Standard name | |
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Human Ortholog | |
Description | Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 2 | 3 | 4 |
Bud | 0 | 0 | 0 | 1 | 0 | 1 | 0 | – | 6 | 2 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 12 | 5 | 3 | 5 | 12 | 19 |
Bud Neck | 0 | 1 | 2 | 0 | 4 | 0 | 3 | – | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 4 | 5 | 8 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 2 | 2 | – | 1 | 1 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 85 | 82 | 66 | 40 | 65 | 7 | 52 | – | 28 | 57 | 12 | 20 | 119 | 248 | 230 | 38 | 43 | 34 | 64 | 62 | 47 | 71 | 200 | 177 |
Endoplasmic Reticulum | 0 | 5 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10 | 5 | 12 | 1 | 0 | 1 | 1 | 6 | 3 |
Endosome | 35 | 11 | 10 | 4 | 8 | 0 | 3 | – | 0 | 0 | 0 | 0 | 42 | 55 | 38 | 14 | 12 | 4 | 17 | 16 | 6 | 8 | 17 | 16 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 5 | 1 | 6 | 2 | 0 | 4 | 2 | 4 |
Mitochondria | 46 | 33 | 8 | 6 | 6 | 26 | 41 | – | 93 | 93 | 66 | 64 | 4 | 3 | 0 | 9 | 5 | 8 | 13 | 16 | 12 | 20 | 31 | 22 |
Nucleus | 84 | 96 | 52 | 31 | 39 | 19 | 63 | – | 51 | 53 | 40 | 40 | 38 | 48 | 47 | 106 | 115 | 87 | 141 | 148 | 68 | 19 | 17 | 17 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 4 | 1 | 0 | 2 | 0 | 2 |
Nucleolus | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 3 | 1 | 1 | 10 | 4 | 2 | 1 | 1 | 3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 3 | 2 | 0 | 3 | 9 | 0 | 8 | – | 4 | 4 | 3 | 0 | 1 | 2 | 0 | 5 | 2 | 3 | 32 | 25 | 10 | 13 | 29 | 19 |
Vac/Vac Membrane | 136 | 145 | 22 | 13 | 30 | 1 | 15 | – | 3 | 5 | 5 | 3 | 92 | 159 | 157 | 44 | 61 | 45 | 112 | 120 | 55 | 51 | 58 | 74 |
Unique Cell Count | 329 | 328 | 145 | 89 | 149 | 46 | 162 | 148 | 171 | 97 | 102 | 263 | 463 | 412 | 200 | 222 | 170 | 439 | 419 | 222 | 218 | 401 | 391 | |
Labelled Cell Count | 391 | 375 | 160 | 98 | 163 | 56 | 187 | 190 | 219 | 131 | 134 | 296 | 519 | 475 | 236 | 252 | 196 | 439 | 419 | 222 | 218 | 401 | 391 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.4 | 4.5 | 5.2 | 4.8 | 5.3 | 3.5 | 4.3 | – | 3.7 | 4.1 | 3.5 | 4.0 | 5.5 | 5.5 | 5.6 | 7.1 | 7.6 | 7.0 | 4.8 | 4.7 | 4.9 |
Std Deviation (1e-4) | 1.1 | 0.7 | 1.2 | 0.8 | 1.7 | 0.7 | 1.1 | – | 1.2 | 1.7 | 0.7 | 1.5 | 1.5 | 1.6 | 1.9 | 1.7 | 2.0 | 1.9 | 1.8 | 1.6 | 1.9 |
Intensity Change (Log2) | – | – | – | -0.11 | 0.04 | -0.57 | -0.27 | – | -0.47 | -0.33 | -0.55 | -0.37 | 0.08 | 0.09 | 0.12 | 0.46 | 0.55 | 0.44 | -0.12 | -0.13 | -0.08 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 1.6 | 2.8 | 2.4 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.3395 | -0.9479 | -1.2177 | -1.5875 | -1.4289 | -1.2398 | 0.7818 | 0.8977 | 0.6643 | 1.4862 | 0.2004 | 1.2091 | 2.6555 | 3.2192 | 3.3157 | 2.876 | 3.0606 | 3.4961 |
Actin | 0.0158 | 0.0005 | 0.0031 | 0.0011 | 0.0051 | 0.0009 | 0.0159 | 0.0009 | 0.0015 | 0.0049 | 0.0006 | 0.0022 | 0.0003 | 0.0004 | 0.0003 | 0.0003 | 0.0004 | 0.0003 |
Bud | 0.0003 | 0.0001 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0.0004 | 0.0042 | 0.0053 | 0.0009 | 0.0006 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0006 |
Bud Neck | 0.0014 | 0.0019 | 0.0013 | 0.0146 | 0.0073 | 0.0029 | 0.0022 | 0.0012 | 0.0007 | 0.0085 | 0.0013 | 0.0055 | 0.0018 | 0.0007 | 0.0009 | 0.0017 | 0.0009 | 0.0043 |
Bud Periphery | 0.0004 | 0.0001 | 0.0022 | 0.0001 | 0.0006 | 0.0001 | 0.0005 | 0.0014 | 0.0015 | 0.001 | 0.0008 | 0.0023 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0002 |
Bud Site | 0.0009 | 0.0045 | 0.0011 | 0.0007 | 0.0016 | 0.0003 | 0.0049 | 0.0067 | 0.0036 | 0.0126 | 0.0006 | 0.0037 | 0.0021 | 0.0016 | 0.0006 | 0.0008 | 0.0001 | 0.0002 |
Cell Periphery | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0 | 0.0003 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 |
Cytoplasm | 0.1609 | 0.1771 | 0.113 | 0.0698 | 0.0765 | 0.1061 | 0.1207 | 0.2429 | 0.2132 | 0.1902 | 0.3902 | 0.1191 | 0.1634 | 0.135 | 0.0945 | 0.0766 | 0.1355 | 0.0966 |
Cytoplasmic Foci | 0.0207 | 0.0091 | 0.0113 | 0.0087 | 0.0072 | 0.0126 | 0.0656 | 0.0137 | 0.0203 | 0.0412 | 0.0226 | 0.0066 | 0.0116 | 0.0035 | 0.0117 | 0.0034 | 0.0058 | 0.0042 |
Eisosomes | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0056 | 0.0075 | 0.0053 | 0.0015 | 0.006 | 0.003 | 0.0059 | 0.0062 | 0.0071 | 0.0018 | 0.0039 | 0.0049 | 0.0039 | 0.0041 | 0.0033 | 0.0058 | 0.0028 | 0.0018 |
Endosome | 0.0149 | 0.0093 | 0.0209 | 0.0057 | 0.0345 | 0.0091 | 0.0375 | 0.0073 | 0.0227 | 0.08 | 0.0073 | 0.0092 | 0.0068 | 0.0037 | 0.0088 | 0.005 | 0.0026 | 0.003 |
Golgi | 0.0031 | 0.0003 | 0.0033 | 0.0036 | 0.0032 | 0.0009 | 0.0115 | 0.0003 | 0.003 | 0.0323 | 0.0003 | 0.0008 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 |
Lipid Particles | 0.0053 | 0.0017 | 0.0109 | 0.0109 | 0.0204 | 0.0042 | 0.0444 | 0.001 | 0.0022 | 0.0191 | 0.0005 | 0.0043 | 0.0009 | 0.0003 | 0.0025 | 0.0005 | 0.0006 | 0.0003 |
Mitochondria | 0.0028 | 0.001 | 0.0046 | 0.0173 | 0.003 | 0.0016 | 0.0107 | 0.0011 | 0.0027 | 0.0096 | 0.0009 | 0.0027 | 0.0008 | 0.0005 | 0.0081 | 0.0012 | 0.0005 | 0.0005 |
None | 0.1893 | 0.2249 | 0.1605 | 0.1927 | 0.1253 | 0.1328 | 0.2804 | 0.2943 | 0.2734 | 0.2697 | 0.1697 | 0.1981 | 0.246 | 0.2716 | 0.2369 | 0.2826 | 0.3208 | 0.2201 |
Nuclear Periphery | 0.0436 | 0.0542 | 0.0562 | 0.0191 | 0.0948 | 0.0231 | 0.02 | 0.0272 | 0.0351 | 0.0072 | 0.0119 | 0.0263 | 0.0174 | 0.0156 | 0.0213 | 0.0363 | 0.0113 | 0.0091 |
Nucleolus | 0.0064 | 0.0075 | 0.0097 | 0.0095 | 0.0302 | 0.0124 | 0.0045 | 0.0055 | 0.0051 | 0.0031 | 0.0032 | 0.0108 | 0.0061 | 0.0058 | 0.0088 | 0.013 | 0.0041 | 0.0092 |
Nucleus | 0.4255 | 0.4271 | 0.5117 | 0.4769 | 0.4915 | 0.6057 | 0.2916 | 0.3442 | 0.3216 | 0.2865 | 0.2911 | 0.5386 | 0.4692 | 0.5298 | 0.516 | 0.493 | 0.4677 | 0.6032 |
Peroxisomes | 0.0032 | 0.0002 | 0.0064 | 0.0066 | 0.0039 | 0.0006 | 0.0312 | 0.0005 | 0.0076 | 0.014 | 0.003 | 0.001 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 |
Punctate Nuclear | 0.0948 | 0.0674 | 0.0701 | 0.1592 | 0.0794 | 0.0807 | 0.0417 | 0.0344 | 0.0673 | 0.0116 | 0.0865 | 0.057 | 0.0653 | 0.0243 | 0.0823 | 0.0749 | 0.0452 | 0.0443 |
Vacuole | 0.0036 | 0.0041 | 0.0053 | 0.0013 | 0.0056 | 0.002 | 0.0085 | 0.0059 | 0.0048 | 0.0041 | 0.0044 | 0.0046 | 0.0029 | 0.0024 | 0.0025 | 0.0031 | 0.0011 | 0.0014 |
Vacuole Periphery | 0.0014 | 0.0011 | 0.0023 | 0.0006 | 0.0031 | 0.0006 | 0.0014 | 0.0008 | 0.0011 | 0.0013 | 0.0004 | 0.0012 | 0.0005 | 0.0003 | 0.0005 | 0.0011 | 0.0002 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.6786 | 16.3037 | 19.1553 | 20.7547 | 9.8527 | 28.861 | 16.4847 | 19.4706 | 24.9248 | 17.8573 |
Translational Efficiency | 0.4012 | 0.4782 | 0.4497 | 0.5707 | 0.7501 | 0.3746 | 0.3013 | 0.4119 | 0.4516 | 0.4536 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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