Standard name
Human Ortholog
Description Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 – 0 0 0 0.06 – – – 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm – 0 0 0 0.11 0 0 – 0 0.07 0.05 0 – – – 0 0 0.07 0 0 0 0 0 0.06
Endoplasmic Reticulum – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Endosome – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria – 0 0 0 0 0 0 – 0 0 0.05 0 – – – 0 0 0 0 0 0 0 0 0
Nucleus – 0.93 0.79 0.91 0.81 0.73 0.76 – 0.65 0.67 0.73 0.71 – – – 0.89 0.78 0.74 0.85 0.85 0.78 0.58 0.73 0.67
Nuclear Periphery – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus – 0.22 0.43 0.2 0.12 0.41 0.27 – 0.56 0.41 0.52 0.59 – – – 0.16 0.17 0.16 0.13 0.09 0.15 0.35 0 0.06
Peroxisomes – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0.05 0 0 0 0.07 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 1 – 0 0 0 0 – – – 0 1 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 1 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 1 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 1 1 0 – 3 0 0 8 – – – 0 1 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm – 2 1 3 15 5 9 – 5 14 4 2 – – – 4 9 10 0 0 1 0 0 1
Endoplasmic Reticulum – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 2 3 0 0 0 0 0 0
Endosome – 0 0 0 0 1 0 – 0 0 0 0 – – – 0 2 4 0 2 0 0 0 0
Golgi – 0 0 0 0 1 1 – 0 1 0 0 – – – 1 0 1 0 2 0 0 0 0
Mitochondria – 3 0 1 0 3 3 – 4 5 4 2 – – – 0 2 1 0 0 0 0 0 0
Nucleus – 179 33 73 113 95 163 – 93 129 55 92 – – – 129 156 106 52 171 51 3 10 13
Nuclear Periphery – 0 0 0 0 1 1 – 0 1 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus – 42 18 16 17 53 58 – 80 79 39 76 – – – 23 35 23 7 17 9 2 0 1
Peroxisomes – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 – 0 0 0 0 – – – 0 2 0 0 1 0 0 0 0
Vac/Vac Membrane – 0 0 0 1 1 1 – 0 2 0 0 – – – 3 9 7 0 5 1 0 0 1
Unique Cell Count 193 42 80 139 130 214 144 193 75 129 145 200 144 61 203 66 6 15 20
Labelled Cell Count 226 52 93 147 161 239 185 231 102 180 160 219 155 61 203 66 6 15 20


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 19.7 12.3 14.9 17.9 13.9 14.7 – 11.2 14.1 13.5 11.7 – – – 21.1 21.6 19.4 – – –
Std Deviation (1e-4) – 5.0 3.0 5.5 8.7 6.0 5.2 – 3.4 7.3 6.2 3.7 – – – 6.8 7.4 5.6 – – –
Intensity Change (Log2) – – – 0.28 0.55 0.18 0.25 – -0.13 0.2 0.14 -0.07 – – – 0.78 0.82 0.66 – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Cytoplasm 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Nucleus 2.0 0.4 -0.7 -0.3 – -1.7 -1.5 -0.6 -0.9 – – – 1.7 -0.1 -0.7
Nuclear Periphery 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Nucleolus -2.7 -4.4 -0.2 -2.0 – 1.5 -0.2 0.9 1.8 – – – -3.7 -3.6 -3.7
Peroxisomes 0 0 0 0 – 0 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 – – – 0 0 0