Standard name | |
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Human Ortholog | |
Description | Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 1 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 2 | 1 | – | – | – | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 2 | 0 | 2 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | – | – | – | 3 | 0 | 0 | 1 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 62 | 275 | 51 | 42 | 40 | 52 | – | 130 | 57 | 34 | – | 28 | 138 | 147 | 133 | – | – | – | 7 | 15 | 7 | 11 | 13 | 13 |
Endoplasmic Reticulum | 1 | 13 | 3 | 0 | 0 | 0 | – | 0 | 1 | 1 | – | 2 | 4 | 6 | 6 | – | – | – | 0 | 4 | 2 | 2 | 4 | 2 |
Endosome | 25 | 24 | 24 | 8 | 34 | 12 | – | 17 | 7 | 7 | – | 9 | 30 | 28 | 33 | – | – | – | 25 | 64 | 74 | 58 | 102 | 105 |
Golgi | 0 | 5 | 0 | 1 | 1 | 1 | – | 3 | 1 | 1 | – | 0 | 0 | 1 | 1 | – | – | – | 2 | 2 | 3 | 3 | 4 | 4 |
Mitochondria | 12 | 4 | 21 | 10 | 4 | 14 | – | 9 | 4 | 1 | – | 6 | 1 | 0 | 0 | – | – | – | 1 | 4 | 4 | 2 | 1 | 2 |
Nucleus | 1 | 3 | 1 | 0 | 1 | 0 | – | 1 | 0 | 1 | – | 0 | 1 | 0 | 2 | – | – | – | 6 | 4 | 0 | 6 | 3 | 3 |
Nuclear Periphery | 0 | 3 | 0 | 1 | 1 | 0 | – | 1 | 2 | 0 | – | 0 | 0 | 2 | 0 | – | – | – | 6 | 15 | 2 | 2 | 7 | 6 |
Nucleolus | 2 | 1 | 5 | 6 | 6 | 10 | – | 7 | 5 | 6 | – | 7 | 1 | 2 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 2 | – | 1 | 1 | 0 | – | 1 | 1 | 0 | 0 | – | – | – | 1 | 0 | 4 | 2 | 1 | 2 |
Vac/Vac Membrane | 165 | 241 | 101 | 24 | 62 | 49 | – | 41 | 11 | 12 | – | 6 | 161 | 139 | 111 | – | – | – | 180 | 402 | 79 | 140 | 170 | 146 |
Unique Cell Count | 221 | 477 | 170 | 73 | 118 | 112 | 183 | 76 | 57 | 49 | 257 | 258 | 226 | 237 | 521 | 184 | 233 | 318 | 297 | |||||
Labelled Cell Count | 271 | 571 | 209 | 92 | 149 | 140 | 210 | 89 | 63 | 59 | 338 | 327 | 287 | 237 | 521 | 184 | 233 | 318 | 297 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.8 | 9.8 | 6.5 | 8.0 | 8.5 | 7.2 | – | 8.5 | 7.8 | 8.1 | – | 7.5 | 9.0 | 9.2 | 9.0 | – | – | – | 9.0 | 9.6 | 9.5 |
Std Deviation (1e-4) | 1.6 | 1.8 | 1.3 | 1.9 | 2.2 | 1.6 | – | 2.7 | 2.7 | 2.3 | – | 2.3 | 1.7 | 1.5 | 1.4 | – | – | – | 1.8 | 1.9 | 2.2 |
Intensity Change (Log2) | – | – | – | 0.3 | 0.4 | 0.15 | – | 0.39 | 0.27 | 0.32 | – | 0.21 | 0.47 | 0.5 | 0.47 | – | – | – | 0.47 | 0.57 | 0.55 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Cytoplasm | 4.0 | 0.7 | 2.8 | – | 7.7 | 6.6 | 4.0 | – | 3.5 | 4.8 | 5.5 | 5.7 | – | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Endosome | -0.7 | 3.1 | -0.8 | – | -1.4 | -1.1 | -0.3 | – | 0.7 | -0.7 | -1.0 | 0.1 | – | – | – |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Mitochondria | 0.3 | -2.7 | 0 | – | -2.5 | -1.7 | -2.3 | – | 0 | -5.5 | -5.8 | -5.4 | – | – | – |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Nucleolus | 0 | 0 | 2.2 | – | 0.5 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – |
Vacuole | -3.8 | -1.2 | -2.6 | – | -7.1 | -6.5 | -5.0 | – | -5.8 | 0.7 | -1.1 | -2.0 | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.7895 | 6.926 | 6.1571 | 5.5639 | 5.3461 | 6.2763 | 2.8905 | 5.4656 | 4.8917 | 3.7473 | 4.2785 | 4.6414 | 4.8437 | 6.8257 | 6.6591 | 5.7329 | 6.6029 | 6.384 |
Actin | 0.003 | 0 | 0.0034 | 0 | 0.0044 | 0.0075 | 0.0176 | 0 | 0.0115 | 0.0033 | 0.0203 | 0.0003 | 0.015 | 0.0001 | 0.0002 | 0.0001 | 0.0543 | 0 |
Bud | 0.0008 | 0.0013 | 0.0003 | 0.0002 | 0.0002 | 0.002 | 0.0012 | 0.0014 | 0.0006 | 0.0003 | 0.0003 | 0.0006 | 0.0009 | 0.0011 | 0.0006 | 0.0007 | 0.0008 | 0.0004 |
Bud Neck | 0.0005 | 0.0001 | 0.0006 | 0.0001 | 0.0002 | 0.0003 | 0.0017 | 0.0006 | 0.0003 | 0.0001 | 0.0019 | 0.0004 | 0.001 | 0.0002 | 0.0005 | 0.0007 | 0.0022 | 0.0001 |
Bud Periphery | 0.0009 | 0.0008 | 0.0004 | 0.0005 | 0.0005 | 0.0014 | 0.0039 | 0.0008 | 0.0024 | 0.0008 | 0.0005 | 0.0018 | 0.0019 | 0.0006 | 0.0008 | 0.0008 | 0.0015 | 0.0005 |
Bud Site | 0.0012 | 0.0002 | 0.0012 | 0 | 0.0002 | 0.0003 | 0.0016 | 0.0027 | 0.0028 | 0.0006 | 0.0005 | 0.0001 | 0.0016 | 0.0008 | 0.0048 | 0.0008 | 0.0016 | 0.0002 |
Cell Periphery | 0.0004 | 0.0003 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0005 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0001 |
Cytoplasm | 0.0075 | 0.0199 | 0.0127 | 0.0027 | 0.0143 | 0.0115 | 0.0153 | 0.0363 | 0.0123 | 0.0006 | 0.009 | 0.0116 | 0.0166 | 0.0508 | 0.0317 | 0.0333 | 0.0084 | 0.008 |
Cytoplasmic Foci | 0.0088 | 0.0025 | 0.0046 | 0.0005 | 0.0023 | 0.0052 | 0.0155 | 0.0066 | 0.0096 | 0.0067 | 0.0244 | 0.0082 | 0.0083 | 0.009 | 0.0055 | 0.031 | 0.0132 | 0.0058 |
Eisosomes | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0.0006 | 0 |
Endoplasmic Reticulum | 0.0073 | 0.0021 | 0.0029 | 0.0038 | 0.0086 | 0.0015 | 0.0097 | 0.0049 | 0.0057 | 0.0028 | 0.0029 | 0.0052 | 0.0073 | 0.0038 | 0.0044 | 0.0027 | 0.0041 | 0.0018 |
Endosome | 0.0741 | 0.0732 | 0.0942 | 0.0645 | 0.1064 | 0.0624 | 0.1883 | 0.1391 | 0.1432 | 0.0549 | 0.1745 | 0.12 | 0.1142 | 0.0817 | 0.1826 | 0.2556 | 0.1841 | 0.1031 |
Golgi | 0.0067 | 0.0011 | 0.0068 | 0.0008 | 0.0044 | 0.0045 | 0.019 | 0.0042 | 0.0057 | 0.0031 | 0.0095 | 0.002 | 0.0049 | 0.0014 | 0.0102 | 0.0056 | 0.0436 | 0.0029 |
Lipid Particles | 0.0054 | 0.0001 | 0.0054 | 0.0001 | 0.0108 | 0.0016 | 0.0114 | 0.0014 | 0.0022 | 0.0084 | 0.0028 | 0.0009 | 0.0078 | 0.0006 | 0.0014 | 0.0034 | 0.0151 | 0.0002 |
Mitochondria | 0.0192 | 0.0034 | 0.0088 | 0.0027 | 0.0427 | 0.0031 | 0.0267 | 0.0067 | 0.0155 | 0.0145 | 0.0378 | 0.0064 | 0.0086 | 0.0017 | 0.0069 | 0.0112 | 0.0068 | 0.0031 |
None | 0.0016 | 0.0004 | 0.0014 | 0.0001 | 0.0017 | 0.0003 | 0.0027 | 0.0005 | 0.0005 | 0.0002 | 0.0013 | 0.0011 | 0.0048 | 0.001 | 0.0003 | 0.0025 | 0.0029 | 0.0001 |
Nuclear Periphery | 0.0224 | 0.0248 | 0.0285 | 0.0199 | 0.0523 | 0.0245 | 0.0534 | 0.0474 | 0.0482 | 0.0184 | 0.0158 | 0.0401 | 0.073 | 0.0259 | 0.0241 | 0.0083 | 0.0307 | 0.0335 |
Nucleolus | 0.0034 | 0.0004 | 0.0007 | 0.0001 | 0.0008 | 0.0012 | 0.0016 | 0.0004 | 0.0037 | 0.0001 | 0.001 | 0.0006 | 0.0026 | 0.0011 | 0.0008 | 0.0006 | 0.0017 | 0.0005 |
Nucleus | 0.0079 | 0.003 | 0.0077 | 0.0014 | 0.0136 | 0.0049 | 0.0083 | 0.0093 | 0.0096 | 0.0007 | 0.0044 | 0.008 | 0.0491 | 0.0039 | 0.0035 | 0.003 | 0.0029 | 0.005 |
Peroxisomes | 0.0021 | 0.0002 | 0.0019 | 0 | 0.0004 | 0.0019 | 0.0019 | 0.0001 | 0.0048 | 0.0467 | 0.0014 | 0.0001 | 0.0076 | 0.0001 | 0.0006 | 0.0004 | 0.005 | 0.0001 |
Punctate Nuclear | 0.0012 | 0 | 0.0024 | 0 | 0.0033 | 0.0007 | 0.003 | 0.0002 | 0.0032 | 0.0001 | 0.0093 | 0.0015 | 0.0042 | 0.0004 | 0.0004 | 0.0002 | 0.0179 | 0.0001 |
Vacuole | 0.2746 | 0.3139 | 0.2538 | 0.2861 | 0.2018 | 0.2182 | 0.2609 | 0.2337 | 0.1886 | 0.2283 | 0.2443 | 0.2073 | 0.2687 | 0.3241 | 0.2673 | 0.2612 | 0.2246 | 0.2497 |
Vacuole Periphery | 0.5511 | 0.5522 | 0.5623 | 0.6165 | 0.5304 | 0.6468 | 0.3558 | 0.5035 | 0.5295 | 0.6093 | 0.438 | 0.5837 | 0.4013 | 0.4914 | 0.4529 | 0.3779 | 0.3778 | 0.5848 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 16.6175 | 33.6715 | 16.1672 | 21.0007 | 27.2908 | 24.3589 | 25.5339 | 31.764 | 28.2222 | 24.855 |
Translational Efficiency | 1.2279 | 0.5084 | 1.117 | 0.9513 | 0.6233 | 0.6848 | 1.1193 | 0.7958 | 0.936 | 1.1968 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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