Standard name | |
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Human Ortholog | |
Description | Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bud | – | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Bud Neck | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | – | 0 | 1 | 2 | 3 | 0 | 3 | 2 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | – | 122 | 108 | 103 | 221 | 159 | 173 | 203 | 130 | 134 | 105 | 107 | 62 | 226 | 254 | 122 | 97 | 106 | 15 | 128 | 101 | 108 | 160 | 220 |
Endoplasmic Reticulum | – | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4 | 0 | 3 | 3 | 1 | 0 | 0 | 0 | 4 | 1 | 1 |
Endosome | – | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 2 | 2 | 0 |
Golgi | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mitochondria | – | 5 | 0 | 1 | 1 | 10 | 29 | 21 | 68 | 58 | 53 | 53 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 |
Nucleus | – | 0 | 1 | 1 | 0 | 5 | 3 | 1 | 2 | 6 | 4 | 3 | 3 | 1 | 0 | 3 | 1 | 3 | 0 | 0 | 1 | 1 | 1 | 0 |
Nuclear Periphery | – | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | – | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Vac/Vac Membrane | – | 1 | 3 | 6 | 13 | 7 | 12 | 17 | 7 | 9 | 8 | 9 | 0 | 0 | 2 | 2 | 4 | 6 | 0 | 0 | 4 | 2 | 2 | 3 |
Unique Cell Count | 129 | 111 | 112 | 227 | 173 | 204 | 231 | 180 | 171 | 148 | 157 | 63 | 230 | 254 | 126 | 100 | 112 | 16 | 137 | 114 | 126 | 174 | 234 | |
Labelled Cell Count | 132 | 113 | 115 | 241 | 183 | 224 | 246 | 212 | 212 | 177 | 182 | 65 | 232 | 257 | 135 | 105 | 118 | 16 | 137 | 114 | 126 | 174 | 234 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | – | 5.8 | 8.1 | 8.1 | 7.8 | 6.3 | 5.7 | 5.8 | 4.8 | 5.3 | 5.1 | 4.9 | 6.2 | 8.7 | 8.2 | 10.9 | 12.4 | 14.1 | 10.3 | 9.2 | 8.8 |
Std Deviation (1e-4) | – | 1.0 | 2.1 | 3.1 | 1.9 | 1.9 | 1.5 | 1.6 | 1.7 | 2.4 | 2.1 | 1.3 | 1.5 | 2.1 | 2.1 | 2.0 | 2.5 | 3.1 | 2.9 | 2.0 | 2.4 |
Intensity Change (Log2) | – | – | – | -0.0 | -0.05 | -0.35 | -0.5 | -0.47 | -0.76 | -0.61 | -0.67 | -0.72 | -0.38 | 0.09 | 0.01 | 0.43 | 0.61 | 0.79 | 0.35 | 0.18 | 0.12 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.8 | 0 | -1.9 | -3.4 | -2.8 | -5.4 | -4.5 | -5.5 | -5.9 | 0.5 | 0.6 | 2.6 | -0.2 | -0.1 | -1.0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 4.2 | 3.3 | 0 | 6.9 | 7.1 | 6.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 1.2 | 0 | 1.3 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.0693 | 4.942 | 3.6148 | 3.6583 | 3.3572 | 3.5098 | 6.3465 | 7.5179 | 7.0281 | 6.6544 | 5.72 | 7.0544 | 3.394 | 4.1946 | 3.2072 | 3.3856 | 4.0151 | 3.4807 |
Actin | 0.0368 | 0.0014 | 0.0121 | 0.0018 | 0.0336 | 0.0015 | 0.0236 | 0.0044 | 0.0253 | 0.0072 | 0.0233 | 0.0019 | 0.059 | 0.0007 | 0.016 | 0.0004 | 0.0024 | 0.0094 |
Bud | 0.0013 | 0.0003 | 0.001 | 0.0075 | 0.0001 | 0.0003 | 0.0008 | 0.001 | 0.0004 | 0.0012 | 0.0004 | 0.0002 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 |
Bud Neck | 0.0053 | 0.0002 | 0.0006 | 0.0008 | 0.0007 | 0.0012 | 0.0008 | 0.0003 | 0.0006 | 0.0008 | 0.0004 | 0.0011 | 0.0028 | 0.0003 | 0.005 | 0.0003 | 0.0005 | 0.001 |
Bud Periphery | 0.0015 | 0.0001 | 0.0007 | 0.0026 | 0.0001 | 0.0003 | 0.0011 | 0.0007 | 0.0003 | 0.0009 | 0.0004 | 0.0001 | 0.0009 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0001 |
Bud Site | 0.0115 | 0.0009 | 0.0026 | 0.0013 | 0.0003 | 0.0014 | 0.0028 | 0.005 | 0.0014 | 0.0008 | 0.0004 | 0.0001 | 0.005 | 0.0006 | 0.0013 | 0.0001 | 0 | 0.0001 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0016 | 0.0001 | 0.0001 | 0 | 0 | 0 |
Cytoplasm | 0.7751 | 0.942 | 0.8676 | 0.8808 | 0.887 | 0.9173 | 0.7806 | 0.9237 | 0.849 | 0.8518 | 0.8315 | 0.9037 | 0.7367 | 0.9404 | 0.9037 | 0.9653 | 0.8784 | 0.9525 |
Cytoplasmic Foci | 0.0326 | 0.003 | 0.018 | 0.005 | 0.0262 | 0.0096 | 0.0382 | 0.0026 | 0.0103 | 0.0094 | 0.0212 | 0.0086 | 0.0278 | 0.0017 | 0.0037 | 0.0021 | 0.0014 | 0.0044 |
Eisosomes | 0.0003 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.001 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0032 | 0.0028 | 0.0032 | 0.0016 | 0.0013 | 0.0026 | 0.0069 | 0.0018 | 0.0041 | 0.0049 | 0.0048 | 0.0025 | 0.0123 | 0.0018 | 0.0019 | 0.0018 | 0.0015 | 0.0037 |
Endosome | 0.029 | 0.0018 | 0.0101 | 0.0161 | 0.0047 | 0.0072 | 0.0167 | 0.0005 | 0.0036 | 0.0031 | 0.016 | 0.0027 | 0.03 | 0.0005 | 0.0024 | 0.0009 | 0.0014 | 0.0083 |
Golgi | 0.0099 | 0.0001 | 0.0086 | 0.0164 | 0.0027 | 0.0016 | 0.0037 | 0.0001 | 0.0009 | 0.0009 | 0.0121 | 0.0004 | 0.0064 | 0.0001 | 0.0017 | 0 | 0 | 0.0019 |
Lipid Particles | 0.0044 | 0 | 0.0046 | 0.009 | 0.0067 | 0.0007 | 0.0042 | 0 | 0.0004 | 0.0003 | 0.0128 | 0.0008 | 0.0052 | 0 | 0.0048 | 0 | 0 | 0.001 |
Mitochondria | 0.0207 | 0.0001 | 0.0073 | 0.0399 | 0.0006 | 0.0099 | 0.0172 | 0.0002 | 0.0008 | 0.0012 | 0.004 | 0.0003 | 0.0023 | 0.0001 | 0.0164 | 0.0001 | 0.0012 | 0.0005 |
None | 0.0281 | 0.0338 | 0.0403 | 0.0055 | 0.006 | 0.0175 | 0.0655 | 0.0537 | 0.0923 | 0.1052 | 0.0326 | 0.0623 | 0.0613 | 0.0482 | 0.0335 | 0.0096 | 0.0042 | 0.0085 |
Nuclear Periphery | 0.0036 | 0.0035 | 0.002 | 0.001 | 0.003 | 0.005 | 0.0063 | 0.0009 | 0.0036 | 0.0018 | 0.0114 | 0.0011 | 0.0225 | 0.0008 | 0.0009 | 0.0012 | 0.0519 | 0.0014 |
Nucleolus | 0.0005 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0005 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0004 | 0 | 0.0003 | 0 | 0.0002 | 0 |
Nucleus | 0.0164 | 0.0078 | 0.0065 | 0.0042 | 0.0139 | 0.0174 | 0.0072 | 0.0035 | 0.0033 | 0.0059 | 0.0023 | 0.0047 | 0.0145 | 0.0039 | 0.0024 | 0.0168 | 0.0528 | 0.0055 |
Peroxisomes | 0.0098 | 0.0001 | 0.0109 | 0.0019 | 0.0047 | 0.0013 | 0.0177 | 0.0001 | 0.0017 | 0.0007 | 0.0223 | 0.007 | 0.0038 | 0.0001 | 0.0035 | 0 | 0.0001 | 0.0006 |
Punctate Nuclear | 0.0024 | 0.0005 | 0.0016 | 0.0004 | 0.0073 | 0.0024 | 0.0048 | 0.0007 | 0.0011 | 0.0026 | 0.0021 | 0.0021 | 0.0035 | 0.0003 | 0.0005 | 0.0004 | 0.0023 | 0.0007 |
Vacuole | 0.0053 | 0.0013 | 0.0017 | 0.0026 | 0.0007 | 0.0017 | 0.0011 | 0.0004 | 0.0004 | 0.0009 | 0.0006 | 0.0003 | 0.0014 | 0.0002 | 0.0007 | 0.0006 | 0.0004 | 0.0004 |
Vacuole Periphery | 0.0019 | 0.0001 | 0.0003 | 0.0014 | 0.0002 | 0.0005 | 0.0005 | 0.0001 | 0.0003 | 0.0002 | 0.0009 | 0.0001 | 0.0013 | 0 | 0.0005 | 0.0001 | 0.0007 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 7.0191 | 8.7845 | 13.9682 | 15.3868 | 23.6615 | 4.2091 | 8.882 | 17.9843 | 14.752 | 17.1659 |
Translational Efficiency | 4.6787 | 4.2802 | 2.2231 | 2.2102 | 1.7218 | 7.3302 | 3.3123 | 1.8281 | 2.1842 | 2.713 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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