Standard name | |
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Human Ortholog | |
Description | Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bud | 0 | 1 | – | 0 | 0 | 1 | 1 | 0 | 2 | 4 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 5 | 3 | 0 | 2 | 4 | 1 |
Bud Neck | 0 | 2 | – | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 0 | 1 | 0 | 1 | 1 | – | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | – | 0 | 1 | 0 | 1 | 1 | 4 | 4 | 4 | 3 | 0 | 0 | 0 | – | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 9 | 20 | – | 4 | 3 | 6 | 7 | 13 | 13 | 8 | 5 | 7 | 21 | 34 | 71 | – | 27 | 29 | 5 | 10 | 1 | 4 | 6 | 5 |
Endoplasmic Reticulum | 0 | 3 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 12 | 15 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 3 | 1 | – | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 2 | 5 | – | 20 | 9 | 5 | 10 | 0 | 0 | 2 | 4 |
Golgi | 0 | 1 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 3 | 2 | 5 | 2 | 1 | 0 | 0 |
Mitochondria | 27 | 175 | – | 3 | 6 | 33 | 22 | 36 | 125 | 84 | 52 | 52 | 5 | 1 | 3 | – | 15 | 6 | 3 | 12 | 0 | 2 | 3 | 7 |
Nucleus | 241 | 387 | – | 29 | 12 | 44 | 76 | 107 | 78 | 98 | 51 | 53 | 138 | 208 | 148 | – | 175 | 120 | 217 | 402 | 30 | 88 | 124 | 119 |
Nuclear Periphery | 0 | 0 | – | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleolus | 2 | 2 | – | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | – | 0 | 1 | 18 | 35 | 1 | 12 | 17 | 19 |
Peroxisomes | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
SpindlePole | 6 | 17 | – | 0 | 1 | 1 | 3 | 10 | 0 | 5 | 2 | 0 | 5 | 4 | 2 | – | 12 | 7 | 15 | 24 | 0 | 6 | 5 | 13 |
Vac/Vac Membrane | 17 | 10 | – | 3 | 0 | 3 | 1 | 4 | 3 | 2 | 1 | 1 | 6 | 6 | 10 | – | 25 | 24 | 24 | 67 | 7 | 11 | 17 | 13 |
Unique Cell Count | 275 | 498 | 39 | 18 | 76 | 99 | 141 | 151 | 145 | 80 | 77 | 172 | 250 | 235 | 252 | 188 | 305 | 586 | 47 | 138 | 186 | 191 | ||
Labelled Cell Count | 305 | 619 | 40 | 24 | 92 | 114 | 175 | 228 | 209 | 117 | 118 | 181 | 256 | 241 | 290 | 215 | 305 | 586 | 47 | 138 | 186 | 191 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.1 | 4.0 | – | 4.8 | 3.8 | 4.1 | 4.1 | 4.2 | 3.3 | 3.6 | 3.5 | 3.6 | 5.4 | 5.5 | 4.7 | 4.8 | 6.2 | 6.5 | 5.9 | 6.2 | 6.5 |
Std Deviation (1e-4) | 0.7 | 0.6 | – | 1.1 | 0.4 | 0.8 | 1.1 | 0.6 | 0.5 | 0.8 | 0.5 | 0.5 | 0.8 | 1.2 | 0.9 | 1.2 | 1.5 | 1.4 | 1.4 | 1.4 | 1.6 |
Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.8064 | 2.4551 | 2.5212 | 2.2312 | 2.5894 | 2.6302 | 5.6163 | 5.6144 | 5.7083 | 5.9557 | 5.5708 | 5.4886 | 2.6957 | 2.6553 | 2.6749 | 2.7603 | 2.8604 | 2.6866 |
Actin | 0.0482 | 0.0001 | 0.001 | 0.0682 | 0.0484 | 0.0008 | 0.0228 | 0.0002 | 0.0106 | 0.0007 | 0.0095 | 0.0023 | 0.0032 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 |
Bud | 0.0007 | 0.0001 | 0.0001 | 0.0017 | 0.0006 | 0.0002 | 0.0007 | 0.0004 | 0.0003 | 0.0025 | 0.0002 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 |
Bud Neck | 0.002 | 0.0005 | 0.0003 | 0.001 | 0.0027 | 0.0042 | 0.005 | 0.0015 | 0.0006 | 0.0014 | 0.0013 | 0.0016 | 0.0005 | 0.0003 | 0.0005 | 0.0002 | 0.0013 | 0.002 |
Bud Periphery | 0.0022 | 0 | 0.0003 | 0.0044 | 0.0008 | 0.0004 | 0.0011 | 0.0003 | 0.0007 | 0.005 | 0.0002 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0.0019 | 0.0004 | 0.001 | 0.0019 | 0.003 | 0.0011 | 0.0056 | 0.0029 | 0.0011 | 0.0204 | 0.0007 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0 | 0.0001 | 0.0001 |
Cell Periphery | 0.0005 | 0 | 0.0006 | 0.0003 | 0.0002 | 0.0001 | 0.0006 | 0.0001 | 0.0001 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0098 | 0.0037 | 0.0056 | 0.0011 | 0.028 | 0.0018 | 0.0158 | 0.0141 | 0.0031 | 0.0025 | 0.0091 | 0.0014 | 0.0096 | 0.0061 | 0.0036 | 0.0035 | 0.0039 | 0.0036 |
Cytoplasmic Foci | 0.0155 | 0.0001 | 0.0011 | 0.0033 | 0.002 | 0.0023 | 0.0041 | 0.0008 | 0.0096 | 0.0027 | 0.015 | 0.0013 | 0.0088 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0001 |
Eisosomes | 0.0005 | 0.0001 | 0.0007 | 0.0003 | 0.0012 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0109 | 0.0003 | 0.0007 | 0.0012 | 0.0038 | 0.0005 | 0.0052 | 0.0019 | 0.003 | 0.0007 | 0.0009 | 0.0013 | 0.0009 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 |
Endosome | 0.0286 | 0.0002 | 0.0013 | 0.0185 | 0.0085 | 0.0059 | 0.0124 | 0.0013 | 0.0134 | 0.0082 | 0.0219 | 0.0105 | 0.0051 | 0.0002 | 0.0005 | 0.0002 | 0.0003 | 0.0001 |
Golgi | 0.0119 | 0 | 0.0009 | 0.0105 | 0.0027 | 0.0038 | 0.0074 | 0.0001 | 0.0056 | 0.0008 | 0.0083 | 0.0015 | 0.0009 | 0 | 0 | 0 | 0.0001 | 0 |
Lipid Particles | 0.032 | 0 | 0.0006 | 0.0099 | 0.004 | 0.0007 | 0.0038 | 0.0002 | 0.006 | 0.0026 | 0.0182 | 0.0011 | 0.0025 | 0 | 0.0001 | 0 | 0.0002 | 0 |
Mitochondria | 0.0107 | 0.0002 | 0.0053 | 0.0414 | 0.0072 | 0.0014 | 0.0053 | 0.0003 | 0.0034 | 0.0007 | 0.0031 | 0.0017 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 |
None | 0.0235 | 0.0166 | 0.0355 | 0.0019 | 0.0029 | 0.0021 | 0.0202 | 0.0276 | 0.0166 | 0.0018 | 0.0244 | 0.0007 | 0.0116 | 0.0109 | 0.0089 | 0.0137 | 0.0375 | 0.0056 |
Nuclear Periphery | 0.0278 | 0.0092 | 0.0082 | 0.0082 | 0.0188 | 0.002 | 0.0372 | 0.0086 | 0.0133 | 0.0032 | 0.0184 | 0.0101 | 0.0089 | 0.0042 | 0.0026 | 0.0052 | 0.0034 | 0.0025 |
Nucleolus | 0.0192 | 0.0183 | 0.0147 | 0.0056 | 0.0723 | 0.0488 | 0.0311 | 0.0263 | 0.0162 | 0.0133 | 0.0328 | 0.0359 | 0.0156 | 0.014 | 0.0135 | 0.0078 | 0.0255 | 0.0389 |
Nucleus | 0.6947 | 0.9356 | 0.912 | 0.806 | 0.7647 | 0.9102 | 0.776 | 0.8779 | 0.8527 | 0.9137 | 0.7776 | 0.9054 | 0.8737 | 0.9268 | 0.9435 | 0.9583 | 0.8488 | 0.9336 |
Peroxisomes | 0.0322 | 0 | 0.0012 | 0.005 | 0.0031 | 0.0002 | 0.0031 | 0.0001 | 0.0033 | 0.001 | 0.0256 | 0.0004 | 0.0041 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0159 | 0.0141 | 0.0082 | 0.0028 | 0.0196 | 0.0122 | 0.0383 | 0.0336 | 0.038 | 0.0064 | 0.0313 | 0.0236 | 0.0528 | 0.0362 | 0.0257 | 0.0105 | 0.0777 | 0.0131 |
Vacuole | 0.0065 | 0.0003 | 0.0006 | 0.0033 | 0.0038 | 0.0009 | 0.0027 | 0.0014 | 0.0011 | 0.0111 | 0.0007 | 0.0004 | 0.0005 | 0.0002 | 0.0002 | 0 | 0.0001 | 0.0001 |
Vacuole Periphery | 0.0048 | 0.0001 | 0.0003 | 0.0035 | 0.0017 | 0.0002 | 0.0013 | 0.0002 | 0.0011 | 0.0008 | 0.0006 | 0.0004 | 0.0002 | 0 | 0.0001 | 0.0001 | 0 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 11.9805 | 25.7036 | 15.8943 | 30.03 | 14.7566 | 14.3686 | 16.7845 | 27.042 | 25.3701 | 29.7453 |
Translational Efficiency | 1.8207 | 1.0606 | 2.178 | 1.1785 | 2.2587 | 1.9028 | 1.8289 | 1.5722 | 1.7789 | 1.4717 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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