Standard name | |
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Human Ortholog | |
Description | Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 0 | 0 | 1 | 1 | 1 | 4 | 3 | 5 | 2 | 8 | 8 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 |
Bud | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 2 | 3 | 2 | 7 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 14 | 4 | 5 | 11 | 1 | 17 | 16 | 10 | 14 | 30 | 27 | 9 | 6 | 7 | 5 | 4 | 2 | 0 | 0 | 0 | 1 | 2 | 1 |
Cytoplasm | 182 | 256 | 76 | 77 | 181 | 79 | 174 | 224 | 119 | 127 | 245 | 246 | 184 | 261 | 368 | 194 | 124 | 183 | 198 | 252 | 95 | 194 | 290 | 339 |
Endoplasmic Reticulum | 3 | 4 | 3 | 1 | 9 | 2 | 7 | 4 | 7 | 1 | 17 | 13 | 4 | 2 | 2 | 9 | 2 | 5 | 3 | 2 | 0 | 6 | 8 | 9 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Mitochondria | 2 | 0 | 0 | 0 | 0 | 26 | 16 | 39 | 41 | 54 | 103 | 111 | 3 | 0 | 1 | 4 | 2 | 4 | 3 | 0 | 0 | 2 | 6 | 1 |
Nucleus | 1 | 1 | 0 | 1 | 2 | 0 | 3 | 1 | 0 | 1 | 4 | 5 | 0 | 0 | 0 | 3 | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 0 | 0 | 0 | 4 | 4 | 22 | 24 | 11 | 9 | 21 | 43 | 0 | 0 | 0 | 33 | 20 | 13 | 0 | 2 | 0 | 2 | 1 | 0 |
Unique Cell Count | 187 | 261 | 79 | 79 | 194 | 99 | 214 | 283 | 170 | 174 | 363 | 389 | 188 | 263 | 371 | 223 | 141 | 197 | 218 | 262 | 101 | 212 | 319 | 363 |
Labelled Cell Count | 193 | 277 | 83 | 85 | 209 | 115 | 246 | 313 | 197 | 212 | 437 | 460 | 200 | 269 | 378 | 255 | 155 | 215 | 218 | 262 | 101 | 212 | 319 | 363 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 8.6 | 9.5 | 8.8 | 8.4 | 9.5 | 5.8 | 8.2 | 7.8 | 7.2 | 7.3 | 7.3 | 7.4 | 9.4 | 10.0 | 10.0 | 12.4 | 12.0 | 12.5 | 8.1 | 8.6 | 9.6 |
Std Deviation (1e-4) | 1.8 | 1.3 | 1.3 | 1.2 | 1.6 | 1.2 | 1.8 | 1.6 | 1.6 | 1.6 | 1.4 | 1.5 | 1.4 | 1.5 | 1.7 | 4.1 | 3.8 | 3.6 | 1.3 | 1.5 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.07 | 0.11 | -0.6 | -0.1 | -0.17 | -0.29 | -0.27 | -0.28 | -0.26 | 0.09 | 0.18 | 0.19 | 0.49 | 0.44 | 0.51 | -0.12 | -0.03 | 0.13 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0.8 | 0 | 0 | 0.9 | 1.0 | 0.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.5 | -0.9 | -3.2 | -3.2 | -3.6 | -4.7 | -4.3 | -5.2 | -5.8 | 0.8 | 2.0 | 2.1 | -2.3 | -2.0 | -1.0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.9 | 0 | 3.5 | 4.8 | 5.6 | 5.4 | 5.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 3.0 | 2.7 | 0 | 0 | 0 | 3.1 | 0 | 0 | 0 | 3.6 | 3.5 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.3682 | 3.5797 | 3.1111 | 2.9959 | 2.5889 | 2.98 | 4.1658 | 6.1213 | 5.8385 | 5.2309 | 5.4614 | 5.5903 | 5.9216 | 7.6581 | 7.0095 | 6.8446 | 6.3888 | 6.7624 |
Actin | 0.0143 | 0.0105 | 0.016 | 0.0038 | 0.0135 | 0.0018 | 0.0225 | 0.0004 | 0.0042 | 0.0032 | 0.009 | 0.0026 | 0.0012 | 0.0002 | 0.0043 | 0.0003 | 0.0018 | 0.0011 |
Bud | 0.0006 | 0.0007 | 0.0051 | 0.0005 | 0.0005 | 0.0002 | 0.0009 | 0.0021 | 0.0046 | 0.0011 | 0.0012 | 0.0004 | 0.0001 | 0.0003 | 0.0006 | 0.0005 | 0.0002 | 0.0001 |
Bud Neck | 0.0018 | 0.0003 | 0.0012 | 0.0004 | 0.0012 | 0.0013 | 0.0032 | 0.0007 | 0.0005 | 0.0005 | 0.0003 | 0.0021 | 0.0002 | 0.0001 | 0.0005 | 0.0003 | 0.0005 | 0.0015 |
Bud Periphery | 0.0006 | 0.0004 | 0.0055 | 0.0003 | 0.0002 | 0.0001 | 0.001 | 0.0005 | 0.0014 | 0.0011 | 0.0013 | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0 |
Bud Site | 0.0024 | 0.0015 | 0.0044 | 0.0009 | 0.0006 | 0.0001 | 0.003 | 0.0161 | 0.0032 | 0.0005 | 0.0004 | 0.0004 | 0.0003 | 0.0009 | 0.001 | 0.0005 | 0.0002 | 0.0001 |
Cell Periphery | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 |
Cytoplasm | 0.7956 | 0.9039 | 0.8386 | 0.8741 | 0.7726 | 0.8953 | 0.7124 | 0.9394 | 0.9339 | 0.864 | 0.9157 | 0.9497 | 0.9078 | 0.9693 | 0.9359 | 0.8957 | 0.9177 | 0.9581 |
Cytoplasmic Foci | 0.0406 | 0.0163 | 0.0295 | 0.032 | 0.0425 | 0.0205 | 0.0304 | 0.0205 | 0.0119 | 0.0172 | 0.0079 | 0.0112 | 0.0133 | 0.0108 | 0.0166 | 0.0238 | 0.0227 | 0.0081 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0111 | 0.0044 | 0.0048 | 0.0049 | 0.0042 | 0.0114 | 0.0243 | 0.001 | 0.0019 | 0.0028 | 0.0073 | 0.0032 | 0.0216 | 0.0017 | 0.004 | 0.0037 | 0.0065 | 0.0068 |
Endosome | 0.0508 | 0.0186 | 0.0365 | 0.0465 | 0.0693 | 0.0303 | 0.0538 | 0.0103 | 0.0137 | 0.0548 | 0.0326 | 0.0122 | 0.0135 | 0.0046 | 0.0192 | 0.0591 | 0.0279 | 0.0137 |
Golgi | 0.0087 | 0.0054 | 0.0085 | 0.0107 | 0.0075 | 0.0035 | 0.014 | 0.0008 | 0.005 | 0.0086 | 0.0078 | 0.004 | 0.0027 | 0.0017 | 0.0033 | 0.0023 | 0.0028 | 0.0012 |
Lipid Particles | 0.0038 | 0.0004 | 0.007 | 0.0026 | 0.0227 | 0.0005 | 0.0151 | 0.0002 | 0.0006 | 0.0055 | 0.0005 | 0.0013 | 0.0016 | 0.0001 | 0.0002 | 0.0002 | 0.0013 | 0.0006 |
Mitochondria | 0.011 | 0.003 | 0.0061 | 0.003 | 0.0021 | 0.0014 | 0.0197 | 0.0001 | 0.0092 | 0.02 | 0.0064 | 0.0015 | 0.0006 | 0.0002 | 0.0005 | 0.0003 | 0.0004 | 0.0005 |
None | 0.0353 | 0.0276 | 0.0168 | 0.0059 | 0.0218 | 0.0274 | 0.0258 | 0.0048 | 0.0042 | 0.0036 | 0.0025 | 0.0035 | 0.0303 | 0.0073 | 0.0091 | 0.0038 | 0.0125 | 0.005 |
Nuclear Periphery | 0.004 | 0.0006 | 0.0018 | 0.0016 | 0.001 | 0.0007 | 0.0208 | 0.0003 | 0.0005 | 0.0013 | 0.0028 | 0.0006 | 0.0011 | 0.0002 | 0.0005 | 0.001 | 0.0008 | 0.0006 |
Nucleolus | 0.0008 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0007 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.0023 | 0.0008 | 0.0009 | 0.0012 | 0.0009 | 0.0008 | 0.0163 | 0.0009 | 0.0009 | 0.0016 | 0.0009 | 0.0008 | 0.0009 | 0.0005 | 0.0007 | 0.0011 | 0.001 | 0.0007 |
Peroxisomes | 0.0082 | 0.0017 | 0.0107 | 0.0042 | 0.0267 | 0.001 | 0.0176 | 0.0002 | 0.0012 | 0.0014 | 0.0002 | 0.0024 | 0.0014 | 0.0006 | 0.0004 | 0.0001 | 0.0003 | 0.0001 |
Punctate Nuclear | 0.002 | 0.0003 | 0.0012 | 0.0009 | 0.0038 | 0.0002 | 0.0027 | 0.0003 | 0.0003 | 0.0005 | 0.0002 | 0.001 | 0.0007 | 0.0001 | 0.0002 | 0.0007 | 0.0004 | 0.0003 |
Vacuole | 0.0045 | 0.0029 | 0.004 | 0.005 | 0.007 | 0.0026 | 0.0091 | 0.0013 | 0.002 | 0.0094 | 0.0018 | 0.0019 | 0.0021 | 0.0012 | 0.0022 | 0.0051 | 0.0024 | 0.0011 |
Vacuole Periphery | 0.0012 | 0.0006 | 0.0011 | 0.0015 | 0.0016 | 0.0007 | 0.006 | 0.0002 | 0.0005 | 0.0027 | 0.0011 | 0.0007 | 0.0003 | 0.0001 | 0.0004 | 0.0012 | 0.0004 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 140.5355 | 122.0407 | 117.1946 | 120.8477 | 122.8619 | 121.9975 | 124.847 | 123.4555 | 131.9542 | 138.0746 |
Translational Efficiency | 1.8166 | 1.8993 | 1.9138 | 1.693 | 1.8964 | 2.3176 | 2.0007 | 1.9156 | 2.0127 | 1.9799 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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