| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 1 | 2 | 2 | – | – | 5 | 28 | 8 | 3 | 9 | 15 |
| Bud | 0 | 6 | 17 | 11 | 13 | 22 | 22 | 23 | 18 | 14 | 24 | 43 | 1 | 4 | 1 | 1 | – | – | 1 | 7 | 2 | 1 | 2 | 6 |
| Bud Neck | 0 | 0 | 1 | 0 | 2 | 1 | 4 | 0 | 0 | 1 | 1 | 3 | 1 | 2 | 0 | 0 | – | – | 0 | 5 | 2 | 1 | 7 | 5 |
| Bud Site | 1 | 0 | 5 | 3 | 2 | 9 | 13 | 7 | 9 | 11 | 7 | 9 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – |
| Cell Periphery | 1 | 16 | 6 | 7 | 1 | 3 | 1 | 2 | 2 | 0 | 1 | 3 | 6 | 4 | 4 | 3 | – | – | 0 | 2 | 1 | 0 | 0 | 1 |
| Cytoplasm | 62 | 114 | 63 | 64 | 94 | 104 | 108 | 116 | 77 | 117 | 165 | 145 | 39 | 69 | 109 | 3 | – | – | 28 | 21 | 11 | 3 | 6 | 4 |
| Endoplasmic Reticulum | 1 | 14 | 3 | 1 | 3 | 2 | 1 | 1 | 0 | 2 | 1 | 2 | 15 | 7 | 6 | 1 | – | – | 0 | 6 | 4 | 3 | 3 | 2 |
| Endosome | 1 | 23 | 6 | 33 | 22 | 6 | 1 | 0 | 1 | 1 | 0 | 0 | 15 | 36 | 57 | 2 | – | – | 3 | 42 | 27 | 18 | 19 | 22 |
| Golgi | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 1 | 2 | 9 | – | – | 0 | 10 | 3 | 3 | 5 | 12 |
| Mitochondria | 23 | 234 | 254 | 195 | 318 | 294 | 426 | 356 | 275 | 303 | 358 | 437 | 48 | 43 | 17 | 2 | – | – | 44 | 365 | 273 | 187 | 165 | 183 |
| Nucleus | 2 | 3 | 0 | 0 | 5 | 8 | 9 | 7 | 9 | 8 | 5 | 4 | 2 | 0 | 2 | 0 | – | – | 0 | 1 | 0 | 1 | 0 | 0 |
| Nuclear Periphery | 0 | 1 | 2 | 1 | 0 | 1 | 4 | 1 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 3 | 1 | 2 | 2 | 3 |
| Nucleolus | 4 | 0 | 3 | 2 | 1 | 3 | 3 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | – | – | 0 | 3 | 1 | 1 | 0 | 1 |
| Peroxisomes | 1 | 17 | 14 | 22 | 10 | 4 | 5 | 4 | 0 | 1 | 0 | 4 | 1 | 10 | 21 | 3 | – | – | 0 | 11 | 22 | 9 | 11 | 11 |
| SpindlePole | 4 | 15 | 24 | 25 | 21 | 36 | 22 | 33 | 20 | 29 | 20 | 44 | 9 | 6 | 5 | 1 | – | – | 2 | 9 | 4 | 5 | 4 | 5 |
| Vac/Vac Membrane | 3 | 62 | 11 | 7 | 24 | 14 | 9 | 6 | 4 | 8 | 10 | 1 | 31 | 32 | 42 | 7 | – | – | 2 | 36 | 6 | 15 | 11 | 24 |
| Unique Cell Count | 89 | 418 | 336 | 283 | 426 | 386 | 509 | 438 | 337 | 405 | 475 | 551 | 161 | 174 | 231 | 30 | 100 | 569 | 383 | 264 | 255 | 305 | ||
| Labelled Cell Count | 103 | 510 | 409 | 371 | 516 | 507 | 628 | 558 | 416 | 498 | 596 | 695 | 188 | 215 | 270 | 35 | 100 | 569 | 383 | 264 | 255 | 305 | ||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 6.0 | 4.6 | 3.5 | 3.7 | 3.4 | 3.4 | 2.8 | 2.8 | 2.7 | 2.6 | 2.4 | 2.5 | 5.9 | 5.4 | 5.7 | 8.4 | – | – | 6.0 | 6.4 | 6.3 |
| Std Deviation (1e-4) | 4.1 | 0.9 | 0.8 | 1.2 | 1.1 | 1.2 | 1.1 | 1.0 | 0.8 | 0.8 | 0.6 | 0.7 | 0.9 | 0.9 | 1.4 | 1.9 | – | – | 1.2 | 4.8 | 1.3 |
| Intensity Change (Log2) | – | – | – | 0.08 | -0.03 | -0.07 | -0.33 | -0.35 | -0.4 | -0.43 | -0.57 | -0.47 | 0.75 | 0.62 | 0.7 | 1.26 | – | – | 0.77 | 0.87 | 0.84 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | -0.2683 | 0.0307 | -0.131 | -0.0703 | -0.3778 | 0.0609 | 2.3885 | 2.0477 | 2.0966 | 2.4274 | 1.5822 | 2.1733 | -0.8934 | -0.6121 | -0.6813 | -0.5941 | -0.7108 | -0.4879 |
| Actin | 0.0073 | 0.0034 | 0.0044 | 0.0026 | 0.0086 | 0.0042 | 0.0728 | 0.0137 | 0.0338 | 0.0358 | 0.0462 | 0.0095 | 0.0141 | 0.0057 | 0.0192 | 0.0058 | 0.0008 | 0.0077 |
| Bud | 0.0014 | 0.0035 | 0.0039 | 0.0013 | 0.0009 | 0.0009 | 0.0046 | 0.0097 | 0.0087 | 0.0145 | 0.0022 | 0.002 | 0.0018 | 0.0053 | 0.0019 | 0.0029 | 0.0012 | 0.0015 |
| Bud Neck | 0.0032 | 0.0044 | 0.0042 | 0.0009 | 0.0011 | 0.0057 | 0.0071 | 0.0012 | 0.0018 | 0.0028 | 0.0011 | 0.0112 | 0.0025 | 0.0013 | 0.0027 | 0.0031 | 0.0004 | 0.0093 |
| Bud Periphery | 0.0047 | 0.006 | 0.0144 | 0.005 | 0.0042 | 0.0038 | 0.0165 | 0.0175 | 0.0212 | 0.052 | 0.0078 | 0.0099 | 0.0075 | 0.0072 | 0.0065 | 0.0118 | 0.0035 | 0.0046 |
| Bud Site | 0.0077 | 0.032 | 0.0092 | 0.0012 | 0.0006 | 0.0015 | 0.0327 | 0.0142 | 0.0165 | 0.0184 | 0.0031 | 0.0023 | 0.0072 | 0.0463 | 0.0064 | 0.0024 | 0.0007 | 0.0015 |
| Cell Periphery | 0.0018 | 0.0011 | 0.0014 | 0.0007 | 0.0011 | 0.0008 | 0.0041 | 0.0019 | 0.0061 | 0.0045 | 0.0029 | 0.0018 | 0.0022 | 0.0023 | 0.0021 | 0.0026 | 0.0007 | 0.001 |
| Cytoplasm | 0.0842 | 0.0736 | 0.069 | 0.063 | 0.0779 | 0.0901 | 0.0791 | 0.114 | 0.0933 | 0.1016 | 0.1217 | 0.0691 | 0.0624 | 0.0912 | 0.066 | 0.1324 | 0.1042 | 0.0923 |
| Cytoplasmic Foci | 0.1073 | 0.0886 | 0.1047 | 0.076 | 0.135 | 0.0937 | 0.0872 | 0.1076 | 0.1053 | 0.1249 | 0.0673 | 0.1136 | 0.1366 | 0.1188 | 0.0858 | 0.1001 | 0.1142 | 0.1301 |
| Eisosomes | 0.0013 | 0.0006 | 0.001 | 0.0006 | 0.0006 | 0.0009 | 0.0017 | 0.0008 | 0.0024 | 0.0008 | 0.0008 | 0.0006 | 0.0037 | 0.0008 | 0.0013 | 0.0006 | 0.0006 | 0.0006 |
| Endoplasmic Reticulum | 0.0092 | 0.0035 | 0.0028 | 0.0018 | 0.0038 | 0.0054 | 0.0082 | 0.0085 | 0.0044 | 0.004 | 0.0025 | 0.0039 | 0.0076 | 0.0044 | 0.0064 | 0.0028 | 0.0038 | 0.0028 |
| Endosome | 0.0959 | 0.1031 | 0.055 | 0.0585 | 0.1734 | 0.0821 | 0.1382 | 0.1592 | 0.0891 | 0.1183 | 0.0883 | 0.0907 | 0.1189 | 0.1155 | 0.089 | 0.0835 | 0.124 | 0.0785 |
| Golgi | 0.0136 | 0.0323 | 0.0196 | 0.0246 | 0.0203 | 0.0158 | 0.0531 | 0.06 | 0.043 | 0.0356 | 0.0384 | 0.0366 | 0.0355 | 0.0428 | 0.0429 | 0.0204 | 0.0231 | 0.0225 |
| Lipid Particles | 0.0257 | 0.0132 | 0.0133 | 0.0063 | 0.0296 | 0.0238 | 0.0282 | 0.0166 | 0.0164 | 0.0083 | 0.0062 | 0.0207 | 0.0488 | 0.0156 | 0.0242 | 0.0091 | 0.03 | 0.0294 |
| Mitochondria | 0.102 | 0.1848 | 0.2464 | 0.2766 | 0.085 | 0.2163 | 0.1728 | 0.2685 | 0.2463 | 0.2266 | 0.2633 | 0.2701 | 0.2059 | 0.1745 | 0.3113 | 0.2809 | 0.2714 | 0.3043 |
| None | 0.4514 | 0.3724 | 0.3918 | 0.4657 | 0.3514 | 0.3961 | 0.2248 | 0.1501 | 0.2453 | 0.1104 | 0.2907 | 0.2783 | 0.2652 | 0.2979 | 0.275 | 0.2278 | 0.2523 | 0.2377 |
| Nuclear Periphery | 0.0073 | 0.0036 | 0.0016 | 0.0005 | 0.0146 | 0.0013 | 0.004 | 0.0031 | 0.0012 | 0.0024 | 0.001 | 0.0037 | 0.0025 | 0.0014 | 0.0051 | 0.0012 | 0.0017 | 0.0014 |
| Nucleolus | 0.0065 | 0.0022 | 0.0022 | 0.0007 | 0.003 | 0.0017 | 0.0011 | 0.0013 | 0.001 | 0.0016 | 0.0006 | 0.0008 | 0.0029 | 0.001 | 0.0013 | 0.0011 | 0.0013 | 0.0013 |
| Nucleus | 0.0051 | 0.0033 | 0.0026 | 0.0008 | 0.0035 | 0.0016 | 0.0017 | 0.0031 | 0.0016 | 0.0045 | 0.001 | 0.0015 | 0.0028 | 0.0016 | 0.0016 | 0.0025 | 0.0014 | 0.0018 |
| Peroxisomes | 0.0342 | 0.0485 | 0.0354 | 0.0072 | 0.0482 | 0.0381 | 0.0384 | 0.0186 | 0.0384 | 0.0844 | 0.0436 | 0.0574 | 0.0478 | 0.0509 | 0.0377 | 0.0698 | 0.0422 | 0.0545 |
| Punctate Nuclear | 0.0074 | 0.0022 | 0.0017 | 0.0007 | 0.0201 | 0.0019 | 0.0032 | 0.0008 | 0.0015 | 0.0014 | 0.0009 | 0.0028 | 0.003 | 0.0012 | 0.0015 | 0.0013 | 0.0029 | 0.0028 |
| Vacuole | 0.0178 | 0.0132 | 0.011 | 0.0031 | 0.0112 | 0.0103 | 0.016 | 0.0239 | 0.0168 | 0.0382 | 0.007 | 0.0095 | 0.0171 | 0.0113 | 0.0081 | 0.0316 | 0.0131 | 0.0105 |
| Vacuole Periphery | 0.0049 | 0.0044 | 0.0045 | 0.0022 | 0.0059 | 0.004 | 0.0046 | 0.0056 | 0.006 | 0.0088 | 0.0035 | 0.0041 | 0.0039 | 0.0031 | 0.0038 | 0.0063 | 0.0065 | 0.0039 |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 14.927 | 21.3501 | 11.882 | 11.3185 | 17.8052 | 9.548 | 14.3015 | 14.5698 | 11.5981 | 16.1893 |
| Translational Efficiency | 1.4059 | 1.6246 | 1.5096 | 1.2011 | 1.0079 | 1.6748 | 1.622 | 1.2347 | 1.4403 | 1.0493 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | ✘ |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 1876 | 2724 | 1070 | 2612 | 1525 | 2010 | 1743 | 1835 | 3401 | 4734 | 2813 | 4447 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 696.61 | 809.08 | 776.42 | 891.57 | 674.84 | 724.09 | 831.53 | 869.69 | 686.85 | 772.99 | 810.57 | 882.54 |
| Standard Deviation | 82.31 | 106.31 | 107.11 | 121.16 | 104.03 | 96.47 | 100.12 | 123.48 | 93.31 | 110.54 | 106.26 | 122.60 |
| Intensity Change Log 2 | — | 0.215931 | 0.156486 | 0.355997 | — | 0.101624 | 0.301223 | 0.365956 | — | 0.160816 | 0.229521 | 0.360906 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000534 | 0.000685 | 0.002817 | 0.009837 | 0.000423 | 0.000729 | 0.003943 | 0.007155 | 0.000485 | 0.000704 | 0.003515 | 0.008730 |
| Bud Neck | 0.016172 | 0.012951 | 0.028668 | 0.055992 | 0.021621 | 0.012737 | 0.054658 | 0.049274 | 0.018616 | 0.012860 | 0.044772 | 0.053220 |
| Bud Site | 0.014844 | 0.022012 | 0.052771 | 0.152835* | 0.027390 | 0.013203 | 0.111064* | 0.142569* | 0.020470 | 0.018272 | 0.088891 | 0.148599* |
| Cell Periphery | 0.000305 | 0.000218 | 0.000180 | 0.000277 | 0.000684 | 0.000349 | 0.000251 | 0.000359 | 0.000475 | 0.000274 | 0.000224 | 0.000311 |
| Cytoplasm | 0.028838 | 0.016244 | 0.205177* | 0.213729* | 0.018418 | 0.015143 | 0.149074* | 0.196079* | 0.024165 | 0.015776 | 0.170414* | 0.206446* |
| Cytoplasmic Foci | 0.080952 | 0.066603 | 0.126623 | 0.075504 | 0.053709 | 0.073662 | 0.088823 | 0.117520 | 0.068737 | 0.069600 | 0.103201 | 0.092842 |
| Eisosomes | 0.000150 | 0.000077 | 0.000103 | 0.000125 | 0.000115 | 0.000112 | 0.000115 | 0.000173 | 0.000134 | 0.000092 | 0.000111 | 0.000145 |
| Endoplasmic Reticulum | 0.001431 | 0.000537 | 0.008056 | 0.001994 | 0.001072 | 0.000636 | 0.004840 | 0.001921 | 0.001270 | 0.000579 | 0.006063 | 0.001964 |
| Endosome | 0.071202 | 0.073830 | 0.040545 | 0.025031 | 0.074003 | 0.102721 | 0.038090 | 0.043542 | 0.072458 | 0.086097 | 0.039024 | 0.032669 |
| Golgi | 0.073721 | 0.100905 | 0.023348 | 0.024729 | 0.082111 | 0.118422* | 0.022719 | 0.027614 | 0.077483 | 0.108343 | 0.022958 | 0.025920 |
| Lipid Particles | 0.008443 | 0.002791 | 0.006985 | 0.001454 | 0.006988 | 0.010116 | 0.003325 | 0.002586 | 0.007791 | 0.005901 | 0.004717 | 0.001921 |
| Mitochondria | 0.619145* | 0.590123* | 0.054779 | 0.114506* | 0.629219* | 0.549934* | 0.136385* | 0.090669 | 0.623662* | 0.573060* | 0.105344* | 0.104670* |
| Mitotic Spindle | 0.006045 | 0.027899 | 0.087850 | 0.095138 | 0.005519 | 0.011370 | 0.105938* | 0.057319 | 0.005809 | 0.020881 | 0.099058 | 0.079532 |
| None | 0.000579 | 0.000522 | 0.002453 | 0.000975 | 0.004269 | 0.001072 | 0.001382 | 0.000848 | 0.002234 | 0.000756 | 0.001789 | 0.000923 |
| Nuclear Periphery | 0.000237 | 0.000147 | 0.002959 | 0.000760 | 0.000206 | 0.000207 | 0.001244 | 0.000398 | 0.000223 | 0.000173 | 0.001897 | 0.000610 |
| Nuclear Periphery Foci | 0.000226 | 0.000145 | 0.002980 | 0.000321 | 0.000357 | 0.000363 | 0.000885 | 0.000431 | 0.000285 | 0.000238 | 0.001682 | 0.000367 |
| Nucleolus | 0.000536 | 0.000626 | 0.005308 | 0.000841 | 0.002109 | 0.000946 | 0.003027 | 0.000950 | 0.001242 | 0.000762 | 0.003894 | 0.000886 |
| Nucleus | 0.003148 | 0.003338 | 0.169445* | 0.032243 | 0.005059 | 0.003586 | 0.090719 | 0.035131 | 0.004005 | 0.003443 | 0.120665 | 0.033435 |
| Peroxisomes | 0.020655 | 0.024031 | 0.027811 | 0.063692 | 0.016165 | 0.026788 | 0.051165 | 0.078609 | 0.018641 | 0.025201 | 0.042282 | 0.069847 |
| Vacuole | 0.031750 | 0.037573 | 0.133471 | 0.123755 | 0.026014 | 0.035653 | 0.120258 | 0.140803 | 0.029178 | 0.036758 | 0.125284 | 0.130790 |
| Vacuole Periphery | 0.021086 | 0.018741 | 0.017670 | 0.006261 | 0.024548 | 0.022250 | 0.012096 | 0.006050 | 0.022638 | 0.020231 | 0.014216 | 0.006174 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | -1.25 | -5.43 | -11.82 | -11.59 | -6.84 | -1.20 | -9.72 | -11.59 | -10.23 | -3.97 | -1.71 | -11.04 | -15.94 | -15.16 | -7.68 |
| Bud Neck | 1.89 | -5.12 | -15.63 | -19.07 | -8.64 | 3.84 | -10.05 | -7.98 | -13.63 | 3.00 | 4.13 | -12.16 | -16.78 | -23.39 | -1.97 |
| Bud Site | -4.63 | -11.09 | -29.90* | -27.64* | -16.03 | 5.88 | -17.24 | -19.22 | -24.21 | -3.11 | 1.55 | -21.56 | -34.60 | -36.79* | -10.54 |
| Cell Periphery | 2.73 | 4.49 | 2.54 | -0.51 | -2.71 | 3.89 | 5.64 | 4.39 | 0.67 | -2.29 | 4.76 | 6.63 | 5.13 | 0.32 | -2.68 |
| Cytoplasm | 5.34 | -23.18 | -39.74 | -44.54 | -3.39 | 1.42 | -25.31 | -32.21 | -33.56 | -7.31 | 5.03 | -33.71 | -51.29 | -55.65 | -9.07 |
| Cytoplasmic Foci | 4.06 | -7.63 | 3.64 | -0.51 | 10.89 | -5.22 | -8.20 | -12.86 | -8.41 | -4.97 | -0.25 | -9.68 | -5.87 | -6.24 | 4.81 |
| Eisosomes | 7.49 | 3.93 | 3.49 | -7.87 | -0.89 | 0.22 | -0.14 | -3.27 | -4.74 | -5.37 | 5.18 | 2.54 | 0.09 | -8.13 | -4.08 |
| Endoplasmic Reticulum | 2.85 | -12.01 | -2.06 | -9.35 | 12.03 | 1.82 | -10.93 | -3.66 | -7.22 | 8.94 | 3.40 | -15.50 | -3.72 | -11.79 | 14.73 |
| Endosome | -0.72 | 9.76 | 17.36 | 21.00 | 7.67 | -6.44 | 11.13 | 10.24 | 17.90 | -0.80 | -4.85 | 15.08 | 19.86 | 27.40 | 5.58 |
| Golgi | -6.49 | 15.02 | 17.28 | 25.77 | 0.90 | -6.82 | 15.82 | 15.08 | 22.95 | -0.94 | -9.32 | 22.12 | 22.95 | 34.47 | 0.14 |
| Lipid Particles | 5.25 | 1.13 | 6.85 | 2.23 | 8.89 | -2.14 | 3.50 | 4.48 | 6.64 | 3.15 | 2.15 | 3.87 | 8.20 | 6.87 | 9.86 |
| Mitochondria | 3.01 | 68.02* | 64.75* | 69.29* | -7.74 | 6.87 | 50.16* | 58.22* | 56.04* | 7.35 | 6.79 | 79.00* | 86.96* | 88.89* | 2.55 |
| Mitotic Spindle | -12.54 | -14.03 | -21.98 | -14.70 | -0.11 | -5.20 | -20.42* | -15.05 | -12.62 | 8.84 | -13.54 | -24.67 | -26.53 | -19.10 | 5.51 |
| None | 0.60 | -9.74 | -3.40 | -3.98 | 5.79 | 3.21 | 2.97 | 3.40 | 0.41 | 2.26 | 3.29 | 1.13 | 2.67 | -1.96 | 4.97 |
| Nuclear Periphery | 1.46 | -4.42 | -6.74 | -7.59 | 2.93 | -0.01 | -9.69 | -5.61 | -6.67 | 6.78 | 1.07 | -7.26 | -8.30 | -9.29 | 4.31 |
| Nuclear Periphery Foci | 1.35 | -8.60 | -2.83 | -6.92 | 8.16 | 0.04 | -3.68 | -2.00 | -1.05 | 2.71 | 0.60 | -9.02 | -3.31 | -2.83 | 8.12 |
| Nucleolus | -0.61 | -9.75 | -4.16 | -2.98 | 8.76 | 2.41 | -2.36 | 2.52 | -0.02 | 5.26 | 2.13 | -7.33 | 1.14 | -2.13 | 8.92 |
| Nucleus | -0.32 | -24.15 | -23.38 | -23.07 | 16.67 | 1.27 | -21.46 | -17.13 | -17.97 | 10.37 | 0.78 | -31.93 | -28.78 | -29.22 | 18.72 |
| Peroxisomes | -1.63 | -2.45 | -11.07 | -10.03 | -8.04 | -4.97 | -10.85 | -14.56 | -10.97 | -4.37 | -4.41 | -10.28 | -18.00 | -14.77 | -6.72 |
| Vacuole | -2.58 | -19.91 | -32.18 | -31.16 | -4.98 | -4.02 | -24.62 | -29.41 | -27.30 | -8.08 | -4.58 | -31.33 | -43.70 | -41.43 | -9.53 |
| Vacuole Periphery | 1.88 | 2.95 | 15.46 | 15.72 | 6.75 | 1.30 | 8.39 | 13.14 | 15.90 | 6.48 | 2.30 | 8.79 | 20.03 | 22.31 | 9.39 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication |
| Localization | |
| Cell Percentages | mitochondrion (96%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | mito-2 |
Aac3
Aac3
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Aac3-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
