Standard name | |
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Human Ortholog | |
Description | Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 1 | 1 | 0 | 0 | 1 |
Bud | 0 | 0 | 0 | 0 | 2 | 4 | 1 | 5 | 5 | – | 6 | 8 | 0 | 1 | 1 | 0 | 0 | – | 2 | 3 | 3 | 8 | 4 | 5 |
Bud Neck | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | – | 1 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 3 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 3 | 7 | – | 5 | 7 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 13 | 25 | 49 | 32 | 75 | 80 | 103 | 109 | 106 | – | 82 | 109 | 65 | 110 | 139 | 4 | 3 | – | 11 | 13 | 28 | 28 | 53 | 65 |
Endoplasmic Reticulum | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 1 | 2 | 0 | – | 0 | 0 | 1 | 0 | 1 | 2 |
Endosome | 0 | 2 | 1 | 0 | 17 | 2 | 4 | 1 | 2 | – | 0 | 0 | 0 | 6 | 1 | 1 | 1 | – | 4 | 4 | 6 | 3 | 1 | 8 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 1 | 1 | 0 |
Mitochondria | 2 | 51 | 53 | 75 | 71 | 172 | 155 | 176 | 218 | – | 260 | 329 | 13 | 14 | 57 | 1 | 0 | – | 4 | 6 | 17 | 4 | 10 | 9 |
Nucleus | 85 | 142 | 47 | 46 | 61 | 42 | 68 | 48 | 54 | – | 54 | 56 | 127 | 92 | 52 | 10 | 10 | – | 85 | 173 | 61 | 81 | 52 | 27 |
Nuclear Periphery | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 1 | 0 | 1 | 1 | 0 | 0 | 0 | – | 1 | 0 | 3 | 0 | 0 | 0 |
Nucleolus | 1 | 2 | 0 | 0 | 8 | 2 | 1 | 1 | 2 | – | 2 | 3 | 0 | 0 | 0 | 0 | 0 | – | 2 | 4 | 2 | 2 | 1 | 2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 1 | 11 | 1 | 1 | 2 | 9 | – | 2 | 7 | 0 | 1 | 0 | 0 | 0 | – | 5 | 13 | 13 | 13 | 9 | 9 |
Vac/Vac Membrane | 14 | 63 | 16 | 5 | 39 | 21 | 31 | 16 | 14 | – | 20 | 21 | 46 | 55 | 47 | 11 | 4 | – | 24 | 38 | 58 | 56 | 81 | 71 |
Unique Cell Count | 109 | 235 | 150 | 128 | 238 | 262 | 291 | 285 | 309 | 337 | 408 | 232 | 253 | 262 | 23 | 18 | 146 | 266 | 205 | 210 | 225 | 214 | ||
Labelled Cell Count | 116 | 288 | 167 | 159 | 290 | 328 | 368 | 361 | 418 | 433 | 541 | 252 | 283 | 298 | 29 | 18 | 146 | 266 | 205 | 210 | 225 | 214 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.3 | 4.0 | 3.5 | 3.4 | 3.9 | 3.3 | 3.6 | 3.0 | 2.9 | – | 2.9 | 2.6 | 4.5 | 4.4 | 3.8 | 6.1 | 9.0 | – | 4.6 | 4.7 | 5.3 |
Std Deviation (1e-4) | 0.8 | 0.6 | 0.8 | 1.0 | 1.8 | 1.1 | 2.0 | 1.1 | 1.2 | – | 1.0 | 0.8 | 1.1 | 1.1 | 1.0 | 1.2 | 3.6 | – | 1.6 | 2.1 | 2.4 |
Intensity Change (Log2) | – | – | – | -0.06 | 0.15 | -0.09 | 0.04 | -0.22 | -0.3 | – | -0.3 | -0.45 | 0.37 | 0.33 | 0.12 | 0.8 | 1.35 | – | 0.4 | 0.41 | 0.58 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.9052 | 1.6955 | 1.8785 | 1.9636 | 1.5672 | 1.4339 | 2.4942 | 2.5995 | 2.6024 | 2.1891 | 3.0577 | 2.4297 | 2.8933 | 3.0126 | 3.294 | 3.3673 | 3.7181 | 2.8544 |
Actin | 0.0846 | 0.0008 | 0.0132 | 0.0201 | 0.0169 | 0.0081 | 0.0493 | 0.0002 | 0.0026 | 0.0033 | 0.0069 | 0.0067 | 0.0224 | 0.0001 | 0.0006 | 0.0123 | 0.0361 | 0.0002 |
Bud | 0.0023 | 0.0001 | 0.0003 | 0.0003 | 0.0005 | 0 | 0.0008 | 0.0001 | 0.0004 | 0.0001 | 0.0014 | 0.0002 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0 |
Bud Neck | 0.0167 | 0.0006 | 0.0071 | 0.0024 | 0.0014 | 0.0036 | 0.0019 | 0.0091 | 0.0028 | 0.0024 | 0.0031 | 0.0032 | 0.0049 | 0.0006 | 0.0007 | 0.0009 | 0.0012 | 0.013 |
Bud Periphery | 0.0048 | 0.0001 | 0.0007 | 0.0005 | 0.0006 | 0.0001 | 0.0011 | 0.0001 | 0.0007 | 0.0001 | 0.0022 | 0.0005 | 0.0008 | 0.0001 | 0.0004 | 0.0001 | 0.0004 | 0.0001 |
Bud Site | 0.0122 | 0.0008 | 0.0031 | 0.002 | 0.0067 | 0.0001 | 0.0037 | 0.0041 | 0.0009 | 0.0003 | 0.004 | 0.0006 | 0.0084 | 0.0014 | 0.0005 | 0.0001 | 0.0029 | 0.0001 |
Cell Periphery | 0.0009 | 0.0001 | 0.0003 | 0.0003 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0005 | 0 | 0 | 0 | 0.0001 | 0 |
Cytoplasm | 0.0236 | 0.0288 | 0.0067 | 0.0088 | 0.0039 | 0.0058 | 0.0366 | 0.0557 | 0.0167 | 0.0043 | 0.0139 | 0.0103 | 0.0467 | 0.0363 | 0.0075 | 0.01 | 0.0142 | 0.0158 |
Cytoplasmic Foci | 0.0335 | 0.0013 | 0.0032 | 0.0393 | 0.028 | 0.0006 | 0.028 | 0.0007 | 0.0086 | 0.0059 | 0.0494 | 0.0075 | 0.0046 | 0.0005 | 0.0082 | 0.0066 | 0.0133 | 0.0003 |
Eisosomes | 0.0008 | 0 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0004 | 0 | 0 | 0 | 0.0004 | 0.0001 | 0.0003 | 0 | 0 | 0.0001 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0077 | 0.0026 | 0.0006 | 0.0023 | 0.0015 | 0.0004 | 0.0023 | 0.0015 | 0.0008 | 0.0005 | 0.004 | 0.0013 | 0.0048 | 0.0016 | 0.0005 | 0.0031 | 0.0006 | 0.0006 |
Endosome | 0.0301 | 0.0028 | 0.0032 | 0.0316 | 0.0242 | 0.0015 | 0.0223 | 0.0008 | 0.0129 | 0.0083 | 0.0797 | 0.0082 | 0.0116 | 0.0007 | 0.0066 | 0.0084 | 0.0124 | 0.0005 |
Golgi | 0.013 | 0.0007 | 0.0017 | 0.0302 | 0.0094 | 0.001 | 0.0107 | 0 | 0.0039 | 0.0014 | 0.0274 | 0.0038 | 0.0049 | 0 | 0.0066 | 0.0014 | 0.0087 | 0 |
Lipid Particles | 0.0263 | 0.0008 | 0.0012 | 0.0232 | 0.0503 | 0.0024 | 0.0246 | 0.0001 | 0.0027 | 0.0022 | 0.0157 | 0.0096 | 0.0069 | 0.0001 | 0.0033 | 0.0011 | 0.0037 | 0 |
Mitochondria | 0.0086 | 0.005 | 0.0013 | 0.0186 | 0.006 | 0.0011 | 0.0127 | 0.0003 | 0.0036 | 0.0009 | 0.0354 | 0.0137 | 0.004 | 0.0003 | 0.0022 | 0.0004 | 0.0028 | 0.0002 |
None | 0.0201 | 0.0222 | 0.0155 | 0.0093 | 0.0062 | 0.0104 | 0.0448 | 0.0927 | 0.0256 | 0.0009 | 0.0771 | 0.0276 | 0.0998 | 0.0382 | 0.0589 | 0.0583 | 0.1221 | 0.0225 |
Nuclear Periphery | 0.0628 | 0.021 | 0.021 | 0.0131 | 0.0147 | 0.0075 | 0.0199 | 0.0099 | 0.0083 | 0.0121 | 0.0141 | 0.0146 | 0.0151 | 0.009 | 0.0256 | 0.0187 | 0.0104 | 0.0076 |
Nucleolus | 0.0168 | 0.0166 | 0.0141 | 0.0086 | 0.0152 | 0.0123 | 0.0059 | 0.0106 | 0.0327 | 0.0186 | 0.0046 | 0.0109 | 0.0063 | 0.019 | 0.0243 | 0.0278 | 0.0166 | 0.0115 |
Nucleus | 0.5382 | 0.8598 | 0.8797 | 0.7244 | 0.7268 | 0.9224 | 0.6465 | 0.7895 | 0.8511 | 0.8841 | 0.5842 | 0.8462 | 0.7305 | 0.878 | 0.8261 | 0.8058 | 0.7252 | 0.8904 |
Peroxisomes | 0.0179 | 0.0008 | 0.0011 | 0.0333 | 0.0137 | 0.0009 | 0.0306 | 0 | 0.0033 | 0.0038 | 0.0285 | 0.0043 | 0.0028 | 0 | 0.0031 | 0.0002 | 0.0052 | 0 |
Punctate Nuclear | 0.0678 | 0.0326 | 0.0226 | 0.0136 | 0.0708 | 0.021 | 0.0521 | 0.0237 | 0.0151 | 0.05 | 0.0365 | 0.029 | 0.0214 | 0.0131 | 0.0235 | 0.0439 | 0.0223 | 0.0368 |
Vacuole | 0.0078 | 0.0022 | 0.003 | 0.0161 | 0.0013 | 0.0003 | 0.0038 | 0.0007 | 0.006 | 0.0003 | 0.0066 | 0.0008 | 0.002 | 0.0009 | 0.0007 | 0.0003 | 0.0008 | 0.0003 |
Vacuole Periphery | 0.0035 | 0.0004 | 0.0004 | 0.0021 | 0.0015 | 0.0003 | 0.0018 | 0.0001 | 0.0012 | 0.0003 | 0.0048 | 0.0008 | 0.0008 | 0.0001 | 0.0004 | 0.0004 | 0.0003 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.1118 | 7.5135 | 7.1365 | 11.6589 | 13.2948 | 15.4566 | 10.4838 | 7.9988 | 10.01 | 14.7461 |
Translational Efficiency | 0.6218 | 0.4794 | 0.5042 | 0.4797 | 0.3286 | 0.421 | 0.3438 | 0.3372 | 0.4155 | 0.3935 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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