Standard name | |
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Human Ortholog | |
Description | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 2 | 5 | 2 | 7 | 6 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 11 | 3 | 1 | 6 | 6 | 5 | 13 | 2 | 3 | 12 | 67 | 53 |
Bud | 2 | 3 | 0 | 11 | 6 | 4 | 23 | 17 | 29 | 14 | 19 | 9 | 8 | 15 | 7 | 1 | 7 | 1 | 0 | 0 | 0 | 2 | 10 | 14 |
Bud Neck | 1 | 0 | 0 | 3 | 11 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 2 | 6 | 5 | 0 | 1 | 0 | 1 | 0 | 1 | 3 | 12 | 10 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 2 | 5 | 5 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 0 | 1 | 0 | 1 | 0 | 3 | 5 |
Cytoplasm | 77 | 36 | 19 | 79 | 216 | 125 | 108 | 80 | 34 | 32 | 32 | 31 | 33 | 78 | 121 | 25 | 25 | 34 | 37 | 18 | 16 | 15 | 68 | 123 |
Endoplasmic Reticulum | 21 | 29 | 3 | 7 | 13 | 0 | 3 | 1 | 2 | 5 | 2 | 10 | 6 | 0 | 1 | 5 | 12 | 12 | 29 | 18 | 12 | 9 | 33 | 45 |
Endosome | 1 | 5 | 0 | 15 | 23 | 41 | 41 | 31 | 12 | 5 | 1 | 11 | 49 | 214 | 242 | 82 | 104 | 95 | 23 | 26 | 6 | 44 | 130 | 107 |
Golgi | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 5 | 0 | 6 | 0 | 5 | 14 | 10 |
Mitochondria | 70 | 22 | 0 | 31 | 26 | 99 | 261 | 275 | 303 | 310 | 257 | 276 | 40 | 41 | 27 | 19 | 26 | 22 | 44 | 27 | 36 | 49 | 163 | 196 |
Nucleus | 0 | 1 | 0 | 1 | 3 | 4 | 6 | 8 | 10 | 9 | 9 | 10 | 0 | 2 | 4 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear Periphery | 3 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 5 | 3 | 3 | 8 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 2 | 3 | 3 |
Nucleolus | 0 | 2 | 0 | 0 | 1 | 2 | 4 | 2 | 11 | 2 | 6 | 2 | 9 | 11 | 11 | 2 | 3 | 7 | 0 | 0 | 0 | 0 | 4 | 2 |
Peroxisomes | 0 | 0 | 0 | 3 | 1 | 8 | 6 | 7 | 2 | 1 | 1 | 2 | 30 | 100 | 113 | 1 | 9 | 13 | 4 | 2 | 0 | 23 | 57 | 29 |
SpindlePole | 2 | 1 | 2 | 49 | 22 | 27 | 53 | 52 | 37 | 27 | 18 | 17 | 99 | 242 | 184 | 40 | 44 | 30 | 5 | 2 | 4 | 10 | 41 | 35 |
Vac/Vac Membrane | 0 | 5 | 0 | 3 | 14 | 21 | 26 | 24 | 15 | 25 | 9 | 25 | 3 | 24 | 23 | 25 | 32 | 22 | 7 | 7 | 1 | 4 | 14 | 17 |
Unique Cell Count | 148 | 90 | 25 | 184 | 314 | 276 | 433 | 410 | 362 | 367 | 290 | 331 | 226 | 554 | 539 | 160 | 200 | 180 | 176 | 115 | 91 | 189 | 644 | 677 |
Labelled Cell Count | 179 | 111 | 27 | 212 | 345 | 333 | 539 | 502 | 468 | 441 | 362 | 407 | 292 | 738 | 740 | 209 | 275 | 248 | 176 | 115 | 91 | 189 | 644 | 677 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.4 | 4.9 | 5.0 | 5.1 | 5.2 | 4.4 | 4.2 | 4.8 | 4.1 | 4.2 | 3.8 | 4.3 | 5.8 | 6.0 | 5.7 | 6.4 | 6.8 | 6.6 | 5.2 | 5.6 | 5.6 |
Std Deviation (1e-4) | 0.4 | 0.8 | 0.5 | 1.4 | 1.5 | 1.3 | 1.5 | 1.5 | 1.0 | 1.0 | 0.9 | 0.8 | 1.4 | 1.5 | 1.7 | 1.3 | 1.2 | 1.3 | 1.5 | 1.9 | 1.7 |
Intensity Change (Log2) | – | – | – | 0.02 | 0.04 | -0.2 | -0.26 | -0.07 | -0.31 | -0.26 | -0.4 | -0.22 | 0.2 | 0.25 | 0.18 | 0.36 | 0.44 | 0.4 | 0.05 | 0.15 | 0.14 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.4251 | 0.9336 | 0.6119 | 0.7664 | 0.2638 | 0.8275 | 1.095 | 1.66 | 1.4098 | 1.3013 | 0.6523 | 1.0786 | 0.2752 | 0.4244 | 0.3833 | 0.7473 | 0.8237 | 0.4147 |
Actin | 0.0007 | 0.0004 | 0.002 | 0.0027 | 0.0003 | 0.0003 | 0.0348 | 0.0022 | 0.0155 | 0.0348 | 0.0101 | 0.0004 | 0.0188 | 0.0006 | 0.0241 | 0.045 | 0.0402 | 0.0014 |
Bud | 0.0035 | 0.0044 | 0.0001 | 0.0021 | 0 | 0.0013 | 0.0006 | 0.0002 | 0.0002 | 0.0014 | 0.0002 | 0 | 0.0003 | 0 | 0.0007 | 0.0006 | 0.0011 | 0.0001 |
Bud Neck | 0.0003 | 0.0004 | 0.0037 | 0.0006 | 0.0001 | 0.0005 | 0.0027 | 0.0003 | 0.0008 | 0.0256 | 0.0006 | 0.0004 | 0.0007 | 0.0003 | 0.0066 | 0.0009 | 0.0009 | 0.0004 |
Bud Periphery | 0.0014 | 0.0005 | 0.0003 | 0.0011 | 0.0001 | 0.0006 | 0.0012 | 0.0003 | 0.0002 | 0.0025 | 0.0004 | 0.0002 | 0.0004 | 0 | 0.0009 | 0.0008 | 0.0018 | 0.0002 |
Bud Site | 0.0005 | 0.0073 | 0.0031 | 0.0016 | 0.0001 | 0.0003 | 0.0026 | 0.0084 | 0.0023 | 0.0084 | 0.0008 | 0.0001 | 0.0014 | 0.0005 | 0.0083 | 0.0017 | 0.0062 | 0.0006 |
Cell Periphery | 0.0003 | 0.0002 | 0.0003 | 0.0014 | 0 | 0.0002 | 0.0005 | 0.0001 | 0.0001 | 0.0007 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0001 |
Cytoplasm | 0.014 | 0.0094 | 0.0054 | 0.0134 | 0.0008 | 0.0111 | 0.0262 | 0.0229 | 0.0164 | 0.0062 | 0.0305 | 0.0052 | 0.0079 | 0.003 | 0.0145 | 0.0067 | 0.0049 | 0.0094 |
Cytoplasmic Foci | 0.0919 | 0.1017 | 0.1137 | 0.0739 | 0.1076 | 0.0872 | 0.1355 | 0.1299 | 0.1547 | 0.1107 | 0.1228 | 0.1117 | 0.1273 | 0.1331 | 0.1164 | 0.1377 | 0.13 | 0.092 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0003 | 0.0001 | 0.0002 | 0.0004 | 0.0001 | 0 | 0.0002 | 0 | 0.0003 | 0.0003 | 0.0005 | 0.0001 |
Endoplasmic Reticulum | 0.0023 | 0.0015 | 0.0014 | 0.0104 | 0.0004 | 0.0007 | 0.0033 | 0.0032 | 0.0037 | 0.003 | 0.009 | 0.002 | 0.0075 | 0.0127 | 0.0116 | 0.0013 | 0.0088 | 0.0029 |
Endosome | 0.099 | 0.1289 | 0.0865 | 0.1036 | 0.024 | 0.0572 | 0.0965 | 0.1161 | 0.1041 | 0.1197 | 0.1417 | 0.0784 | 0.1464 | 0.1396 | 0.1125 | 0.0845 | 0.1725 | 0.0836 |
Golgi | 0.0339 | 0.0329 | 0.0306 | 0.0463 | 0.021 | 0.0222 | 0.0435 | 0.0305 | 0.035 | 0.0542 | 0.0409 | 0.0222 | 0.0363 | 0.0509 | 0.0533 | 0.0598 | 0.0473 | 0.0358 |
Lipid Particles | 0.6489 | 0.5898 | 0.6215 | 0.3713 | 0.7309 | 0.6941 | 0.5022 | 0.5925 | 0.4636 | 0.4839 | 0.5148 | 0.6681 | 0.5385 | 0.5439 | 0.4816 | 0.4736 | 0.4322 | 0.6505 |
Mitochondria | 0.0053 | 0.0022 | 0.0077 | 0.0141 | 0.0008 | 0.0054 | 0.0191 | 0.01 | 0.0221 | 0.0147 | 0.0073 | 0.012 | 0.0052 | 0.0015 | 0.013 | 0.021 | 0.0768 | 0.008 |
None | 0.0126 | 0.0018 | 0.007 | 0.0617 | 0.0005 | 0.0109 | 0.022 | 0.0269 | 0.0724 | 0.017 | 0.0111 | 0.0039 | 0.0081 | 0.0198 | 0.0365 | 0.0467 | 0.0009 | 0.0223 |
Nuclear Periphery | 0.0058 | 0.0016 | 0.0047 | 0.0247 | 0.0159 | 0.0075 | 0.0091 | 0.0033 | 0.0053 | 0.0015 | 0.0106 | 0.0078 | 0.0124 | 0.0089 | 0.0046 | 0.0015 | 0.0039 | 0.0086 |
Nucleolus | 0.002 | 0.0019 | 0.0023 | 0.0054 | 0.0003 | 0.005 | 0.0028 | 0.0008 | 0.0008 | 0.0029 | 0.0018 | 0.0008 | 0.0096 | 0.0012 | 0.0007 | 0.0003 | 0.0006 | 0.0018 |
Nucleus | 0.0016 | 0.002 | 0.0012 | 0.0057 | 0.0001 | 0.0022 | 0.0042 | 0.0008 | 0.0007 | 0.0006 | 0.0013 | 0.0004 | 0.0067 | 0.0005 | 0.001 | 0.0003 | 0.0007 | 0.0024 |
Peroxisomes | 0.0613 | 0.0821 | 0.0997 | 0.2368 | 0.0804 | 0.0721 | 0.0628 | 0.0382 | 0.0867 | 0.1036 | 0.0597 | 0.0754 | 0.0545 | 0.0654 | 0.1014 | 0.1121 | 0.0557 | 0.0645 |
Punctate Nuclear | 0.0093 | 0.0197 | 0.0046 | 0.0099 | 0.0153 | 0.0172 | 0.0209 | 0.0051 | 0.009 | 0.0033 | 0.029 | 0.0064 | 0.0101 | 0.0101 | 0.0047 | 0.003 | 0.0055 | 0.0116 |
Vacuole | 0.0039 | 0.0099 | 0.0029 | 0.0086 | 0.0005 | 0.0025 | 0.0067 | 0.0063 | 0.0043 | 0.0035 | 0.004 | 0.0028 | 0.0054 | 0.0061 | 0.0053 | 0.0013 | 0.0068 | 0.0023 |
Vacuole Periphery | 0.0014 | 0.0013 | 0.001 | 0.0044 | 0.0008 | 0.0015 | 0.0025 | 0.0017 | 0.0018 | 0.0014 | 0.0032 | 0.0017 | 0.0022 | 0.0018 | 0.0017 | 0.001 | 0.0024 | 0.0013 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 66.671 | 70.5264 | 37.5918 | 44.624 | 82.8401 | 47.7544 | 70.3048 | 57.2801 | 54.138 | 68.9417 |
Translational Efficiency | 0.7489 | 0.7914 | 0.7862 | 0.6171 | 0.5972 | 0.8099 | 0.6504 | 0.6 | 0.4872 | 0.5372 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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