Standard name
Human Ortholog
Description CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.16 0 0.05 0 0 0 0 – 0 0 0 0 0 0.05 0 0.06 0 0.18 0 0 0 0 0 0
Cytoplasm 0.58 0.97 0.96 0.97 0.93 0.89 0.83 – 0.72 0.74 0.69 0.7 0.99 0.99 0.99 0.86 0.93 0.9 0.91 0.96 0.93 0.97 0.93 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Endosome 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0 0 0 0.15 0.09 – 0.26 0.21 0.31 0.28 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleus 0.16 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.16 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.1 – 0.1 0.07 0.06 0.06 0 0 0 0.12 0.13 0.13 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 2 1 0 – 1 3 6 8 0 1 0 0 0 0 0 0 2 0 2 3
Bud 0 0 0 0 2 8 0 – 6 3 17 7 2 0 0 0 0 0 0 0 0 0 2 6
Bud Neck 0 0 0 0 0 1 1 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 0 11 12 12 5 17 – 18 23 26 24 10 28 16 7 1 7 0 0 0 0 0 0
Cytoplasm 11 93 219 452 468 421 552 – 397 423 416 488 505 540 675 96 62 35 250 94 220 222 456 462
Endoplasmic Reticulum 0 1 3 1 0 4 2 – 5 9 1 26 0 0 0 7 3 0 5 0 2 2 6 6
Endosome 1 0 0 2 2 3 3 – 1 3 6 2 1 0 1 1 0 0 0 0 1 0 4 4
Golgi 0 0 3 1 0 0 0 – 0 0 1 0 0 1 0 1 0 1 0 0 3 0 2 4
Mitochondria 0 5 0 6 20 70 61 – 143 123 190 192 2 0 2 6 1 1 8 0 3 1 4 4
Nucleus 3 0 1 2 0 3 4 – 7 4 6 3 0 0 0 1 3 0 0 0 0 0 0 0
Nuclear Periphery 3 0 0 1 1 0 0 – 3 2 0 2 0 0 1 0 0 0 1 0 0 0 0 1
Nucleolus 1 0 0 0 0 0 1 – 0 3 2 1 0 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 1 0 1 – 1 0 0 1 0 0 0 0 0 0 0 0 2 0 1 4
Vac/Vac Membrane 0 1 1 12 21 8 68 – 55 43 36 41 4 1 4 13 9 5 3 0 0 0 2 3
Unique Cell Count 19 96 228 467 501 474 666 554 575 606 697 509 543 680 111 67 39 277 98 238 230 488 509
Labelled Cell Count 22 100 238 489 529 524 710 638 639 708 795 524 571 700 132 79 49 277 98 238 230 488 509


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 6.1 7.2 6.9 7.7 5.8 6.8 – 6.1 6.5 6.3 6.3 8.1 8.5 8.7 10.6 10.8 11.1 6.9 7.1 7.5
Std Deviation (1e-4) 10.7 0.9 0.9 1.2 1.1 1.2 1.1 – 1.2 1.2 1.1 1.1 1.1 1.3 1.3 2.3 2.8 2.6 0.9 1.1 1.7
Intensity Change (Log2) – – – -0.04 0.09 -0.31 -0.07 – -0.23 -0.13 -0.2 -0.18 0.17 0.24 0.27 0.56 0.59 0.63 -0.05 -0.02 0.06


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.6 -1.7 -3.1 -1.7 – -1.1 -0.5 -0.3 -0.9 -2.2 0.2 -1.9 0.6 0 0
Cytoplasm 0.5 -1.4 -3.2 -5.0 – -7.6 -7.2 -8.3 -8.0 3.0 3.5 3.4 -3.2 -1.2 -1.7
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 1.8 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.1 6.1 4.7 – 8.5 7.6 9.6 8.9 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.7 0 4.8 – 4.7 4.0 3.4 3.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.693 1.277 0.9393 0.8922 0.6578 1.0272 2.1719 2.8597 2.5764 2.0502 2.2988 2.7498 3.5526 4.8097 4.4428 4.1474 4.2287 4.527
Actin 0.0433 0.0008 0.0136 0.048 0.0434 0.0155 0.022 0.0004 0.0228 0.001 0.018 0.0045 0.0162 0.0007 0.0111 0.0171 0.0005 0.0019
Bud 0.0019 0.0001 0.0014 0.0003 0.0009 0.0002 0.0008 0.0003 0.0113 0.0016 0.0008 0.0003 0.0005 0.0016 0.0005 0.0002 0.0002 0.0002
Bud Neck 0.0025 0.0002 0.0004 0.0004 0.0004 0.0005 0.003 0.0001 0.0016 0.0005 0.0038 0.0013 0.0019 0.0004 0.0004 0.0002 0.0003 0.0029
Bud Periphery 0.0038 0.0001 0.0017 0.0002 0.0015 0.0002 0.0009 0.0001 0.0073 0.0009 0.0018 0.0003 0.0006 0.0009 0.0004 0.0001 0.0001 0.0002
Bud Site 0.0183 0.0027 0.0016 0.0006 0.001 0.0002 0.0072 0.0021 0.0178 0.0006 0.0032 0.0004 0.0025 0.0089 0.0019 0.0001 0.0004 0.001
Cell Periphery 0.0015 0.0002 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0005 0.0001 0.0003 0 0.0003 0.0005 0.0002 0 0 0
Cytoplasm 0.655 0.8767 0.7951 0.8117 0.7382 0.8745 0.6461 0.8797 0.7823 0.8941 0.6652 0.892 0.773 0.8626 0.8157 0.8491 0.8376 0.8929
Cytoplasmic Foci 0.0303 0.0196 0.02 0.0268 0.0469 0.0106 0.0339 0.006 0.0238 0.031 0.0116 0.0102 0.0207 0.0056 0.0139 0.021 0.0202 0.0126
Eisosomes 0.0006 0.0001 0.0002 0.0002 0.0002 0.0001 0.0003 0 0.0002 0 0.0003 0 0.0001 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0125 0.0045 0.0083 0.0023 0.0046 0.0036 0.0105 0.0019 0.0037 0.002 0.0034 0.0024 0.0049 0.0015 0.0027 0.0015 0.0013 0.0019
Endosome 0.0373 0.0174 0.0392 0.0574 0.0328 0.0099 0.0416 0.0024 0.0151 0.0131 0.0337 0.012 0.0121 0.0019 0.0053 0.0143 0.017 0.0064
Golgi 0.0135 0.0012 0.0167 0.0228 0.0419 0.0075 0.0097 0.0002 0.0085 0.0013 0.0178 0.0048 0.0037 0.0002 0.0017 0.0011 0.0025 0.0012
Lipid Particles 0.0046 0.0004 0.0016 0.0015 0.0137 0.0099 0.023 0.0001 0.0039 0.0005 0.0253 0.0015 0.0044 0.0002 0.0009 0.002 0.0004 0.0006
Mitochondria 0.0244 0.0002 0.0088 0.0036 0.0423 0.0059 0.0096 0.0001 0.0075 0.0004 0.0844 0.0024 0.0063 0.0003 0.0004 0.0002 0.0019 0.0003
None 0.0892 0.0706 0.0738 0.0175 0.017 0.0497 0.1249 0.1035 0.0711 0.045 0.0993 0.0471 0.1378 0.1111 0.1388 0.0649 0.1133 0.0732
Nuclear Periphery 0.0156 0.0007 0.0053 0.0009 0.003 0.0006 0.0214 0.0005 0.0019 0.0007 0.0147 0.0029 0.0012 0.0004 0.0006 0.0006 0.0004 0.0006
Nucleolus 0.0013 0.0001 0.0001 0 0.0001 0 0.001 0 0.0008 0.0001 0.0008 0.0001 0.0003 0.0002 0.0001 0.0001 0 0.0001
Nucleus 0.0084 0.0009 0.0019 0.0008 0.0011 0.001 0.0038 0.0009 0.0059 0.0012 0.0022 0.0015 0.0015 0.0011 0.0011 0.0007 0.0012 0.0008
Peroxisomes 0.009 0.0001 0.0007 0.001 0.0038 0.0082 0.0164 0.0001 0.0048 0.0022 0.0044 0.0132 0.0082 0.0001 0.0017 0.0068 0.0009 0.0013
Punctate Nuclear 0.0118 0.0003 0.0015 0.0006 0.0029 0.0003 0.0185 0.0003 0.0051 0.0007 0.003 0.0005 0.0016 0.0004 0.0007 0.017 0.0004 0.0014
Vacuole 0.0098 0.0026 0.0063 0.0024 0.003 0.0014 0.0031 0.0011 0.0033 0.0026 0.0033 0.0016 0.0017 0.0013 0.0017 0.0025 0.001 0.0006
Vacuole Periphery 0.0056 0.0004 0.0017 0.0009 0.0013 0.0003 0.0023 0.0001 0.0007 0.0006 0.003 0.0007 0.0005 0.0002 0.0002 0.0004 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.2912 4.3453 13.9723 10.6264 5.2519 9.7162 12.4482 15.3208 13.9308 12.3183
Translational Efficiency 1.7514 3.2887 1.1197 1.4682 1.6656 1.7397 1.4094 1.346 1.478 1.2482

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1604 367 1655 1840 1903 2632 1998 1671 3507 2999 3653 3511

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 767.57 962.80 1120.14 1168.60 779.53 876.16 1064.22 1182.24 774.06 886.76 1089.55 1175.09
Standard Deviation 97.41 122.45 146.99 177.51 99.33 108.03 139.63 194.73 98.63 113.51 145.70 186.03
Intensity Change Log 2 — 0.326938 0.545309 0.606411 — 0.168590 0.449120 0.600846 — 0.249324 0.497644 0.603610

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000419 0.000337 0.000174 0.000291 0.000102 0.000157 0.000351 0.000283 0.000247 0.000179 0.000271 0.000288
Bud Neck 0.012556 0.007330 0.001196 0.002091 0.004322 0.009284 0.000893 0.001487 0.008088 0.009045 0.001030 0.001804
Bud Site 0.012726 0.025586 0.007747 0.015616 0.005232 0.013545 0.009158 0.017946 0.008660 0.015018 0.008519 0.016725
Cell Periphery 0.000115 0.000151 0.000063 0.000094 0.000089 0.000088 0.000042 0.000103 0.000101 0.000096 0.000052 0.000099
Cytoplasm 0.564689* 0.599651* 0.792324* 0.795434* 0.672077* 0.653358* 0.854327* 0.815589* 0.622961* 0.646786* 0.826236* 0.805026*
Cytoplasmic Foci 0.213774* 0.215737* 0.028224 0.040258 0.170437 0.096405 0.026204 0.042059 0.190258* 0.111008 0.027119 0.041116
Eisosomes 0.000111 0.000053 0.000013 0.000006 0.000060 0.000031 0.000006 0.000005 0.000083 0.000034 0.000009 0.000006
Endoplasmic Reticulum 0.001402 0.001539 0.001080 0.000181 0.001040 0.000792 0.000187 0.000160 0.001206 0.000883 0.000591 0.000171
Endosome 0.018551 0.018744 0.003424 0.003939 0.009956 0.010148 0.001503 0.003386 0.013887 0.011200 0.002373 0.003676
Golgi 0.008633 0.003729 0.000315 0.001171 0.002859 0.002513 0.000302 0.001213 0.005500 0.002662 0.000308 0.001191
Lipid Particles 0.004167 0.001760 0.000749 0.000758 0.002805 0.001474 0.000265 0.000795 0.003428 0.001509 0.000484 0.000775
Mitochondria 0.002887 0.000368 0.000077 0.000160 0.001478 0.002206 0.000061 0.000313 0.002123 0.001981 0.000068 0.000232
Mitotic Spindle 0.002958 0.003884 0.005353 0.006349 0.001169 0.008567 0.002577 0.004955 0.001987 0.007994 0.003834 0.005685
None 0.003511 0.000548 0.001906 0.000640 0.002572 0.004608 0.002834 0.000440 0.003002 0.004111 0.002413 0.000545
Nuclear Periphery 0.000170 0.000126 0.000259 0.000140 0.000130 0.000219 0.000082 0.000113 0.000148 0.000208 0.000163 0.000127
Nuclear Periphery Foci 0.000384 0.001089 0.002522 0.000909 0.000749 0.000202 0.001502 0.000855 0.000582 0.000310 0.001964 0.000883
Nucleolus 0.000845 0.000198 0.000154 0.000195 0.000327 0.000853 0.000137 0.000229 0.000564 0.000773 0.000145 0.000211
Nucleus 0.045801 0.022653 0.049345 0.009675 0.051532 0.062582 0.040541 0.008473 0.048911 0.057696 0.044529 0.009103
Peroxisomes 0.002535 0.003013 0.000225 0.001137 0.001270 0.001705 0.000343 0.000600 0.001848 0.001865 0.000290 0.000882
Vacuole 0.101143 0.089447 0.104513 0.119978 0.070742 0.129378 0.058538 0.098764 0.084646 0.124492 0.079367 0.109882
Vacuole Periphery 0.002621 0.004058 0.000337 0.000979 0.001053 0.001883 0.000147 0.002230 0.001770 0.002149 0.000233 0.001574

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.18 1.01 0.68 1.49 -1.42 -1.25 -1.38 -2.39 -1.39 0.10 0.59 0.05 -0.17 -1.52 -0.30
Bud Neck 4.23 12.51 11.50 5.79 -2.74 -6.77 10.43 8.24 11.55 -4.43 -1.29 15.44 13.55 12.01 -4.66
Bud Site -4.75 3.59 -0.92 4.29 -4.56 -7.55 -2.72 -7.54 -1.83 -5.03 -5.83 0.98 -6.63 -0.28 -6.78
Cell Periphery -2.06 6.84 3.24 3.68 -2.59 0.08 10.87 -1.45 -1.30 -5.05 0.52 11.83 0.62 0.03 -5.88
Cytoplasm -1.96 -23.22 -24.97 -11.35 -0.63 2.56 -23.29 -16.94 -19.70 3.54 -3.66 -32.33 -28.78 -22.74 2.41
Cytoplasmic Foci 0.07 38.02 35.04 16.54 -5.34 16.06 35.33 29.63 16.57 -7.13 19.82 51.53 45.61 23.33 -8.87
Eisosomes 7.11 16.17 17.61 8.76 4.83 6.15 12.13 12.37 16.02 2.07 12.44 20.05 21.26 18.33 5.26
Endoplasmic Reticulum -0.32 1.41 6.46 2.32 3.02 1.38 5.95 6.18 5.33 1.39 1.83 4.06 8.93 5.67 3.17
Endosome 0.13 13.38 12.92 7.26 -1.20 -0.21 13.77 10.04 11.35 -5.47 3.38 18.61 16.21 13.55 -5.07
Golgi 7.41 16.47 13.29 4.99 -2.21 1.02 12.69 5.93 3.95 -3.21 7.80 20.00 14.14 5.19 -3.73
Lipid Particles 5.69 11.14 10.97 3.14 -0.64 4.75 11.29 8.19 3.14 -4.92 7.97 15.78 13.68 4.01 -4.85
Mitochondria 7.67 8.78 8.57 2.73 -1.61 -1.22 2.89 2.39 5.44 -1.80 0.35 6.76 6.22 5.93 -2.21
Mitotic Spindle -0.33 -1.34 -1.52 -0.47 -0.10 -5.26 -1.30 -2.88 2.18 -1.86 -4.68 -1.83 -3.17 2.12 -1.41
None 3.96 2.33 3.89 -0.04 5.87 -2.74 0.44 8.30 5.96 11.68 -1.55 2.29 6.64 5.84 11.90
Nuclear Periphery 0.83 -4.17 0.55 0.12 2.23 -3.82 0.71 0.41 2.35 0.17 -2.87 -3.11 0.61 1.93 1.77
Nuclear Periphery Foci -2.73 -11.02 -3.28 0.66 6.67 8.45 -6.61 -2.11 -10.21 4.91 4.70 -12.79 -3.60 -5.96 7.89
Nucleolus 4.12 4.36 4.00 -0.44 -1.72 -4.00 9.60 1.48 4.29 -1.19 -1.44 5.62 4.32 4.62 -1.87
Nucleus 7.31 -2.35 17.99 5.00 19.95 -4.60 2.66 26.37 26.81 24.74 -4.34 0.07 31.00 26.92 31.01
Peroxisomes -1.03 13.88 6.69 5.00 -4.54 -1.58 4.20 2.99 6.36 -3.65 -0.03 10.75 6.28 5.90 -5.50
Vacuole 0.83 -3.79 -7.76 -6.01 -2.94 -14.41 -3.23 -9.00 3.27 -6.09 -11.19 -4.89 -12.31 -0.68 -6.74
Vacuole Periphery -0.65 8.85 6.23 1.56 -3.99 -5.46 8.53 -1.55 0.06 -3.45 -1.22 11.66 1.66 2.29 -4.47
Standard name
Human Ortholog
Description CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Rtr1

Rtr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available