Standard name | |
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Human Ortholog | |
Description | Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 3 | 1 | 0 | 3 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 5 | 1 | 1 | 6 | 13 |
Bud | 22 | 11 | 6 | 22 | 20 | 16 | 35 | 78 | 35 | 36 | 42 | 70 | 24 | 38 | 34 | 20 | 4 | 3 | 5 | 3 | 0 | 2 | 4 | 7 |
Bud Neck | 4 | 2 | 0 | 0 | 4 | 2 | 6 | 13 | 4 | 5 | 4 | 3 | 0 | 2 | 4 | 3 | 1 | 1 | 3 | 2 | 0 | 1 | 0 | 6 |
Bud Site | 20 | 10 | 4 | 11 | 5 | 24 | 27 | 28 | 13 | 26 | 25 | 39 | 12 | 5 | 12 | 8 | 3 | 4 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 7 | 3 | 2 | 5 | 7 | 14 | 15 | 19 | 10 | 12 | 19 | 10 | 11 | 32 | 73 | 21 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2 |
Endosome | 30 | 25 | 2 | 9 | 19 | 6 | 3 | 6 | 1 | 3 | 5 | 5 | 99 | 172 | 228 | 79 | 25 | 16 | 87 | 51 | 25 | 53 | 82 | 111 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 10 | 8 | 1 | 5 | 4 | 12 |
Mitochondria | 120 | 85 | 40 | 60 | 47 | 54 | 81 | 92 | 68 | 103 | 87 | 156 | 55 | 45 | 41 | 22 | 7 | 3 | 9 | 9 | 6 | 8 | 9 | 20 |
Nucleus | 3 | 0 | 1 | 1 | 1 | 4 | 3 | 4 | 7 | 5 | 2 | 3 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 41 | 8 | 11 | 16 | 20 | 29 | 29 | 25 | 19 | 20 | 16 | 29 | 22 | 20 | 17 | 17 | 6 | 4 | 2 | 0 | 0 | 1 | 0 | 1 |
Peroxisomes | 129 | 86 | 12 | 49 | 84 | 41 | 52 | 45 | 18 | 36 | 29 | 60 | 235 | 342 | 323 | 110 | 56 | 33 | 102 | 63 | 39 | 109 | 152 | 220 |
SpindlePole | 197 | 61 | 42 | 100 | 155 | 168 | 242 | 337 | 127 | 180 | 138 | 295 | 264 | 381 | 403 | 153 | 85 | 65 | 156 | 50 | 34 | 126 | 165 | 125 |
Vac/Vac Membrane | 2 | 3 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 6 | 8 | 8 | 3 | 4 | 1 | 2 | 0 | 0 | 0 | 1 |
Unique Cell Count | 366 | 192 | 85 | 176 | 239 | 252 | 333 | 447 | 208 | 267 | 242 | 437 | 437 | 608 | 679 | 258 | 126 | 91 | 390 | 202 | 117 | 316 | 437 | 534 |
Labelled Cell Count | 575 | 299 | 122 | 275 | 367 | 359 | 493 | 648 | 306 | 426 | 367 | 674 | 734 | 1046 | 1149 | 445 | 197 | 136 | 390 | 202 | 117 | 316 | 437 | 534 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.7 | 5.3 | 4.5 | 4.6 | 4.6 | 3.9 | 3.2 | 3.6 | 3.5 | 2.9 | 3.3 | 2.8 | 6.0 | 5.4 | 4.7 | 6.8 | 7.1 | 7.7 | 5.5 | 5.1 | 5.8 |
Std Deviation (1e-4) | 0.7 | 0.9 | 0.8 | 1.5 | 1.3 | 1.4 | 1.1 | 1.0 | 1.6 | 1.1 | 1.7 | 1.2 | 1.6 | 1.5 | 1.5 | 2.2 | 2.0 | 2.2 | 1.3 | 1.2 | 1.8 |
Intensity Change (Log2) | – | – | – | 0.04 | 0.02 | -0.22 | -0.48 | -0.34 | -0.38 | -0.62 | -0.47 | -0.68 | 0.4 | 0.25 | 0.06 | 0.59 | 0.65 | 0.77 | 0.27 | 0.17 | 0.36 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | 0 | – | 0 | -0.3 | 0 | 0.2 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | 0 | – | 4.3 | 5.2 | 0 | 5.3 | 3.7 | 3.3 |
Golgi | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | 0 | – | -7.5 | -10.4 | 0 | -8.0 | -7.1 | -6.8 |
Nuclear Periphery | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | 0 | – | -2.7 | 0 | 0 | -1.9 | -2.1 | -2.0 |
Peroxisomes | – | – | – | – | – | – | – | 0 | – | 6.7 | 7.3 | 0 | 4.8 | 4.6 | 3.4 |
SpindlePole | – | – | – | – | – | – | – | 0 | – | 1.9 | 2.3 | 0 | 1.6 | 2.6 | 3.0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | 1.8 | – | 0 | 0 | 2.5 | 1.8 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.2601 | 3.3116 | 3.0986 | 2.4052 | 2.7848 | 2.9926 | 1.6946 | 1.9461 | 1.7901 | 1.0873 | 1.6142 | 1.86 | 3.9296 | 4.2401 | 3.6315 | 4.1946 | 4.0041 | 3.9836 |
Actin | 0.0245 | 0.013 | 0.0144 | 0.0013 | 0.0035 | 0.0151 | 0.0388 | 0.0073 | 0.0112 | 0.0061 | 0.006 | 0.0081 | 0.0204 | 0.0053 | 0.0438 | 0.0086 | 0.0045 | 0.0134 |
Bud | 0.0005 | 0.0015 | 0.001 | 0.0001 | 0.0002 | 0.0004 | 0.0005 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0003 | 0.0003 | 0.0008 | 0.0004 | 0.0001 | 0.0001 | 0.0002 |
Bud Neck | 0.0028 | 0.0007 | 0.0011 | 0.0002 | 0.0005 | 0.0096 | 0.0012 | 0.0009 | 0.0009 | 0.0006 | 0.0003 | 0.0006 | 0.0005 | 0.0004 | 0.0005 | 0.0106 | 0.0004 | 0.0044 |
Bud Periphery | 0.0004 | 0.001 | 0.0011 | 0 | 0.0002 | 0.0004 | 0.0006 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0006 | 0.0003 | 0.0006 | 0.0003 | 0.0001 | 0 | 0.0002 |
Bud Site | 0.0032 | 0.0161 | 0.0133 | 0.0002 | 0.0004 | 0.0016 | 0.0048 | 0.002 | 0.0007 | 0.0024 | 0.0003 | 0.0017 | 0.0019 | 0.0117 | 0.0023 | 0.0005 | 0.0002 | 0.0005 |
Cell Periphery | 0.0001 | 0.0001 | 0.0005 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 |
Cytoplasm | 0.0027 | 0.0071 | 0.003 | 0.0007 | 0.0012 | 0.0027 | 0.0047 | 0.0013 | 0.0015 | 0.0003 | 0.0006 | 0.0005 | 0.0138 | 0.0007 | 0.0073 | 0.0007 | 0.0003 | 0.0013 |
Cytoplasmic Foci | 0.249 | 0.2791 | 0.2583 | 0.2275 | 0.2259 | 0.2279 | 0.2937 | 0.2923 | 0.2832 | 0.2305 | 0.3233 | 0.254 | 0.3038 | 0.3784 | 0.3015 | 0.2567 | 0.1561 | 0.2507 |
Eisosomes | 0.0002 | 0 | 0.0002 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0024 | 0.0008 | 0.0007 | 0 | 0.0002 | 0.0002 | 0.0012 | 0.0002 | 0.0028 | 0.0001 | 0.0002 | 0.0004 | 0.0027 | 0 | 0.0023 | 0 | 0.0001 | 0.0001 |
Endosome | 0.0784 | 0.0489 | 0.0533 | 0.0324 | 0.0941 | 0.0444 | 0.0585 | 0.0513 | 0.0499 | 0.0375 | 0.062 | 0.0191 | 0.0572 | 0.0238 | 0.0277 | 0.025 | 0.0437 | 0.033 |
Golgi | 0.0476 | 0.0332 | 0.0501 | 0.033 | 0.1199 | 0.0478 | 0.0397 | 0.028 | 0.0509 | 0.069 | 0.0534 | 0.0366 | 0.0577 | 0.0179 | 0.0416 | 0.0354 | 0.0343 | 0.0491 |
Lipid Particles | 0.1213 | 0.0634 | 0.0699 | 0.1059 | 0.0615 | 0.1282 | 0.1501 | 0.0525 | 0.0838 | 0.0776 | 0.0436 | 0.12 | 0.0961 | 0.0704 | 0.0596 | 0.0861 | 0.0248 | 0.0982 |
Mitochondria | 0.0099 | 0.0137 | 0.0245 | 0.0014 | 0.0627 | 0.0156 | 0.0172 | 0.0022 | 0.0341 | 0.0302 | 0.0647 | 0.0072 | 0.0202 | 0.0036 | 0.0191 | 0.002 | 0.0041 | 0.0109 |
None | 0.0042 | 0.0006 | 0.0044 | 0 | 0.0001 | 0.0002 | 0.0058 | 0.0002 | 0.0024 | 0.0001 | 0.0003 | 0.0005 | 0.0031 | 0.0004 | 0.0006 | 0.0001 | 0.0001 | 0.0002 |
Nuclear Periphery | 0.005 | 0.0009 | 0.004 | 0 | 0.0002 | 0.0021 | 0.0119 | 0.0002 | 0.011 | 0 | 0.0003 | 0.0004 | 0.0081 | 0 | 0.004 | 0 | 0 | 0.0001 |
Nucleolus | 0.0015 | 0.0008 | 0.0012 | 0 | 0.0001 | 0.0006 | 0.0008 | 0.001 | 0.0002 | 0.0006 | 0.0001 | 0.0004 | 0.0006 | 0.0006 | 0.0002 | 0 | 0 | 0.0001 |
Nucleus | 0.0019 | 0.0013 | 0.0011 | 0 | 0.0001 | 0.0018 | 0.0066 | 0.0011 | 0.0011 | 0.0001 | 0.0001 | 0.0004 | 0.0039 | 0.0001 | 0.0004 | 0 | 0 | 0.0001 |
Peroxisomes | 0.416 | 0.5011 | 0.4807 | 0.5958 | 0.3942 | 0.4797 | 0.3482 | 0.534 | 0.4583 | 0.4675 | 0.4375 | 0.5402 | 0.3713 | 0.4809 | 0.459 | 0.5724 | 0.7297 | 0.5283 |
Punctate Nuclear | 0.0247 | 0.007 | 0.0104 | 0.0013 | 0.0337 | 0.0189 | 0.0134 | 0.0239 | 0.006 | 0.0751 | 0.0056 | 0.0082 | 0.0362 | 0.0038 | 0.0277 | 0.0016 | 0.0007 | 0.0085 |
Vacuole | 0.0028 | 0.0075 | 0.005 | 0.0001 | 0.0007 | 0.0018 | 0.001 | 0.0009 | 0.0008 | 0.0011 | 0.0007 | 0.0005 | 0.0011 | 0.0005 | 0.001 | 0.0001 | 0.0005 | 0.0004 |
Vacuole Periphery | 0.0009 | 0.0022 | 0.0018 | 0.0001 | 0.0006 | 0.0009 | 0.0009 | 0.0002 | 0.0008 | 0.0004 | 0.0005 | 0.0003 | 0.0008 | 0.0001 | 0.0005 | 0.0001 | 0.0002 | 0.0002 |
R1 | R2 | |||||||||
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G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.5883 | 14.2953 | 6.895 | 20.4727 | 13.4768 | 20.7773 | 22.223 | 20.2426 | 22.406 | 22.5723 |
Translational Efficiency | 0.5859 | 0.8659 | 1.9788 | 0.7196 | 1.003 | 0.8886 | 0.6963 | 0.8901 | 0.7466 | 0.7551 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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