Standard name | |
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Human Ortholog | |
Description | Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 2 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 1 | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | 6 | – | 3 | 3 | 5 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 1 | 1 | 12 | 25 | 13 | 24 | – | 8 | 18 | 16 | 9 | 1 | 46 | 55 | 23 | 21 | 15 | 0 | 3 | 0 | 0 | 1 | 1 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 6 | 1 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 |
Mitochondria | 7 | 1 | 1 | 2 | 0 | 15 | 15 | – | 35 | 36 | 33 | 23 | 0 | 1 | 0 | 2 | 8 | 7 | 0 | 1 | 0 | 1 | 0 | 1 |
Nucleus | 122 | 83 | 38 | 191 | 389 | 303 | 427 | – | 292 | 328 | 151 | 248 | 26 | 238 | 259 | 247 | 271 | 121 | 117 | 107 | 73 | 70 | 219 | 206 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 2 | 4 | 0 | 1 | 0 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 38 | 4 | 9 | 6 | 15 | 47 | 63 | – | 79 | 87 | 67 | 82 | 4 | 11 | 18 | 26 | 26 | 15 | 13 | 5 | 6 | 7 | 17 | 29 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 3 | 2 | 1 | 5 | – | 2 | 5 | 1 | 2 | 2 | 3 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4 |
Vac/Vac Membrane | 0 | 3 | 0 | 2 | 9 | 5 | 5 | – | 8 | 7 | 3 | 6 | 0 | 3 | 8 | 3 | 7 | 10 | 2 | 2 | 1 | 1 | 14 | 7 |
Unique Cell Count | 133 | 90 | 43 | 210 | 425 | 343 | 491 | 350 | 422 | 201 | 312 | 29 | 292 | 331 | 288 | 316 | 155 | 134 | 124 | 86 | 85 | 265 | 261 | |
Labelled Cell Count | 168 | 94 | 49 | 216 | 441 | 385 | 548 | 430 | 495 | 278 | 381 | 33 | 308 | 349 | 306 | 346 | 173 | 134 | 124 | 86 | 85 | 265 | 261 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.0 | 8.8 | 7.3 | 8.5 | 9.0 | 7.3 | 7.3 | – | 6.2 | 6.9 | 6.2 | 6.5 | 9.1 | 8.9 | 8.5 | 10.8 | 10.8 | 10.3 | 6.5 | 7.8 | 8.2 |
Std Deviation (1e-4) | 1.2 | 1.6 | 1.4 | 2.3 | 2.4 | 2.1 | 2.2 | – | 1.9 | 2.0 | 2.1 | 1.8 | 2.0 | 2.4 | 2.5 | 2.6 | 2.8 | 2.8 | 0.9 | 1.5 | 1.5 |
Intensity Change (Log2) | – | – | – | 0.22 | 0.3 | -0.01 | -0.0 | – | -0.23 | -0.08 | -0.25 | -0.17 | 0.32 | 0.29 | 0.21 | 0.56 | 0.57 | 0.5 | -0.18 | 0.1 | 0.18 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2.4 | 2.5 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | – | 0 | 0 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.5 | 0.7 | 0 | -0.3 | – | -0.8 | -1.6 | -1.9 | -1.4 | 0.2 | -1.1 | -1.5 | -0.5 | -0.5 | -1.5 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | -1.3 | -1.5 | – | 0.2 | 0 | 1.6 | 0.8 | -0.8 | 0 | 0 | 0 | 0 | -2.0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.8215 | 2.7062 | 2.2936 | 1.9985 | 1.9526 | 2.1698 | 4.9829 | 4.6095 | 4.0466 | 3.7567 | 4.5779 | 3.9162 | 3.5138 | 3.0955 | 2.8652 | 3.0185 | 2.632 | 3.0035 |
Actin | 0.0014 | 0.0001 | 0.0113 | 0.0244 | 0.0001 | 0.003 | 0.0085 | 0 | 0.0001 | 0.0001 | 0.0179 | 0.0008 | 0.0232 | 0 | 0.0002 | 0 | 0.0093 | 0.0009 |
Bud | 0.0001 | 0 | 0.0005 | 0.0003 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0009 | 0.0017 | 0.0002 | 0 | 0 | 0 | 0.0002 | 0 |
Bud Neck | 0.0007 | 0.0001 | 0.0036 | 0.0003 | 0.0005 | 0.0007 | 0.0004 | 0 | 0 | 0 | 0.0019 | 0.0005 | 0.0007 | 0 | 0 | 0 | 0.0024 | 0.0005 |
Bud Periphery | 0.0001 | 0 | 0.0008 | 0.0005 | 0.0001 | 0.0002 | 0.0004 | 0 | 0.0001 | 0 | 0.002 | 0.0019 | 0.0004 | 0 | 0 | 0 | 0.0005 | 0 |
Bud Site | 0.004 | 0.0001 | 0.0056 | 0.0004 | 0.0001 | 0.0002 | 0.001 | 0 | 0.0002 | 0 | 0.0042 | 0.002 | 0.0004 | 0 | 0.0001 | 0 | 0.0003 | 0.0001 |
Cell Periphery | 0.0001 | 0 | 0.0005 | 0.0001 | 0 | 0 | 0.0002 | 0 | 0 | 0 | 0.0006 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0003 | 0 |
Cytoplasm | 0.012 | 0 | 0.0024 | 0.0009 | 0.0001 | 0.0002 | 0.0147 | 0 | 0.0005 | 0.0018 | 0.0067 | 0.0016 | 0.0014 | 0 | 0.0006 | 0 | 0.0009 | 0.0002 |
Cytoplasmic Foci | 0.0091 | 0 | 0.0049 | 0.0162 | 0 | 0.0032 | 0.0043 | 0 | 0.0001 | 0.0041 | 0.02 | 0.0003 | 0.0041 | 0 | 0.001 | 0 | 0.0003 | 0.0004 |
Eisosomes | 0 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0004 | 0 | 0 | 0 | 0.0003 | 0.0001 |
Endoplasmic Reticulum | 0.0039 | 0 | 0.0006 | 0.0002 | 0 | 0.0003 | 0.0099 | 0 | 0.0002 | 0.0009 | 0.0023 | 0.0003 | 0.001 | 0 | 0.0001 | 0 | 0.0048 | 0.0001 |
Endosome | 0.0037 | 0.0001 | 0.0102 | 0.0599 | 0.0001 | 0.0028 | 0.0074 | 0 | 0.0003 | 0.0018 | 0.0231 | 0.0009 | 0.007 | 0 | 0.001 | 0 | 0.0096 | 0.0005 |
Golgi | 0.003 | 0.0002 | 0.0032 | 0.0142 | 0 | 0.0022 | 0.0007 | 0 | 0 | 0.0002 | 0.0082 | 0.0002 | 0.0019 | 0 | 0.0001 | 0 | 0.002 | 0.0002 |
Lipid Particles | 0.004 | 0.0001 | 0.007 | 0.0022 | 0 | 0.0125 | 0.0019 | 0 | 0 | 0.0023 | 0.0112 | 0 | 0.0032 | 0 | 0.0002 | 0 | 0.0011 | 0.0008 |
Mitochondria | 0.0006 | 0.0118 | 0.0111 | 0.0562 | 0.0008 | 0.0011 | 0.0015 | 0.0001 | 0.0009 | 0.0001 | 0.0103 | 0.0007 | 0.0042 | 0 | 0.0001 | 0.0001 | 0.003 | 0.0001 |
None | 0.001 | 0 | 0.0118 | 0.0001 | 0.0001 | 0.0002 | 0.002 | 0 | 0.0001 | 0.0008 | 0.0048 | 0.0001 | 0.0015 | 0 | 0.0013 | 0 | 0.0023 | 0.0017 |
Nuclear Periphery | 0.0029 | 0.0005 | 0.0016 | 0.0002 | 0.0028 | 0.0045 | 0.0269 | 0.0001 | 0.0024 | 0.0072 | 0.0153 | 0.0004 | 0.0049 | 0.0001 | 0.0005 | 0.0001 | 0.0082 | 0.0006 |
Nucleolus | 0.0277 | 0.0243 | 0.0175 | 0.0154 | 0.1215 | 0.1449 | 0.0155 | 0.0141 | 0.0215 | 0.0083 | 0.1049 | 0.0457 | 0.0202 | 0.0198 | 0.0133 | 0.0129 | 0.1559 | 0.0524 |
Nucleus | 0.9178 | 0.9615 | 0.9014 | 0.7703 | 0.8668 | 0.8146 | 0.8961 | 0.9787 | 0.9724 | 0.953 | 0.7016 | 0.9411 | 0.9102 | 0.9798 | 0.9799 | 0.9867 | 0.7934 | 0.9376 |
Peroxisomes | 0.0021 | 0.0002 | 0.0033 | 0.0356 | 0 | 0.0016 | 0.0002 | 0 | 0 | 0 | 0.0018 | 0.0001 | 0.0009 | 0 | 0.0002 | 0 | 0.0001 | 0.0002 |
Punctate Nuclear | 0.0048 | 0.0009 | 0.0012 | 0.0002 | 0.0067 | 0.0072 | 0.005 | 0.0068 | 0.0003 | 0.019 | 0.0307 | 0.0002 | 0.0126 | 0.0001 | 0.0011 | 0.0001 | 0.0028 | 0.0036 |
Vacuole | 0.0008 | 0.0001 | 0.0011 | 0.0013 | 0.0002 | 0.0002 | 0.0015 | 0 | 0.0004 | 0.0002 | 0.0207 | 0.0011 | 0.0009 | 0 | 0.0001 | 0 | 0.0012 | 0.0001 |
Vacuole Periphery | 0.0003 | 0.0001 | 0.0004 | 0.0012 | 0.0002 | 0.0003 | 0.0016 | 0 | 0.0005 | 0.0002 | 0.0107 | 0.0002 | 0.0007 | 0 | 0 | 0 | 0.0012 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 7.2666 | 6.9956 | 9.6405 | 14.1365 | 11.958 | 13.9665 | 14.1464 | 13.8103 | 13.3498 | 14.9182 |
Translational Efficiency | 2.2665 | 2.4829 | 1.719 | 1.1753 | 1.2854 | 1.2609 | 1.2459 | 1.4951 | 1.632 | 1.4481 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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