Standard name
Human Ortholog
Description Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.08 0.1 0 0 0 0 0
Bud 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.06 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0.1 0.06 0 0 0 0 0 0
Cytoplasm 0.11 0.09 0 0.05 0 0 0 0 0 0 0 0 0.08 0.15 0.26 0.6 0.4 0.48 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 0.07 0 0.08 0 0 0 0 0 0
Endosome 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0.11 0.08 0.23 0.09 0.1 0.11 0.11 0.08 0.06 0.05 0 0.07
Golgi 0.1 0 0 0 0 0 0 0 0 0 0 0 0.17 0.1 0 0 0 0 0.12 0.05 0 0.06 0.06 0.06
Mitochondria 0.64 0.77 0.93 0.88 0.89 0.91 0.93 0.94 0.95 0.94 0.95 0.96 0.52 0.48 0.33 0.18 0.16 0.11 0.43 0.69 0.78 0.64 0.68 0.61
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0.05 0.05 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0 0 0.05 0.07 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.18 0.05 0 0 0.06 0 0.07 0.06 0.05 0.05
SpindlePole 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0
Vac/Vac Membrane 0.14 0.16 0 0 0.1 0 0.05 0.06 0 0 0 0 0.2 0.13 0.21 0 0.07 0.2 0 0.06 0 0.06 0.06 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 3 0 0 0 0 0 0 0 0 0 4 5 0 3 6 5 12 9 2 4 4 9
Bud 1 3 15 8 7 16 13 25 21 10 10 21 2 1 2 2 3 2 1 3 0 1 3 9
Bud Neck 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 1 1 0 0 1 0 4 6 3
Bud Site 1 1 1 1 2 11 5 7 3 7 9 18 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 14 5 3 6 1 3 2 4 7 2 5 8 5 5 4 7 4 0 1 0 0 0 0
Cytoplasm 10 39 9 13 9 11 10 10 6 11 7 8 14 28 52 52 27 31 5 7 0 2 1 2
Endoplasmic Reticulum 1 8 1 0 2 8 2 2 8 4 5 2 6 18 2 6 3 5 0 3 1 2 2 2
Endosome 3 22 3 15 7 3 3 2 1 4 0 1 19 15 47 8 7 7 12 41 19 10 12 18
Golgi 9 15 0 0 0 0 0 0 0 0 0 1 29 19 4 0 1 1 14 26 8 11 15 16
Mitochondria 56 331 269 212 261 395 482 528 552 554 351 453 87 88 66 16 11 7 50 351 233 128 195 169
Nucleus 1 2 4 1 3 11 12 15 6 8 6 6 2 2 1 2 1 1 0 2 0 1 2 1
Nuclear Periphery 2 1 3 2 9 14 26 15 30 32 24 27 1 0 0 0 0 0 0 2 2 1 2 4
Nucleolus 5 4 1 2 11 19 24 38 32 26 14 21 1 0 0 0 0 0 0 1 0 1 0 0
Peroxisomes 1 16 12 15 2 1 3 9 4 4 2 1 5 1 36 4 1 0 6 15 21 12 14 15
SpindlePole 0 7 6 8 5 8 14 28 14 17 1 7 7 6 5 3 6 2 2 6 1 1 3 2
Vac/Vac Membrane 12 69 13 8 30 16 27 31 22 26 15 17 33 24 41 3 5 13 3 28 4 12 17 19
Unique Cell Count 87 428 290 241 293 432 516 563 580 588 371 473 168 183 200 87 67 64 119 510 299 199 286 279
Labelled Cell Count 107 532 345 288 354 514 624 712 704 711 446 588 218 213 261 104 79 78 119 510 299 199 286 279


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.4 5.5 4.6 5.1 5.0 4.8 4.2 4.3 4.1 4.1 4.4 4.2 6.8 6.1 6.2 5.7 6.1 6.0 7.5 7.0 7.1
Std Deviation (1e-4) 4.1 1.2 0.9 1.4 1.2 1.4 1.2 1.1 1.0 0.9 1.1 1.0 1.4 1.2 1.1 1.0 1.7 1.3 8.6 1.6 1.7
Intensity Change (Log2) – – – 0.15 0.12 0.06 -0.14 -0.12 -0.17 -0.16 -0.08 -0.12 0.56 0.41 0.44 0.31 0.41 0.38 0.69 0.6 0.62


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud -1.0 -1.8 0 0 0 0 0 0 0 -2.2 -2.7 -2.5 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0.3 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.3 0 -0.4 -1.0 -1.2 -2.2 -1.2 -1.0 -1.3 2.5 4.8 7.5 12.6 9.1 10.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 5.1 0 0 0 0
Endosome 3.3 0 0 0 0 0 0 0 0 5.0 4.0 8.1 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 7.3 5.6 0 0 0 0
Mitochondria -1.9 -1.5 0 0 0 0 0 0 0 -10.2 -11.0 -14.0 -14.2 -13.7 -14.3
Nucleus 0 0 1.1 0.9 1.2 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 1.7 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 2.9 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1.1 -2.7 0 0 0 0 0 0 0 -0.6 -2.3 5.1 0 0 0
SpindlePole 0.9 -0.3 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.7 2.7 -0.5 0.5 0.6 -0.5 0 -0.3 -0.6 5.2 3.4 5.6 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.448 0.6642 0.5262 0.0867 0.4561 0.4049 2.2806 2.9183 2.4914 2.2047 1.8639 2.7382 -0.0457 0.4387 -0.0584 0.0884 -0.1994 0.29
Actin 0.0292 0.0077 0.0227 0.0108 0.0091 0.0082 0.0469 0.0224 0.0211 0.0102 0.0052 0.0211 0.0127 0.0156 0.0108 0.0025 0.0021 0.0096
Bud 0.0017 0.0032 0.0033 0.0038 0.0054 0.0035 0.0037 0.0059 0.005 0.0036 0.003 0.0022 0.0016 0.0036 0.0021 0.0025 0.0013 0.0017
Bud Neck 0.0066 0.0018 0.0061 0.002 0.026 0.0082 0.003 0.0021 0.0089 0.0474 0.003 0.0057 0.0028 0.0028 0.003 0.0028 0.0027 0.0162
Bud Periphery 0.0046 0.0071 0.0116 0.0133 0.0158 0.0067 0.0072 0.0101 0.0143 0.0081 0.0055 0.0068 0.0046 0.0068 0.0051 0.0119 0.0032 0.0061
Bud Site 0.0179 0.0239 0.0151 0.0101 0.0232 0.0023 0.031 0.0944 0.0337 0.0074 0.0147 0.0026 0.0118 0.0553 0.0091 0.0117 0.002 0.0041
Cell Periphery 0.0014 0.0016 0.0025 0.0016 0.0011 0.0012 0.0035 0.0022 0.0098 0.0126 0.0021 0.0015 0.003 0.0029 0.0013 0.005 0.0013 0.0019
Cytoplasm 0.0708 0.1374 0.1072 0.1282 0.083 0.1109 0.0623 0.113 0.1078 0.1056 0.0716 0.0974 0.0843 0.1488 0.1218 0.1103 0.1297 0.108
Cytoplasmic Foci 0.1221 0.1377 0.1115 0.1057 0.0716 0.1123 0.1048 0.1272 0.0933 0.0909 0.1119 0.1359 0.1465 0.1922 0.133 0.1509 0.1096 0.1329
Eisosomes 0.0011 0.0007 0.0009 0.0004 0.0004 0.0004 0.002 0.0008 0.0017 0.0037 0.0009 0.0008 0.0011 0.0013 0.0005 0.0004 0.0003 0.001
Endoplasmic Reticulum 0.0099 0.0032 0.0048 0.0028 0.0057 0.0038 0.0178 0.0036 0.0042 0.002 0.0019 0.0035 0.0074 0.004 0.0055 0.0039 0.0036 0.0038
Endosome 0.1455 0.1182 0.1106 0.0827 0.0789 0.1315 0.1367 0.1127 0.1074 0.1321 0.1456 0.1083 0.1642 0.1491 0.1069 0.1526 0.164 0.1147
Golgi 0.0379 0.042 0.0261 0.0367 0.0366 0.0349 0.0514 0.0623 0.0495 0.0566 0.0587 0.0572 0.0388 0.0474 0.0334 0.0267 0.048 0.0484
Lipid Particles 0.0319 0.0115 0.0139 0.0054 0.0282 0.0221 0.0236 0.0048 0.0081 0.0018 0.0072 0.0164 0.0464 0.0169 0.0146 0.0114 0.0097 0.0247
Mitochondria 0.1045 0.1109 0.1692 0.1974 0.2126 0.1899 0.1777 0.2381 0.2983 0.3646 0.3542 0.2467 0.1445 0.1207 0.1927 0.1393 0.1234 0.2325
None 0.3438 0.3309 0.3408 0.3582 0.3202 0.3051 0.2647 0.1387 0.1963 0.1229 0.1806 0.2188 0.2701 0.1758 0.3154 0.298 0.3585 0.2279
Nuclear Periphery 0.0147 0.0026 0.0024 0.001 0.0054 0.0025 0.0129 0.0006 0.0009 0.0003 0.0003 0.002 0.0014 0.0008 0.0012 0.0015 0.0005 0.0008
Nucleolus 0.0021 0.0022 0.0016 0.0011 0.0053 0.0011 0.0011 0.0016 0.001 0.0004 0.0005 0.0006 0.0009 0.001 0.0009 0.0007 0.0008 0.0023
Nucleus 0.004 0.0038 0.0028 0.002 0.0032 0.0024 0.002 0.0021 0.0015 0.0007 0.0005 0.0009 0.0012 0.0014 0.0016 0.0014 0.0015 0.0014
Peroxisomes 0.0269 0.0363 0.0259 0.0223 0.0485 0.0369 0.0239 0.0422 0.0221 0.0128 0.0223 0.0614 0.0409 0.0395 0.028 0.0463 0.0254 0.0495
Punctate Nuclear 0.0061 0.0059 0.0036 0.002 0.0078 0.0027 0.0017 0.001 0.0013 0.0003 0.0003 0.0014 0.0018 0.0018 0.0014 0.0022 0.0008 0.0016
Vacuole 0.0128 0.0087 0.0135 0.0103 0.0084 0.0097 0.0183 0.0111 0.0108 0.0099 0.0071 0.0062 0.0111 0.0098 0.0094 0.0135 0.0078 0.0076
Vacuole Periphery 0.0042 0.0025 0.0039 0.0022 0.0035 0.0039 0.004 0.0029 0.0032 0.006 0.0028 0.0026 0.0029 0.0023 0.0024 0.0044 0.0036 0.0033

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.3743 10.5721 10.1984 13.4937 6.1334 10.6379 14.4307 11.1827 18.0767 18.2338
Translational Efficiency 1.2866 1.3444 1.4275 1.3462 2.2996 1.968 0.9572 1.4874 1.1248 0.8525

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (74%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Odc1

Odc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Odc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available