| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 1 | 0 | 3 | 1 | 1 | 0 |
| Bud | 1 | 0 | 1 | 1 | 4 | 2 | 6 | 1 | 7 | 7 | 1 | 4 | – | 1 | 0 | 1 | 0 | – | 1 | 1 | 1 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 2 | 1 | 4 | 0 | 0 | – | 0 | 0 | 3 | 4 | – | 0 | 1 | 2 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – |
| Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | – | 0 | 1 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 |
| Cytoplasm | 77 | 164 | 178 | 118 | 141 | 146 | 205 | 221 | 143 | 195 | 32 | 37 | – | 67 | 101 | 102 | 45 | – | 61 | 142 | 109 | 24 | 62 | 44 |
| Endoplasmic Reticulum | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | – | 0 | 1 | 4 | 7 | – | 1 | 0 | 1 | 0 | 0 | 0 |
| Endosome | 0 | 3 | 0 | 1 | 3 | 3 | 0 | 1 | 0 | 1 | 0 | 0 | – | 0 | 1 | 6 | 3 | – | 5 | 4 | 7 | 0 | 2 | 0 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 1 | 2 | 0 | 1 | 2 |
| Mitochondria | 21 | 13 | 23 | 17 | 20 | 50 | 97 | 66 | 87 | 118 | 32 | 46 | – | 1 | 5 | 11 | 0 | – | 17 | 13 | 48 | 4 | 5 | 4 |
| Nucleus | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | – | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 2 | 1 | 6 | 6 | 9 | 8 | 5 | 7 | 1 | 1 | – | 0 | 0 | 3 | 5 | – | 4 | 3 | 5 | 0 | 0 | 0 |
| Vac/Vac Membrane | 2 | 3 | 0 | 0 | 2 | 0 | 1 | 3 | 0 | 3 | 0 | 0 | – | 0 | 0 | 3 | 4 | – | 4 | 7 | 4 | 0 | 3 | 5 |
| Unique Cell Count | 86 | 178 | 197 | 129 | 165 | 182 | 271 | 264 | 197 | 268 | 55 | 68 | 67 | 108 | 119 | 59 | 103 | 184 | 196 | 33 | 80 | 64 | ||
| Labelled Cell Count | 101 | 184 | 206 | 140 | 181 | 210 | 326 | 306 | 248 | 337 | 67 | 89 | 69 | 111 | 134 | 68 | 103 | 184 | 196 | 33 | 80 | 64 | ||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 3.2 | 3.5 | 3.5 | 3.1 | 3.6 | 2.9 | 2.3 | 3.0 | 2.5 | 2.3 | 2.5 | 2.4 | – | 4.0 | 4.2 | 5.3 | 5.2 | – | – | 3.9 | 4.8 |
| Std Deviation (1e-4) | 1.3 | 0.7 | 1.8 | 1.0 | 2.1 | 1.3 | 0.8 | 1.9 | 1.3 | 1.1 | 0.6 | 1.3 | – | 1.9 | 2.0 | 2.5 | 1.4 | – | – | 1.5 | 2.1 |
| Intensity Change (Log2) | – | – | – | -0.19 | 0.03 | -0.26 | -0.59 | -0.25 | -0.47 | -0.59 | -0.52 | -0.58 | – | 0.19 | 0.27 | 0.58 | 0.55 | – | – | 0.16 | 0.44 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | 0.0731 | 0 | 0.0342 | 0.0002 | 0.0011 | 0.0002 | 0.1149 | 0 | 0.0512 | 0.0002 | 0.001 | 0.0046 |
| Bud | – | – | – | – | – | – | 0.0023 | 0 | 0.0026 | 0.0038 | 0 | 0.0003 | 0.0011 | 0 | 0.0008 | 0 | 0.0016 | 0.0007 |
| Bud Neck | – | – | – | – | – | – | 0.0014 | 0 | 0.0077 | 0.0003 | 0 | 0.0001 | 0.0105 | 0 | 0.0047 | 0 | 0.0003 | 0.0055 |
| Bud Periphery | – | – | – | – | – | – | 0.006 | 0 | 0.0013 | 0.0071 | 0 | 0.0004 | 0.0024 | 0 | 0.0012 | 0 | 0.0011 | 0.0015 |
| Bud Site | – | – | – | – | – | – | 0.0066 | 0 | 0.0197 | 0.004 | 0.0001 | 0.0001 | 0.0145 | 0 | 0.0098 | 0 | 0.0048 | 0.0015 |
| Cell Periphery | – | – | – | – | – | – | 0.001 | 0 | 0.0004 | 0.0006 | 0.0002 | 0 | 0.0011 | 0 | 0.0013 | 0 | 0.0002 | 0.0002 |
| Cytoplasm | – | – | – | – | – | – | 0.022 | 0.0112 | 0.011 | 0.0154 | 0.0213 | 0.0373 | 0.0198 | 0.0034 | 0.0115 | 0.0176 | 0.0362 | 0.0327 |
| Cytoplasmic Foci | – | – | – | – | – | – | 0.0558 | 0.0007 | 0.0634 | 0.0131 | 0.0197 | 0.0147 | 0.0986 | 0.0004 | 0.0218 | 0.0012 | 0.0074 | 0.0089 |
| Eisosomes | – | – | – | – | – | – | 0.0011 | 0.0002 | 0.0005 | 0.0002 | 0.0007 | 0.0001 | 0.0021 | 0.0001 | 0.0018 | 0.0003 | 0 | 0.0002 |
| Endoplasmic Reticulum | – | – | – | – | – | – | 0.02 | 0.0001 | 0.0004 | 0.0008 | 0.0141 | 0.0004 | 0.0054 | 0 | 0.0015 | 0.0006 | 0.0061 | 0.0003 |
| Endosome | – | – | – | – | – | – | 0.0471 | 0 | 0.0175 | 0.0123 | 0.0421 | 0.005 | 0.0622 | 0 | 0.0269 | 0.0002 | 0.0629 | 0.0005 |
| Golgi | – | – | – | – | – | – | 0.0136 | 0 | 0.0107 | 0.0019 | 0.0058 | 0.0005 | 0.0141 | 0 | 0.0088 | 0 | 0.0045 | 0.0005 |
| Lipid Particles | – | – | – | – | – | – | 0.0275 | 0.0001 | 0.0252 | 0.0777 | 0.0421 | 0.0012 | 0.0843 | 0 | 0.0221 | 0.0002 | 0.0007 | 0.001 |
| Mitochondria | – | – | – | – | – | – | 0.0115 | 0.0001 | 0.0326 | 0.002 | 0.0008 | 0.0006 | 0.013 | 0 | 0.0234 | 0.0003 | 0.0076 | 0.002 |
| None | – | – | – | – | – | – | 0.5977 | 0.9872 | 0.736 | 0.8103 | 0.846 | 0.9359 | 0.348 | 0.9959 | 0.7579 | 0.9781 | 0.8279 | 0.9343 |
| Nuclear Periphery | – | – | – | – | – | – | 0.0129 | 0.0001 | 0.0006 | 0.0025 | 0.0021 | 0.0002 | 0.0425 | 0 | 0.0009 | 0.0002 | 0.0077 | 0.0001 |
| Nucleolus | – | – | – | – | – | – | 0.0015 | 0 | 0.0038 | 0.0163 | 0.0001 | 0.0001 | 0.0161 | 0 | 0.0007 | 0.0001 | 0.0004 | 0.0002 |
| Nucleus | – | – | – | – | – | – | 0.0046 | 0 | 0.0006 | 0.0069 | 0.0001 | 0.0002 | 0.0513 | 0 | 0.0007 | 0.0003 | 0.0082 | 0.0001 |
| Peroxisomes | – | – | – | – | – | – | 0.0472 | 0 | 0.0251 | 0.0032 | 0.0011 | 0.0011 | 0.0355 | 0 | 0.0217 | 0.0001 | 0.0003 | 0.0048 |
| Punctate Nuclear | – | – | – | – | – | – | 0.0229 | 0.0001 | 0.0041 | 0.0094 | 0.0005 | 0.0004 | 0.016 | 0 | 0.0022 | 0.0002 | 0.0007 | 0.0002 |
| Vacuole | – | – | – | – | – | – | 0.0207 | 0 | 0.0015 | 0.0088 | 0.0014 | 0.001 | 0.02 | 0 | 0.0275 | 0.0001 | 0.0152 | 0.0002 |
| Vacuole Periphery | – | – | – | – | – | – | 0.0035 | 0 | 0.001 | 0.0032 | 0.0006 | 0.0003 | 0.0268 | 0 | 0.0015 | 0 | 0.0049 | 0 |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 22.4352 | 10.9395 | 24.3527 | 29.5011 | 20.7143 | 26.4997 | 23.5044 | 26.3361 | 24.7883 | 24.1084 |
| Translational Efficiency | 0.899 | 1.7844 | 0.9627 | 1.0553 | 1.1375 | 0.7754 | 0.8669 | 0.9283 | 1.0865 | 0.9497 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 856 | 627 | 108 | 1374 | 1806 | 1561 | 1516 | 943 | 2662 | 2188 | 1624 | 2317 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 639.37 | 720.84 | 846.52 | 781.30 | 680.22 | 708.32 | 760.48 | 778.20 | 667.08 | 711.91 | 766.20 | 780.04 |
| Standard Deviation | 69.36 | 92.45 | 90.07 | 105.31 | 76.05 | 85.79 | 102.58 | 111.41 | 76.38 | 87.93 | 104.03 | 107.84 |
| Intensity Change Log 2 | — | 0.173028 | 0.404893 | 0.289226 | — | 0.058400 | 0.160909 | 0.194140 | — | 0.115078 | 0.284280 | 0.240994 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000628 | 0.000552 | 0.000549 | 0.003985 | 0.000086 | 0.000317 | 0.000443 | 0.000973 | 0.000260 | 0.000384 | 0.000450 | 0.002759 |
| Bud Neck | 0.026441 | 0.045481 | 0.004318 | 0.012878 | 0.030564 | 0.053326 | 0.004900 | 0.011325 | 0.029238 | 0.051078 | 0.004861 | 0.012246 |
| Bud Site | 0.014360 | 0.023958 | 0.010519 | 0.034834 | 0.004350 | 0.017238 | 0.013506 | 0.045327 | 0.007569 | 0.019164 | 0.013308 | 0.039105 |
| Cell Periphery | 0.000347 | 0.000227 | 0.000263 | 0.000319 | 0.000149 | 0.000142 | 0.000190 | 0.000466 | 0.000213 | 0.000166 | 0.000195 | 0.000379 |
| Cytoplasm | 0.420583* | 0.273438* | 0.132778* | 0.430115* | 0.418224* | 0.330469* | 0.454536* | 0.439125* | 0.418983* | 0.314126* | 0.433138* | 0.433782* |
| Cytoplasmic Foci | 0.206086* | 0.274218* | 0.021964 | 0.024729 | 0.219235* | 0.273501* | 0.019835 | 0.032975 | 0.215007* | 0.273706* | 0.019977 | 0.028085 |
| Eisosomes | 0.000230 | 0.000185 | 0.000123 | 0.000056 | 0.000202 | 0.000165 | 0.000045 | 0.000077 | 0.000211 | 0.000171 | 0.000050 | 0.000065 |
| Endoplasmic Reticulum | 0.000659 | 0.001066 | 0.008227 | 0.002498 | 0.000615 | 0.000652 | 0.001987 | 0.001623 | 0.000629 | 0.000770 | 0.002402 | 0.002142 |
| Endosome | 0.039387 | 0.048930 | 0.007574 | 0.014224 | 0.016879 | 0.040865 | 0.004335 | 0.009616 | 0.024117 | 0.043176 | 0.004550 | 0.012349 |
| Golgi | 0.018169 | 0.010125 | 0.000493 | 0.007363 | 0.001922 | 0.009524 | 0.001454 | 0.003015 | 0.007146 | 0.009696 | 0.001390 | 0.005593 |
| Lipid Particles | 0.017452 | 0.010626 | 0.006038 | 0.001416 | 0.011631 | 0.009128 | 0.001293 | 0.001978 | 0.013503 | 0.009558 | 0.001609 | 0.001645 |
| Mitochondria | 0.032791 | 0.031175 | 0.003150 | 0.003818 | 0.005741 | 0.026752 | 0.001096 | 0.002932 | 0.014440 | 0.028019 | 0.001232 | 0.003457 |
| Mitotic Spindle | 0.002147 | 0.012523 | 0.006457 | 0.051851 | 0.001508 | 0.011179 | 0.008086 | 0.026699 | 0.001714 | 0.011564 | 0.007978 | 0.041614 |
| None | 0.005166 | 0.002986 | 0.004574 | 0.006949 | 0.002485 | 0.002792 | 0.008128 | 0.016432 | 0.003347 | 0.002848 | 0.007892 | 0.010809 |
| Nuclear Periphery | 0.000671 | 0.000587 | 0.001964 | 0.001801 | 0.000584 | 0.000614 | 0.001097 | 0.001047 | 0.000612 | 0.000607 | 0.001155 | 0.001495 |
| Nuclear Periphery Foci | 0.000999 | 0.000459 | 0.001580 | 0.000912 | 0.000243 | 0.000287 | 0.000502 | 0.000835 | 0.000486 | 0.000337 | 0.000574 | 0.000881 |
| Nucleolus | 0.002057 | 0.003867 | 0.002477 | 0.000916 | 0.001562 | 0.002413 | 0.000878 | 0.001262 | 0.001721 | 0.002830 | 0.000985 | 0.001057 |
| Nucleus | 0.139968* | 0.128948 | 0.710179* | 0.294945* | 0.218091* | 0.105647 | 0.423568* | 0.283321* | 0.192969* | 0.112324 | 0.442629* | 0.290214* |
| Peroxisomes | 0.023209 | 0.032366 | 0.001186 | 0.001344 | 0.007525 | 0.029915 | 0.000687 | 0.003446 | 0.012568 | 0.030617 | 0.000721 | 0.002199 |
| Vacuole | 0.045326 | 0.092893 | 0.072229 | 0.102447 | 0.057344 | 0.081794 | 0.052772 | 0.114243 | 0.053479 | 0.084974 | 0.054066 | 0.107248 |
| Vacuole Periphery | 0.003322 | 0.005390 | 0.003358 | 0.002599 | 0.001060 | 0.003280 | 0.000662 | 0.003282 | 0.001788 | 0.003885 | 0.000841 | 0.002877 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | 0.25 | -0.13 | -1.77 | -2.06 | -1.84 | -4.96 | -1.62 | -3.59 | -2.20 | -1.52 | -1.30 | -0.65 | -2.94 | -2.66 | -2.49 |
| Bud Neck | -3.70 | 6.52 | 5.31 | 8.44 | -2.86 | -6.28 | 11.50 | 8.59 | 14.26 | -3.62 | -7.36 | 13.32 | 10.26 | 16.79 | -5.36 |
| Bud Site | -2.69 | 0.71 | -1.94 | 0.84 | -1.68 | -8.92 | -3.53 | -6.77 | -3.21 | -4.67 | -7.83 | -1.64 | -7.63 | -2.33 | -5.30 |
| Cell Periphery | 1.56 | 0.91 | 1.82 | 0.72 | 1.68 | 0.67 | -0.89 | -2.97 | -3.15 | -2.47 | 1.80 | 1.28 | -0.54 | -2.29 | -1.78 |
| Cytoplasm | 10.71 | 17.42 | 6.53 | -5.61 | -13.62 | 9.48 | 1.00 | 5.59 | -2.18 | 4.40 | 13.62 | 3.30 | 9.19 | -4.18 | 4.52 |
| Cytoplasmic Foci | -6.42 | 27.05 | 30.25 | 29.38 | 0.57 | -7.11 | 40.85 | 37.80 | 40.67 | -3.67 | -9.46 | 49.84 | 49.22 | 51.10 | -1.86 |
| Eisosomes | 1.80 | 3.02 | 7.20 | 10.57 | 5.96 | 2.34 | 9.86 | 7.74 | 11.44 | -7.48 | 3.01 | 12.02 | 10.80 | 16.50 | -5.12 |
| Endoplasmic Reticulum | -3.33 | -4.42 | -9.79 | -8.17 | 3.07 | -0.39 | -2.72 | -11.51 | -10.89 | -0.76 | -1.92 | -3.63 | -14.04 | -12.89 | -0.57 |
| Endosome | -1.76 | 7.85 | 8.79 | 10.92 | 0.44 | -9.14 | 9.05 | 7.56 | 14.93 | -2.02 | -7.74 | 12.56 | 11.13 | 18.10 | -2.25 |
| Golgi | 2.99 | 7.25 | 5.94 | 4.50 | -2.58 | -7.77 | 1.58 | 0.61 | 6.85 | -0.55 | -2.11 | 6.47 | 4.86 | 7.59 | -1.65 |
| Lipid Particles | 2.72 | 4.66 | 7.00 | 8.13 | 6.04 | 2.47 | 12.46 | 11.68 | 9.87 | -2.59 | 3.73 | 12.82 | 12.81 | 12.93 | -0.25 |
| Mitochondria | 0.46 | 7.20 | 7.49 | 7.80 | 0.19 | -9.12 | 5.68 | 4.36 | 11.53 | -2.05 | -5.60 | 9.21 | 8.46 | 13.89 | -2.88 |
| Mitotic Spindle | -3.42 | -1.25 | -8.38 | -4.15 | -3.23 | -5.14 | -3.92 | -6.08 | -2.60 | -3.53 | -6.18 | -4.09 | -10.36 | -5.36 | -6.48 |
| None | 2.17 | 1.28 | 0.03 | -2.47 | -1.38 | -0.73 | -6.13 | -3.69 | -3.37 | -1.44 | 0.79 | -4.62 | -3.86 | -4.20 | -0.49 |
| Nuclear Periphery | 0.42 | -7.84 | -11.03 | -14.02 | -2.61 | -0.31 | -12.07 | -11.35 | -8.44 | -2.29 | -0.07 | -12.53 | -16.13 | -14.62 | -7.43 |
| Nuclear Periphery Foci | 1.15 | -2.00 | -0.16 | -4.36 | 2.81 | -1.03 | -6.82 | -6.85 | -6.31 | -3.38 | 0.92 | -1.58 | -3.34 | -7.64 | -3.26 |
| Nucleolus | -2.21 | -0.20 | 1.94 | 3.26 | 2.56 | -2.77 | 3.52 | 2.57 | 5.08 | -0.76 | -3.36 | 3.81 | 2.85 | 5.33 | -0.43 |
| Nucleus | 0.85 | -18.47 | -22.91 | -20.69 | 10.72 | 18.10 | -24.91 | -9.16 | -20.58 | 10.89 | 15.38 | -31.46 | -20.71 | -32.51 | 12.78 |
| Peroxisomes | -2.18 | 7.40 | 7.50 | 10.32 | 1.14 | -11.49 | 10.13 | 6.46 | 14.69 | -2.52 | -9.54 | 11.11 | 10.33 | 18.51 | -2.49 |
| Vacuole | -8.15 | -4.71 | -21.30 | -12.13 | -3.37 | -7.06 | -6.78 | -18.10 | -14.75 | -13.76 | -10.53 | -8.81 | -27.53 | -20.28 | -17.67 |
| Vacuole Periphery | -2.12 | 0.55 | 3.42 | 5.27 | 0.80 | -6.86 | 2.22 | -0.74 | 1.93 | -1.42 | -5.68 | 3.72 | 1.18 | 5.26 | -1.51 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin |
| Localization | |
| Cell Percentages | — |
| Cell Cycle Regulation | No |
| Subcompartmental Group | N/A |
Mic60
Mic60
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Mic60-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
