Standard name | |
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Human Ortholog | |
Description | 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 3 |
Bud | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 1 | 6 | 3 | 19 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 12 | 5 | 5 | 4 | 12 | 19 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 2 | 1 | 4 | 8 | 7 | 3 | 4 | 4 | 5 | 5 | 0 | 2 | 5 | 12 | 11 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 281 | 203 | 289 | 298 | 452 | 317 | 361 | 347 | 192 | 235 | 225 | 248 | 323 | 548 | 600 | 289 | 324 | 260 | 259 | 181 | 270 | 251 | 422 | 413 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 1 | 4 | 6 | 7 | 3 | 5 | 1 | 0 | 3 | 3 | 3 | 4 | 6 | 4 | 1 | 1 | 1 | 0 | 5 | 3 |
Endosome | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 0 | 1 | 1 | 3 | 0 | 1 | 1 | 2 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Mitochondria | 4 | 2 | 0 | 1 | 6 | 34 | 54 | 22 | 80 | 57 | 96 | 57 | 0 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 2 | 2 | 4 | 0 |
Nucleus | 2 | 1 | 0 | 2 | 4 | 4 | 5 | 14 | 2 | 9 | 10 | 9 | 2 | 9 | 3 | 1 | 1 | 2 | 1 | 3 | 2 | 0 | 2 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 3 | 5 | 8 |
Vac/Vac Membrane | 0 | 2 | 6 | 7 | 35 | 37 | 85 | 54 | 34 | 68 | 45 | 48 | 11 | 22 | 17 | 25 | 46 | 17 | 6 | 4 | 1 | 8 | 9 | 7 |
Unique Cell Count | 285 | 208 | 295 | 305 | 485 | 376 | 466 | 430 | 278 | 333 | 344 | 353 | 334 | 568 | 621 | 312 | 355 | 279 | 293 | 203 | 292 | 282 | 478 | 475 |
Labelled Cell Count | 287 | 212 | 299 | 309 | 504 | 406 | 520 | 450 | 322 | 386 | 403 | 380 | 340 | 587 | 633 | 334 | 390 | 290 | 293 | 203 | 292 | 282 | 478 | 475 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.3 | 10.4 | 8.1 | 8.1 | 8.3 | 7.1 | 7.2 | 7.9 | 6.9 | 7.8 | 7.2 | 8.2 | 12.9 | 13.0 | 13.2 | 19.1 | 21.1 | 20.2 | 7.8 | 8.1 | 8.3 |
Std Deviation (1e-4) | 2.5 | 3.7 | 2.1 | 2.5 | 2.3 | 1.9 | 2.0 | 2.3 | 2.5 | 2.9 | 3.7 | 3.6 | 5.8 | 5.4 | 6.0 | 7.6 | 11.1 | 8.0 | 2.2 | 2.5 | 2.3 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.03 | -0.18 | -0.17 | -0.04 | -0.24 | -0.06 | -0.17 | 0.01 | 0.67 | 0.68 | 0.7 | 1.23 | 1.38 | 1.32 | -0.06 | -0.01 | 0.03 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.8 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.6 | 2.2 | 0 |
Cytoplasm | -0.2 | -3.0 | -5.9 | -7.8 | -7.0 | -9.4 | -9.2 | -10.3 | -9.3 | -1.0 | -1.2 | -1.1 | -3.1 | -3.7 | -2.8 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.3 | 6.1 | 3.9 | 9.9 | 7.5 | 9.8 | 7.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.2 | 3.1 | 4.1 | 6.7 | 5.1 | 4.8 | 7.1 | 5.1 | 5.3 | 1.0 | 1.4 | 0.6 | 3.3 | 5.1 | 2.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 7.1332 | 9.1052 | 9.0664 | 8.3436 | 8.0112 | 8.7586 | 5.9889 | 7.8352 | 7.3037 | 7.0082 | 5.9269 | 7.8721 | 9.1817 | 12.4018 | 11.1871 | 11.9348 | 8.3251 | 10.8902 |
Actin | 0.0068 | 0.0012 | 0.0021 | 0.0019 | 0.0015 | 0.0015 | 0.0243 | 0.0052 | 0.003 | 0.001 | 0.0048 | 0.0011 | 0.0021 | 0.0019 | 0.0006 | 0.0003 | 0.0022 | 0.0006 |
Bud | 0.0018 | 0.0063 | 0.0026 | 0.0115 | 0.004 | 0.0008 | 0.0022 | 0.0037 | 0.0036 | 0.0008 | 0.0282 | 0.0003 | 0.0003 | 0.0032 | 0.0008 | 0.001 | 0.015 | 0.0015 |
Bud Neck | 0.002 | 0.0005 | 0.0011 | 0.0032 | 0.0014 | 0.0017 | 0.0088 | 0.0005 | 0.0005 | 0.001 | 0.0013 | 0.0019 | 0.0004 | 0.0004 | 0.0005 | 0.0005 | 0.0008 | 0.0015 |
Bud Periphery | 0.0009 | 0.0027 | 0.0014 | 0.0053 | 0.001 | 0.0004 | 0.0019 | 0.0014 | 0.0016 | 0.0021 | 0.012 | 0.0002 | 0.0002 | 0.0012 | 0.0004 | 0.0004 | 0.0167 | 0.0012 |
Bud Site | 0.0049 | 0.0059 | 0.0026 | 0.0044 | 0.0012 | 0.0003 | 0.0049 | 0.0152 | 0.0021 | 0.0004 | 0.0027 | 0.0002 | 0.0011 | 0.0027 | 0.002 | 0.0003 | 0.0016 | 0.0002 |
Cell Periphery | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 |
Cytoplasm | 0.8586 | 0.918 | 0.9159 | 0.8417 | 0.8357 | 0.8993 | 0.8101 | 0.9278 | 0.9122 | 0.8856 | 0.8252 | 0.9085 | 0.9479 | 0.9511 | 0.9603 | 0.9175 | 0.9229 | 0.9433 |
Cytoplasmic Foci | 0.0151 | 0.004 | 0.0065 | 0.0063 | 0.0175 | 0.0118 | 0.0118 | 0.0046 | 0.0058 | 0.004 | 0.0075 | 0.0085 | 0.0044 | 0.0047 | 0.0023 | 0.0029 | 0.0023 | 0.0028 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0054 | 0.002 | 0.0024 | 0.0031 | 0.0039 | 0.0034 | 0.0088 | 0.0015 | 0.0019 | 0.0032 | 0.0024 | 0.0025 | 0.0027 | 0.0018 | 0.0016 | 0.0011 | 0.0021 | 0.0024 |
Endosome | 0.0108 | 0.0024 | 0.0026 | 0.0028 | 0.0035 | 0.0059 | 0.0242 | 0.0012 | 0.0035 | 0.0011 | 0.0082 | 0.0041 | 0.003 | 0.001 | 0.001 | 0.0278 | 0.0013 | 0.0018 |
Golgi | 0.001 | 0.0002 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0044 | 0.0003 | 0.0004 | 0.0001 | 0.007 | 0.0002 | 0.0007 | 0.0001 | 0.0001 | 0.0022 | 0.0001 | 0 |
Lipid Particles | 0.0007 | 0 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0024 | 0 | 0.0001 | 0.0001 | 0.0161 | 0.0001 | 0.0012 | 0 | 0 | 0.0006 | 0 | 0 |
Mitochondria | 0.0008 | 0.0005 | 0.0005 | 0.0014 | 0.0046 | 0.0009 | 0.0045 | 0.0003 | 0.0009 | 0.0008 | 0.0066 | 0.0004 | 0.0009 | 0.0003 | 0.0002 | 0.0121 | 0.0003 | 0.0002 |
None | 0.0292 | 0.0074 | 0.0096 | 0.0235 | 0.0106 | 0.0119 | 0.0454 | 0.0149 | 0.0437 | 0.0749 | 0.0442 | 0.0337 | 0.0083 | 0.0058 | 0.0051 | 0.0047 | 0.0038 | 0.0027 |
Nuclear Periphery | 0.0092 | 0.0041 | 0.0049 | 0.0074 | 0.0105 | 0.0059 | 0.0186 | 0.002 | 0.0024 | 0.0019 | 0.0032 | 0.0066 | 0.0039 | 0.0028 | 0.0029 | 0.0015 | 0.0034 | 0.0038 |
Nucleolus | 0.0004 | 0.0002 | 0.0001 | 0.0018 | 0.0022 | 0.0002 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0.0007 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 |
Nucleus | 0.0418 | 0.0387 | 0.0387 | 0.0732 | 0.0836 | 0.0469 | 0.014 | 0.0168 | 0.0149 | 0.0197 | 0.0205 | 0.0266 | 0.0186 | 0.0179 | 0.0198 | 0.01 | 0.0238 | 0.0347 |
Peroxisomes | 0.0012 | 0.0002 | 0.002 | 0.0004 | 0.0008 | 0.0002 | 0.0022 | 0.0017 | 0.0003 | 0.0002 | 0.0021 | 0.0003 | 0.0002 | 0.0021 | 0.0001 | 0.0002 | 0.0001 | 0 |
Punctate Nuclear | 0.0055 | 0.0021 | 0.0046 | 0.0074 | 0.0132 | 0.0061 | 0.0053 | 0.0014 | 0.0015 | 0.0009 | 0.0032 | 0.0023 | 0.0014 | 0.001 | 0.001 | 0.0002 | 0.0012 | 0.0012 |
Vacuole | 0.0032 | 0.003 | 0.0015 | 0.0034 | 0.0034 | 0.002 | 0.0038 | 0.0011 | 0.0011 | 0.0013 | 0.0027 | 0.0015 | 0.0019 | 0.0015 | 0.0012 | 0.01 | 0.0019 | 0.0016 |
Vacuole Periphery | 0.0005 | 0.0003 | 0.0003 | 0.0006 | 0.0005 | 0.0004 | 0.0012 | 0.0001 | 0.0003 | 0.0003 | 0.0011 | 0.0004 | 0.0003 | 0.0002 | 0.0002 | 0.0064 | 0.0003 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 48.2538 | 42.1774 | 39.8331 | 44.6042 | 34.0622 | 56.8008 | 51.6108 | 46.4451 | 51.3903 | 39.5074 |
Translational Efficiency | 1.1326 | 1.3758 | 1.5938 | 1.2703 | 1.2614 | 1.2564 | 1.5011 | 1.7474 | 1.4771 | 1.5217 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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