Standard name | |
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Human Ortholog | |
Description | Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | – | 0 | 0 | 1 | 0 | 2 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | 0 | 1 | 0 | 0 | 1 | 0 | 3 | 6 | – | 4 | 1 | 1 | 2 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 4 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 1 | 3 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 22 | 43 | 110 | 110 | 227 | 355 | 394 | 505 | – | 350 | 190 | 412 | 132 | 197 | – | 56 | 36 | 31 | 2 | 6 | 7 | 16 | 30 | 29 |
Endoplasmic Reticulum | 1 | 8 | 0 | 0 | 14 | 10 | 14 | 9 | – | 3 | 1 | 6 | 6 | 19 | – | 18 | 19 | 12 | 1 | 1 | 8 | 1 | 3 | 7 |
Endosome | 3 | 1 | 7 | 5 | 9 | 10 | 4 | 9 | – | 3 | 0 | 1 | 1 | 5 | – | 10 | 4 | 6 | 0 | 6 | 0 | 3 | 3 | 6 |
Golgi | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | – | 1 | 2 | 1 | 0 | 0 | – | 4 | 4 | 4 | 0 | 1 | 0 | 1 | 2 | 1 |
Mitochondria | 4 | 12 | 8 | 8 | 8 | 8 | 6 | 10 | – | 39 | 7 | 15 | 0 | 0 | – | 5 | 1 | 0 | 3 | 6 | 1 | 0 | 3 | 6 |
Nucleus | 18 | 11 | 16 | 16 | 0 | 11 | 26 | 50 | – | 34 | 10 | 21 | 9 | 0 | – | 142 | 114 | 74 | 2 | 14 | 2 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | – | 1 | 1 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
Nucleolus | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 1 | 1 | 0 | 0 | – | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | – | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 2 |
Vac/Vac Membrane | 60 | 63 | 116 | 123 | 133 | 272 | 429 | 645 | – | 281 | 140 | 305 | 36 | 28 | – | 283 | 269 | 201 | 94 | 100 | 189 | 150 | 224 | 262 |
Unique Cell Count | 90 | 122 | 212 | 212 | 347 | 564 | 698 | 1029 | 582 | 301 | 645 | 168 | 239 | 409 | 372 | 271 | 109 | 148 | 212 | 182 | 280 | 332 | ||
Labelled Cell Count | 109 | 140 | 258 | 263 | 393 | 668 | 878 | 1241 | 717 | 353 | 766 | 188 | 254 | 521 | 450 | 332 | 109 | 148 | 212 | 182 | 280 | 332 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.1 | 6.4 | 6.1 | 6.1 | 8.6 | 8.6 | 8.3 | 8.9 | – | 7.3 | 8.9 | 8.9 | 6.5 | 6.9 | – | 12.7 | 12.9 | 12.7 | 7.1 | 7.1 | 7.0 |
Std Deviation (1e-4) | 1.5 | 1.9 | 2.0 | 2.0 | 2.4 | 2.3 | 2.2 | 2.4 | – | 3.3 | 2.9 | 2.9 | 1.2 | 1.8 | – | 3.8 | 4.0 | 3.9 | 1.7 | 1.8 | 1.6 |
Intensity Change (Log2) | – | – | – | 0.0 | 0.49 | 0.48 | 0.43 | 0.53 | – | 0.26 | 0.54 | 0.54 | 0.09 | 0.17 | – | 1.05 | 1.07 | 1.05 | 0.22 | 0.22 | 0.18 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Cytoplasm | 0 | 3.2 | 2.8 | 1.2 | -0.7 | – | 2.1 | 2.5 | 3.1 | 5.4 | 6.9 | – | -10.2 | -11.3 | -9.7 |
Endoplasmic Reticulum | 0 | 3.0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 4.2 | – | 3.1 | 3.3 | 3.1 |
Endosome | -0.6 | -0.5 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | -0.8 | – | -0.6 | 0 | -0.7 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Mitochondria | 0 | -1.0 | 0 | 0 | 0 | – | 1.5 | -1.0 | -1.1 | 0 | 0 | – | 0 | 0 | 0 |
Nucleus | 0 | -5.2 | -3.8 | -2.3 | -1.6 | – | -0.9 | -2.1 | -2.7 | -0.9 | -4.3 | – | 7.4 | 6.5 | 5.5 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 |
Vacuole | 0.7 | -3.8 | -1.6 | 1.8 | 2.2 | – | -1.6 | -1.8 | -1.9 | -6.6 | -9.8 | – | 3.6 | 4.3 | 4.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.1962 | 1.0703 | 0.6933 | 0.4051 | 0.8886 | 0.7949 | 0.3613 | 1.6794 | 0.9709 | 0.2758 | 0.8925 | 1.2271 | -0.0935 | 0.7171 | -0.2211 | -0.1773 | 0.025 | -0.0474 |
Actin | 0.019 | 0.0001 | 0.002 | 0.0015 | 0.0324 | 0.0002 | 0.0124 | 0.0028 | 0.0011 | 0.0039 | 0.0315 | 0.0012 | 0.0098 | 0 | 0.0003 | 0.0001 | 0.0233 | 0 |
Bud | 0.0022 | 0.0049 | 0.0049 | 0.0006 | 0.0124 | 0.0005 | 0.0007 | 0.0017 | 0.0033 | 0.0012 | 0.001 | 0.0003 | 0.0002 | 0.0009 | 0.0006 | 0.0006 | 0.0002 | 0.0002 |
Bud Neck | 0.0017 | 0.0015 | 0.0005 | 0.0045 | 0.0034 | 0.0014 | 0.0025 | 0.0019 | 0.0012 | 0.0015 | 0.0018 | 0.0015 | 0.0009 | 0.0003 | 0.0009 | 0.0003 | 0.0004 | 0.0017 |
Bud Periphery | 0.0018 | 0.0011 | 0.0049 | 0.0015 | 0.0057 | 0.0007 | 0.0011 | 0.0022 | 0.006 | 0.0026 | 0.0022 | 0.0011 | 0.0004 | 0.0021 | 0.0008 | 0.001 | 0.0003 | 0.0004 |
Bud Site | 0.0156 | 0.0037 | 0.0103 | 0.0032 | 0.0062 | 0.0008 | 0.0064 | 0.0036 | 0.0042 | 0.0023 | 0.0026 | 0.0005 | 0.0013 | 0.0018 | 0.0035 | 0.0006 | 0.0004 | 0.0003 |
Cell Periphery | 0.0014 | 0.0016 | 0.0005 | 0.0006 | 0.0009 | 0.0006 | 0.0023 | 0.0012 | 0.0011 | 0.0012 | 0.0014 | 0.0019 | 0.0014 | 0.001 | 0.0012 | 0.0003 | 0.0004 | 0.0009 |
Cytoplasm | 0.1177 | 0.1764 | 0.1279 | 0.1358 | 0.1124 | 0.1365 | 0.116 | 0.0895 | 0.0969 | 0.0715 | 0.0549 | 0.1145 | 0.1436 | 0.2676 | 0.1893 | 0.1045 | 0.1427 | 0.2421 |
Cytoplasmic Foci | 0.0426 | 0.0317 | 0.0667 | 0.0826 | 0.0639 | 0.046 | 0.0627 | 0.0225 | 0.0353 | 0.0365 | 0.0348 | 0.0365 | 0.0312 | 0.0349 | 0.0524 | 0.0317 | 0.0827 | 0.0368 |
Eisosomes | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0005 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0005 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0205 | 0.0236 | 0.0162 | 0.0082 | 0.0039 | 0.0142 | 0.035 | 0.0245 | 0.0333 | 0.0081 | 0.0413 | 0.036 | 0.0776 | 0.0359 | 0.0296 | 0.0047 | 0.0192 | 0.0209 |
Endosome | 0.1013 | 0.1305 | 0.2217 | 0.1907 | 0.2099 | 0.2146 | 0.1876 | 0.1675 | 0.2026 | 0.211 | 0.2013 | 0.1925 | 0.1796 | 0.123 | 0.2088 | 0.216 | 0.2763 | 0.1275 |
Golgi | 0.0068 | 0.0024 | 0.013 | 0.018 | 0.0509 | 0.0035 | 0.0074 | 0.0028 | 0.0047 | 0.0085 | 0.0026 | 0.0029 | 0.0035 | 0.0014 | 0.0032 | 0.0024 | 0.0079 | 0.0008 |
Lipid Particles | 0.0343 | 0.0098 | 0.0189 | 0.013 | 0.0534 | 0.012 | 0.0342 | 0.0042 | 0.0167 | 0.0108 | 0.0038 | 0.0122 | 0.0226 | 0.008 | 0.0106 | 0.014 | 0.0255 | 0.0036 |
Mitochondria | 0.0046 | 0.0026 | 0.0263 | 0.0135 | 0.0467 | 0.0104 | 0.0155 | 0.0042 | 0.0119 | 0.0175 | 0.0018 | 0.0103 | 0.0063 | 0.0012 | 0.0073 | 0.0012 | 0.0018 | 0.0006 |
None | 0.3715 | 0.3161 | 0.2724 | 0.3503 | 0.118 | 0.203 | 0.2094 | 0.1835 | 0.1814 | 0.1173 | 0.1132 | 0.0905 | 0.218 | 0.2408 | 0.1589 | 0.293 | 0.0727 | 0.1611 |
Nuclear Periphery | 0.0112 | 0.0132 | 0.0117 | 0.0074 | 0.0092 | 0.0068 | 0.0277 | 0.0227 | 0.0203 | 0.017 | 0.0074 | 0.0268 | 0.0381 | 0.0143 | 0.0147 | 0.0063 | 0.0163 | 0.0084 |
Nucleolus | 0.0014 | 0.002 | 0.0014 | 0.0072 | 0.0053 | 0.0013 | 0.0031 | 0.0019 | 0.0027 | 0.0016 | 0.0022 | 0.0017 | 0.0016 | 0.0022 | 0.0017 | 0.0006 | 0.0006 | 0.0008 |
Nucleus | 0.005 | 0.0067 | 0.0043 | 0.012 | 0.0068 | 0.0061 | 0.011 | 0.0099 | 0.0079 | 0.0092 | 0.0056 | 0.0151 | 0.011 | 0.0053 | 0.0101 | 0.0037 | 0.0027 | 0.0075 |
Peroxisomes | 0.0208 | 0.002 | 0.0068 | 0.0064 | 0.0585 | 0.0025 | 0.0063 | 0.0004 | 0.0062 | 0.0123 | 0.0037 | 0.0031 | 0.0022 | 0.0005 | 0.0011 | 0.0003 | 0.0468 | 0.0002 |
Punctate Nuclear | 0.0102 | 0.0011 | 0.0062 | 0.0035 | 0.0052 | 0.0031 | 0.0115 | 0.0009 | 0.0018 | 0.0011 | 0.0008 | 0.0019 | 0.0075 | 0.0043 | 0.0013 | 0.0007 | 0.0187 | 0.0009 |
Vacuole | 0.1931 | 0.2532 | 0.1579 | 0.1298 | 0.1683 | 0.3094 | 0.2208 | 0.4035 | 0.3221 | 0.3845 | 0.4296 | 0.3977 | 0.2194 | 0.2317 | 0.268 | 0.2767 | 0.2315 | 0.3548 |
Vacuole Periphery | 0.017 | 0.0156 | 0.0251 | 0.0097 | 0.0261 | 0.0265 | 0.0258 | 0.0485 | 0.0393 | 0.0803 | 0.0566 | 0.0517 | 0.0232 | 0.0226 | 0.0356 | 0.041 | 0.0296 | 0.0306 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 15.0359 | 16.543 | 20.7151 | 28.9392 | 21.7441 | 11.5597 | 32.6692 | 32.4568 | 37.1992 | 32.5903 |
Translational Efficiency | 1.1644 | 0.8115 | 0.8642 | 0.9091 | 0.7558 | 2.448 | 0.7965 | 0.8731 | 1.0132 | 0.7947 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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