Standard name | |
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Human Ortholog | |
Description | Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 0 | 3 | 4 | 15 | 1 | 7 | 8 | 15 |
Bud | 7 | 28 | 11 | 4 | 8 | 6 | 12 | 23 | 19 | 14 | 8 | 7 | 19 | 20 | 7 | 12 | 6 | 13 | 1 | 15 | 0 | 4 | 11 | 14 |
Bud Neck | 5 | 7 | 2 | 1 | 1 | 0 | 1 | 1 | 3 | 1 | 0 | 0 | 4 | 2 | 1 | 0 | 0 | 0 | 1 | 6 | 0 | 5 | 3 | 9 |
Bud Site | 4 | 10 | 2 | 0 | 1 | 3 | 4 | 4 | 4 | 2 | 3 | 1 | 5 | 0 | 0 | 2 | 0 | 6 | – | – | – | – | – | – |
Cell Periphery | 3 | 11 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 2 | 12 | 6 | 4 | 10 | 3 | 9 | 0 | 0 | 0 | 0 | 1 | 0 |
Cytoplasm | 21 | 72 | 12 | 3 | 9 | 9 | 10 | 11 | 9 | 5 | 8 | 4 | 99 | 106 | 112 | 47 | 16 | 28 | 3 | 17 | 0 | 28 | 19 | 14 |
Endoplasmic Reticulum | 1 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 8 | 5 | 3 | 3 | 0 | 0 | 1 | 1 | 3 |
Endosome | 25 | 84 | 1 | 1 | 9 | 7 | 5 | 4 | 1 | 1 | 0 | 0 | 184 | 181 | 201 | 101 | 20 | 47 | 65 | 104 | 31 | 58 | 88 | 115 |
Golgi | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3 | 11 | 42 | 68 | 24 | 6 | 16 | 2 | 9 | 9 | 11 |
Mitochondria | 154 | 227 | 69 | 51 | 76 | 138 | 145 | 221 | 142 | 154 | 177 | 148 | 159 | 188 | 153 | 48 | 36 | 21 | 71 | 152 | 31 | 64 | 62 | 91 |
Nucleus | 3 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear Periphery | 2 | 4 | 0 | 1 | 1 | 11 | 15 | 9 | 4 | 8 | 10 | 12 | 0 | 1 | 1 | 2 | 4 | 0 | 1 | 0 | 0 | 2 | 1 | 2 |
Nucleolus | 4 | 7 | 1 | 0 | 4 | 15 | 7 | 7 | 7 | 12 | 7 | 8 | 3 | 4 | 4 | 13 | 3 | 11 | 2 | 2 | 0 | 2 | 4 | 3 |
Peroxisomes | 46 | 144 | 28 | 10 | 25 | 23 | 10 | 23 | 3 | 5 | 9 | 3 | 275 | 248 | 320 | 255 | 82 | 136 | 64 | 82 | 38 | 88 | 94 | 128 |
SpindlePole | 50 | 142 | 36 | 16 | 21 | 19 | 21 | 39 | 17 | 13 | 7 | 5 | 146 | 132 | 98 | 156 | 74 | 94 | 50 | 115 | 15 | 87 | 106 | 98 |
Vac/Vac Membrane | 11 | 34 | 1 | 1 | 3 | 1 | 0 | 6 | 1 | 0 | 1 | 2 | 33 | 20 | 34 | 17 | 11 | 14 | 3 | 8 | 0 | 5 | 6 | 9 |
Unique Cell Count | 254 | 500 | 123 | 68 | 115 | 175 | 173 | 268 | 168 | 172 | 192 | 156 | 597 | 584 | 641 | 495 | 256 | 294 | 286 | 552 | 129 | 374 | 427 | 528 |
Labelled Cell Count | 338 | 772 | 167 | 90 | 159 | 233 | 233 | 349 | 214 | 219 | 233 | 195 | 946 | 912 | 948 | 721 | 330 | 410 | 286 | 552 | 129 | 374 | 427 | 528 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.3 | 4.9 | 4.2 | 3.7 | 4.6 | 4.5 | 4.3 | 4.8 | 4.8 | 5.0 | 5.3 | 5.4 | 5.8 | 5.7 | 6.0 | 8.0 | 8.9 | 8.5 | 4.6 | 4.6 | 5.6 |
Std Deviation (1e-4) | 0.9 | 1.1 | 1.4 | 1.0 | 1.2 | 1.3 | 1.2 | 1.5 | 1.5 | 1.6 | 1.6 | 1.6 | 1.4 | 1.5 | 1.8 | 4.6 | 2.0 | 1.8 | 1.4 | 1.4 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.19 | 0.11 | 0.08 | 0.02 | 0.18 | 0.17 | 0.25 | 0.31 | 0.36 | 0.45 | 0.42 | 0.49 | 0.92 | 1.06 | 1.0 | 0.11 | 0.12 | 0.39 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.5978 | 4.0775 | 4.5044 | 4.2622 | 4.2841 | 4.2958 | 4.9985 | 3.9614 | 3.965 | 3.1972 | 4.0037 | 3.8381 | 5.807 | 4.8537 | 5.3568 | 5.9309 | 4.6089 | 5.2957 |
Actin | 0.0414 | 0.0152 | 0.0093 | 0.0052 | 0.0021 | 0.0103 | 0.0886 | 0.0423 | 0.0128 | 0.0059 | 0.0355 | 0.0177 | 0.018 | 0.0286 | 0.0238 | 0.0072 | 0.0871 | 0.0262 |
Bud | 0.0011 | 0.0061 | 0.0009 | 0.0007 | 0.0222 | 0.0001 | 0.0004 | 0.0022 | 0.0012 | 0.0008 | 0.0005 | 0.0005 | 0.0009 | 0.005 | 0.0028 | 0.0002 | 0.0008 | 0.0005 |
Bud Neck | 0.0018 | 0.0019 | 0.0005 | 0.0011 | 0.0013 | 0.0007 | 0.001 | 0.0004 | 0.0111 | 0.0004 | 0.0012 | 0.0103 | 0.0035 | 0.0039 | 0.0065 | 0.0062 | 0.0008 | 0.0014 |
Bud Periphery | 0.0018 | 0.0032 | 0.0018 | 0.0007 | 0.0475 | 0.0002 | 0.0011 | 0.0021 | 0.0032 | 0.0013 | 0.0008 | 0.0011 | 0.0013 | 0.0049 | 0.0044 | 0.0003 | 0.0011 | 0.0005 |
Bud Site | 0.0052 | 0.0319 | 0.0057 | 0.0041 | 0.0205 | 0.0004 | 0.0019 | 0.0072 | 0.0055 | 0.0015 | 0.0016 | 0.0006 | 0.0049 | 0.0566 | 0.0185 | 0.006 | 0.0022 | 0.0008 |
Cell Periphery | 0.0003 | 0.0005 | 0.0001 | 0.0002 | 0.0007 | 0.0001 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0004 | 0.0004 | 0.0001 | 0.0004 | 0.0001 |
Cytoplasm | 0.0023 | 0.0092 | 0.0016 | 0.0049 | 0.006 | 0.0013 | 0.0193 | 0.0024 | 0.0046 | 0.0071 | 0.0015 | 0.0039 | 0.0017 | 0.007 | 0.0061 | 0.0003 | 0.0095 | 0.0078 |
Cytoplasmic Foci | 0.0815 | 0.1863 | 0.0849 | 0.2217 | 0.0683 | 0.1042 | 0.179 | 0.1981 | 0.1488 | 0.2587 | 0.1785 | 0.1634 | 0.1594 | 0.218 | 0.1667 | 0.1572 | 0.1365 | 0.1837 |
Eisosomes | 0.0006 | 0.0002 | 0.0002 | 0.0001 | 0.0009 | 0.0002 | 0.0008 | 0.0002 | 0.0002 | 0.0001 | 0.0011 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0003 | 0.0001 |
Endoplasmic Reticulum | 0.0009 | 0.0009 | 0.0004 | 0.0002 | 0.0008 | 0 | 0.0063 | 0.0006 | 0.0008 | 0.0006 | 0.0007 | 0.0017 | 0.0005 | 0.001 | 0.0014 | 0.0001 | 0.0012 | 0.0004 |
Endosome | 0.0641 | 0.0726 | 0.042 | 0.0553 | 0.0375 | 0.0115 | 0.0534 | 0.0359 | 0.0176 | 0.0523 | 0.0184 | 0.0259 | 0.066 | 0.0506 | 0.044 | 0.0381 | 0.0582 | 0.0327 |
Golgi | 0.0564 | 0.0464 | 0.034 | 0.0682 | 0.0466 | 0.0241 | 0.0295 | 0.0418 | 0.0263 | 0.0627 | 0.0291 | 0.0422 | 0.0483 | 0.053 | 0.0671 | 0.0445 | 0.0424 | 0.0516 |
Lipid Particles | 0.1653 | 0.0639 | 0.1183 | 0.0662 | 0.0606 | 0.1316 | 0.0834 | 0.0779 | 0.0409 | 0.061 | 0.1283 | 0.0791 | 0.2014 | 0.0609 | 0.0887 | 0.0787 | 0.1603 | 0.1519 |
Mitochondria | 0.0795 | 0.0384 | 0.1151 | 0.1718 | 0.0391 | 0.1962 | 0.0601 | 0.055 | 0.0927 | 0.0271 | 0.0219 | 0.081 | 0.0613 | 0.1053 | 0.0859 | 0.1687 | 0.0427 | 0.0897 |
None | 0.0026 | 0.0602 | 0.0351 | 0.0011 | 0.1373 | 0.054 | 0.0362 | 0.0427 | 0.0373 | 0.0529 | 0.0517 | 0.015 | 0.0012 | 0.0103 | 0.0245 | 0.0001 | 0.0712 | 0.0094 |
Nuclear Periphery | 0.0009 | 0.0009 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0.0181 | 0.0004 | 0.0004 | 0.0018 | 0.0015 | 0.0032 | 0.0029 | 0.0014 | 0.0011 | 0.0001 | 0.0006 | 0.0002 |
Nucleolus | 0.0009 | 0.0015 | 0.0006 | 0.0002 | 0.0022 | 0.0002 | 0.0005 | 0.0003 | 0.001 | 0.0006 | 0.0012 | 0.0016 | 0.0037 | 0.0095 | 0.0015 | 0.0004 | 0.001 | 0.003 |
Nucleus | 0.0005 | 0.0015 | 0.0003 | 0.0001 | 0.0007 | 0.0001 | 0.0019 | 0.0002 | 0.0006 | 0.0006 | 0.0006 | 0.0049 | 0.0017 | 0.0009 | 0.0006 | 0.0001 | 0.0009 | 0.0003 |
Peroxisomes | 0.4856 | 0.4093 | 0.5455 | 0.3838 | 0.5 | 0.4601 | 0.4029 | 0.4816 | 0.5414 | 0.4591 | 0.5187 | 0.5177 | 0.4017 | 0.3538 | 0.4454 | 0.4452 | 0.3773 | 0.4239 |
Punctate Nuclear | 0.0013 | 0.0459 | 0.0019 | 0.0123 | 0.0012 | 0.0036 | 0.013 | 0.0072 | 0.052 | 0.0028 | 0.0062 | 0.0274 | 0.0025 | 0.0122 | 0.0062 | 0.0451 | 0.0018 | 0.0127 |
Vacuole | 0.0037 | 0.0028 | 0.0008 | 0.0014 | 0.0037 | 0.0004 | 0.0011 | 0.0009 | 0.0009 | 0.0016 | 0.0004 | 0.0012 | 0.0104 | 0.0102 | 0.003 | 0.0006 | 0.0027 | 0.0016 |
Vacuole Periphery | 0.0021 | 0.0011 | 0.0006 | 0.0007 | 0.0006 | 0.0007 | 0.0011 | 0.0004 | 0.0004 | 0.001 | 0.0003 | 0.0011 | 0.0083 | 0.0063 | 0.0014 | 0.0006 | 0.0011 | 0.0013 |
R1 | R2 | |||||||||
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G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 28.3514 | 11.6447 | 18.8066 | 28.1216 | 22.8501 | 19.9116 | 23.3748 | 32.4877 | 28.7925 | 30.3497 |
Translational Efficiency | 0.9695 | 1.1069 | 0.7682 | 0.5359 | 0.6272 | 1.4037 | 0.725 | 0.4904 | 0.7251 | 0.7179 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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