Standard name
Human Ortholog
Description Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0.05 0 0 0 0 0.07 0 0 0.06 0.08
Bud 0.06 0 0.11 0.11 0.17 0.19 0.18 0.16 0.16 0.19 0.17 0.07 0.06 0.05 0.08 0.06 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0.06 0 0.07 0.07 0 0 0.05 0.07 0.08 0 0 0 0 0.05 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0 0.05 0.06 0.06 0.07 0.05 0 0 0 0 0 0.09 0.05 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.08 0.11 0.05 0.07 0.11 0 0.08 0.07 0.11 0 0 0.06 0.14 0.16 0.14 0.22 0.12 0.09 0.11 0.11 0.12 0.1 0.08
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.48 0.5 0.33 0.36 0.36 0.66 0.53 0.47 0.37 0.63 0.53 0.19 0.09 0.07 0.2 0.09 0.08 0 0.07 0 0.05 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Peroxisomes 0.64 0.59 0.64 0.68 0.58 0.31 0.35 0.33 0.5 0.36 0.39 0.63 0.71 0.69 0.44 0.54 0.55 0.75 0.6 0.72 0.72 0.7 0.73
SpindlePole 0.19 0.15 0.36 0.3 0.32 0.2 0.3 0.33 0.37 0.25 0.3 0.35 0.37 0.37 0.47 0.44 0.44 0.05 0.06 0.07 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 13 3 7 6 0 28 5 5 4 12 11 30 28 26 6 1 2 11 14 20 12 32 42
Bud 22 7 66 54 118 145 164 130 146 189 172 26 40 25 26 22 11 1 3 4 0 6 3
Bud Neck 1 2 6 2 4 9 8 6 1 3 2 3 3 1 5 7 4 2 3 6 0 7 5
Bud Site 15 8 37 19 45 52 29 28 47 69 83 4 6 4 14 20 9
Cell Periphery 2 3 0 0 1 0 3 4 4 3 3 2 6 1 2 0 0 0 0 0 0 0 0
Cytoplasm 5 10 24 16 34 46 50 52 42 37 35 11 12 20 29 19 13 1 1 0 0 0 1
Endoplasmic Reticulum 5 0 2 1 0 7 1 1 2 0 1 1 0 0 2 8 2 0 0 3 2 2 0
Endosome 29 23 30 33 74 21 68 54 106 11 17 22 91 78 46 84 32 32 24 64 48 54 42
Golgi 0 1 0 0 0 0 0 0 0 0 0 10 9 9 9 4 4 9 2 6 8 6 10
Mitochondria 168 107 196 174 245 513 472 377 341 620 528 71 58 36 67 33 23 12 15 15 19 24 16
Nucleus 2 1 2 3 1 5 4 5 3 3 4 1 1 1 5 8 2 0 1 0 0 0 0
Nuclear Periphery 1 1 3 3 4 0 0 1 0 1 2 0 1 2 1 1 6 0 1 1 0 0 0
Nucleolus 8 5 11 13 8 8 20 16 6 9 21 2 13 6 17 19 5 0 0 0 0 0 0
Peroxisomes 225 125 378 326 395 241 314 265 470 349 387 237 450 342 146 204 151 279 129 436 295 392 364
SpindlePole 68 32 212 144 218 155 265 264 348 248 302 131 235 184 158 165 120 18 12 40 16 22 7
Vac/Vac Membrane 2 9 0 0 3 1 2 7 7 2 6 3 4 3 3 3 4 0 3 2 0 3 3
Unique Cell Count 353 213 595 479 679 782 896 797 932 979 1003 375 634 493 334 378 275 372 217 608 411 561 501
Labelled Cell Count 566 337 974 794 1150 1231 1405 1215 1527 1556 1574 554 957 738 536 598 388 372 217 608 411 561 501


Peroxisomes

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 5.7 4.5 4.6 4.3 4.0 3.5 3.7 3.7 3.4 3.5 6.5 6.3 6.4 6.6 6.4 6.6 6.7 6.7 6.7
Std Deviation (1e-4) 0.9 1.3 1.1 1.7 1.7 1.5 1.1 1.2 1.0 1.1 0.8 1.1 1.0 1.3 1.4 1.5 1.6 1.4 1.3 1.3
Intensity Change (Log2) 0.02 -0.07 -0.18 -0.36 -0.3 -0.3 -0.4 -0.38 0.52 0.47 0.5 0.55 0.5 0.55 0.57 0.58 0.56


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 5.4 3.4 3.9 0 0 0
Bud 0 0 0 0 0 0 0 0 -2.2 -3.0 -3.6 -1.6 -2.8 -3.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 1.1 0
Bud Site 0 0 0 0 0 0 0 0 -3.9 -5.0 -4.7 -1.3 -0.6 -1.8
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.6 0.8 1.5 1.3 2.0 0.4 -0.3 -0.6 -0.9 -2.2 0 2.9 0.7 0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0.6 5.5 5.9 4.7 8.1 3.5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 -4.8 -10.3 -10.3 -4.2 -8.7 -7.8
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 -1.7 0.3 -0.8 2.8 2.8 0
Peroxisomes 0 0 0 0 0 0 0 0 -0.1 2.8 2.0 -5.8 -3.0 -2.4
SpindlePole 0 0 0 0 0 0 0 0 -0.2 0.5 0.6 3.5 2.5 2.3
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1912 3.7479 3.7082 3.3708 3.4068 3.1553 2.5497 2.4217 2.7641 1.9264 2.0902 2.5296 2.0251 1.4017 1.688 1.877 1.7491 1.4032
Actin 0.0812 0.0222 0.0132 0.0566 0.0928 0.0027 0.0017 0.0065 0.0094 0.0003 0.0003 0.0035 0.0306 0.0194 0.0476 0.0418 0.0053 0.0198
Bud 0.0008 0.0026 0.0008 0.0007 0.0006 0 0 0.0024 0.0003 0 0.0001 0 0.0011 0.0016 0.0006 0.0002 0.0001 0.0014
Bud Neck 0.0108 0.0035 0.0018 0.0018 0.0012 0.0003 0.0002 0.0005 0.007 0.0003 0.0002 0.0001 0.0007 0.0085 0.0031 0.0018 0.0002 0.0015
Bud Periphery 0.0011 0.0025 0.0008 0.0013 0.0008 0 0 0.0024 0.0002 0 0.0001 0 0.0009 0.002 0.0009 0.0004 0.0002 0.0006
Bud Site 0.0115 0.0318 0.0336 0.0015 0.0024 0.0001 0.0003 0.0106 0.0047 0 0.0002 0.0001 0.0018 0.0257 0.0024 0.0008 0.0006 0.0018
Cell Periphery 0.0006 0.0002 0.0001 0.0002 0.0002 0 0 0.0001 0 0 0 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.0041 0.0001 0.0021 0.0005 0.0006 0 0 0.0003 0 0 0.0001 0 0.0033 0.0002 0.0024 0.0005 0 0.0012
Cytoplasmic Foci 0.1501 0.1342 0.0989 0.0533 0.0515 0.0715 0.0781 0.0925 0.0734 0.0375 0.0524 0.0627 0.0984 0.1327 0.091 0.0856 0.065 0.078
Eisosomes 0.0003 0 0.0001 0.0003 0.0007 0 0 0 0 0 0 0 0.0002 0.0001 0.0001 0.0005 0 0.0001
Endoplasmic Reticulum 0.0023 0 0.0002 0.0003 0.0011 0 0 0 0 0 0 0 0.0017 0 0.0017 0.0015 0 0.001
Endosome 0.0274 0.0044 0.0091 0.0251 0.0331 0.0029 0.0034 0.0063 0.0031 0.0011 0.0126 0.0021 0.0173 0.0068 0.0057 0.0096 0.0023 0.0071
Golgi 0.023 0.0119 0.0131 0.0494 0.081 0.0095 0.0087 0.0127 0.0083 0.0057 0.0103 0.0072 0.0152 0.0129 0.0112 0.0159 0.0097 0.0087
Lipid Particles 0.0717 0.0738 0.047 0.1167 0.2245 0.1594 0.1016 0.0471 0.0474 0.0892 0.083 0.0816 0.129 0.0587 0.0525 0.16 0.1113 0.1083
Mitochondria 0.012 0.0063 0.0145 0.0431 0.0828 0.0032 0.0056 0.0034 0.004 0.0012 0.0023 0.0011 0.0221 0.0122 0.0092 0.0142 0.0633 0.0063
None 0.0044 0.0001 0.0004 0.0005 0.0007 0 0 0.0001 0 0 0 0 0.0034 0.0002 0.0006 0.0014 0 0.0008
Nuclear Periphery 0.0229 0 0.0057 0.0002 0.0013 0 0.0001 0.0001 0 0 0 0 0.0073 0.0001 0.0019 0.0055 0 0.009
Nucleolus 0.0017 0.0041 0.0012 0.0002 0.0004 0.0001 0.0004 0.0028 0.0033 0 0.0004 0.0002 0.0034 0.0035 0.0003 0.0006 0.0009 0.0009
Nucleus 0.0144 0.0004 0.0105 0.0001 0.0002 0 0 0.0004 0.0001 0 0.0001 0 0.0035 0.0026 0.0008 0.0008 0.0001 0.0016
Peroxisomes 0.5451 0.6893 0.7376 0.6442 0.4159 0.7469 0.7985 0.8018 0.8348 0.8644 0.8354 0.8345 0.6428 0.7042 0.7633 0.6376 0.7395 0.744
Punctate Nuclear 0.0121 0.0086 0.0066 0.0021 0.0071 0.0031 0.0009 0.0086 0.0036 0.0002 0.0011 0.0066 0.0141 0.0078 0.0038 0.0202 0.0008 0.0072
Vacuole 0.0014 0.0036 0.0019 0.0011 0.0006 0.0001 0.0003 0.0012 0.0002 0 0.0009 0 0.0019 0.0004 0.0005 0.0003 0.0003 0.0004
Vacuole Periphery 0.0013 0.0005 0.0006 0.0008 0.0007 0.0001 0.0002 0.0001 0.0001 0 0.0003 0 0.0012 0.0002 0.0005 0.0007 0.0002 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.7311 14.4431 11.9782 13.1065 13.5545 18.9973 14.3886 16.5238 16.7966 15.613
Translational Efficiency 1.1733 0.8701 1.2103 1.3102 1.1024 0.8098 1.1543 0.9673 1.0535 1.0686

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2179 1492 1736 1546 2149 1603 3182 2043 4328 3095 4918 3589

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 679.37 761.83 893.47 888.24 719.61 755.86 884.13 912.37 699.35 758.74 887.43 901.98
Standard Deviation 82.98 108.89 126.46 121.29 99.29 504.24 127.71 126.08 93.63 370.69 127.35 124.61
Intensity Change Log 2 0.165272 0.395222 0.386752 0.070904 0.297043 0.342404 0.117502 0.345555 0.364110

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.019770 0.020669 0.024831 0.035208 0.009890 0.015252 0.012036 0.053319 0.014864 0.017864 0.016552 0.045517
Bud Neck 0.002001 0.001722 0.004600 0.006074 0.002465 0.002792 0.007496 0.004011 0.002232 0.002276 0.006473 0.004900
Bud Site 0.003080 0.006492 0.017616 0.046999 0.005508 0.007494 0.039797 0.036393 0.004286 0.007011 0.031967 0.040961
Cell Periphery 0.000098 0.000109 0.000527 0.000124 0.000179 0.000129 0.000141 0.000130 0.000138 0.000119 0.000278 0.000128
Cytoplasm 0.002853 0.002865 0.004364 0.015044 0.003059 0.003042 0.020938 0.015313 0.002955 0.002957 0.015087 0.015197
Cytoplasmic Foci 0.125148 0.090426 0.099076 0.094024 0.101538 0.122080 0.077072 0.067792 0.113425 0.106821 0.084839 0.079092
Eisosomes 0.000213 0.000105 0.000135 0.000080 0.000084 0.000107 0.000078 0.000131 0.000149 0.000106 0.000098 0.000109
Endoplasmic Reticulum 0.000029 0.000116 0.000374 0.000189 0.000027 0.000099 0.000096 0.000097 0.000028 0.000107 0.000195 0.000137
Endosome 0.017481 0.035007 0.028721 0.034571 0.029478 0.052465 0.017544 0.016601 0.023438 0.044049 0.021489 0.024342
Golgi 0.030578 0.045955 0.022408 0.017992 0.034462 0.072856 0.013403 0.016607 0.032506 0.059888 0.016581 0.017204
Lipid Particles 0.018653 0.036451 0.057015 0.015347 0.022777 0.038413 0.006652 0.009757 0.020700 0.037468 0.024430 0.012165
Mitochondria 0.008500 0.010305 0.004520 0.008578 0.009390 0.017685 0.014146 0.009844 0.008942 0.014128 0.010748 0.009298
Mitotic Spindle 0.001912 0.006750 0.125745* 0.085642 0.002746 0.006655 0.048592 0.020637 0.002326 0.006701 0.075826 0.048638
None 0.000134 0.000150 0.000053 0.000070 0.000442 0.000118 0.000096 0.000069 0.000287 0.000133 0.000081 0.000070
Nuclear Periphery 0.000003 0.000015 0.000131 0.000134 0.000009 0.000016 0.000059 0.000021 0.000006 0.000015 0.000084 0.000070
Nuclear Periphery Foci 0.000052 0.000456 0.002117 0.001116 0.000302 0.000305 0.000600 0.000261 0.000176 0.000378 0.001136 0.000629
Nucleolus 0.000048 0.000214 0.000492 0.000262 0.000091 0.000295 0.000298 0.000071 0.000069 0.000256 0.000367 0.000153
Nucleus 0.000434 0.000445 0.000767 0.000241 0.000083 0.000530 0.000240 0.000085 0.000260 0.000489 0.000426 0.000153
Peroxisomes 0.768630* 0.741051* 0.604316* 0.632293* 0.777168* 0.658939* 0.739296* 0.747040* 0.772870* 0.698523* 0.691650* 0.697612*
Vacuole 0.000336 0.000463 0.002083 0.005084 0.000244 0.000541 0.001296 0.001466 0.000290 0.000503 0.001574 0.003025
Vacuole Periphery 0.000047 0.000235 0.000109 0.000928 0.000057 0.000185 0.000124 0.000354 0.000052 0.000209 0.000119 0.000602

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.35 -1.88 -4.88 -4.47 -3.14 -3.21 -1.66 -13.45 -11.09 -12.63 -1.99 -1.21 -13.21 -11.45 -12.50
Bud Neck 0.53 -4.84 -5.95 -6.96 -2.36 -0.58 -8.21 -2.72 -2.22 5.71 -0.13 -9.80 -6.18 -6.53 3.11
Bud Site -2.79 -9.37 -14.52 -12.95 -8.98 -1.34 -16.18 -12.30 -10.80 1.15 -2.82 -18.97 -19.06 -16.80 -4.09
Cell Periphery -0.56 -1.55 -1.69 -1.17 1.43 1.40 1.07 1.49 -0.03 0.85 0.88 -1.42 0.36 -0.81 1.51
Cytoplasm -0.07 -2.30 -9.04 -8.96 -7.84 -0.14 -15.64 -10.14 -9.70 3.64 -0.15 -15.32 -13.55 -13.22 -0.34
Cytoplasmic Foci 6.72 5.06 5.99 -0.88 1.06 -4.02 6.03 7.97 11.87 2.69 1.81 8.91 10.34 8.37 2.04
Eisosomes 2.05 1.39 2.52 3.06 2.73 -2.91 0.85 -4.61 -2.42 -5.85 1.60 1.84 1.46 -0.49 -1.23
Endoplasmic Reticulum -4.08 -6.32 -8.30 -3.01 3.04 -3.56 -4.52 -5.90 0.40 0.91 -5.38 -7.69 -10.06 -1.72 2.66
Endosome -6.83 -5.58 -7.08 0.07 -2.31 -7.27 6.14 5.94 11.97 0.58 -10.03 1.40 -0.65 9.26 -2.03
Golgi -5.40 4.56 6.92 11.45 3.70 -11.43 13.39 10.29 17.94 -3.11 -12.27 13.36 12.07 21.09 -0.76
Lipid Particles -5.17 -10.42 1.43 6.09 11.30 -4.27 7.87 5.63 8.83 -2.20 -6.69 -1.90 5.29 10.68 7.45
Mitochondria -0.96 2.95 0.05 1.01 -2.93 -3.94 -3.25 -0.28 3.63 2.79 -3.65 -1.64 -0.24 3.42 1.35
Mitotic Spindle -4.47 -22.43* -17.96 -16.62 5.36 -4.08 -19.91* -9.90 -7.06 9.79 -6.07 -29.36 -19.96 -17.50 7.91
None -0.21 0.84 0.78 1.74 -0.31 1.06 1.14 1.22 1.60 1.72 0.98 1.27 1.35 2.37 1.34
Nuclear Periphery -5.22 -11.48 -3.37 -3.06 0.05 -2.67 -10.21 -5.85 -1.83 7.69 -5.39 -15.51 -3.81 -3.23 1.06
Nuclear Periphery Foci -2.24 -4.88 -3.52 -1.67 2.40 -0.23 -2.65 0.19 0.50 3.07 -2.16 -5.78 -3.32 -1.35 2.82
Nucleolus -2.07 -2.64 -3.76 -0.70 1.80 -1.59 -2.74 0.74 1.79 3.06 -2.44 -3.70 -2.95 1.16 2.86
Nucleus -0.35 -1.43 0.21 0.56 1.59 -1.27 -2.77 -0.38 1.24 2.47 -1.25 -1.77 0.33 1.40 2.12
Peroxisomes 3.10 17.80 14.72 10.76 -2.08 12.49 5.47 3.67 -8.75 -1.26 11.26 14.52 12.35 0.78 -0.80
Vacuole -0.78 -3.42 -5.36 -5.26 -3.42 -2.96 -4.98 -3.23 -2.57 -0.16 -2.13 -5.75 -6.20 -5.84 -3.22
Vacuole Periphery -2.10 -3.82 -2.06 -1.58 -1.89 -4.46 -2.40 -1.78 -1.00 -1.31 -3.44 -3.57 -2.65 -1.84 -2.28
Standard name
Human Ortholog
Description Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant
Localization
Cell Percentages peroxisome (81%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pex13

Pex13


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pex13-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available