Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.11 – 0.05 0 0 0 0 0 0 0 0 0.05 0 0 0.11 0.12 0.08 0 0 0 0 0 0
Cytoplasm 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.06 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0 0.09 0 0 0 0 0 0 0 0 0 0.06 0.09 0.11 0.06 0 0 0 0 0.05 0.05
Golgi 0 0 – 0.15 0.08 0 0 0 0 0 0 0 0.17 0.39 0.35 0.29 0.27 0.21 0 0.08 0 0.05 0.11 0.08
Mitochondria 0.99 1.0 – 0.92 0.81 0.87 0.89 0.86 0.92 0.9 0.94 0.95 0.82 0.73 0.7 0.15 0.1 0.05 0.85 0.79 0.81 0.73 0.65 0.67
Nucleus 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.08 0.06 – 0 0 0.09 0.1 0.08 0.08 0.06 0.1 0.06 0.06 0.05 0 0 0 0.06 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0.05 0.07 0.07 0.05 0.07 0.07 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.16 0.24 0.06 0 0.05 0.06 0.07 0.08
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.1 0 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.17 – 0.06 0.14 0.09 0.09 0.07 0.07 0.07 0.07 0 0.15 0.1 0.15 0.26 0.24 0.21 0 0.07 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 – 10 1 2 1 4 1 1 1 1 1 3 0 0 1 4 2 0 0 1 8 10
Bud 3 0 – 4 8 7 6 14 12 11 11 5 0 1 1 4 3 9 0 0 0 0 1 2
Bud Neck 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 – 0 1 2 3 3 3 6 2 5 0 0 0 0 1 2 – – – – – –
Cell Periphery 5 2 – 11 5 10 8 5 0 3 1 1 8 5 7 21 11 9 0 0 0 0 0 0
Cytoplasm 0 0 – 2 7 11 9 7 12 3 5 3 4 4 8 8 3 3 0 0 0 0 1 1
Endoplasmic Reticulum 3 1 – 3 1 2 0 7 1 4 3 1 4 5 4 6 1 5 0 0 0 0 1 0
Endosome 2 0 – 8 28 8 4 12 3 2 0 3 4 5 12 17 10 7 6 0 2 5 16 21
Golgi 2 0 – 36 23 4 0 2 1 3 0 2 28 77 74 57 24 24 8 2 0 7 35 31
Mitochondria 279 18 – 220 240 334 431 474 445 357 364 384 135 144 150 29 9 6 239 23 40 111 213 264
Nucleus 0 0 – 1 1 3 8 4 7 6 4 1 0 0 0 2 1 2 0 0 0 1 0 1
Nuclear Periphery 23 1 – 4 4 34 49 45 40 24 37 23 10 10 9 6 2 7 1 0 0 2 4 4
Nucleolus 10 0 – 2 9 20 33 38 22 29 28 18 3 1 4 8 5 6 0 0 1 1 2 1
Peroxisomes 3 0 – 5 3 4 6 7 5 2 2 5 4 7 10 20 14 28 15 0 2 9 24 31
SpindlePole 1 0 – 6 7 4 10 10 9 14 6 8 2 3 3 11 9 3 1 0 0 0 1 2
Vac/Vac Membrane 27 3 – 15 41 33 43 36 35 28 29 18 24 19 32 52 21 24 2 1 0 8 13 15
Unique Cell Count 282 18 239 295 384 484 549 483 395 388 403 165 197 213 198 89 115 280 30 50 153 330 394
Labelled Cell Count 359 25 327 379 478 611 668 597 493 493 478 227 284 314 241 115 139 280 30 50 153 330 394


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 6.7 – 7.2 7.5 6.4 6.1 6.5 6.2 6.2 5.6 6.2 8.3 8.6 8.0 9.1 9.0 9.1 8.3 8.8 8.5
Std Deviation (1e-4) 1.0 1.3 – 1.2 1.7 1.4 1.2 1.2 1.6 1.4 1.2 1.3 1.3 1.5 1.2 1.9 1.6 1.9 1.9 2.3 1.9
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.8074 7.3199 6.7933 6.0526 5.7195 6.8711 6.0632 6.8364 6.208 5.5276 6.7906 6.6377 4.4615 5.3217 5.617 2.2613 4.9779 5.0045
Actin 0.0371 0.0092 0.0049 0.0058 0.0072 0.0012 0.0212 0.0014 0.0112 0.0033 0.0014 0.0034 0.0561 0.0226 0.01 0.1698 0.0004 0.0023
Bud 0.0005 0.0003 0.0003 0.0003 0.0004 0.0007 0.0003 0.0001 0.0002 0.0012 0 0.0002 0.0007 0.0017 0.0002 0.0179 0 0.0001
Bud Neck 0.0051 0.0001 0.0002 0.0004 0.0001 0.0001 0.0026 0.0001 0.002 0.0001 0 0.0001 0.0002 0.0009 0.0002 0.001 0 0.0003
Bud Periphery 0.001 0.0004 0.0006 0.0008 0.0007 0.0038 0.0005 0.0004 0.0003 0.0044 0.0001 0.0007 0.0027 0.003 0.0004 0.0179 0 0.0002
Bud Site 0.0025 0.0018 0.0015 0.0006 0.0004 0.0001 0.0039 0.0004 0.0022 0.0011 0 0.0002 0.0013 0.0144 0.0009 0.0214 0 0.0002
Cell Periphery 0.0004 0.0003 0.0003 0.0002 0.0005 0.0001 0.0003 0.0002 0.0001 0.0005 0 0.0004 0.0003 0.0018 0.0002 0.0005 0.0001 0.0001
Cytoplasm 0.0032 0.0001 0.0001 0.0003 0.0002 0 0.002 0 0.0003 0.0073 0 0.0008 0.0001 0.0031 0.0001 0.0148 0 0.0001
Cytoplasmic Foci 0.0124 0.0021 0.0026 0.0117 0.0151 0.0027 0.0238 0.002 0.0061 0.0461 0.0003 0.0044 0.0055 0.0048 0.0016 0.0964 0 0.0029
Eisosomes 0.0005 0.0007 0.0003 0.0003 0.0004 0.0001 0.0004 0.0002 0.0002 0.0001 0.0001 0.0002 0.0005 0.0004 0.0007 0.0005 0.0008 0.0001
Endoplasmic Reticulum 0.0013 0.0001 0.0001 0.0004 0.0002 0.0001 0.0007 0.0001 0.0005 0.0016 0 0.0019 0.0012 0.0005 0.0001 0.0065 0 0
Endosome 0.029 0.0097 0.0049 0.0264 0.0058 0.0035 0.0113 0.0058 0.0062 0.0177 0.0009 0.008 0.002 0.0111 0.0037 0.1407 0 0.0123
Golgi 0.0207 0.0084 0.007 0.0092 0.0085 0.007 0.0071 0.0111 0.0073 0.0033 0.0082 0.0097 0.004 0.0069 0.0105 0.0567 0.0001 0.0087
Lipid Particles 0.0399 0.0052 0.0054 0.0086 0.0158 0.0048 0.0306 0.0167 0.0077 0.0082 0.0002 0.0084 0.0174 0.0068 0.0031 0.0174 0 0.0072
Mitochondria 0.7856 0.9351 0.9484 0.9115 0.9022 0.9655 0.8512 0.9228 0.939 0.8138 0.9873 0.9413 0.8483 0.866 0.952 0.3784 0.9982 0.8783
None 0.0014 0 0.0001 0.0004 0.0002 0 0.0045 0 0.0005 0.0048 0 0.0025 0.0003 0.0002 0 0.0032 0 0
Nuclear Periphery 0.0046 0.0005 0.0001 0.0003 0.0007 0.0001 0.0008 0.0009 0.0009 0.0129 0 0.0021 0.0011 0.0005 0.0001 0.0098 0 0.0001
Nucleolus 0.0006 0.0002 0.0018 0.0001 0.0003 0.0001 0.0013 0.0002 0.0003 0.0011 0 0.0002 0.0006 0.001 0.0002 0.0009 0 0.0038
Nucleus 0.0116 0.0001 0.0002 0.0002 0.0003 0.0001 0.0006 0.0001 0.0002 0.0161 0 0.0003 0.0223 0.0009 0.0001 0.0043 0 0.0551
Peroxisomes 0.0329 0.0185 0.0166 0.0142 0.0113 0.0065 0.0217 0.0179 0.0118 0.0098 0.0014 0.0089 0.0282 0.0251 0.0019 0.0168 0.0002 0.0122
Punctate Nuclear 0.0017 0 0.0001 0.0002 0.0269 0.0001 0.0079 0 0.0013 0.0064 0 0.0012 0.0002 0.0003 0 0.0154 0 0.0001
Vacuole 0.0046 0.0031 0.0025 0.0054 0.0008 0.0006 0.0029 0.0058 0.0006 0.0129 0 0.0008 0.0018 0.0204 0.0035 0.0059 0 0.0127
Vacuole Periphery 0.0033 0.0042 0.0022 0.0026 0.0022 0.0027 0.0042 0.0137 0.0009 0.0276 0.0002 0.0043 0.0052 0.0078 0.0105 0.0037 0 0.0031

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 34.648 55.2752 38.1878 48.2247 34.5558 52.2096 50.8298 50.7284 53.978 52.8813
Translational Efficiency 1.2744 0.828 1.1406 1.0206 1.1743 1.0648 1.0767 1.1471 1.2264 1.1647

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mrp51

Mrp51


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mrp51-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available