Standard name
Human Ortholog
Description Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.52 0.68 0.73 0.71 0.62 0.59 0.55 0.43 0.51 – 0.45 0.47 0.59 0.57 0.57 0.35 0.15 0.17 0.72 0.7 0.76 0.67 0.76 0.71
Bud 0.1 0.18 0.22 0.27 0.3 0.22 0.27 0.22 0.19 – 0.13 0.1 0.14 0.14 0.11 0.06 0.09 0 0 0 0 0.06 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0
Bud Site 0 0 0 0.06 0.05 0.06 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.22 0.29 0.23 0.16 0.15 0.17 0.16 0.18 0.24 – 0.2 0.23 0.47 0.5 0.58 0.09 0.18 0.17 0.15 0.1 0.1 0.1 0.13 0.15
Cytoplasm 0 0.06 0.08 0.06 0.1 0 0.11 0.11 0.09 – 0.07 0 0.06 0.08 0.07 0.1 0.19 0.16 0 0 0 0 0 0
Endoplasmic Reticulum 0.09 0.13 0.06 0.05 0.08 0.13 0.15 0.07 0.14 – 0.12 0.12 0.07 0.06 0.11 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.44 0.12 0.08 0 0.05 0.06 0.13 0.13 0.13 – 0.08 0.16 0.17 0.19 0.1 0.65 0.71 0.54 0 0 0 0 0 0
Mitochondria 0.12 0.07 0.25 0.41 0.17 0.41 0.31 0.36 0.57 – 0.61 0.68 0.08 0.06 0.15 0.18 0.09 0.17 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.06 0.06 0 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 156 182 144 89 82 53 65 80 70 – 68 72 113 106 125 40 13 11 323 299 175 116 216 239
Bud 31 47 43 34 40 20 32 41 26 – 20 15 27 26 25 7 8 2 7 13 2 11 7 10
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 10 18 4 8 6 6
Bud Site 1 4 7 7 7 5 2 0 1 – 2 3 5 0 0 0 0 0 – – – – – –
Cell Periphery 66 78 45 20 20 15 19 34 33 – 30 35 91 94 128 10 16 11 68 41 23 18 36 50
Cytoplasm 12 16 16 7 13 2 13 20 12 – 10 6 11 15 15 11 17 10 1 4 0 4 0 1
Endoplasmic Reticulum 26 36 12 6 11 12 18 14 20 – 19 19 14 11 24 3 2 0 10 14 10 5 8 11
Endosome 2 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 3 8 3 1 1 1
Golgi 133 32 16 1 7 5 15 24 18 – 12 24 32 36 21 73 63 34 3 6 4 1 0 4
Mitochondria 36 19 49 51 23 37 37 68 79 – 92 104 16 12 33 20 8 11 12 12 1 4 2 5
Nucleus 0 0 0 0 0 0 0 0 0 – 1 2 0 0 0 2 0 1 0 0 0 0 0 0
Nuclear Periphery 1 0 0 0 1 0 0 0 2 – 0 0 0 0 1 0 0 0 1 3 0 0 0 0
Nucleolus 5 3 0 2 4 1 5 4 2 – 1 1 0 1 0 1 1 1 0 0 0 0 0 0
Peroxisomes 1 0 12 8 4 5 0 5 1 – 2 0 2 1 4 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 4 6 0 0 1 0 1 4 0 – 1 1 1 0 0 1 1 2 0 5 0 0 0 1
Unique Cell Count 300 268 197 125 133 90 118 188 138 152 152 192 187 219 113 89 63 448 430 231 174 284 340
Labelled Cell Count 474 423 344 226 213 155 207 294 264 258 282 312 302 376 168 129 83 448 430 231 174 284 340


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 26.9 22.9 15.5 16.2 20.1 19.8 19.2 19.3 18.6 – 16.9 17.3 25.5 26.2 23.9 36.1 37.2 39.1 23.3 25.4 25.7
Std Deviation (1e-4) 7.2 5.7 3.8 3.1 5.2 5.6 5.2 5.4 5.3 – 5.1 5.0 6.0 7.3 7.1 14.7 13.4 14.5 6.0 5.8 6.0
Intensity Change (Log2) – – – 0.06 0.38 0.35 0.31 0.32 0.27 – 0.12 0.16 0.72 0.75 0.62 1.22 1.26 1.33 0.59 0.71 0.73


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.4 -2.2 -2.4 -3.3 -6.1 -4.2 – -5.4 -4.9 -3.0 -3.4 -3.4 -6.5 -9.2 -7.8
Bud 1.1 1.7 0.1 1.1 0 -0.7 – -2.1 -3.0 -2.0 -2.0 -2.9 -3.6 -2.6 -3.4
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0.9 0.8 0 0 0 0 – 0 0 -0.5 0 0 0 0 0
Cell Periphery -1.5 -1.7 -1.2 -1.4 -1.2 0.2 – -0.7 0 5.1 5.6 7.4 -3.1 -0.9 -0.9
Cytoplasm -0.9 0.5 -1.9 0.9 0.8 0.2 – -0.5 -1.6 -0.9 0 -0.5 0.5 2.7 1.8
Endoplasmic Reticulum -0.5 0.8 2.1 2.7 0.5 2.6 – 2.1 2.1 0.5 -0.1 1.8 -1.4 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi -2.9 -1.0 -0.8 1.3 1.5 1.5 – -0.1 2.2 2.6 3.2 0.5 10.6 11.0 8.0
Mitochondria 3.0 -1.6 2.8 1.3 2.4 6.0 – 6.7 8.1 -4.4 -4.9 -2.5 -1.5 -3.1 -1.2
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0.1 -1.3 -0.2 0 -1.6 -2.5 – -2.3 -3.1 -2.7 -3.0 -2.3 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 32.1116 32.0736 32.2936 30.3786 29.4638 31.75 26.645 23.67 25.9191 24.1639 23.35 25.3815 22.5552 25.4283 24.7449 25.3425 22.389 26.3657
Actin 0.3421 0.4508 0.4209 0.2489 0.413 0.2681 0.1166 0.4547 0.2977 0.1431 0.1941 0.2066 0.5118 0.5207 0.5623 0.5411 0.591 0.4922
Bud 0.001 0.001 0.0008 0.0006 0.0009 0.0006 0.0006 0.0012 0.0015 0.0008 0.0003 0.0009 0.0012 0.0007 0.0007 0.0009 0.0022 0.0006
Bud Neck 0.0228 0.0166 0.0493 0.0396 0.0241 0.0723 0.0123 0.0145 0.0457 0.0097 0.0244 0.0937 0.0091 0.0176 0.0638 0.052 0.0102 0.0984
Bud Periphery 0.0026 0.0017 0.0027 0.0027 0.003 0.0034 0.0027 0.0025 0.0074 0.0099 0.0022 0.0059 0.002 0.0011 0.0013 0.0037 0.0079 0.0022
Bud Site 0.0468 0.1564 0.0417 0.0024 0.0059 0.0022 0.0279 0.1246 0.0459 0.0011 0.0012 0.0021 0.0442 0.2108 0.084 0.0029 0.0336 0.0021
Cell Periphery 0.0319 0.0186 0.0289 0.0229 0.0197 0.0246 0.0566 0.0202 0.0371 0.0536 0.0453 0.0599 0.0091 0.0092 0.0085 0.0127 0.0141 0.0188
Cytoplasm 0.0005 0.0003 0.0004 0.0003 0.0003 0.0002 0.0012 0.0019 0.0004 0.0005 0.0005 0.0003 0.0003 0.0003 0.0001 0.0003 0.0008 0.0002
Cytoplasmic Foci 0.0009 0.0007 0.0005 0.0003 0.0007 0.0003 0.0007 0.0016 0.0003 0.0002 0.0007 0.0002 0.0023 0.0006 0.0004 0.0004 0.0076 0.0002
Eisosomes 0.5283 0.3426 0.4361 0.6687 0.5156 0.6109 0.7585 0.3522 0.5557 0.7395 0.6873 0.6077 0.3772 0.2352 0.2766 0.3753 0.2782 0.371
Endoplasmic Reticulum 0.0011 0.001 0.0015 0.0016 0.0019 0.001 0.0018 0.0027 0.0007 0.0112 0.0016 0.0028 0.0005 0.0001 0.0001 0.001 0.0009 0.0003
Endosome 0.0005 0.0001 0.0003 0.0003 0.0003 0.0003 0.0005 0.0005 0.0001 0.0002 0.0004 0.0003 0.0009 0.0001 0 0.0002 0.0011 0.0001
Golgi 0.0162 0.0058 0.0098 0.0079 0.0076 0.0056 0.0099 0.0162 0.0029 0.0259 0.0325 0.0092 0.0145 0.0014 0.0006 0.0072 0.0048 0.0021
Lipid Particles 0.0013 0.0008 0.0017 0.0008 0.0028 0.001 0.005 0.0029 0.0007 0.0009 0.0077 0.0008 0.0029 0.0003 0.0002 0.0008 0.0016 0.0002
Mitochondria 0.0013 0.0014 0.0024 0.0019 0.0022 0.0074 0.0025 0.0019 0.0012 0.001 0.0005 0.0065 0.0183 0.0009 0.0004 0.0007 0.0088 0.0108
None 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0003 0.0004 0.0002 0.0004 0.0001 0.0002 0.0003 0.0001 0.0001 0.0001 0.0038 0.0001
Nuclear Periphery 0.0004 0.0002 0.0005 0.0004 0.0006 0.0002 0.0005 0.0003 0.0003 0.0011 0.0003 0.0006 0.0002 0 0 0.0003 0.0002 0.0001
Nucleolus 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0 0.0001 0.0002 0.0003 0 0.0001 0 0.0274 0.0001
Nucleus 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0029 0
Peroxisomes 0.0011 0.0011 0.001 0.0003 0.0006 0.0006 0.0004 0.0004 0.0005 0.0001 0.0001 0.0004 0.0046 0.0009 0.0005 0.0002 0.0012 0.0004
Punctate Nuclear 0 0 0 0 0 0 0 0.0001 0 0 0 0 0.0001 0 0 0 0.0008 0
Vacuole 0.0006 0.0004 0.0008 0.0003 0.0003 0.0006 0.0016 0.0007 0.0012 0.0006 0.0004 0.0011 0.0002 0.0001 0.0001 0.0001 0.0008 0.0001
Vacuole Periphery 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0002 0.0001 0.0003 0.0001 0 0 0.0001 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 116.0358 83.2686 72.7344 102.1677 85.5745 96.0223 89.3647 96.764 100.5963 105.3406
Translational Efficiency 1.3892 1.3217 1.4926 1.0091 1.2649 1.5828 1.0104 1.0072 1.1686 1.1238

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
84 844 324 973 1254 1749 432 541 1338 2593 756 1514

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1695.98 1913.46 3754.98 2603.26 1717.58 1743.75 2737.25 2668.79 1716.22 1798.99 3173.42 2626.68
Standard Deviation 267.30 376.43 721.76 704.37 336.77 355.55 535.31 588.51 332.88 371.10 800.41 666.03
Intensity Change Log 2 — 0.174065 1.146686 0.618200 — 0.021816 0.672350 0.635808 — 0.099466 0.927437 0.627087

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.232410* 0.254503* 0.095186 0.281720* 0.196391* 0.208997* 0.211146* 0.202894* 0.198652* 0.223809* 0.161449* 0.253553*
Bud Neck 0.054874 0.042818 0.051417 0.034544 0.035690 0.034440 0.066999 0.042829 0.036895 0.037167 0.060321 0.037505
Bud Site 0.031307 0.012244 0.008973 0.074298 0.014325 0.014888 0.032677 0.060049 0.015391 0.014028 0.022518 0.069207
Cell Periphery 0.148532* 0.064266 0.029345 0.205534* 0.113828* 0.125910* 0.079096 0.176241* 0.116007* 0.105845* 0.057774 0.195067*
Cytoplasm 0.000080 0.000050 0.000035 0.001705 0.000528 0.000246 0.000167 0.000159 0.000500 0.000182 0.000110 0.001153
Cytoplasmic Foci 0.000444 0.000288 0.001541 0.001526 0.000575 0.000948 0.000254 0.000659 0.000567 0.000733 0.000806 0.001216
Eisosomes 0.494426* 0.586071* 0.762648* 0.262428* 0.608523* 0.583037* 0.577613* 0.475081* 0.601360* 0.584024* 0.656914* 0.338416*
Endoplasmic Reticulum 0.016367 0.022021 0.021135 0.042890 0.015543 0.012408 0.016411 0.017229 0.015594 0.015537 0.018436 0.033721
Endosome 0.003640 0.004557 0.002789 0.012220 0.003726 0.004592 0.002443 0.002832 0.003721 0.004581 0.002591 0.008865
Golgi 0.008271 0.004567 0.003395 0.014024 0.002619 0.003217 0.001156 0.002317 0.002974 0.003656 0.002116 0.009841
Lipid Particles 0.001451 0.002343 0.013120 0.050991 0.001144 0.001411 0.004054 0.008595 0.001164 0.001714 0.007939 0.035841
Mitochondria 0.003331 0.004328 0.002347 0.005399 0.003661 0.005962 0.002919 0.004935 0.003641 0.005430 0.002674 0.005233
Mitotic Spindle 0.000500 0.000264 0.000178 0.001021 0.000883 0.000576 0.000192 0.001148 0.000859 0.000475 0.000186 0.001067
None 0.000144 0.000179 0.000077 0.000157 0.000255 0.000227 0.000083 0.000095 0.000248 0.000211 0.000080 0.000135
Nuclear Periphery 0.000206 0.000255 0.000894 0.000725 0.000316 0.000220 0.000390 0.000566 0.000309 0.000231 0.000606 0.000668
Nuclear Periphery Foci 0.000136 0.000042 0.000076 0.000191 0.000120 0.000049 0.000065 0.000072 0.000121 0.000047 0.000069 0.000148
Nucleolus 0.000019 0.000016 0.000022 0.000033 0.000019 0.000021 0.000021 0.000023 0.000019 0.000020 0.000021 0.000029
Nucleus 0.000223 0.000133 0.000142 0.000314 0.000199 0.000147 0.000282 0.000212 0.000201 0.000142 0.000222 0.000277
Peroxisomes 0.000230 0.000337 0.000306 0.001954 0.000472 0.000613 0.000232 0.000082 0.000456 0.000523 0.000264 0.001285
Vacuole 0.000967 0.000599 0.006174 0.006827 0.000893 0.001427 0.003658 0.003326 0.000897 0.001158 0.004737 0.005576
Vacuole Periphery 0.002444 0.000119 0.000199 0.001499 0.000290 0.000663 0.000143 0.000657 0.000425 0.000486 0.000167 0.001198

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.68 4.22 -1.51 -1.88 -13.06 -1.18 -0.90 -0.45 0.48 0.46 -2.61 3.19 -5.01 -3.11 -7.80
Bud Neck 1.46 0.35 2.55 2.43 2.80 0.47 -5.67 -2.01 -2.54 4.10 -0.12 -5.41 -0.26 -0.18 5.50
Bud Site 2.16 2.53 -4.35 -11.79 -12.40 -0.27 -3.90 -7.16 -7.14 -3.54 0.73 -2.33 -12.79 -13.66 -9.81
Cell Periphery 3.22 4.57 -2.07 -14.00 -17.92 -1.62 4.01 -5.01 -4.14 -7.51 1.53 8.36 -8.86 -11.28 -16.77
Cytoplasm 1.64 1.58 -2.10 -2.13 -2.15 0.93 -0.43 1.25 0.79 0.90 1.14 -0.06 -1.18 -1.94 -0.94
Cytoplasmic Foci 0.86 -0.91 -2.88 -3.53 -0.02 -1.29 1.40 -0.34 0.60 -1.11 -0.77 -0.49 -2.31 -1.64 -0.74
Eisosomes -2.45 -6.83 6.29 21.88 26.36* 2.05 1.73 7.75 6.56 4.68 1.52 -3.64 21.09 22.99 21.60
Endoplasmic Reticulum -1.17 -0.85 -5.10 -5.06 -4.30 1.50 -0.25 -0.51 -1.59 -0.22 0.03 -1.00 -6.39 -7.01 -4.68
Endosome -0.94 0.84 -6.48 -7.40 -8.92 -1.70 2.59 1.63 3.10 -0.71 -2.00 2.64 -7.08 -6.02 -8.90
Golgi 0.60 0.78 -0.91 -4.52 -4.31 -0.87 3.00 0.40 1.11 -1.78 -0.93 0.94 -5.14 -4.72 -5.48
Lipid Particles -0.87 -3.31 -10.77 -10.69 -6.67 -0.96 -2.93 -2.74 -2.57 -1.58 -1.76 -4.27 -11.15 -10.91 -8.01
Mitochondria -0.92 0.83 -1.70 -1.02 -2.60 -2.87 0.93 -1.72 1.11 -2.23 -2.81 1.52 -2.27 0.23 -3.27
Mitotic Spindle 1.70 2.30 -1.82 -2.79 -3.07 0.68 1.97 -0.35 -0.78 -1.41 1.03 2.07 -0.57 -1.78 -2.99
None -1.21 2.82 -0.60 0.96 -6.34 1.11 2.66 6.92 9.11 0.62 1.59 4.37 5.05 5.85 -1.22
Nuclear Periphery -1.17 -5.75 -8.61 -9.16 1.38 3.88 -1.62 -2.59 -3.65 -1.60 3.36 -5.06 -7.20 -9.42 -0.79
Nuclear Periphery Foci 1.41 0.89 -0.86 -6.92 -4.87 0.89 0.37 0.63 -1.04 0.54 1.01 0.51 -0.41 -6.07 -2.88
Nucleolus 0.70 -0.50 -2.55 -3.63 -1.95 -0.69 -0.78 -1.31 -0.44 0.14 -0.26 -0.95 -3.15 -2.84 -1.41
Nucleus 2.83 2.51 -2.29 -5.85 -5.50 2.50 -0.96 0.07 -3.91 0.97 2.92 -0.90 -2.15 -6.42 0.78
Peroxisomes -0.85 -0.32 -2.68 -2.52 -2.44 -0.63 1.05 1.92 4.45 1.30 -0.34 0.88 -1.84 -1.82 -2.40
Vacuole 1.36 -5.64 -7.41 -8.19 -0.74 -0.62 -4.37 -3.54 -2.51 0.83 -0.30 -6.10 -6.93 -6.88 -1.20
Vacuole Periphery 0.98 0.95 0.38 -4.38 -4.12 -1.23 1.16 -0.96 0.02 -1.43 -0.21 1.37 -2.57 -2.42 -4.31
Standard name
Human Ortholog
Description Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15
Localization
Cell Percentages actin (57%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ede1

Ede1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ede1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available