Standard name | |
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Human Ortholog | |
Description | Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud | 0 | 0 | 0 | 0 | 0 | 3 | 0 | – | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud Site | 0 | 1 | 0 | 1 | 0 | 11 | 9 | – | 10 | 7 | 6 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 4 | 4 | 6 | 14 | 16 | 16 | 29 | – | 13 | 15 | 14 | 7 | 40 | 67 | 77 | 5 | 5 | 4 | 1 | 2 | 0 | 0 | 1 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
Endosome | 0 | 0 | 0 | 1 | 0 | 0 | 1 | – | 1 | 2 | 0 | 1 | 0 | 2 | 7 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 6 | 9 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 0 | 1 | 1 | 1 |
Mitochondria | 9 | 18 | 0 | 8 | 1 | 125 | 24 | – | 95 | 74 | 81 | 85 | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 2 | 4 | 1 | 8 | 8 |
Nucleus | 364 | 337 | 233 | 208 | 182 | 247 | 287 | – | 260 | 291 | 223 | 253 | 357 | 357 | 345 | 124 | 85 | 88 | 350 | 347 | 222 | 205 | 278 | 243 |
Nuclear Periphery | 3 | 3 | 0 | 6 | 2 | 0 | 6 | – | 7 | 6 | 1 | 5 | 4 | 7 | 14 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 6 | 11 |
Nucleolus | 7 | 1 | 2 | 2 | 2 | 2 | 4 | – | 8 | 11 | 8 | 6 | 13 | 32 | 38 | 7 | 4 | 5 | 12 | 4 | 3 | 15 | 52 | 46 |
Peroxisomes | 1 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 1 | 0 | 1 | – | 0 | 2 | 1 | 1 | 1 | 11 | 5 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 6 | 5 |
Vac/Vac Membrane | 6 | 13 | 2 | 3 | 7 | 1 | 10 | – | 4 | 9 | 2 | 2 | 1 | 10 | 8 | 10 | 2 | 5 | 15 | 13 | 7 | 32 | 97 | 123 |
Unique Cell Count | 381 | 358 | 242 | 228 | 205 | 287 | 334 | 310 | 344 | 267 | 289 | 408 | 468 | 465 | 144 | 95 | 100 | 396 | 378 | 244 | 264 | 470 | 463 | |
Labelled Cell Count | 395 | 378 | 244 | 243 | 212 | 405 | 371 | 401 | 419 | 337 | 375 | 419 | 491 | 501 | 151 | 99 | 105 | 396 | 378 | 244 | 264 | 470 | 463 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.7 | 6.7 | 6.9 | 6.5 | 7.0 | 4.2 | 5.6 | – | 4.8 | 5.1 | 4.9 | 4.9 | 7.4 | 6.8 | 7.3 | 9.8 | 9.8 | 8.9 | 6.3 | 6.8 | 7.1 |
Std Deviation (1e-4) | 1.2 | 1.3 | 1.2 | 1.3 | 1.9 | 1.3 | 1.8 | – | 1.4 | 1.4 | 1.3 | 1.1 | 1.8 | 1.6 | 1.9 | 3.0 | 2.6 | 2.0 | 1.3 | 1.2 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.09 | 0.02 | -0.71 | -0.3 | – | -0.53 | -0.43 | -0.49 | -0.48 | 0.09 | -0.01 | 0.09 | 0.5 | 0.51 | 0.37 | -0.13 | -0.02 | 0.03 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 3.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2.0 | 2.6 | 1.8 | 3.1 | – | 1.1 | 1.2 | 1.6 | 0 | 3.5 | 4.9 | 5.5 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 4.3 | – | 0 | 7.7 | 9.3 | 9.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -2.3 | -3.1 | -4.0 | -4.1 | – | -4.7 | -4.5 | -4.7 | -3.6 | -3.7 | -6.7 | -7.2 | -3.7 | -2.4 | -2.9 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 1.9 | 0 | 0 | 1.9 | 3.6 | 4.0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 1.8 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.0013 | 1.3051 | 1.3744 | 0.9617 | 1.3978 | 1.2733 | 2.3989 | 2.5227 | 2.4471 | 1.9887 | 1.9024 | 2.4979 | 5.1618 | 5.4721 | 5.2137 | 5.5347 | 5.6193 | 5.39 |
Actin | 0.061 | 0 | 0.0032 | 0.0116 | 0.0313 | 0.0057 | 0.0031 | 0 | 0.0023 | 0 | 0.0056 | 0.0002 | 0.0088 | 0 | 0.0095 | 0.0223 | 0.0166 | 0 |
Bud | 0.0017 | 0 | 0.0004 | 0.001 | 0.0014 | 0.0002 | 0.0003 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 |
Bud Neck | 0.0054 | 0.0002 | 0.0004 | 0.0031 | 0.014 | 0.002 | 0.0031 | 0.0002 | 0.0004 | 0.0002 | 0.0005 | 0.0009 | 0.0016 | 0.0001 | 0.0004 | 0.0048 | 0.0006 | 0.0009 |
Bud Periphery | 0.0041 | 0.0001 | 0.0023 | 0.0024 | 0.0019 | 0.0008 | 0.0006 | 0 | 0.0002 | 0 | 0.0001 | 0.0003 | 0.0005 | 0.0001 | 0.0004 | 0.0002 | 0.0001 | 0.0001 |
Bud Site | 0.0159 | 0.0001 | 0.0009 | 0.004 | 0.0347 | 0.0006 | 0.0029 | 0.0001 | 0.0006 | 0 | 0 | 0.0001 | 0.0003 | 0.0002 | 0.0006 | 0.0011 | 0.0001 | 0.0001 |
Cell Periphery | 0.0008 | 0.0001 | 0.0009 | 0.0007 | 0.0007 | 0.0003 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0 | 0 |
Cytoplasm | 0.006 | 0.0001 | 0.0034 | 0.0012 | 0.0013 | 0.002 | 0.0007 | 0.0008 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0021 | 0.0001 | 0.0004 | 0.0058 | 0.0007 | 0.0007 |
Cytoplasmic Foci | 0.0255 | 0 | 0.0045 | 0.0035 | 0.0132 | 0.004 | 0.0033 | 0 | 0.0002 | 0 | 0.0001 | 0.0015 | 0.0006 | 0 | 0.0015 | 0.0083 | 0.0011 | 0.0007 |
Eisosomes | 0.0003 | 0 | 0 | 0.0002 | 0.0005 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0023 | 0 | 0.0001 | 0.0004 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0044 | 0 | 0.0016 | 0.0022 | 0.0017 | 0.001 | 0.0016 | 0 | 0.0005 | 0 | 0.0008 | 0.0001 | 0.0039 | 0 | 0.0001 | 0.0016 | 0.0031 | 0.0004 |
Endosome | 0.0219 | 0 | 0.004 | 0.0102 | 0.0419 | 0.0081 | 0.0048 | 0.0002 | 0.0008 | 0 | 0.0036 | 0.0003 | 0.0058 | 0 | 0.0011 | 0.0054 | 0.0181 | 0.0015 |
Golgi | 0.0097 | 0 | 0.0041 | 0.0124 | 0.027 | 0.0027 | 0.001 | 0 | 0.0003 | 0 | 0.0009 | 0.0002 | 0.0012 | 0 | 0.0009 | 0.0027 | 0.0045 | 0.0001 |
Lipid Particles | 0.0205 | 0 | 0.0118 | 0.0146 | 0.0596 | 0.0021 | 0.002 | 0 | 0.0003 | 0 | 0.0004 | 0.0016 | 0.0015 | 0 | 0.002 | 0.0135 | 0.0027 | 0.0007 |
Mitochondria | 0.0164 | 0.0003 | 0.0121 | 0.0054 | 0.0201 | 0.0028 | 0.002 | 0.0001 | 0.0014 | 0.0001 | 0.0016 | 0.0015 | 0.0015 | 0.0004 | 0.007 | 0.001 | 0.0017 | 0.0001 |
None | 0.0032 | 0 | 0.0004 | 0.0004 | 0.0007 | 0.0005 | 0.0009 | 0.0002 | 0.0001 | 0.0003 | 0.0003 | 0.0001 | 0.0137 | 0 | 0.0022 | 0.0444 | 0.0012 | 0.001 |
Nuclear Periphery | 0.0265 | 0.0029 | 0.0125 | 0.0056 | 0.0073 | 0.0156 | 0.0113 | 0.0075 | 0.0061 | 0.0023 | 0.0159 | 0.0013 | 0.0162 | 0.0007 | 0.0014 | 0.0177 | 0.0163 | 0.0027 |
Nucleolus | 0.0273 | 0.0495 | 0.0747 | 0.039 | 0.0129 | 0.062 | 0.04 | 0.0489 | 0.0668 | 0.0497 | 0.0298 | 0.0706 | 0.0392 | 0.0538 | 0.0663 | 0.055 | 0.0372 | 0.0601 |
Nucleus | 0.709 | 0.9441 | 0.8531 | 0.8751 | 0.7091 | 0.8791 | 0.913 | 0.9379 | 0.9146 | 0.9454 | 0.937 | 0.911 | 0.8839 | 0.9437 | 0.8931 | 0.7796 | 0.8892 | 0.9142 |
Peroxisomes | 0.0093 | 0 | 0.0033 | 0.0024 | 0.0095 | 0.0011 | 0.002 | 0 | 0.0002 | 0 | 0.0001 | 0.0021 | 0.0003 | 0 | 0.0043 | 0.0117 | 0.0003 | 0 |
Punctate Nuclear | 0.0145 | 0.0019 | 0.0016 | 0.0019 | 0.0078 | 0.0065 | 0.0055 | 0.0032 | 0.0041 | 0.0016 | 0.0017 | 0.0075 | 0.0108 | 0.0003 | 0.0071 | 0.0227 | 0.0049 | 0.0163 |
Vacuole | 0.0112 | 0.0004 | 0.0033 | 0.0024 | 0.0019 | 0.0019 | 0.001 | 0.0003 | 0.0003 | 0 | 0.0003 | 0.0003 | 0.004 | 0.0003 | 0.0008 | 0.001 | 0.0004 | 0.0004 |
Vacuole Periphery | 0.0054 | 0.0002 | 0.0017 | 0.0008 | 0.0016 | 0.001 | 0.0007 | 0.0002 | 0.0002 | 0 | 0.0008 | 0.0003 | 0.0014 | 0.0002 | 0.0005 | 0.0005 | 0.0009 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 8.8508 | 12.3077 | 14.3516 | 9.4537 | 10.2004 | 11.7946 | 6.6666 | 8.3991 | 14.4054 | 12.339 |
Translational Efficiency | 4.8763 | 2.7942 | 1.981 | 3.8011 | 3.5724 | 2.6882 | 3.5235 | 2.712 | 1.7443 | 2.5463 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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