Standard name | |
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Human Ortholog | |
Description | Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 4 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 4 | 8 | 4 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 4 | 8 | 9 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 2 | 2 | 3 | 1 | 9 | 5 | 12 | 9 | 5 | 7 | 0 | 2 | 2 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 270 | 284 | 386 | 208 | 252 | 379 | 436 | 357 | 374 | 430 | 404 | 376 | 419 | 632 | 611 | 143 | 202 | 177 | 258 | 256 | 382 | 349 | 365 | 402 |
Endoplasmic Reticulum | 1 | 2 | 5 | 2 | 4 | 11 | 15 | 9 | 9 | 17 | 3 | 8 | 2 | 6 | 3 | 3 | 4 | 5 | 3 | 0 | 1 | 1 | 4 | 6 |
Endosome | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 1 | 3 | 2 | 0 | 2 | 0 | 1 | 2 | 1 | 2 | 0 | 4 | 9 | 23 |
Golgi | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 2 | 0 | 6 | 28 |
Mitochondria | 1 | 0 | 0 | 5 | 11 | 35 | 97 | 58 | 83 | 92 | 100 | 92 | 1 | 0 | 0 | 2 | 2 | 1 | 0 | 1 | 0 | 2 | 2 | 6 |
Nucleus | 3 | 0 | 5 | 1 | 4 | 9 | 18 | 15 | 18 | 16 | 15 | 10 | 3 | 16 | 9 | 2 | 1 | 3 | 3 | 9 | 4 | 24 | 29 | 24 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Nucleolus | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 9 |
Vac/Vac Membrane | 1 | 5 | 18 | 64 | 44 | 36 | 110 | 129 | 115 | 76 | 105 | 122 | 39 | 33 | 72 | 21 | 15 | 16 | 0 | 6 | 3 | 4 | 16 | 17 |
Unique Cell Count | 272 | 291 | 401 | 265 | 304 | 444 | 616 | 529 | 558 | 593 | 568 | 566 | 452 | 645 | 654 | 158 | 212 | 192 | 274 | 288 | 400 | 396 | 462 | 548 |
Labelled Cell Count | 276 | 293 | 417 | 285 | 320 | 471 | 692 | 587 | 620 | 644 | 640 | 630 | 467 | 689 | 699 | 178 | 228 | 207 | 274 | 288 | 400 | 396 | 462 | 548 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.7 | 10.9 | 10.7 | 9.4 | 9.4 | 8.5 | 8.3 | 8.7 | 8.2 | 7.9 | 8.0 | 7.8 | 12.4 | 12.1 | 11.4 | 13.6 | 12.7 | 13.2 | 12.4 | 12.3 | 14.1 |
Std Deviation (1e-4) | 1.8 | 2.4 | 1.9 | 1.7 | 1.8 | 1.8 | 1.8 | 1.9 | 1.8 | 1.7 | 1.8 | 1.8 | 2.3 | 2.0 | 2.0 | 3.6 | 2.9 | 3.0 | 2.5 | 2.5 | 2.8 |
Intensity Change (Log2) | – | – | – | -0.18 | -0.18 | -0.33 | -0.37 | -0.3 | -0.39 | -0.44 | -0.42 | -0.45 | 0.21 | 0.17 | 0.09 | 0.34 | 0.25 | 0.3 | 0.22 | 0.2 | 0.4 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 2.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -7.2 | -6.0 | -5.4 | -10.1 | -10.8 | -11.0 | -9.6 | -9.9 | -11.2 | -2.3 | 1.7 | -2.0 | -2.7 | -0.6 | -2.1 |
Endoplasmic Reticulum | 0 | 0 | 1.3 | 1.3 | 0.6 | 0.5 | 1.7 | 0 | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.7 | 8.4 | 6.8 | 8.1 | 8.3 | 8.9 | 8.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0.9 | 1.8 | 1.7 | 2.0 | 1.6 | 1.5 | 0.6 | 0 | 1.4 | 0.2 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 7.6 | 4.6 | 2.1 | 6.3 | 8.2 | 7.1 | 4.4 | 6.4 | 7.4 | 2.4 | 0.5 | 3.7 | 3.7 | 1.3 | 1.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 7.1099 | 7.5801 | 7.7622 | 6.6917 | 6.8739 | 7.6029 | 4.4077 | 5.8866 | 5.4204 | 5.0324 | 4.9291 | 5.642 | 5.2444 | 6.0483 | 5.5234 | 5.3784 | 5.0271 | 5.5186 |
Actin | 0.0292 | 0.0019 | 0.0093 | 0.0008 | 0.0359 | 0.0008 | 0.0454 | 0.0007 | 0.0134 | 0.0311 | 0.0044 | 0.0004 | 0.0094 | 0.0009 | 0.0108 | 0.0016 | 0.0289 | 0.0052 |
Bud | 0.0009 | 0.0012 | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0.0009 | 0.0004 | 0.0023 | 0.0006 | 0.0002 | 0.0003 | 0.0011 | 0.0033 | 0.0007 | 0.0002 | 0.0019 | 0.0009 |
Bud Neck | 0.009 | 0.0004 | 0.0008 | 0.0006 | 0.0005 | 0.0014 | 0.0134 | 0.0006 | 0.0131 | 0.0017 | 0.0005 | 0.0034 | 0.0065 | 0.0007 | 0.0014 | 0.0013 | 0.0067 | 0.0076 |
Bud Periphery | 0.001 | 0.0004 | 0.0005 | 0 | 0.0002 | 0 | 0.0009 | 0.0002 | 0.0011 | 0.0005 | 0.0003 | 0.0001 | 0.001 | 0.001 | 0.0003 | 0.0001 | 0.001 | 0.0008 |
Bud Site | 0.0033 | 0.0043 | 0.0051 | 0.0003 | 0.0004 | 0.0001 | 0.0118 | 0.0032 | 0.0081 | 0.0024 | 0.0002 | 0.0004 | 0.0059 | 0.0159 | 0.0057 | 0.0004 | 0.0021 | 0.0007 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0.0007 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 |
Cytoplasm | 0.7426 | 0.906 | 0.8369 | 0.9554 | 0.8466 | 0.924 | 0.7667 | 0.9483 | 0.8811 | 0.7588 | 0.8412 | 0.9493 | 0.826 | 0.9014 | 0.867 | 0.83 | 0.794 | 0.8475 |
Cytoplasmic Foci | 0.0235 | 0.0158 | 0.0251 | 0.0025 | 0.0171 | 0.006 | 0.0162 | 0.002 | 0.0061 | 0.0271 | 0.0054 | 0.0039 | 0.0155 | 0.0047 | 0.0065 | 0.0124 | 0.0141 | 0.0072 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0005 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0005 | 0 |
Endoplasmic Reticulum | 0.0127 | 0.0029 | 0.0031 | 0.003 | 0.0037 | 0.0026 | 0.014 | 0.0033 | 0.0023 | 0.0025 | 0.0021 | 0.0024 | 0.0071 | 0.0021 | 0.0023 | 0.0028 | 0.0092 | 0.003 |
Endosome | 0.0269 | 0.0038 | 0.0119 | 0.0012 | 0.0169 | 0.0019 | 0.0405 | 0.0006 | 0.0061 | 0.0492 | 0.0454 | 0.0024 | 0.0192 | 0.0042 | 0.0072 | 0.0027 | 0.0279 | 0.0059 |
Golgi | 0.0054 | 0.0015 | 0.0036 | 0.0001 | 0.0035 | 0.0001 | 0.01 | 0.0001 | 0.0083 | 0.0318 | 0.0081 | 0.0001 | 0.0029 | 0.0002 | 0.0023 | 0.0003 | 0.009 | 0.0005 |
Lipid Particles | 0.002 | 0.0002 | 0.0014 | 0 | 0.0144 | 0 | 0.004 | 0 | 0.0015 | 0.0031 | 0.0013 | 0 | 0.0052 | 0.0001 | 0.0007 | 0.0003 | 0.0107 | 0.0006 |
Mitochondria | 0.0012 | 0.0003 | 0.0023 | 0.0002 | 0.0006 | 0.0002 | 0.0041 | 0.0001 | 0.0114 | 0.0361 | 0.0549 | 0.0002 | 0.0036 | 0.0004 | 0.001 | 0.0003 | 0.0023 | 0.0005 |
None | 0.1117 | 0.038 | 0.0609 | 0.0144 | 0.0189 | 0.0366 | 0.028 | 0.0208 | 0.0082 | 0.0033 | 0.0193 | 0.0041 | 0.0186 | 0.0124 | 0.0144 | 0.0094 | 0.0121 | 0.0149 |
Nuclear Periphery | 0.0125 | 0.0022 | 0.0028 | 0.0022 | 0.0061 | 0.002 | 0.0127 | 0.0015 | 0.0018 | 0.0032 | 0.0009 | 0.0023 | 0.0102 | 0.0046 | 0.0038 | 0.0062 | 0.017 | 0.0084 |
Nucleolus | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0001 | 0 | 0.001 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0.0005 | 0.0003 | 0.0004 | 0.0002 | 0.0009 | 0.0005 |
Nucleus | 0.0089 | 0.0152 | 0.0235 | 0.0169 | 0.0091 | 0.0217 | 0.015 | 0.0161 | 0.0308 | 0.0374 | 0.009 | 0.0281 | 0.0524 | 0.0408 | 0.0679 | 0.1185 | 0.0366 | 0.0789 |
Peroxisomes | 0.0027 | 0.0022 | 0.0065 | 0.0001 | 0.0165 | 0.0003 | 0.0021 | 0.0001 | 0.0011 | 0.0069 | 0.0006 | 0.0001 | 0.0043 | 0.0001 | 0.0012 | 0.0006 | 0.0065 | 0.0004 |
Punctate Nuclear | 0.0039 | 0.0027 | 0.0034 | 0.0016 | 0.0077 | 0.0011 | 0.0039 | 0.0013 | 0.001 | 0.0022 | 0.0004 | 0.0017 | 0.0063 | 0.0054 | 0.005 | 0.0116 | 0.0146 | 0.0151 |
Vacuole | 0.0018 | 0.0007 | 0.0012 | 0.0005 | 0.001 | 0.0007 | 0.0062 | 0.0004 | 0.0009 | 0.0013 | 0.0035 | 0.0009 | 0.0028 | 0.0012 | 0.0009 | 0.0009 | 0.0026 | 0.0011 |
Vacuole Periphery | 0.0005 | 0.0001 | 0.0003 | 0.0001 | 0.0004 | 0.0001 | 0.0022 | 0.0001 | 0.0004 | 0.0006 | 0.0019 | 0.0001 | 0.001 | 0.0002 | 0.0002 | 0.0001 | 0.0011 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 85.3673 | 66.8215 | 58.0363 | 91.8814 | 81.4975 | 72.1612 | 73.8972 | 89.6466 | 76.6839 | 98.2224 |
Translational Efficiency | 1.5431 | 1.541 | 1.7262 | 0.8616 | 1.2493 | 1.8303 | 1.3542 | 0.8073 | 1.1994 | 1.1271 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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