Standard name
Human Ortholog
Description Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.35 0.36 0.45 0.33 0.32 0.21 0.12 0.14 0.15 0.11 0.09 0.12 0.15 0.11 0 0.19 0.24 0.2 0.31 0.31 0.4 0.31 0.35 0.33
Bud 0.11 0.1 0.14 0.07 0.11 0.09 0.11 0.1 0.09 0.08 0.07 0.09 0.07 0.06 0 0 0.07 0 0.18 0.11 0.09 0.17 0.13 0.1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.24 0.26 0.19 0.19 0.18 0.14
Bud Site 0.2 0.1 0.1 0 0.05 0.07 0.05 0.05 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.23 0.23 0.3 0.29 0.18 0.08 0.1 0.09 0.18 0.11 0.15 0.17 0.49 0.42 0.45 0.41 0.5 0.45 0.12 0.08 0.17 0.12 0.11 0.09
Cytoplasm 0.4 0.39 0.3 0.42 0.37 0.41 0.48 0.49 0.5 0.46 0.47 0.45 0.72 0.76 0.9 0.54 0.35 0.58 0.1 0.13 0.06 0.14 0.15 0.26
Endoplasmic Reticulum 0.07 0.14 0.08 0.18 0.22 0.22 0.17 0.11 0.11 0.09 0.11 0.07 0.05 0.06 0 0.05 0 0 0 0 0.05 0 0 0
Endosome 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0 0.06 0.05 0.18 0.16 0.21 0.28 0.39 0.38 0.38 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.09 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0 0.06 0.08 0 0.07 0.05 0 0 0 0 0 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 85 181 101 59 96 63 39 66 56 39 24 38 40 25 9 26 22 18 90 203 116 37 87 93
Bud 26 49 31 13 32 29 37 45 33 30 18 28 19 13 7 5 6 3 52 73 26 20 31 28
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 71 171 54 23 44 40
Bud Site 47 48 23 7 14 22 15 21 15 14 4 8 5 1 0 4 3 1 – – – – – –
Cell Periphery 54 113 67 52 54 23 33 44 64 41 39 54 134 97 157 55 46 41 34 53 49 13 27 25
Cytoplasm 95 194 68 76 112 125 160 226 182 169 121 143 196 174 315 72 32 53 29 81 17 16 36 74
Endoplasmic Reticulum 18 71 17 32 65 68 57 52 40 32 28 24 13 14 8 7 2 3 6 24 13 3 10 8
Endosome 11 5 3 5 2 8 7 1 1 1 1 1 2 0 2 1 0 1 3 10 2 1 2 1
Golgi 0 3 0 2 1 0 0 1 0 0 2 0 0 0 0 0 3 0 0 4 1 0 1 1
Mitochondria 13 3 2 10 14 56 52 98 100 141 98 120 0 0 1 1 0 0 1 6 4 1 2 3
Nucleus 0 4 5 2 1 2 1 8 3 4 2 4 0 2 0 3 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 2 2 1 3 1 1 4 4 3 0 0 0 0 0 1 0 2 1 0 0 1
Nucleolus 2 2 2 0 0 0 5 7 3 2 2 4 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 2 3 6 1 5 1 2 3 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 5 2 0 1 1 0 1 0 1 0 0 1 0 0 7 8 2 1 1 0 0 0 0
Vac/Vac Membrane 0 16 0 4 16 7 21 38 15 26 12 13 1 1 1 6 5 2 2 7 1 0 2 1
Unique Cell Count 240 498 223 179 301 306 333 465 363 365 260 320 272 230 349 134 92 92 296 649 291 120 251 283
Labelled Cell Count 354 697 327 265 415 406 432 612 514 504 355 441 411 327 500 187 127 125 296 649 291 120 251 283


Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.4 11.1 9.6 9.0 9.2 8.5 7.9 8.0 8.0 6.8 7.5 7.5 10.1 9.3 9.5 11.8 13.9 14.2 8.9 8.5 9.4
Std Deviation (1e-4) 1.6 1.9 1.6 1.7 1.9 1.8 1.8 1.8 1.9 1.7 1.9 1.9 1.3 1.4 1.4 2.0 2.4 2.8 1.4 1.2 1.1
Intensity Change (Log2) – – – -0.09 -0.06 -0.17 -0.27 -0.26 -0.25 -0.5 -0.35 -0.35 0.07 -0.04 -0.02 0.3 0.54 0.56 -0.11 -0.17 -0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.5 -3.1 -6.1 -8.9 -8.9 -7.9 -9.6 -9.0 -8.8 -7.5 -8.2 -12.6 -4.9 -3.5 -4.3
Bud -2.1 -1.1 -1.6 -1.0 -1.7 -1.8 -2.2 -2.5 -1.9 -2.5 -3.0 -5.6 -3.1 -1.8 -2.8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site -2.4 -2.5 -1.3 -2.7 -2.9 -3.0 -3.1 -4.2 -3.9 -4.1 -4.7 -6.1 -2.5 -2.1 -2.8
Cell Periphery -0.2 -3.3 -6.8 -6.1 -6.9 -3.5 -5.7 -4.0 -3.6 4.3 2.7 3.6 2.1 3.4 2.5
Cytoplasm 2.5 1.6 2.4 4.1 4.5 4.7 3.8 3.6 3.3 9.2 9.6 14.8 4.4 0.7 4.5
Endoplasmic Reticulum 3.1 4.4 4.5 3.2 1.5 1.3 0.5 1.2 -0.1 -1.3 -0.6 -3.0 -0.9 -1.8 -1.4
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.7 2.5 6.3 5.7 7.0 8.3 10.3 9.9 10.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.5 0 3.8 4.4 3.1 4.1 3.2 3.0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.9059 6.1329 6.1752 5.7696 5.2468 6.0905 9.5999 8.9386 9.3679 9.0571 8.5997 9.2155 8.5559 9.6313 9.6924 9.8407 9.5012 9.1989
Actin 0.1693 0.0767 0.1404 0.1429 0.1785 0.2062 0.1631 0.0744 0.1059 0.1085 0.2011 0.1632 0.1609 0.0563 0.127 0.0442 0.3424 0.1177
Bud 0.0112 0.0164 0.0101 0.0063 0.0351 0.0167 0.0147 0.0138 0.0142 0.012 0.0239 0.0093 0.0061 0.005 0.003 0.0112 0.0129 0.0077
Bud Neck 0.0685 0.0169 0.3818 0.2489 0.104 0.4036 0.0458 0.0169 0.3509 0.2686 0.2155 0.5161 0.096 0.0549 0.4535 0.2423 0.1669 0.5996
Bud Periphery 0.0312 0.0239 0.0452 0.0449 0.0973 0.1261 0.0445 0.0153 0.0406 0.0871 0.1139 0.0678 0.0162 0.0095 0.0152 0.105 0.0531 0.0466
Bud Site 0.186 0.5164 0.2025 0.0183 0.03 0.0209 0.2441 0.5537 0.2951 0.055 0.0444 0.0162 0.275 0.5186 0.2165 0.0099 0.0273 0.0119
Cell Periphery 0.0896 0.0323 0.0247 0.0635 0.0962 0.0564 0.1211 0.0285 0.0334 0.0707 0.0782 0.0506 0.0862 0.0165 0.0242 0.0531 0.0239 0.0228
Cytoplasm 0.1682 0.2993 0.0893 0.353 0.2739 0.0821 0.2338 0.2864 0.1076 0.3759 0.296 0.1654 0.1381 0.3061 0.0701 0.5241 0.2381 0.1616
Cytoplasmic Foci 0.0424 0.004 0.0125 0.0067 0.0139 0.0054 0.0147 0.0022 0.0049 0.0021 0.0042 0.0014 0.0343 0.0083 0.0166 0.001 0.0066 0.0034
Eisosomes 0.0062 0.0006 0.001 0.0007 0.0012 0.0012 0.0031 0.0007 0.0006 0.0005 0.0028 0.0008 0.0031 0.0005 0.001 0.0003 0.001 0.0004
Endoplasmic Reticulum 0.0169 0.0025 0.0075 0.0051 0.0146 0.0052 0.0099 0.0016 0.0027 0.008 0.0057 0.0029 0.0209 0.0073 0.0123 0.0037 0.0054 0.0032
Endosome 0.0519 0.0016 0.0206 0.0349 0.0121 0.0166 0.0265 0.0005 0.0116 0.0008 0.0012 0.0008 0.0459 0.002 0.0121 0.0004 0.0135 0.0059
Golgi 0.0264 0.0023 0.0165 0.019 0.0279 0.0167 0.0112 0.0013 0.0084 0.0023 0.0033 0.0014 0.021 0.0019 0.0073 0.0008 0.0191 0.0035
Lipid Particles 0.0273 0.0009 0.0063 0.0096 0.0253 0.0062 0.0075 0.0003 0.003 0.0008 0.0014 0.0004 0.0141 0.0044 0.0108 0.0002 0.0038 0.0028
Mitochondria 0.012 0.0003 0.0261 0.0235 0.0616 0.0221 0.0028 0.0002 0.0051 0.0002 0.0003 0.0007 0.0318 0.0002 0.0072 0.0001 0.0047 0.0017
None 0.0075 0.0011 0.0049 0.0063 0.0014 0.0032 0.0136 0.0009 0.0086 0.0006 0.0025 0.0008 0.0113 0.0032 0.0046 0.0006 0.0715 0.0014
Nuclear Periphery 0.0155 0.0004 0.0019 0.0007 0.002 0.0031 0.0121 0.0003 0.0012 0.0008 0.0006 0.0002 0.0095 0.0006 0.0016 0.0005 0.0015 0.0026
Nucleolus 0.0026 0.0002 0.0004 0.0004 0.0004 0.0004 0.0018 0.0001 0.0003 0.0002 0.0002 0.0001 0.0015 0.0001 0.0004 0.0001 0.0004 0.0003
Nucleus 0.0055 0.0009 0.0009 0.001 0.0015 0.0014 0.0069 0.0011 0.0009 0.0012 0.001 0.0004 0.0027 0.0006 0.0011 0.0005 0.001 0.001
Peroxisomes 0.0255 0.0004 0.0029 0.001 0.0158 0.0019 0.0062 0.0003 0.0021 0.0002 0.0009 0.0002 0.0045 0.0019 0.0103 0 0.0015 0.001
Punctate Nuclear 0.0142 0.0003 0.0006 0.0006 0.0005 0.0012 0.0101 0.0003 0.0004 0.0002 0.0006 0.0001 0.0112 0.0006 0.0025 0.0001 0.0034 0.0024
Vacuole 0.0176 0.0023 0.0031 0.0095 0.0056 0.0026 0.0055 0.0012 0.002 0.0043 0.0022 0.001 0.0076 0.0014 0.0022 0.0017 0.0013 0.0018
Vacuole Periphery 0.0047 0.0001 0.0009 0.0033 0.0012 0.001 0.0009 0.0001 0.0005 0.0002 0.0001 0.0001 0.002 0.0001 0.0004 0.0001 0.0005 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 32.3665 17.7548 16.5905 24.7828 29.566 24.9967 20.9438 21.9888 22.6046 29.9961
Translational Efficiency 1.9574 2.1353 1.9963 1.5666 1.5413 2.6902 1.6303 1.5667 1.8603 1.6778

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1810 465 59 1625 957 1713 173 194 2767 2178 232 1819

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 844.75 924.16 1156.97 981.26 947.33 845.64 1227.98 1022.88 880.23 862.40 1209.92 985.70
Standard Deviation 126.37 139.76 132.56 129.79 124.22 132.07 133.47 136.99 134.78 137.57 136.78 131.21
Intensity Change Log 2 — 0.129618 0.453755 0.216111 — -0.163823 0.374348 0.110698 — -0.018049 0.412324 0.161348

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.016749 0.105255* 0.155906* 0.079834 0.043061 0.048132 0.106703* 0.034574 0.025849 0.060327 0.119216* 0.075007
Bud Neck 0.194875* 0.104601 0.059794 0.065073 0.137114 0.131497 0.080612 0.044013 0.174897 0.125754 0.075318 0.062827
Bud Site 0.543609* 0.453976* 0.534352* 0.451188* 0.462656* 0.479456* 0.524438* 0.429179* 0.515610* 0.474016* 0.526959* 0.448840*
Cell Periphery 0.039056 0.018911 0.027969 0.009583 0.045937 0.025462 0.016097 0.003335 0.041436 0.024064 0.019116 0.008916
Cytoplasm 0.123135* 0.176114* 0.061649 0.275621* 0.230557* 0.174773* 0.113899* 0.183681* 0.160288* 0.175059* 0.100611* 0.265816*
Cytoplasmic Foci 0.025254 0.043491 0.036261 0.011455 0.036040 0.048076 0.022646 0.036938 0.028985 0.047097 0.026108 0.014173
Eisosomes 0.002508 0.004064 0.003137 0.001753 0.005494 0.003943 0.003206 0.000886 0.003541 0.003969 0.003189 0.001660
Endoplasmic Reticulum 0.003554 0.003573 0.009374 0.001251 0.003388 0.002568 0.003326 0.001495 0.003497 0.002782 0.004864 0.001277
Endosome 0.010316 0.016465 0.024422 0.003270 0.005099 0.020437 0.002658 0.017026 0.008512 0.019589 0.008193 0.004737
Golgi 0.004815 0.010400 0.012401 0.002701 0.006098 0.019456 0.000663 0.001423 0.005259 0.017523 0.003648 0.002565
Lipid Particles 0.002272 0.003682 0.026610 0.000905 0.001500 0.003142 0.001871 0.002670 0.002005 0.003257 0.008162 0.001093
Mitochondria 0.005428 0.005100 0.000074 0.003284 0.001229 0.013112 0.000026 0.000342 0.003976 0.011401 0.000038 0.002970
Mitotic Spindle 0.002077 0.002361 0.000347 0.006586 0.000404 0.002383 0.000184 0.003303 0.001498 0.002378 0.000226 0.006236
None 0.001767 0.000146 0.000012 0.000159 0.000229 0.000270 0.000027 0.000241 0.001235 0.000244 0.000023 0.000168
Nuclear Periphery 0.000046 0.000099 0.000045 0.000048 0.000014 0.000071 0.000031 0.000093 0.000035 0.000077 0.000035 0.000053
Nuclear Periphery Foci 0.000464 0.001815 0.004394 0.000367 0.000480 0.000227 0.001881 0.001054 0.000470 0.000566 0.002520 0.000440
Nucleolus 0.000222 0.000344 0.000014 0.000022 0.000034 0.000447 0.000009 0.000061 0.000157 0.000425 0.000010 0.000026
Nucleus 0.003770 0.006952 0.001571 0.014504 0.003652 0.002048 0.004326 0.011931 0.003729 0.003095 0.003625 0.014230
Peroxisomes 0.004038 0.012516 0.004843 0.004430 0.003106 0.008629 0.003293 0.012250 0.003716 0.009459 0.003687 0.005264
Vacuole 0.014309 0.028520 0.036526 0.067393 0.013345 0.013236 0.114052 0.214882* 0.013976 0.016499 0.094336 0.083123
Vacuole Periphery 0.001735 0.001615 0.000298 0.000573 0.000562 0.002635 0.000053 0.000624 0.001329 0.002417 0.000115 0.000578

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.26 -4.62 -13.67 3.67 2.79 -1.16 -3.77 2.92 3.97 4.81 -10.50 -6.56 -10.92 -1.28 3.46
Bud Neck 9.74 8.94 22.10 6.00 0.21 0.67 5.07 12.60 14.74 3.66 8.28 10.82 23.95 15.34 1.84
Bud Site 5.71 0.41 13.56 3.46 3.04 -1.34 -0.90 6.12 7.02 5.29 4.65 0.85 13.44 8.81 5.02
Cell Periphery 5.46 1.35 11.30 3.73 2.28 4.93 6.90 11.76 10.54 4.38 6.42 6.49 15.12 8.84 3.42
Cytoplasm -4.59 3.81 -20.20 -9.51 -14.08 5.57 6.34 2.38 -0.79 -2.82 -2.24 4.06 -15.80 -13.52 -13.53
Cytoplasmic Foci -4.01 -1.05 5.47 6.58 2.11 -3.18 2.28 -0.26 1.70 -1.84 -6.63 0.22 6.70 11.91 2.76
Eisosomes -2.29 -0.46 2.44 4.18 1.25 2.08 2.20 7.12 7.61 2.29 -0.92 0.66 5.92 7.08 1.91
Endoplasmic Reticulum -0.09 -1.99 2.93 4.14 2.73 1.26 -0.08 2.30 1.00 1.84 1.15 -1.48 3.89 3.62 3.72
Endosome -2.10 -1.50 6.52 4.83 2.30 -8.70 3.29 -1.49 1.91 -2.01 -6.98 0.06 4.81 9.73 1.76
Golgi -3.45 -1.27 3.11 4.85 1.71 -7.96 9.06 6.91 11.34 -0.65 -9.18 1.12 4.39 10.82 0.89
Lipid Particles -1.40 -1.68 2.67 2.58 1.76 -3.36 -1.25 -1.40 0.44 -0.76 -2.61 -1.68 2.18 4.46 1.85
Mitochondria 0.35 8.14 2.56 1.90 -3.34 -9.10 7.42 5.05 9.89 -2.25 -6.58 9.05 1.76 7.04 -3.42
Mitotic Spindle -0.49 2.59 -2.35 -1.66 -3.93 -2.67 0.85 -2.75 -0.63 -2.88 -1.20 2.76 -3.00 -2.18 -4.22
None 2.89 3.14 2.78 -0.92 -3.66 -0.36 2.65 0.00 0.31 -1.73 2.59 3.30 2.77 0.37 -3.74
Nuclear Periphery -1.03 -0.21 -1.98 0.61 -0.95 -1.48 -4.76 -4.63 -2.88 -4.12 -1.30 -0.85 -5.04 -0.37 -4.34
Nuclear Periphery Foci -1.46 -2.31 0.17 1.50 2.33 3.48 -4.32 -4.19 -5.23 1.75 -0.41 -4.29 -0.88 0.02 4.17
Nucleolus -0.56 3.48 3.29 1.69 -2.53 -1.73 9.05 -1.24 1.64 -2.76 -1.31 3.72 3.27 2.06 -6.54
Nucleus -2.68 3.73 -13.33 -7.19 -14.62 3.26 -1.31 -4.01 -4.49 -3.49 1.17 -0.59 -14.06 -14.25 -11.71
Peroxisomes -5.95 -0.45 -0.33 5.69 0.30 -8.35 0.01 -2.37 -0.30 -2.31 -8.96 0.27 -1.71 5.86 -1.52
Vacuole -4.21 -2.00 -20.41 -13.21 -4.15 0.19 -7.33 -14.13 -14.14 -6.78 -2.36 -7.43 -23.68 -22.81 -1.27
Vacuole Periphery 0.20 3.97 3.20 2.24 -0.78 -4.79 7.23 0.66 4.66 -1.72 -2.62 5.39 2.99 4.93 -1.97
Standard name
Human Ortholog
Description Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (42%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Pal1

Pal1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pal1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available