Standard name | |
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Human Ortholog | |
Description | Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 |
Bud | 0 | 0 | 6 | 5 | 0 | 5 | 0 | 6 | 3 | – | 7 | 5 | 2 | 0 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 30 | 4 | 6 | 11 | 9 | 11 | 17 | 9 | 21 | – | 13 | 22 | 6 | 2 | 5 | 12 | 38 | 34 | 0 | 0 | 0 | 0 | 1 | 0 |
Cytoplasm | 442 | 239 | 300 | 310 | 349 | 386 | 441 | 423 | 340 | – | 185 | 255 | 251 | 308 | 268 | 526 | 841 | 906 | 442 | 222 | 277 | 149 | 299 | 279 |
Endoplasmic Reticulum | 0 | 2 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | – | 3 | 3 | 0 | 1 | 2 | 11 | 22 | 26 | 2 | 1 | 5 | 0 | 4 | 4 |
Endosome | 3 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | – | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 1 | 2 | 0 | 0 | 1 |
Mitochondria | 5 | 2 | 5 | 25 | 23 | 85 | 106 | 123 | 163 | – | 121 | 139 | 0 | 2 | 10 | 7 | 7 | 10 | 4 | 2 | 6 | 2 | 2 | 2 |
Nucleus | 2 | 1 | 0 | 1 | 2 | 0 | 1 | 5 | 2 | – | 0 | 1 | 0 | 0 | 0 | 12 | 16 | 12 | 0 | 1 | 0 | 1 | 0 | 0 |
Nuclear Periphery | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 12 | 0 | 2 | 2 | 3 | 1 | 6 | 7 | 5 | – | 9 | 5 | 0 | 0 | 0 | 17 | 52 | 51 | 1 | 4 | 1 | 0 | 2 | 3 |
Unique Cell Count | 456 | 244 | 303 | 312 | 360 | 415 | 490 | 503 | 425 | 258 | 339 | 251 | 309 | 273 | 546 | 897 | 966 | 463 | 243 | 299 | 161 | 319 | 303 | |
Labelled Cell Count | 496 | 249 | 319 | 354 | 391 | 490 | 572 | 578 | 534 | 339 | 432 | 259 | 313 | 288 | 587 | 980 | 1043 | 463 | 243 | 299 | 161 | 319 | 303 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.4 | 5.9 | 5.4 | 5.3 | 5.7 | 5.1 | 5.0 | 5.1 | 4.6 | – | 4.5 | 4.5 | 6.6 | 6.3 | 5.5 | 8.8 | 9.9 | 9.2 | 6.3 | 6.4 | 7.7 |
Std Deviation (1e-4) | 1.4 | 1.1 | 1.1 | 1.3 | 1.3 | 1.2 | 1.2 | 1.4 | 1.0 | – | 1.1 | 1.3 | 1.2 | 1.1 | 1.0 | 1.7 | 2.2 | 1.6 | 1.4 | 1.4 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.02 | 0.1 | -0.08 | -0.11 | -0.08 | -0.22 | – | -0.26 | -0.26 | 0.29 | 0.23 | 0.05 | 0.71 | 0.89 | 0.78 | 0.24 | 0.26 | 0.53 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | -0.4 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 1.2 | 0.4 | 0.6 | 1.2 | -0.2 | 0 | – | 0 | 0 | 0.3 | 0 | -0.1 | 0.2 | 1.8 | 1.3 |
Cytoplasm | 0.5 | -1.8 | -3.8 | -5.0 | -6.7 | -7.8 | – | -9.4 | -8.8 | 1.6 | 1.0 | -0.9 | -2.3 | -3.7 | -3.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 2.8 | 2.9 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 3.7 | 3.0 | 7.5 | 7.9 | 8.6 | 0 | – | 0 | 0 | 0 | 0 | 1.5 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | – | 2.4 | 0 | 0 | 0 | 0 | 2.3 | 3.7 | 3.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.8654 | 5.2833 | 4.793 | 4.2265 | 4.2242 | 4.6533 | 2.5972 | 4.951 | 4.3682 | 3.9274 | 3.8403 | 4.3935 | 4.6004 | 6.2036 | 5.0861 | 5.2409 | 5.3746 | 5.2677 |
Actin | 0.0243 | 0.0008 | 0.0246 | 0.0112 | 0.0012 | 0.0006 | 0.0024 | 0.0003 | 0.0014 | 0.0076 | 0.0013 | 0.01 | 0.0346 | 0.0039 | 0.0041 | 0.0013 | 0.012 | 0.0016 |
Bud | 0.0016 | 0.0002 | 0.0033 | 0.0021 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0.0082 | 0.0013 | 0.0002 | 0.0002 | 0.0008 | 0.0021 | 0.0008 | 0.0006 | 0.0012 | 0.0031 |
Bud Neck | 0.0049 | 0.0003 | 0.0017 | 0.0027 | 0.0005 | 0.0009 | 0.0027 | 0.0001 | 0.0002 | 0.0127 | 0.0003 | 0.0024 | 0.0016 | 0.0006 | 0.0007 | 0.0004 | 0.0005 | 0.0013 |
Bud Periphery | 0.002 | 0.0002 | 0.0017 | 0.0064 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0034 | 0.0022 | 0.0002 | 0.0001 | 0.0011 | 0.0015 | 0.001 | 0.0013 | 0.0014 | 0.0028 |
Bud Site | 0.0237 | 0.0033 | 0.0115 | 0.0033 | 0.0032 | 0.0001 | 0.0009 | 0.0026 | 0.001 | 0.0097 | 0.0007 | 0.0003 | 0.0021 | 0.0229 | 0.0043 | 0.001 | 0.0018 | 0.0005 |
Cell Periphery | 0.0021 | 0.0028 | 0.0023 | 0.004 | 0.0003 | 0.0002 | 0.0002 | 0.0003 | 0.0003 | 0.0007 | 0.0001 | 0 | 0.0008 | 0.0011 | 0.0006 | 0.0006 | 0.0004 | 0.0002 |
Cytoplasm | 0.5924 | 0.8419 | 0.8636 | 0.8073 | 0.8456 | 0.9432 | 0.527 | 0.8289 | 0.8131 | 0.8842 | 0.7816 | 0.8768 | 0.6072 | 0.8358 | 0.778 | 0.8077 | 0.7719 | 0.852 |
Cytoplasmic Foci | 0.0103 | 0.0036 | 0.003 | 0.006 | 0.0226 | 0.0028 | 0.0478 | 0.002 | 0.0046 | 0.0052 | 0.0302 | 0.0226 | 0.0555 | 0.0153 | 0.0141 | 0.0202 | 0.0079 | 0.004 |
Eisosomes | 0.0002 | 0.0001 | 0.0002 | 0.0004 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0138 | 0.0052 | 0.0085 | 0.0091 | 0.0027 | 0.0045 | 0.0104 | 0.0059 | 0.0018 | 0.0023 | 0.0054 | 0.0039 | 0.0061 | 0.0033 | 0.0033 | 0.0043 | 0.0019 | 0.0015 |
Endosome | 0.0136 | 0.0076 | 0.0028 | 0.0219 | 0.0057 | 0.0014 | 0.0655 | 0.003 | 0.0009 | 0.0059 | 0.0035 | 0.01 | 0.0383 | 0.0025 | 0.0092 | 0.0363 | 0.0017 | 0.0013 |
Golgi | 0.0026 | 0.0014 | 0.001 | 0.0021 | 0.0004 | 0.0002 | 0.0044 | 0.0004 | 0.0002 | 0.0024 | 0.0026 | 0.0058 | 0.0183 | 0.0006 | 0.0075 | 0.015 | 0.0008 | 0.0003 |
Lipid Particles | 0.0016 | 0.0003 | 0.0006 | 0.0012 | 0.0011 | 0.0001 | 0.0026 | 0.0006 | 0.0001 | 0.0007 | 0.0086 | 0.0005 | 0.0061 | 0.0008 | 0.0011 | 0.0073 | 0.0003 | 0.0001 |
Mitochondria | 0.002 | 0.0003 | 0.0003 | 0.004 | 0.002 | 0.0001 | 0.0009 | 0.0001 | 0.0148 | 0.0007 | 0.0003 | 0.001 | 0.0029 | 0.0002 | 0.009 | 0.0048 | 0.0003 | 0.0001 |
None | 0.2582 | 0.122 | 0.0667 | 0.079 | 0.0358 | 0.0438 | 0.2979 | 0.1538 | 0.1475 | 0.0585 | 0.1213 | 0.062 | 0.1864 | 0.1039 | 0.1587 | 0.0849 | 0.1939 | 0.1289 |
Nuclear Periphery | 0.0176 | 0.004 | 0.0044 | 0.0114 | 0.0545 | 0.0003 | 0.0058 | 0.0004 | 0.0003 | 0.0004 | 0.0006 | 0.0005 | 0.0009 | 0.0008 | 0.0006 | 0.001 | 0.0005 | 0.0003 |
Nucleolus | 0.0014 | 0.0001 | 0.0001 | 0.0006 | 0.0038 | 0 | 0.0008 | 0 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0005 | 0.0001 | 0 |
Nucleus | 0.014 | 0.0029 | 0.0016 | 0.0061 | 0.009 | 0.0007 | 0.0179 | 0.0004 | 0.0007 | 0.0011 | 0.0008 | 0.0006 | 0.001 | 0.0011 | 0.0011 | 0.0013 | 0.0008 | 0.0009 |
Peroxisomes | 0.001 | 0 | 0.0001 | 0.0005 | 0.0002 | 0 | 0.0013 | 0 | 0.0001 | 0.0011 | 0.0353 | 0.0021 | 0.0322 | 0.0006 | 0.0033 | 0.0032 | 0.0005 | 0.0001 |
Punctate Nuclear | 0.0059 | 0.0004 | 0.0007 | 0.0013 | 0.0049 | 0.0001 | 0.0049 | 0.0002 | 0.0003 | 0.0002 | 0.0061 | 0.0006 | 0.0016 | 0.0018 | 0.0005 | 0.0005 | 0.0013 | 0.0006 |
Vacuole | 0.0058 | 0.0024 | 0.0013 | 0.0156 | 0.0034 | 0.0005 | 0.0055 | 0.0005 | 0.0009 | 0.0024 | 0.0006 | 0.0003 | 0.0017 | 0.0009 | 0.0016 | 0.0068 | 0.0006 | 0.0003 |
Vacuole Periphery | 0.0011 | 0.0003 | 0.0002 | 0.0039 | 0.0025 | 0.0001 | 0.0007 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0004 | 0.001 | 0.0001 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 16.6706 | 12.7468 | 15.9963 | 16.7291 | 12.6422 | 16.1374 | 17.5792 | 16.7578 | 12.6871 | 19.2866 |
Translational Efficiency | 0.2486 | 0.3888 | 0.2607 | 0.1758 | 0.2444 | 0.2763 | 0.2386 | 0.1622 | 0.2499 | 0.2178 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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