| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 1 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | 1 | 0 | 0 | 1 | 0 | 0 |
| Bud Neck | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 1 | 1 |
| Bud Site | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | – | – | – | – | – | – |
| Cell Periphery | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 1 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 0 | 4 | – | – | – | – | – | – | – | – | – | – | 15 | 55 | 79 | – | – | – | 0 | 1 | 0 | 1 | 6 | 6 |
| Endoplasmic Reticulum | 2 | 0 | – | – | – | – | – | – | – | – | – | – | 1 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Endosome | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 1 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 33 | 7 | – | – | – | – | – | – | – | – | – | – | 1 | 1 | 0 | – | – | – | 0 | 1 | 0 | 0 | 1 | 1 |
| Nucleus | 131 | 88 | – | – | – | – | – | – | – | – | – | – | 233 | 376 | 435 | – | – | – | 125 | 107 | 0 | 96 | 285 | 285 |
| Nuclear Periphery | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 1 | 0 | 3 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 8 | 4 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 2 | – | – | – | 5 | 1 | 0 | 1 | 7 | 7 |
| Peroxisomes | 0 | 1 | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | – | – | – | – | – | – | – | – | – | – | 2 | 8 | 9 | – | – | – | 0 | 0 | 0 | 0 | 1 | 1 |
| Vac/Vac Membrane | 1 | 1 | – | – | – | – | – | – | – | – | – | – | 0 | 3 | 3 | – | – | – | 3 | 3 | 0 | 6 | 17 | 17 |
| Unique Cell Count | 142 | 98 | 250 | 435 | 520 | 139 | 119 | 1 | 113 | 330 | 330 | |||||||||||||
| Labelled Cell Count | 175 | 105 | 253 | 445 | 532 | 139 | 119 | 1 | 113 | 330 | 330 | |||||||||||||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 5.3 | 6.1 | – | – | – | – | – | – | – | – | – | – | 7.3 | 7.5 | 7.0 | – | – | – | 5.8 | 6.5 | 6.5 |
| Std Deviation (1e-4) | 1.0 | 1.3 | – | – | – | – | – | – | – | – | – | – | 1.2 | 1.5 | 1.5 | – | – | – | 1.1 | 1.0 | 1.0 |
| Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | 0.9995 | 1.0769 | 0.8571 | 0.3879 | 0.9876 | 0.6086 | 1.5035 | 1.5598 | 1.6772 | 1.1364 | 1.3104 | 1.197 | 0.182 | 0.3343 | -0.0803 | 0.3648 | -0.1162 | -0.091 |
| Actin | 0.0233 | 0 | 0.0306 | 0.0111 | 0.0336 | 0.0019 | 0.0115 | 0 | 0.0001 | 0 | 0.0001 | 0.0008 | 0.007 | 0 | 0.0047 | 0.0034 | 0.0145 | 0.0037 |
| Bud | 0.0014 | 0 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0007 | 0 | 0.0002 | 0.001 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0002 | 0 |
| Bud Neck | 0.0018 | 0.0002 | 0.0015 | 0.0008 | 0.0007 | 0.0041 | 0.0032 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0008 | 0.0014 | 0 | 0.0005 | 0.0002 | 0.0006 | 0.0008 |
| Bud Periphery | 0.002 | 0 | 0.0003 | 0.0002 | 0.0006 | 0.0003 | 0.0017 | 0 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0001 |
| Bud Site | 0.0056 | 0.0002 | 0.0027 | 0.0009 | 0.0023 | 0.0002 | 0.0029 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0009 | 0 | 0.0007 | 0.0003 | 0.0011 | 0 |
| Cell Periphery | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0007 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 |
| Cytoplasm | 0.0073 | 0.002 | 0.0104 | 0.0014 | 0.0002 | 0.0003 | 0.008 | 0.002 | 0.0008 | 0.0012 | 0.0009 | 0.0001 | 0.0015 | 0 | 0.0013 | 0.0068 | 0.0011 | 0.0002 |
| Cytoplasmic Foci | 0.0131 | 0.0002 | 0.0103 | 0.019 | 0.0127 | 0.0004 | 0.0251 | 0.0001 | 0.0023 | 0.0023 | 0.002 | 0.0044 | 0.0071 | 0 | 0.0048 | 0.0082 | 0.004 | 0.0001 |
| Eisosomes | 0.0001 | 0 | 0.0004 | 0.0001 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 |
| Endoplasmic Reticulum | 0.0025 | 0.0007 | 0.0029 | 0.0004 | 0.0002 | 0.0003 | 0.0031 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0.001 | 0.0103 | 0.0013 | 0.0001 |
| Endosome | 0.0114 | 0.0007 | 0.0069 | 0.0197 | 0.0249 | 0.0054 | 0.0176 | 0.0002 | 0.0052 | 0 | 0.0313 | 0.0013 | 0.0072 | 0 | 0.013 | 0.0173 | 0.0079 | 0.0003 |
| Golgi | 0.0045 | 0 | 0.006 | 0.0251 | 0.0331 | 0.0035 | 0.006 | 0 | 0.0025 | 0 | 0.0056 | 0.0019 | 0.0018 | 0 | 0.0022 | 0.0026 | 0.0024 | 0.0009 |
| Lipid Particles | 0.0088 | 0.0002 | 0.0027 | 0.0103 | 0.0643 | 0.0025 | 0.0141 | 0 | 0.0052 | 0 | 0.0104 | 0.0034 | 0.0063 | 0 | 0.0043 | 0.0152 | 0.0113 | 0.0003 |
| Mitochondria | 0.0176 | 0.0003 | 0.006 | 0.0041 | 0.0549 | 0.0024 | 0.0104 | 0.0002 | 0.0017 | 0.0003 | 0.0026 | 0.001 | 0.0081 | 0 | 0.0014 | 0.0053 | 0.0013 | 0.0004 |
| None | 0.0096 | 0.0033 | 0.0122 | 0.0024 | 0.0001 | 0.0002 | 0.0037 | 0.0119 | 0.0004 | 0.0009 | 0.0014 | 0 | 0.0018 | 0 | 0.0072 | 0.0078 | 0.0012 | 0.0001 |
| Nuclear Periphery | 0.0112 | 0.0066 | 0.0051 | 0.0019 | 0.0023 | 0.001 | 0.0202 | 0.0035 | 0.0013 | 0.0005 | 0.0077 | 0.0002 | 0.0018 | 0.0002 | 0.0035 | 0.0136 | 0.0066 | 0.0005 |
| Nucleolus | 0.0165 | 0.0161 | 0.0084 | 0.0071 | 0.0138 | 0.0547 | 0.0179 | 0.0141 | 0.0185 | 0.0176 | 0.0351 | 0.0242 | 0.0126 | 0.0077 | 0.0104 | 0.005 | 0.0377 | 0.0231 |
| Nucleus | 0.8234 | 0.9666 | 0.8853 | 0.8798 | 0.7312 | 0.9202 | 0.8135 | 0.9553 | 0.9283 | 0.9545 | 0.8904 | 0.9392 | 0.9256 | 0.9913 | 0.9333 | 0.8583 | 0.8912 | 0.965 |
| Peroxisomes | 0.0112 | 0 | 0.0046 | 0.0077 | 0.0186 | 0.0002 | 0.0134 | 0 | 0.0013 | 0 | 0.001 | 0.005 | 0.007 | 0 | 0.0019 | 0.0408 | 0.0019 | 0.0001 |
| Punctate Nuclear | 0.0198 | 0.0022 | 0.0025 | 0.0068 | 0.0026 | 0.0014 | 0.0172 | 0.012 | 0.0312 | 0.0208 | 0.0081 | 0.0172 | 0.0077 | 0.0006 | 0.008 | 0.0014 | 0.0139 | 0.0041 |
| Vacuole | 0.0062 | 0.0003 | 0.0004 | 0.0006 | 0.0017 | 0.0004 | 0.0041 | 0.0002 | 0.0003 | 0.0001 | 0.0018 | 0.0001 | 0.0007 | 0 | 0.0008 | 0.0021 | 0.0007 | 0.0001 |
| Vacuole Periphery | 0.0023 | 0.0002 | 0.0003 | 0.0003 | 0.0012 | 0.0004 | 0.0048 | 0.0001 | 0.0002 | 0 | 0.001 | 0 | 0.0004 | 0 | 0.0003 | 0.0009 | 0.0005 | 0 |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 6.7281 | 8.0193 | 5.2068 | 11.2077 | 11.9945 | 10.6469 | 9.5019 | 12.1423 | 10.4446 | 11.655 |
| Translational Efficiency | 1.4044 | 0.848 | 1.3529 | 0.6672 | 0.5927 | 0.8296 | 0.8242 | 0.7512 | 0.7347 | 0.5654 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | ✘ |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p |
| Localization | |
| Cell Percentages | nucleus (96%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | nucleus-4 |
Hda3
Hda3
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Hda3-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
