Standard name | |
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Human Ortholog | |
Description | Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud | 2 | 2 | 1 | 0 | 1 | 0 | 1 | 2 | 3 | 1 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 7 | 2 | 0 | 5 | 3 | 13 | 8 | 8 | 8 | 12 | 10 | 8 | 4 | 3 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 218 | 289 | 216 | 131 | 241 | 223 | 322 | 245 | 191 | 208 | 156 | 206 | 249 | 444 | 354 | 142 | 114 | 19 | 217 | 274 | 201 | 125 | 226 | 197 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 1 | 2 | 5 | 3 | 5 | 6 | 8 | 10 | 0 | 0 | 3 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Endosome | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 1 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
Mitochondria | 5 | 0 | 2 | 6 | 3 | 25 | 87 | 64 | 96 | 117 | 114 | 138 | 0 | 2 | 0 | 6 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 2 |
Nucleus | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 2 | 0 | 2 | 1 | 0 | 9 | 19 | 8 | 17 | 7 | 15 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 3 | 4 | 0 | 0 | 1 |
Unique Cell Count | 221 | 292 | 218 | 136 | 245 | 234 | 384 | 309 | 266 | 306 | 244 | 321 | 249 | 446 | 359 | 146 | 117 | 20 | 226 | 288 | 210 | 130 | 232 | 217 |
Labelled Cell Count | 225 | 302 | 222 | 141 | 253 | 254 | 441 | 346 | 315 | 362 | 299 | 384 | 259 | 453 | 362 | 162 | 126 | 20 | 226 | 288 | 210 | 130 | 232 | 217 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.2 | 7.5 | 7.5 | 7.2 | 7.6 | 6.7 | 6.2 | 6.7 | 6.0 | 6.0 | 5.9 | 5.9 | 8.2 | 8.6 | 8.7 | 5.4 | 5.8 | 7.5 | 6.5 | 7.3 | 9.0 |
Std Deviation (1e-4) | 0.8 | 1.2 | 1.4 | 1.4 | 1.2 | 1.1 | 1.6 | 1.4 | 1.2 | 1.4 | 1.4 | 1.3 | 1.5 | 1.3 | 1.3 | 1.4 | 1.4 | 1.5 | 1.2 | 1.5 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.06 | 0.01 | -0.16 | -0.28 | -0.18 | -0.32 | -0.32 | -0.34 | -0.35 | 0.12 | 0.2 | 0.21 | -0.47 | -0.36 | -0.01 | -0.21 | -0.03 | 0.25 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 1.9 | 0 | 0 | 0 | 2.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.8 | -0.7 | -2.4 | -5.8 | -6.8 | -8.2 | -8.9 | -9.5 | -9.6 | 1.5 | 0.7 | -0.5 | -1.3 | -1.2 | -1.6 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.4 | 7.2 | 6.8 | 9.6 | 10.1 | 11.3 | 10.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 3.7 | 0 | 3.5 | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.1638 | 5.316 | 5.0212 | 4.3743 | 4.6322 | 4.9094 | 4.7484 | 5.6603 | 5.5041 | 4.226 | 4.9821 | 5.4758 | 4.9979 | 6.3117 | 5.4445 | 5.719 | 5.4159 | 5.7291 |
Actin | 0.0155 | 0.0003 | 0.014 | 0.0004 | 0.0003 | 0.0018 | 0.027 | 0.0004 | 0.0134 | 0.0129 | 0.0139 | 0.0009 | 0.0063 | 0.0012 | 0.0104 | 0.0004 | 0.0002 | 0.0007 |
Bud | 0.0002 | 0.0002 | 0.0006 | 0.0005 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0017 | 0.0004 | 0.0004 | 0.0002 | 0.0001 | 0.0001 |
Bud Neck | 0.002 | 0.0002 | 0.0009 | 0.0005 | 0.0007 | 0.0013 | 0.0006 | 0.0001 | 0.0008 | 0.0004 | 0.0003 | 0.0005 | 0.0024 | 0.0094 | 0.0117 | 0.0003 | 0.0003 | 0.0006 |
Bud Periphery | 0.0003 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0016 | 0.0003 | 0.0005 | 0.0001 | 0 | 0.0001 |
Bud Site | 0.0043 | 0.0006 | 0.0061 | 0.0004 | 0.0003 | 0.0001 | 0.0007 | 0.0012 | 0.0019 | 0.0005 | 0.0008 | 0 | 0.0079 | 0.0099 | 0.0032 | 0.0002 | 0 | 0.0001 |
Cell Periphery | 0.0007 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0 | 0 | 0.0003 | 0.0003 | 0.0002 | 0 | 0 | 0 |
Cytoplasm | 0.8435 | 0.9828 | 0.9017 | 0.9798 | 0.9826 | 0.9559 | 0.8411 | 0.9743 | 0.887 | 0.9107 | 0.8461 | 0.9415 | 0.7399 | 0.9473 | 0.8423 | 0.9259 | 0.9902 | 0.953 |
Cytoplasmic Foci | 0.0143 | 0.0022 | 0.0141 | 0.003 | 0.0033 | 0.0059 | 0.0156 | 0.0043 | 0.0088 | 0.0173 | 0.0237 | 0.0054 | 0.051 | 0.0107 | 0.0073 | 0.0078 | 0.0025 | 0.0052 |
Eisosomes | 0.0004 | 0 | 0.0002 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0101 | 0.0019 | 0.0033 | 0.0024 | 0.0025 | 0.0075 | 0.0078 | 0.0025 | 0.003 | 0.0019 | 0.0034 | 0.0044 | 0.0047 | 0.0013 | 0.0039 | 0.002 | 0.0006 | 0.0016 |
Endosome | 0.019 | 0.0022 | 0.0054 | 0.0026 | 0.0043 | 0.0047 | 0.0087 | 0.0033 | 0.0077 | 0.0046 | 0.0151 | 0.0046 | 0.0537 | 0.0023 | 0.0146 | 0.0039 | 0.0005 | 0.0093 |
Golgi | 0.0037 | 0.0001 | 0.0017 | 0.0002 | 0.0003 | 0.0011 | 0.0023 | 0.0003 | 0.006 | 0.0051 | 0.0063 | 0.0007 | 0.0147 | 0.0024 | 0.01 | 0.0004 | 0 | 0.0029 |
Lipid Particles | 0.0086 | 0 | 0.003 | 0.0001 | 0 | 0.004 | 0.0022 | 0.0001 | 0.008 | 0.0041 | 0.0129 | 0 | 0.0146 | 0.0005 | 0.0031 | 0.0001 | 0 | 0.0008 |
Mitochondria | 0.0042 | 0.0001 | 0.0011 | 0.0001 | 0.0001 | 0.0005 | 0.0009 | 0.0001 | 0.0058 | 0.0009 | 0.0016 | 0.0008 | 0.0042 | 0.0004 | 0.0187 | 0.0003 | 0 | 0.0046 |
None | 0.0349 | 0.0062 | 0.0309 | 0.0048 | 0.0015 | 0.0101 | 0.0756 | 0.0108 | 0.0375 | 0.008 | 0.0561 | 0.0388 | 0.0706 | 0.0098 | 0.0587 | 0.0555 | 0.0041 | 0.019 |
Nuclear Periphery | 0.014 | 0.0004 | 0.0016 | 0.0008 | 0.0005 | 0.0014 | 0.0025 | 0.0004 | 0.001 | 0.0004 | 0.0008 | 0.0003 | 0.0033 | 0.0002 | 0.0013 | 0.0005 | 0.0002 | 0.0002 |
Nucleolus | 0.0008 | 0 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0005 | 0.0001 | 0.001 | 0 | 0 | 0 |
Nucleus | 0.005 | 0.0009 | 0.0024 | 0.0016 | 0.0013 | 0.0018 | 0.0025 | 0.0007 | 0.001 | 0.0008 | 0.0008 | 0.0009 | 0.0032 | 0.0006 | 0.0013 | 0.0012 | 0.0007 | 0.0006 |
Peroxisomes | 0.0048 | 0 | 0.0078 | 0 | 0 | 0.0018 | 0.0056 | 0 | 0.0076 | 0.0307 | 0.0154 | 0.0001 | 0.0039 | 0.0022 | 0.009 | 0.0001 | 0 | 0.0002 |
Punctate Nuclear | 0.009 | 0.0001 | 0.0027 | 0.0001 | 0.0001 | 0.0003 | 0.0042 | 0.0002 | 0.0077 | 0.0003 | 0.0009 | 0.0002 | 0.0108 | 0.0001 | 0.0007 | 0.0003 | 0.0001 | 0.0001 |
Vacuole | 0.0034 | 0.0014 | 0.0013 | 0.0021 | 0.0014 | 0.0013 | 0.0015 | 0.0007 | 0.0012 | 0.0007 | 0.0012 | 0.0004 | 0.0035 | 0.0005 | 0.001 | 0.0008 | 0.0002 | 0.0005 |
Vacuole Periphery | 0.0012 | 0.0001 | 0.0002 | 0.0003 | 0.0002 | 0.0003 | 0.0003 | 0.0001 | 0.0005 | 0.0001 | 0.0003 | 0.0001 | 0.0009 | 0 | 0.0006 | 0.0002 | 0 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 18.1362 | 7.7821 | 10.1056 | 21.1167 | 18.8115 | 26.8267 | 15.7369 | 24.7831 | 41.0043 | 28.4635 |
Translational Efficiency | 0.8807 | 0.8908 | 1.0643 | 1.1743 | 0.6571 | 1.1687 | 1.012 | 0.8777 | 0.931 | 0.9245 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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