Standard name | |
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Human Ortholog | |
Description | Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | 4 | 4 |
Bud | 1 | 0 | 1 | 2 | 0 | 2 | 1 | – | 3 | 2 | 3 | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 5 | 8 |
Bud Neck | 0 | 0 | 2 | 1 | 1 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 6 | 1 | 1 | 6 | 5 | 2 | 7 | – | 9 | 12 | 7 | 15 | 1 | 1 | 2 | 6 | 3 | 3 | 0 | 0 | 1 | 1 | 2 | 1 |
Cytoplasm | 231 | 83 | 172 | 231 | 291 | 246 | 359 | – | 155 | 228 | 219 | 250 | 319 | 366 | 389 | 163 | 136 | 118 | 205 | 87 | 154 | 147 | 318 | 251 |
Endoplasmic Reticulum | 2 | 1 | 1 | 0 | 0 | 1 | 0 | – | 1 | 3 | 2 | 4 | 1 | 0 | 0 | 6 | 11 | 8 | 2 | 0 | 0 | 2 | 0 | 3 |
Endosome | 1 | 0 | 0 | 0 | 1 | 0 | 3 | – | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 5 | 3 | 1 | 0 | 0 | 1 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Mitochondria | 10 | 4 | 0 | 14 | 1 | 32 | 26 | – | 22 | 60 | 110 | 108 | 3 | 0 | 1 | 6 | 3 | 1 | 17 | 1 | 9 | 4 | 15 | 13 |
Nucleus | 0 | 0 | 0 | 1 | 0 | 4 | 2 | – | 4 | 6 | 5 | 4 | 1 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 1 | 0 | 0 | 1 | 1 | 0 | – | 1 | 1 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 2 | 0 | 6 | – | 4 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 0 | 4 | 7 |
Vac/Vac Membrane | 4 | 0 | 0 | 4 | 2 | 4 | 39 | – | 29 | 31 | 27 | 40 | 1 | 2 | 2 | 4 | 1 | 0 | 2 | 0 | 0 | 0 | 2 | 1 |
Unique Cell Count | 242 | 86 | 174 | 237 | 295 | 273 | 405 | 200 | 302 | 303 | 366 | 326 | 369 | 397 | 167 | 136 | 120 | 250 | 97 | 182 | 165 | 362 | 305 | |
Labelled Cell Count | 255 | 90 | 178 | 259 | 304 | 292 | 444 | 230 | 344 | 374 | 439 | 327 | 371 | 399 | 188 | 154 | 133 | 250 | 97 | 182 | 165 | 362 | 305 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.2 | 3.9 | 5.6 | 5.3 | 6.4 | 4.4 | 6.0 | – | 7.3 | 6.5 | 6.2 | 6.7 | 5.3 | 6.4 | 7.6 | 6.5 | 6.6 | 7.1 | 4.4 | 4.4 | 4.7 |
Std Deviation (1e-4) | 1.6 | 0.8 | 2.0 | 2.0 | 2.7 | 1.6 | 2.5 | – | 5.3 | 3.0 | 2.6 | 5.3 | 1.7 | 3.8 | 4.8 | 1.7 | 2.1 | 2.2 | 1.7 | 1.5 | 1.9 |
Intensity Change (Log2) | – | – | – | -0.08 | 0.2 | -0.35 | 0.1 | – | 0.38 | 0.22 | 0.15 | 0.26 | -0.07 | 0.2 | 0.46 | 0.21 | 0.24 | 0.34 | -0.33 | -0.33 | -0.24 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.4022 | 0.5058 | 0.0492 | -0.3903 | 0.2714 | 0.4818 | 0.994 | 2.7003 | 2.0873 | 1.7121 | 1.0679 | 2.3632 | 2.7082 | 4.3718 | 3.5732 | 3.6378 | 4.3208 | 3.7093 |
Actin | 0.0534 | 0.0004 | 0.0171 | 0.0018 | 0.0631 | 0.0047 | 0.0194 | 0.0008 | 0.0029 | 0.0049 | 0.0005 | 0.0025 | 0.023 | 0.0018 | 0.0041 | 0.0006 | 0.0293 | 0.0008 |
Bud | 0.0007 | 0.0066 | 0.0023 | 0.0002 | 0.0017 | 0.0033 | 0.0011 | 0.0013 | 0.0028 | 0.0019 | 0.001 | 0.0013 | 0.0014 | 0.0045 | 0.0026 | 0.0002 | 0.0009 | 0.0003 |
Bud Neck | 0.0019 | 0.0001 | 0.0021 | 0.0001 | 0.0006 | 0.0019 | 0.0021 | 0.0002 | 0.0003 | 0.0087 | 0.0318 | 0.004 | 0.0023 | 0.0004 | 0.0002 | 0.0003 | 0.0008 | 0.0005 |
Bud Periphery | 0.0013 | 0.0037 | 0.0038 | 0.0002 | 0.0021 | 0.0076 | 0.0016 | 0.0011 | 0.0016 | 0.0018 | 0.0003 | 0.0012 | 0.0015 | 0.0035 | 0.0037 | 0.0002 | 0.0006 | 0.0003 |
Bud Site | 0.0026 | 0.0007 | 0.013 | 0.0002 | 0.0004 | 0.0004 | 0.003 | 0.003 | 0.0014 | 0.0025 | 0.0009 | 0.0027 | 0.002 | 0.0059 | 0.001 | 0.0001 | 0.0013 | 0.0004 |
Cell Periphery | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0.0005 | 0.0002 | 0 | 0.0001 | 0 |
Cytoplasm | 0.3278 | 0.3979 | 0.3902 | 0.2774 | 0.4578 | 0.4315 | 0.5897 | 0.7571 | 0.6967 | 0.7551 | 0.7413 | 0.8009 | 0.431 | 0.5979 | 0.5431 | 0.5507 | 0.5781 | 0.5588 |
Cytoplasmic Foci | 0.0385 | 0.0053 | 0.021 | 0.0267 | 0.0082 | 0.0111 | 0.0246 | 0.0149 | 0.0127 | 0.0266 | 0.0109 | 0.0125 | 0.0149 | 0.004 | 0.0161 | 0.0117 | 0.0116 | 0.005 |
Eisosomes | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0008 | 0.0001 | 0.0001 | 0 | 0.0007 | 0 |
Endoplasmic Reticulum | 0.0076 | 0.0011 | 0.0019 | 0.0017 | 0.0015 | 0.0013 | 0.0066 | 0.0025 | 0.0029 | 0.0033 | 0.0037 | 0.0036 | 0.0028 | 0.0014 | 0.0023 | 0.0028 | 0.0023 | 0.001 |
Endosome | 0.0332 | 0.0011 | 0.0072 | 0.0187 | 0.0042 | 0.0055 | 0.0192 | 0.0039 | 0.0058 | 0.0192 | 0.0057 | 0.0094 | 0.0036 | 0.0017 | 0.0025 | 0.0108 | 0.0081 | 0.0018 |
Golgi | 0.0101 | 0.0001 | 0.0034 | 0.0009 | 0.0068 | 0.0044 | 0.0033 | 0.0003 | 0.0007 | 0.0033 | 0.0002 | 0.001 | 0.0012 | 0.0004 | 0.0007 | 0.0002 | 0.0017 | 0.0003 |
Lipid Particles | 0.0176 | 0.0002 | 0.0042 | 0.0007 | 0.0002 | 0.0019 | 0.0057 | 0.0001 | 0.0007 | 0.0017 | 0.0001 | 0.0022 | 0.0008 | 0.0002 | 0.0002 | 0.0001 | 0.0029 | 0.0006 |
Mitochondria | 0.0054 | 0.0001 | 0.0015 | 0.0014 | 0.0034 | 0.0074 | 0.0027 | 0.0003 | 0.0008 | 0.0022 | 0.0004 | 0.0016 | 0.0022 | 0.0039 | 0.0004 | 0.0003 | 0.0021 | 0.0004 |
None | 0.4432 | 0.5798 | 0.504 | 0.6581 | 0.4435 | 0.5117 | 0.2889 | 0.2086 | 0.2528 | 0.1359 | 0.177 | 0.1339 | 0.5041 | 0.3654 | 0.4161 | 0.4159 | 0.3266 | 0.4249 |
Nuclear Periphery | 0.0133 | 0.0004 | 0.0013 | 0.0009 | 0.0007 | 0.001 | 0.0078 | 0.0009 | 0.0032 | 0.0021 | 0.0015 | 0.0068 | 0.0011 | 0.0007 | 0.0007 | 0.0013 | 0.0222 | 0.0009 |
Nucleolus | 0.0007 | 0.0001 | 0.0037 | 0.0002 | 0.0001 | 0.0001 | 0.0008 | 0.0001 | 0.0002 | 0.0005 | 0.0002 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0004 | 0.0004 |
Nucleus | 0.0065 | 0.0009 | 0.0026 | 0.0015 | 0.0023 | 0.0017 | 0.0063 | 0.0025 | 0.0062 | 0.0076 | 0.0193 | 0.0063 | 0.0023 | 0.0039 | 0.0013 | 0.0025 | 0.003 | 0.0014 |
Peroxisomes | 0.0219 | 0.0001 | 0.0122 | 0.0047 | 0.0003 | 0.0022 | 0.0063 | 0.0004 | 0.0007 | 0.0069 | 0.0001 | 0.0039 | 0.0011 | 0.0004 | 0.003 | 0.0001 | 0.0016 | 0.0003 |
Punctate Nuclear | 0.0103 | 0.0004 | 0.0044 | 0.0014 | 0.0006 | 0.0005 | 0.0044 | 0.0008 | 0.0057 | 0.0089 | 0.0024 | 0.0034 | 0.0013 | 0.0004 | 0.0006 | 0.0008 | 0.0034 | 0.0013 |
Vacuole | 0.0022 | 0.0007 | 0.0033 | 0.0024 | 0.0019 | 0.0011 | 0.0047 | 0.001 | 0.0014 | 0.0059 | 0.0023 | 0.0016 | 0.0017 | 0.0026 | 0.0009 | 0.0011 | 0.0011 | 0.0005 |
Vacuole Periphery | 0.0011 | 0.0001 | 0.0003 | 0.0007 | 0.0005 | 0.0005 | 0.0013 | 0.0001 | 0.0003 | 0.0008 | 0.0003 | 0.0007 | 0.0002 | 0.0003 | 0.0001 | 0.0003 | 0.0012 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 23.3377 | 23.3659 | 12.3847 | 19.2056 | 14.524 | 20.5258 | 24.469 | 22.2098 | 26.1593 | 19.7527 |
Translational Efficiency | 1.167 | 1.0711 | 1.965 | 1.6526 | 1.8337 | 1.8705 | 1.3466 | 1.2054 | 1.5806 | 1.7132 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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