm | 0.0105 | 0.0027 | 0.0004 | 0.0037 | 0.0007 | 0.0007 | 0.0056 | 0.0001 | 0.0003 | 0.0002 | 0.0004 | 0.0002 | 0.0009 | 0 | 0.0003 | 0.0001 | 0.0032 | 0.0001 |
Cytoplasmic Foci | 0.1164 | 0.1594 | 0.1004 | 0.0777 | 0.1251 | 0.0994 | 0.1077 | 0.1082 | 0.1051 | 0.0974 | 0.1128 | 0.108 | 0.1704 | 0.0337 | 0.164 | 0.0775 | 0.4258 | 0.188 |
Eisosomes | 0.0002 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0007 | 0 | 0.0001 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0031 | 0.0002 | 0 | 0.0013 | 0.0011 | 0.0002 | 0.0025 | 0 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0004 | 0 | 0 | 0 | 0.0001 | 0 |
Endosome | 0.0416 | 0.0228 | 0.0139 | 0.0223 | 0.0532 | 0.0107 | 0.0162 | 0.002 | 0.0076 | 0.0062 | 0.0112 | 0.0103 | 0.0298 | 0 | 0.0151 | 0.0014 | 0.1182 | 0.0053 |
Golgi | 0.0285 | 0.0275 | 0.0264 | 0.0229 | 0.0656 | 0.0178 | 0.0172 | 0.0098 | 0.0121 | 0.0233 | 0.0121 | 0.0192 | 0.0489 | 0.0011 | 0.054 | 0.0072 | 0.0179 | 0.0119 |
Lipid Particles | 0.0629 | 0.029 | 0.0491 | 0.0562 | 0.078 | 0.0764 | 0.0407 | 0.0274 | 0.0252 | 0.0743 | 0.0414 | 0.0589 | 0.1499 | 0.0028 | 0.011 | 0.0225 | 0.0345 | 0.1209 |
Mitochondria | 0.0145 | 0.0112 | 0.008 | 0.0401 | 0.0124 | 0.0069 | 0.003 | 0.006 | 0.0102 | 0.0039 | 0.0427 | 0.0091 | 0.0073 | 0.0024 | 0.0292 | 0.0025 | 0.0071 | 0.0019 |
None | 0.0036 | 0.0045 | 0.0008 | 0.0026 | 0.0003 | 0.0006 | 0.0141 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0002 | 0.0008 | 0 | 0.0007 | 0 | 0.0009 | 0 |
Nuclear Periphery | 0.0073 | 0.0002 | 0 | 0.0025 | 0.0017 | 0.0017 | 0.0172 | 0 | 0 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 |
Nucleolus | 0.0015 | 0.0003 | 0.0003 | 0.0023 | 0.0001 | 0.0025 | 0.0031 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0002 |
Nucleus | 0.0046 | 0.0002 | 0.0001 | 0.0027 | 0.0002 | 0.0005 | 0.0051 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 |
Peroxisomes | 0.6289 | 0.6783 | 0.7333 | 0.7181 | 0.6277 | 0.7528 | 0.7241 | 0.7689 | 0.7724 | 0.7385 | 0.7369 | 0.7692 | 0.4686 | 0.9517 | 0.6077 | 0.7965 | 0.3708 | 0.6612 |
Punctate Nuclear | 0.0069 | 0.0115 | 0.0019 | 0.0023 | 0.0037 | 0.0087 | 0.0031 | 0.0006 | 0.0011 | 0.0012 | 0.0016 | 0.0014 | 0.0035 | 0.0001 | 0.0006 | 0.0007 | 0.0139 | 0.0021 |
Vacuole | 0.0018 | 0.0004 | 0.0003 | 0.0049 | 0.0008 | 0.0002 | 0.0011 | 0 | 0.0001 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0 | 0.0001 | 0 | 0.0038 | 0.0001 |
Vacuole Periphery | 0.0009 | 0.0002 | 0.0001 | 0.0036 | 0.0006 | 0.0002 | 0.0008 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 | 0.0011 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 11.4158 | 7.9726 | 15.6184 | 24.2139 | 9.2506 | 11.0529 | 14.5907 | 15.1252 | 19.4257 | 21.1094 |
Translational Efficiency | 0.3534 | 0.4515 | 0.2854 | 0.1593 | 0.2593 | 0.3362 | 0.3228 | 0.2439 | 0.1893 | 0.1032 |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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