Standard name | |
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Human Ortholog | |
Description | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 4 | 1 | 1 | 1 |
Bud | 0 | 3 | 2 | 1 | 0 | 1 | 2 | 4 | 6 | 5 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 7 | 6 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 1 | 0 | 3 | 2 | 3 | 1 | 2 | 3 | 3 | 2 | 1 | 0 | 4 | 1 | 9 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 1 |
Cytoplasm | 160 | 492 | 256 | 148 | 249 | 349 | 329 | 290 | 221 | 247 | 162 | 192 | 230 | 349 | 365 | 312 | 159 | 121 | 159 | 467 | 236 | 96 | 313 | 274 |
Endoplasmic Reticulum | 1 | 3 | 1 | 2 | 0 | 0 | 3 | 1 | 4 | 2 | 4 | 0 | 2 | 0 | 1 | 27 | 13 | 12 | 0 | 3 | 2 | 0 | 1 | 1 |
Endosome | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 1 | 6 | 2 | 1 | 1 | 2 |
Golgi | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 5 | 3 | 0 | 1 | 1 |
Mitochondria | 6 | 10 | 4 | 14 | 11 | 108 | 171 | 141 | 176 | 231 | 169 | 187 | 0 | 1 | 2 | 7 | 1 | 4 | 0 | 4 | 6 | 1 | 3 | 2 |
Nucleus | 0 | 0 | 1 | 1 | 0 | 5 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 2 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 3 | 1 | 3 | 1 |
Vac/Vac Membrane | 0 | 0 | 0 | 1 | 2 | 6 | 5 | 5 | 2 | 8 | 2 | 5 | 0 | 1 | 0 | 3 | 2 | 0 | 0 | 3 | 2 | 0 | 0 | 2 |
Unique Cell Count | 166 | 502 | 258 | 154 | 255 | 389 | 427 | 368 | 326 | 379 | 263 | 291 | 232 | 350 | 366 | 324 | 162 | 127 | 167 | 500 | 271 | 105 | 343 | 302 |
Labelled Cell Count | 168 | 511 | 264 | 171 | 265 | 473 | 516 | 447 | 416 | 497 | 344 | 401 | 232 | 357 | 372 | 365 | 184 | 148 | 167 | 500 | 271 | 105 | 343 | 302 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.2 | 5.2 | 4.6 | 4.4 | 4.3 | 3.9 | 3.2 | 3.7 | 3.3 | 3.0 | 3.3 | 3.1 | 5.3 | 5.4 | 5.5 | 5.8 | 6.8 | 6.9 | 4.8 | 5.4 | 6.0 |
Std Deviation (1e-4) | 0.4 | 0.6 | 1.0 | 1.3 | 1.0 | 1.4 | 0.6 | 1.4 | 1.0 | 0.7 | 1.5 | 0.7 | 1.2 | 1.4 | 1.3 | 1.5 | 1.3 | 1.3 | 1.3 | 2.1 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.07 | -0.08 | -0.25 | -0.51 | -0.32 | -0.49 | -0.61 | -0.47 | -0.57 | 0.21 | 0.24 | 0.25 | 0.33 | 0.56 | 0.59 | 0.07 | 0.24 | 0.39 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -2.2 | -1.4 | -4.8 | -8.0 | -7.5 | -9.8 | -10.4 | -10.8 | -10.0 | -0.1 | 0.9 | 0.9 | -2.3 | -1.0 | -2.6 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.4 | 4.2 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.1041 | 0.7021 | 0.3636 | -0.154 | -0.174 | 0.149 | 1.8414 | 2.1888 | 2.3091 | 2.0534 | 1.7006 | 2.0715 | 2.4905 | 2.7965 | 2.7281 | 2.7182 | 2.9597 | 2.7339 |
Actin | 0.0419 | 0.0201 | 0.0051 | 0.0002 | 0.0003 | 0.0081 | 0.0379 | 0.0037 | 0.0129 | 0.0252 | 0.0198 | 0.0094 | 0.0973 | 0.0013 | 0.0161 | 0.0041 | 0.1415 | 0.0089 |
Bud | 0.0004 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0003 | 0.0007 | 0.0012 | 0.0003 | 0.0006 | 0.01 | 0.0006 | 0.0007 | 0.0003 | 0.001 | 0.001 | 0.0007 | 0.0003 |
Bud Neck | 0.0039 | 0.0003 | 0.0003 | 0.0001 | 0.0001 | 0.0029 | 0.0028 | 0.0002 | 0.0008 | 0.0002 | 0.0004 | 0.0052 | 0.0023 | 0.0002 | 0.0003 | 0.0002 | 0.0018 | 0.0004 |
Bud Periphery | 0.0007 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0013 | 0.0015 | 0.0011 | 0.0006 | 0.0017 | 0.0194 | 0.001 | 0.0015 | 0.0006 | 0.0013 | 0.0024 | 0.0014 | 0.0006 |
Bud Site | 0.0052 | 0.022 | 0.0006 | 0.0001 | 0.0001 | 0.0002 | 0.0067 | 0.0232 | 0.0006 | 0.0007 | 0.0021 | 0.0002 | 0.0027 | 0.0022 | 0.0036 | 0.0005 | 0.0049 | 0.0001 |
Cell Periphery | 0.0005 | 0.0005 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0018 | 0.0005 | 0.0001 | 0.0001 | 0.0011 | 0.0001 | 0.0011 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0001 |
Cytoplasm | 0.2623 | 0.3128 | 0.3675 | 0.4514 | 0.4179 | 0.5108 | 0.1308 | 0.318 | 0.1978 | 0.1445 | 0.2677 | 0.2861 | 0.203 | 0.4564 | 0.3205 | 0.3491 | 0.3456 | 0.4198 |
Cytoplasmic Foci | 0.0063 | 0.0032 | 0.0137 | 0.0021 | 0.0072 | 0.0113 | 0.0269 | 0.0063 | 0.0127 | 0.0197 | 0.0043 | 0.0089 | 0.0268 | 0.0182 | 0.013 | 0.0072 | 0.025 | 0.011 |
Eisosomes | 0.0011 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0003 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0009 | 0.0001 | 0.0003 | 0.0001 | 0.0027 | 0.0001 |
Endoplasmic Reticulum | 0.0026 | 0.0029 | 0.0039 | 0.0032 | 0.0007 | 0.004 | 0.0042 | 0.0013 | 0.0019 | 0.0014 | 0.002 | 0.0013 | 0.0032 | 0.0023 | 0.0015 | 0.0065 | 0.0024 | 0.0013 |
Endosome | 0.0069 | 0.0006 | 0.0114 | 0.0008 | 0.0005 | 0.0021 | 0.0297 | 0.0036 | 0.0101 | 0.0022 | 0.002 | 0.0046 | 0.0133 | 0.0024 | 0.0029 | 0.0052 | 0.0166 | 0.0015 |
Golgi | 0.0126 | 0.0002 | 0.0043 | 0 | 0.0001 | 0.0004 | 0.0097 | 0.0007 | 0.0049 | 0.0045 | 0.0009 | 0.0032 | 0.0077 | 0.0003 | 0.001 | 0.0007 | 0.012 | 0.0007 |
Lipid Particles | 0.0024 | 0.0005 | 0.0076 | 0.0001 | 0.0003 | 0.0005 | 0.0192 | 0.0018 | 0.0037 | 0.0047 | 0.0004 | 0.001 | 0.0162 | 0.001 | 0.0015 | 0.0018 | 0.033 | 0.0012 |
Mitochondria | 0.0079 | 0.0002 | 0.0045 | 0 | 0.0002 | 0.0038 | 0.0114 | 0.0003 | 0.0021 | 0.0009 | 0.0301 | 0.0008 | 0.0033 | 0.0001 | 0.0004 | 0.0009 | 0.0076 | 0.0004 |
None | 0.6387 | 0.6328 | 0.558 | 0.5391 | 0.5704 | 0.4486 | 0.66 | 0.6331 | 0.7442 | 0.7554 | 0.6289 | 0.6718 | 0.5861 | 0.5099 | 0.6267 | 0.608 | 0.3435 | 0.5449 |
Nuclear Periphery | 0.0006 | 0.0006 | 0.0022 | 0.0007 | 0.0002 | 0.0006 | 0.0083 | 0.0006 | 0.001 | 0.0004 | 0.003 | 0.0007 | 0.0029 | 0.0005 | 0.0004 | 0.0038 | 0.0193 | 0.0005 |
Nucleolus | 0.0002 | 0.0001 | 0.0028 | 0.0001 | 0.0001 | 0.0001 | 0.0018 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0008 | 0.0001 | 0.0001 | 0.0003 | 0.0009 | 0.0001 |
Nucleus | 0.0006 | 0.0008 | 0.01 | 0.0009 | 0.0004 | 0.0017 | 0.0036 | 0.0008 | 0.0005 | 0.0006 | 0.0029 | 0.001 | 0.0014 | 0.0008 | 0.0006 | 0.0018 | 0.0017 | 0.0006 |
Peroxisomes | 0.0037 | 0.0007 | 0.0034 | 0 | 0.0002 | 0.0005 | 0.0318 | 0.0014 | 0.0031 | 0.0348 | 0.0017 | 0.0021 | 0.0206 | 0.0003 | 0.0072 | 0.0015 | 0.0281 | 0.0025 |
Punctate Nuclear | 0.0006 | 0.0005 | 0.0025 | 0.0003 | 0.0004 | 0.002 | 0.0074 | 0.0012 | 0.0011 | 0.0017 | 0.0009 | 0.0013 | 0.0062 | 0.0021 | 0.0009 | 0.0024 | 0.0089 | 0.0047 |
Vacuole | 0.0007 | 0.0006 | 0.0012 | 0.0006 | 0.0004 | 0.0005 | 0.0023 | 0.0004 | 0.0008 | 0.0003 | 0.0012 | 0.0005 | 0.0016 | 0.0006 | 0.0004 | 0.0018 | 0.001 | 0.0003 |
Vacuole Periphery | 0.0002 | 0 | 0.0004 | 0 | 0 | 0.0001 | 0.0012 | 0.0001 | 0.0003 | 0.0001 | 0.0006 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0006 | 0.0011 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 20.9553 | 16.1489 | 15.3385 | 19.7029 | 15.4585 | 23.8325 | 22.5329 | 21.1592 | 21.9748 | 21.6287 |
Translational Efficiency | 0.6088 | 0.8516 | 0.6984 | 0.7017 | 0.7329 | 0.7065 | 0.5034 | 0.6084 | 0.6363 | 0.5544 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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