Standard name | |
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Human Ortholog | |
Description | Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 1 | 0 | 1 | 0 | 6 | 4 | 3 | 4 | 5 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 2 | 6 | 4 |
Bud Neck | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 6 | 5 | 6 | 14 | 10 | 9 | 12 | 1 | 2 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 4 | 5 | 6 | 14 | 8 | 7 | 18 | 16 | 7 | 15 | 12 | 10 | 21 | 34 | 52 | 10 | 17 | 7 | 0 | 5 | 0 | 0 | 1 | 0 |
Endoplasmic Reticulum | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 5 | 3 | 0 | 0 | 1 | 0 | 1 | 0 |
Endosome | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 2 | 3 | 5 | 1 | 1 | 2 | 1 | 4 | 1 | 3 | 10 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 1 | 0 | 2 |
Mitochondria | 2 | 42 | 0 | 4 | 4 | 38 | 70 | 43 | 151 | 149 | 213 | 95 | 7 | 2 | 3 | 1 | 3 | 1 | 1 | 1 | 2 | 2 | 6 | 7 |
Nucleus | 172 | 252 | 359 | 348 | 308 | 551 | 490 | 509 | 436 | 442 | 427 | 377 | 251 | 230 | 304 | 204 | 122 | 125 | 142 | 237 | 320 | 75 | 95 | 88 |
Nuclear Periphery | 0 | 1 | 1 | 4 | 2 | 16 | 3 | 5 | 11 | 14 | 3 | 9 | 8 | 5 | 7 | 7 | 1 | 3 | 0 | 0 | 3 | 0 | 3 | 15 |
Nucleolus | 67 | 112 | 38 | 7 | 9 | 44 | 40 | 28 | 39 | 51 | 44 | 45 | 102 | 92 | 93 | 29 | 17 | 15 | 89 | 107 | 103 | 42 | 115 | 94 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 1 | 0 | 2 | 0 | 8 | 1 | 7 | 4 | 7 | 1 | 10 | 3 | 10 | 0 | 0 | 0 | 1 | 0 | 2 | 3 | 1 | 3 | 9 |
Vac/Vac Membrane | 6 | 11 | 12 | 5 | 10 | 14 | 11 | 17 | 4 | 5 | 15 | 10 | 4 | 9 | 13 | 22 | 10 | 21 | 8 | 20 | 21 | 35 | 89 | 78 |
Unique Cell Count | 223 | 353 | 405 | 375 | 330 | 618 | 579 | 592 | 527 | 561 | 571 | 479 | 360 | 347 | 432 | 261 | 162 | 168 | 249 | 383 | 469 | 164 | 331 | 321 |
Labelled Cell Count | 252 | 427 | 418 | 388 | 342 | 691 | 642 | 638 | 672 | 700 | 730 | 580 | 401 | 391 | 478 | 281 | 177 | 177 | 249 | 383 | 469 | 164 | 331 | 321 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 9.5 | 7.6 | 8.6 | 7.8 | 7.5 | 6.0 | 6.0 | 6.2 | 5.2 | 5.1 | 4.8 | 5.4 | 9.1 | 8.7 | 8.4 | 11.1 | 11.6 | 10.8 | 8.6 | 8.4 | 8.6 |
Std Deviation (1e-4) | 1.7 | 1.5 | 1.3 | 1.6 | 1.3 | 1.1 | 1.1 | 1.2 | 1.1 | 1.1 | 1.2 | 1.0 | 2.8 | 2.7 | 2.4 | 2.2 | 2.7 | 2.7 | 1.6 | 1.8 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.15 | -0.2 | -0.52 | -0.53 | -0.47 | -0.74 | -0.77 | -0.84 | -0.67 | 0.08 | 0.02 | -0.03 | 0.36 | 0.43 | 0.33 | -0.01 | -0.04 | -0.0 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 3.3 | 0 | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2.0 | 0.9 | -0.5 | 1.6 | 1.3 | -0.2 | 1.3 | 0.7 | 0.7 | 3.3 | 5.1 | 6.0 | 1.9 | 4.9 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.1 | 7.3 | 5.5 | 11.8 | 11.3 | 0 | 9.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 2.0 | 2.2 | 0.3 | -1.8 | -1.2 | -2.5 | -4.0 | -5.4 | -3.9 | -6.5 | -7.4 | -6.5 | -3.7 | -4.0 | -4.3 |
Nuclear Periphery | 0 | 0 | 2.9 | 0 | 0 | 2.5 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -4.5 | -3.7 | -1.3 | -1.4 | -2.9 | -1.1 | -0.2 | 0 | 0 | 6.8 | 6.2 | 4.8 | 0.7 | 0.4 | -0.2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -1.6 | 0.1 | -0.7 | -1.1 | -0.1 | -2.6 | -2.4 | -0.3 | -0.8 | -1.8 | -0.3 | 0 | 3.1 | 1.8 | 4.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.0645 | 4.8449 | 4.5165 | 3.1471 | 3.2569 | 3.9287 | 6.5218 | 6.5777 | 6.3982 | 5.5991 | 5.9302 | 5.9092 | 5.0179 | 5.1157 | 4.6819 | 4.6329 | 4.8632 | 4.8489 |
Actin | 0.0104 | 0 | 0.0001 | 0 | 0.0032 | 0 | 0.0012 | 0 | 0.0041 | 0.0162 | 0.0144 | 0 | 0.005 | 0 | 0.0065 | 0.0119 | 0.0502 | 0.0046 |
Bud | 0.0004 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0002 | 0.0003 | 0.0001 | 0 | 0.0003 | 0 | 0.0002 | 0.0002 | 0.0005 | 0.0001 |
Bud Neck | 0.0006 | 0.0003 | 0.0002 | 0.0002 | 0.0005 | 0.0011 | 0.0008 | 0.0002 | 0.0004 | 0.0009 | 0.0014 | 0.0006 | 0.0015 | 0.0001 | 0.0005 | 0.0003 | 0.0016 | 0.0008 |
Bud Periphery | 0.0012 | 0.0001 | 0.0002 | 0.0001 | 0.0008 | 0.0003 | 0.0009 | 0 | 0.0003 | 0.0005 | 0.0003 | 0.0001 | 0.001 | 0.0001 | 0.0005 | 0.0002 | 0.0012 | 0.0001 |
Bud Site | 0.0011 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0002 | 0.0006 | 0.0001 | 0.0006 | 0.0015 | 0.0002 | 0.0001 | 0.001 | 0.0001 | 0.001 | 0.0007 | 0.0012 | 0.0001 |
Cell Periphery | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0008 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0004 | 0 | 0.0002 | 0 |
Cytoplasm | 0.0018 | 0.0003 | 0.0003 | 0 | 0.0015 | 0 | 0.0001 | 0 | 0.0006 | 0.0003 | 0.0001 | 0 | 0.0009 | 0 | 0.0003 | 0.0012 | 0.001 | 0.0001 |
Cytoplasmic Foci | 0.0115 | 0 | 0.0077 | 0 | 0.0012 | 0.0001 | 0.0011 | 0 | 0.0029 | 0.003 | 0.0034 | 0.0001 | 0.0033 | 0 | 0.0016 | 0.0091 | 0.0045 | 0.0001 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0.0004 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0004 | 0 |
Endoplasmic Reticulum | 0.0022 | 0 | 0.0001 | 0 | 0.0008 | 0 | 0.0007 | 0 | 0.0012 | 0.0006 | 0.0003 | 0 | 0.0012 | 0 | 0.001 | 0.0005 | 0.0022 | 0.0003 |
Endosome | 0.0072 | 0.0001 | 0.0013 | 0 | 0.0033 | 0.0001 | 0.0053 | 0 | 0.005 | 0.0114 | 0.0035 | 0.0005 | 0.0031 | 0 | 0.0025 | 0.0057 | 0.0218 | 0.0009 |
Golgi | 0.0014 | 0 | 0.0002 | 0 | 0.0005 | 0.0001 | 0.002 | 0 | 0.0017 | 0.0109 | 0.0029 | 0.0001 | 0.0011 | 0 | 0.0006 | 0.002 | 0.0093 | 0.0004 |
Lipid Particles | 0.0072 | 0 | 0.002 | 0 | 0.002 | 0.0015 | 0.0083 | 0 | 0.0064 | 0.006 | 0.0197 | 0.0003 | 0.0118 | 0 | 0.0047 | 0.003 | 0.0127 | 0.0002 |
Mitochondria | 0.0025 | 0.0001 | 0.0009 | 0.0002 | 0.0108 | 0.0008 | 0.0154 | 0.0001 | 0.0067 | 0.0028 | 0.0014 | 0.0004 | 0.0053 | 0.0001 | 0.0042 | 0.0005 | 0.0109 | 0.0002 |
None | 0.0015 | 0 | 0.0001 | 0 | 0.0148 | 0 | 0.0002 | 0 | 0.0003 | 0.0002 | 0.0005 | 0 | 0.0006 | 0 | 0.0005 | 0.0031 | 0.0017 | 0.0001 |
Nuclear Periphery | 0.0081 | 0.0058 | 0.0055 | 0.0081 | 0.0204 | 0.0044 | 0.0073 | 0.0029 | 0.009 | 0.0016 | 0.0066 | 0.0002 | 0.0058 | 0.0004 | 0.0062 | 0.0023 | 0.0366 | 0.0018 |
Nucleolus | 0.4032 | 0.3397 | 0.4857 | 0.379 | 0.3842 | 0.4481 | 0.3735 | 0.4367 | 0.467 | 0.356 | 0.301 | 0.4661 | 0.3975 | 0.4125 | 0.4363 | 0.4327 | 0.4242 | 0.4796 |
Nucleus | 0.5174 | 0.6462 | 0.4915 | 0.6095 | 0.5114 | 0.5389 | 0.5684 | 0.5557 | 0.4847 | 0.5819 | 0.6131 | 0.5284 | 0.5458 | 0.5839 | 0.5267 | 0.5078 | 0.3971 | 0.5082 |
Peroxisomes | 0.0103 | 0 | 0.0002 | 0 | 0.0007 | 0.0001 | 0.0019 | 0 | 0.0035 | 0.0016 | 0.003 | 0 | 0.0032 | 0 | 0.0007 | 0.0067 | 0.0056 | 0 |
Punctate Nuclear | 0.0075 | 0.0018 | 0.0013 | 0.0015 | 0.0167 | 0.002 | 0.003 | 0.0036 | 0.0033 | 0.0029 | 0.0257 | 0.0013 | 0.0066 | 0.0013 | 0.0037 | 0.0118 | 0.0125 | 0.0021 |
Vacuole | 0.0029 | 0.0046 | 0.0009 | 0.0003 | 0.0087 | 0.001 | 0.0053 | 0.0004 | 0.0013 | 0.0005 | 0.0008 | 0.0012 | 0.003 | 0.0006 | 0.0013 | 0.0002 | 0.0019 | 0.0002 |
Vacuole Periphery | 0.0013 | 0.0008 | 0.0011 | 0.0008 | 0.0169 | 0.001 | 0.0033 | 0.0002 | 0.0009 | 0.0004 | 0.0012 | 0.0004 | 0.0013 | 0.0006 | 0.0005 | 0.0001 | 0.0029 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 38.8346 | 39.8672 | 34.5691 | 39.5039 | 29.8856 | 29.5481 | 36.4598 | 30.5689 | 31.7538 | 35.0856 |
Translational Efficiency | 0.7605 | 0.95 | 1.0063 | 0.7731 | 0.8622 | 0.8588 | 0.8141 | 0.8048 | 0.8333 | 0.7957 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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