Standard name | |
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Human Ortholog | |
Description | NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud | 0 | 0 | 1 | 1 | 1 | 0 | 3 | 3 | 3 | 5 | 1 | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 3 |
Bud Neck | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud Site | 0 | 1 | 0 | 1 | 1 | 6 | 7 | 9 | 8 | 16 | 5 | 7 | 1 | 1 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 3 | 10 | 9 | 7 | 14 | 13 | 28 | 10 | 14 | 11 | 11 | 23 | 48 | 80 | 14 | 11 | 5 | 0 | 0 | 0 | 1 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 3 | 4 | 1 | 3 | 1 | 0 | 1 | 5 | 0 | 5 | 3 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Mitochondria | 37 | 52 | 93 | 91 | 91 | 165 | 271 | 364 | 272 | 449 | 163 | 230 | 12 | 15 | 25 | 22 | 10 | 13 | 1 | 2 | 1 | 0 | 1 | 0 |
Nucleus | 82 | 227 | 181 | 185 | 207 | 194 | 230 | 355 | 203 | 303 | 112 | 136 | 176 | 279 | 286 | 213 | 104 | 86 | 77 | 225 | 162 | 105 | 157 | 154 |
Nuclear Periphery | 3 | 2 | 0 | 4 | 1 | 0 | 2 | 1 | 0 | 6 | 5 | 5 | 1 | 1 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 17 | 15 | 14 | 11 | 7 | 9 | 11 | 31 | 11 | 22 | 8 | 5 | 20 | 27 | 43 | 13 | 11 | 10 | 6 | 11 | 22 | 17 | 42 | 41 |
Peroxisomes | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 2 | 2 | 2 | 1 | 0 | 9 | 17 | 5 | 4 | 2 | 0 | 1 | 2 | 2 | 3 | 0 | 0 | 0 | 1 | 2 | 1 | 4 | 6 |
Vac/Vac Membrane | 2 | 5 | 3 | 0 | 0 | 2 | 3 | 4 | 2 | 4 | 1 | 2 | 4 | 3 | 4 | 3 | 2 | 2 | 3 | 7 | 17 | 4 | 16 | 22 |
Unique Cell Count | 90 | 253 | 218 | 221 | 248 | 264 | 364 | 542 | 336 | 532 | 206 | 271 | 211 | 344 | 394 | 237 | 130 | 98 | 91 | 255 | 218 | 134 | 235 | 244 |
Labelled Cell Count | 141 | 308 | 306 | 304 | 317 | 390 | 550 | 814 | 514 | 823 | 308 | 399 | 239 | 386 | 449 | 278 | 148 | 118 | 91 | 255 | 218 | 134 | 235 | 244 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.6 | 5.3 | 4.2 | 4.2 | 4.1 | 3.6 | 3.2 | 3.4 | 3.2 | 2.9 | 3.1 | 2.9 | 6.0 | 5.9 | 5.4 | 6.4 | 7.5 | 8.0 | 5.5 | 5.7 | 6.4 |
Std Deviation (1e-4) | 0.8 | 0.9 | 0.9 | 1.0 | 0.9 | 1.0 | 0.9 | 0.9 | 0.8 | 0.5 | 0.8 | 0.7 | 1.7 | 1.7 | 2.0 | 1.7 | 1.9 | 1.8 | 1.3 | 1.5 | 1.9 |
Intensity Change (Log2) | – | – | – | -0.03 | -0.05 | -0.22 | -0.41 | -0.3 | -0.38 | -0.52 | -0.44 | -0.52 | 0.51 | 0.48 | 0.36 | 0.61 | 0.82 | 0.91 | 0.37 | 0.43 | 0.59 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.3 | -1.0 | 0.4 | -0.6 | 0.3 | -1.0 | -1.4 | 0.4 | -0.3 | 2.5 | 3.6 | 5.3 | 0.6 | 1.5 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8.9 | -11.2 | -10.9 | -8.2 | -6.9 | -5.1 |
Nucleus | 0.2 | 0.1 | -2.5 | -5.1 | -4.8 | -5.6 | -6.8 | -6.4 | -7.6 | 0.1 | -0.6 | -2.9 | 2.1 | -0.7 | 1.1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.2 | 0.6 | 1.8 | -0.4 | 0.7 | 1.2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.3709 | 3.5175 | 3.3166 | 2.9178 | 2.3196 | 3.0952 | 2.1731 | 1.9854 | 2.163 | 2.1505 | 1.9334 | 2.2169 | 3.1693 | 3.7004 | 3.1769 | 3.4544 | 2.6173 | 3.2618 |
Actin | 0.0297 | 0 | 0.0051 | 0 | 0 | 0 | 0.0452 | 0 | 0.0066 | 0.0001 | 0.0001 | 0.0002 | 0.0108 | 0 | 0.0019 | 0.0037 | 0.0005 | 0.0022 |
Bud | 0.001 | 0.0001 | 0.0011 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0007 | 0 | 0 | 0 | 0.0019 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 |
Bud Neck | 0.0014 | 0.0002 | 0.0006 | 0.0001 | 0.001 | 0.0008 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0008 | 0.0007 | 0.0035 | 0.0001 | 0.0001 | 0.0008 | 0.0007 | 0.0009 |
Bud Periphery | 0.0042 | 0.0003 | 0.0026 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0.0012 | 0 | 0.0001 | 0 | 0.0048 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0001 |
Bud Site | 0.0012 | 0.0005 | 0.0026 | 0 | 0.0002 | 0.0001 | 0.0015 | 0 | 0.0024 | 0 | 0.0001 | 0.0001 | 0.0043 | 0 | 0.0003 | 0.0034 | 0.0001 | 0.0001 |
Cell Periphery | 0.002 | 0.0006 | 0.0004 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0015 | 0 | 0 | 0.0001 | 0 | 0.0001 |
Cytoplasm | 0.0029 | 0.0005 | 0.0041 | 0 | 0 | 0 | 0.0076 | 0.0006 | 0.001 | 0 | 0.0001 | 0.0001 | 0.0034 | 0 | 0.0002 | 0.0008 | 0.0002 | 0.0002 |
Cytoplasmic Foci | 0.002 | 0 | 0.0033 | 0 | 0 | 0 | 0.0133 | 0 | 0.0044 | 0.0008 | 0.0071 | 0.0023 | 0.0332 | 0 | 0.0013 | 0.0188 | 0.0001 | 0.0016 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0022 | 0 | 0.0052 | 0 | 0 | 0 | 0.0023 | 0 | 0.0014 | 0 | 0 | 0 | 0.0038 | 0 | 0.0001 | 0.0001 | 0.0002 | 0 |
Endosome | 0.021 | 0.0001 | 0.0056 | 0 | 0.0001 | 0 | 0.0107 | 0.0001 | 0.0073 | 0.0077 | 0.0023 | 0.0028 | 0.0149 | 0 | 0.001 | 0.0061 | 0.0009 | 0.0004 |
Golgi | 0.0042 | 0 | 0.0058 | 0 | 0 | 0 | 0.0032 | 0 | 0.0032 | 0.007 | 0.0009 | 0.0048 | 0.0052 | 0 | 0.002 | 0.0035 | 0.0001 | 0.0007 |
Lipid Particles | 0.0063 | 0 | 0.0025 | 0 | 0 | 0 | 0.0164 | 0 | 0.0018 | 0.0008 | 0.0208 | 0.0003 | 0.0249 | 0 | 0.0027 | 0.0108 | 0.0004 | 0.001 |
Mitochondria | 0.0043 | 0.0003 | 0.024 | 0.0001 | 0.0012 | 0.0001 | 0.001 | 0.0001 | 0.0025 | 0.018 | 0.0004 | 0.0007 | 0.0137 | 0.0001 | 0.0354 | 0.0022 | 0.0005 | 0.0002 |
None | 0.0029 | 0.0001 | 0.003 | 0 | 0.0001 | 0 | 0.011 | 0.0087 | 0.0005 | 0 | 0.0001 | 0 | 0.0018 | 0 | 0.0002 | 0.0006 | 0.0004 | 0.0001 |
Nuclear Periphery | 0.0259 | 0.0026 | 0.0052 | 0.0008 | 0.0009 | 0.0001 | 0.0045 | 0.0012 | 0.0009 | 0.0003 | 0.002 | 0.0012 | 0.031 | 0.0001 | 0.0041 | 0.0008 | 0.0695 | 0.0004 |
Nucleolus | 0.0286 | 0.0596 | 0.0245 | 0.0196 | 0.126 | 0.0765 | 0.0234 | 0.0218 | 0.0156 | 0.0119 | 0.1129 | 0.0607 | 0.1127 | 0.0462 | 0.0232 | 0.0264 | 0.1312 | 0.0761 |
Nucleus | 0.8278 | 0.9307 | 0.8914 | 0.9782 | 0.8657 | 0.9183 | 0.8201 | 0.963 | 0.9397 | 0.952 | 0.8375 | 0.9246 | 0.5625 | 0.953 | 0.914 | 0.9043 | 0.7783 | 0.9035 |
Peroxisomes | 0.0008 | 0 | 0.0022 | 0 | 0 | 0 | 0.0272 | 0 | 0.0086 | 0.0005 | 0.0049 | 0.0004 | 0.0522 | 0 | 0.0051 | 0.0154 | 0.0001 | 0.0111 |
Punctate Nuclear | 0.0114 | 0.0015 | 0.0042 | 0.001 | 0.0037 | 0.004 | 0.0104 | 0.0037 | 0.0009 | 0.0001 | 0.0094 | 0.0009 | 0.0255 | 0.0004 | 0.0077 | 0.0012 | 0.0158 | 0.0009 |
Vacuole | 0.015 | 0.0026 | 0.0057 | 0 | 0.0003 | 0.0001 | 0.0007 | 0.0003 | 0.0008 | 0.0003 | 0.0001 | 0.0001 | 0.0688 | 0 | 0.0002 | 0.0004 | 0.0002 | 0.0002 |
Vacuole Periphery | 0.005 | 0.0002 | 0.0011 | 0 | 0.0002 | 0 | 0.0004 | 0.0001 | 0.0003 | 0.0003 | 0.0001 | 0 | 0.0194 | 0 | 0.0002 | 0.0002 | 0.0008 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 28.0959 | 32.6183 | 31.9495 | 34.8795 | 28.8582 | 38.6561 | 38.5869 | 41.4026 | 33.3473 | 38.0608 |
Translational Efficiency | 0.6286 | 0.4473 | 0.2121 | 0.1973 | 0.4238 | 0.2922 | 0.297 | 0.1993 | 0.1598 | 0.257 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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