Standard name
Human Ortholog
Description Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.99 0.98 0.93 0.92 0.88 – 0.76 0.8 0.72 0.74 0.99 0.99 1.0 0.92 0.96 0.99 0.95 0.95 0.97 0.95 0.96 0.96
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.18 0 – 0.26 0.14 0.3 0.22 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.07 0 0.12 – 0.11 0.09 0.08 0.06 0 0 0 0.05 0.09 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1
Bud 1 0 0 0 0 3 0 – 1 1 1 2 0 0 0 0 0 0 0 2 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 0 2 4 4 2 3 – 1 5 3 7 2 1 4 0 3 3 0 0 0 0 0 0
Cytoplasm 307 527 232 211 309 219 291 – 288 333 148 160 392 376 482 85 93 67 301 497 221 199 362 399
Endoplasmic Reticulum 0 2 2 0 1 0 0 – 0 3 0 2 3 2 2 1 3 2 0 1 0 0 2 2
Endosome 1 0 0 1 0 0 0 – 1 1 0 1 0 0 0 0 0 0 5 1 1 0 2 1
Golgi 0 0 1 1 0 0 0 – 0 0 0 0 0 0 0 0 1 0 2 1 0 0 1 1
Mitochondria 2 3 0 2 3 43 13 – 98 59 62 47 0 0 0 4 1 1 0 2 0 2 1 0
Nucleus 3 2 0 0 1 8 7 – 8 16 6 10 1 4 0 0 2 0 1 5 0 1 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 1 0 1 1 0 0 0 0 0 0 1 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 1 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 0 – 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 5 3 3 6 23 2 38 – 40 38 17 12 0 0 2 5 9 0 0 2 0 1 0 5
Unique Cell Count 315 534 234 216 331 239 330 379 418 205 216 394 380 484 92 97 68 317 522 229 210 379 416
Labelled Cell Count 323 537 240 225 342 277 353 439 457 238 245 398 383 490 95 112 73 317 522 229 210 379 416


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.2 8.2 8.2 8.0 7.9 5.1 6.5 – 5.6 6.0 5.6 6.1 9.1 7.9 8.9 8.8 9.2 9.0 8.1 8.6 8.6
Std Deviation (1e-4) 1.6 1.4 1.2 1.5 1.5 1.5 1.5 – 1.1 1.5 1.3 2.1 1.6 1.5 1.4 1.6 1.7 1.6 1.5 1.7 1.7
Intensity Change (Log2) – – – -0.02 -0.04 -0.67 -0.33 – -0.55 -0.44 -0.54 -0.43 0.16 -0.05 0.12 0.11 0.18 0.14 -0.02 0.08 0.07


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.3 -3.4 -3.9 -4.9 – -7.8 -7.0 -8.3 -7.9 0.5 -0.2 0.7 -3.3 -2.0 -0.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.8 3.1 – 8.5 6.0 9.1 7.5 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 3.0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.2 0 4.6 – 4.4 3.9 3.5 2.5 0 0 0 0 0 0