Standard name
Human Ortholog
Description Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0.1 0.18 0.14 0 0.05 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0 0 0 0 0 0 0.06 0 0.12 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.96 0.96 1.0 0.94 0.93 0.92 0.93 0.89 0.86 0.88 0.84 0.87 0.89 0.83 0.82 0.88 0.87 0.85 0.92 0.95 0.91 0.95 0.89 0.83
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0.05 0.11 0.16 0.1 0.19 0.22 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 3 2 2 0 2 0 0 0 0 0 0 1 2 1 1 1 0
Bud Neck 0 0 0 0 0 0 0 4 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 1 0 0 0 1 1 0 2 3 5 2 8 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 3 11 0 11 18 13 20 22 2 15 8 8 9 31 35 14 11 13 0 1 0 1 0 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 5 1 6 0 0 0 0 0 0
Endosome 0 1 0 0 0 1 1 0 0 0 0 1 0 0 2 0 1 1 1 1 0 0 1 1
Golgi 0 0 0 2 0 0 0 0 0 1 0 0 0 0 0 1 0 0 3 0 0 0 1 0
Mitochondria 12 4 0 0 1 3 5 12 20 12 38 18 0 0 0 4 8 8 1 1 0 0 0 1
Nucleus 241 410 69 215 321 316 477 671 307 320 270 366 77 144 200 289 197 268 238 413 81 82 133 139
Nuclear Periphery 2 1 0 1 0 3 10 2 4 1 1 2 0 0 0 1 1 3 0 0 0 0 0 0
Nucleolus 11 1 1 0 3 17 24 86 58 38 61 91 0 1 5 8 6 14 2 2 0 0 0 4
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 0 1 0 3 0 1 1 1 1 1 2 0 1 1 1 0 0 0 1 1
Vac/Vac Membrane 1 8 0 0 4 6 7 8 8 3 2 4 1 0 2 16 10 22 7 8 3 0 5 12
Unique Cell Count 251 429 69 228 346 345 515 756 358 362 320 422 87 174 244 327 226 316 259 435 89 87 149 168
Labelled Cell Count 271 437 70 230 348 361 544 813 404 399 383 501 88 178 250 338 236 337 259 435 89 87 149 168


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 8.3 6.9 8.4 8.9 7.9 8.2 8.7 7.6 8.3 7.1 7.6 8.5 8.6 8.0 11.4 11.5 10.6 7.3 8.1 8.5
Std Deviation (1e-4) 1.5 1.4 1.3 2.1 1.6 1.7 1.6 1.7 1.8 2.0 1.8 1.8 1.6 1.9 1.9 2.6 3.1 3.2 1.4 1.6 1.5
Intensity Change (Log2) – – – 0.28 0.36 0.18 0.23 0.33 0.13 0.25 0.03 0.13 0.3 0.31 0.2 0.71 0.72 0.61 0.07 0.23 0.3


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 3.8 3.3 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 3.0 0 0 0 0 0 0 0
Nucleus -2.0 -2.3 -2.5 -2.3 -2.9 -3.3 -3.0 -3.5 -3.2 -2.9 -3.7 -3.8 -3.0 -3.1 -3.5
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 2.6 3.3 2.4 3.6 4.0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0